Articles tagged with Drug Targets
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A study by Yale researchers found that a specific transporter gene, SLC26A6, helps prevent calcium oxalate kidney stones. The gene's normal functioning reduces dietary oxalate absorption and increases excretion, thus reducing the risk of kidney stone formation.
Researchers at Georgia Institute of Technology have developed an algorithm that creates accurate three-dimensional models of over 900 GPCRs, a class of proteins targeted by many drugs. These models could help scientists discover new drug compounds more efficiently, and are now freely available to noncommercial users.
Researchers have discovered a functional interaction between the genes MECP2 and BDNF, which could lead to new therapeutic opportunities for Rett syndrome patients. By modulating BDNF expression, it may be possible to delay or reverse disease progression.
A study published in Psychopharmacology found that genetics and environmental factors contribute to the relapse of drug-seeking behavior. The research used rat models to identify glutamate as a neurotransmitter involved in stirring cravings and uncontrollable urges. Dr. Paul J. Kruzich suggests that genetic variations may increase susc...
DrugBank is the world's largest database on drugs and drug targets, providing detailed information on over 3000 drug targets and 4100 approved or experimental drugs. The database supports advanced searches and queries for biologists and chemists, enabling them to discover new drug leads.
Riboswitches are RNA elements that control gene expression in essential metabolic pathways. Researchers at Yale University have identified pyrithiamine as a toxic compound that disrupts these pathways, leading to the development of new antibiotics.
The IUPHAR database provides comprehensive information on GPCRs, including drugs that act on them, target locations in the body, and diseases they may be involved in. This knowledge is freely available to all scientists and drug discoverers worldwide, offering a powerful tool for future research.
A Brandeis University study advances understanding of protein dynamics, proposing that enzymes are more mobile than previously thought. The research linked low-energy and high-energy states to enzyme function, shedding light on improving rational drug design through docking to dynamic targets.
A new report by Express Scripts, Inc. found that U.S. consumers could have saved $20 billion in 2004 by using more generic drugs, with the most dramatic savings potential existing for generic gastrointestinals and anti-cholesterol medications.
Researchers have defined the structure of marine toxins and found they interact with actin, a key protein responsible for cellular growth. The toxins can disrupt actin's activity, leading to cancer cell death, offering new hope for targeted cancer treatments.
A study by John Scott found that the mAKAP signaling system is perturbed in cases of heart disease, leading to cardiomyocyte hypertrophy. Researchers have identified a potential therapeutic target for treating this condition by suppressing the enzyme phosphodiesterase with drugs such as growth hormone.
A recent study reveals that managed care drug cost-control strategies are failing due to flawed contracts and inadequate information sharing between HMOs and doctors. The survey found widespread dissatisfaction with the current approach, which relies on financial incentives to control prescribing practices. The researchers propose thre...
Researchers at Rutgers University have identified the protein snapin as having therapy potential for autism by modulating dendrite patterning. Snapin's interaction with cypin regulates branching, and targeting this pathway could lead to new drugs.
A new drug, CX717, has been shown to reverse the negative effects of sleep deprivation on brain activity and performance in monkeys. The drug targets AMPA receptors involved in cell-to-cell communication, restoring normal brain patterns and improving cognitive function.
Researchers at NIA discover new gene FANCM linked to Fanconi anemia and increased cancer risk. The gene plays crucial role in DNA repair machinery, offering potential targets for treatment.
Researchers found that gefitinib was more effective at inhibiting cell growth and increasing apoptosis in NSCLC cells with mutant EGFR. In contrast, cetuximab showed no significant response in patients with EGFR mutations.
Retinoid X receptor heterodimers are potential therapeutic targets for metabolic syndrome, according to a review article by UT Southwestern's Dr. David Mangelsdorf and Dr. Andrew Shulman. Activating specific RXR complexes may help regulate lipid metabolism and reduce the risk of heart disease and other related illnesses.
The sequencing of three deadly parasite genomes has revealed a core of 6,200 genes in common among the parasites, providing new targets for drug development. This discovery also highlights the potential for designing targeted vaccines and improved diagnostics for each parasite.
