Articles tagged with Drug Targets
Scientists develop 'smart' polymer drug carriers that target diseased cells, improving treatment outcomes for cancer, AIDS, and other diseases. The technology also enables controlled release of drugs over days, weeks, or years.
Researchers have identified 156 probable membrane proteins that could serve as new drug targets to combat antibiotic-resistant salmonella. The study also revealed two previously unknown gene clusters required for producing hair-like strands on the bacteria's surface.
Researchers found that 60% of patients received first-line antibiotics and had a 90.1% success rate, while those who received second-line antibiotics had a similar 90.8% success rate but were more expensive.
Researchers developed a new technique that can target aerosol particles to smaller, harder-to-reach airways in the lungs of people with cystic fibrosis. The method uses fine particles and varying inhalation rates to direct the spray to different areas of the lungs.
Phase I clinical trials show CCI-779's potential as a cancer treatment, inhibiting tumor growth with minimal side effects. The drug targets the mTOR pathway, which may selectively arrest the development of certain cancer cells.
Researchers have discovered two targets for a new generation of cholesterol-lowering drugs that should allow greater precision in managing cholesterol levels. A key compound, LG268, has been shown to completely block the absorption of cholesterol in mice, while also enhancing the production of reverse cholesterol transporters.
Researchers at UNC-CH have developed a gene therapy method that targets specific types of cells, avoiding the less effective 'shotgun' approach. The technique successfully corrects genetic defects in primitive stem cells, which can be used to treat inherited blood disorders like hemophilia and non-inherited illnesses such as cancer.
A nationwide study found that 62% of patients with high cholesterol did not reach recommended targets, with African-Americans facing even greater challenges. Patients who followed doctors' advice on diet and exercise were more likely to reach target levels.
A Johns Hopkins study found that in 83 neighborhood stores, 86% of African-American and white teen buyers successfully purchased cigarettes, often with seductive advertisements targeting minors. The researchers suggest strengthening public awareness of tobacco's health hazards to prevent teen smoking.