Scientists have sequenced the genomes of three parasites responsible for sleeping sickness, Chagas disease, and leishmaniasis, providing critical information for drug and vaccine development. The research identified core genes that could serve as targets for effective drugs against all three parasites.
Researchers at Vanderbilt University have identified a DNA polymorphism that interferes with the binding of antiarrhythmic drugs to a specific ion channel in the heart. This structural change allows for variable drug access to its target site, leading to increased drug resistance in some individuals.
Researchers explore bacterial cooperation as a therapeutic target to combat antibiotic-resistant infections. By understanding how bacteria collaborate, scientists hope to develop novel treatments that can effectively target these complex interactions.
The WEHI team will conduct research on parasite behavior, drug targets, and vaccine development to combat malaria and leishmaniasis. The ultimate goal is to prevent infection or reduce illness severity with effective treatments.
Gene amplification is a common process in cancer cells that can lead to increased production of genes like MITF, which regulates tissue development and tumor progression. Researchers found an over-expression of MITF in melanoma tissue microarrays using the AQUA technology, correlating with decreased patient survival.
A recent study conducted by Johns Hopkins Bloomberg School of Public Health reveals high rates of sexually transmitted infections among young drug users. The study found that nearly 73% of participants were injection drug users and that women were more likely to have syphilis than men.
A new mechanism controlling cholesterol and lipid metabolism has been discovered, with the Fbw7 protein identified as a potential target for treating high cholesterol. The findings also suggest a connection between this protein and cancer, with aspects of its link to diabetes currently under investigation.
Researchers at Mayo Clinic have developed a new treatment for recurrent glioblastoma multiforme, a form of adult brain cancer with dismal prognosis. The 'smart' drug CCI-779 showed significant response in 36 percent of patients, suggesting potential improvement in treatment outcomes.
Researchers have discovered that the enzyme hDOT1L activates a key set of genes in acute myeloid leukemia (AML), leading to unrestrained growth and a hallmark of the disease. The study suggests that targeting hDOT1L could be a promising approach for treating AML, particularly in cases where patients carry specific genetic mutations.
Researchers have reported encouraging results with the novel drug AMN107, which is showing an increasingly strong benefit as doses are raised. Over 90% of patients with earlier stage Chronic Myeloid Leukemia (CML) have achieved a hematologic response, and over 70% of those in advanced stages have also benefited.
Researchers discovered NAADP, a natural molecule with potential as an obesity treatment, that works in cells to regulate satiety. The study found NAADP levels increased rapidly and selectively in response to cholecystokinin, a hormone controlling digestion and appetite.
Researchers discovered that sirtuin1 and PGC1-alpha proteins interact to trigger glucose production in the liver. Targeting this interaction could help control sugar production in people with diabetes, potentially leading to new treatment options.
Parents can significantly boost their credibility in drug talks with teens by offering personal examples of how drugs affected them or their loved ones. Regular communication and ongoing socialization efforts are key to helping teens make healthy lifestyle choices, including avoiding peer pressure and drinking safely.
Researchers found four distinct regions in the human progesterone receptor gene that influence hormone responsiveness. These findings challenge the long-held model of estrogen receptor binding and transcription regulation, suggesting a more complex and tissue-specific process.
Researchers have discovered a novel way to block the smallpox virus by targeting a cellular signaling pathway. The approach, which uses an experimental drug called CI-1033, significantly impaired the production of new virus particles and spread of the virus in infected cells.
A new study from the University of Pennsylvania School of Medicine suggests that PPARã can turn genes both on and off. By targeting this ability to turn off genes without affecting others, researchers may develop drugs called SPPARMs that decrease TZD-related side effects.
Researchers found that statins may break down toxic amyloid-beta by inhibiting the Rho/ROCK pathway, which could lead to new anti-amyloid drug targets. The study suggests that statins may be a promising strategy in treating Alzheimer's disease.
Scientists have identified a key mechanism by which botulinum neurotoxin recognizes and attacks specific nerve cell proteins. The discovery reveals an extensive interaction between the toxin and its target, known as exosites, enabling high specificity.
A new immunosuppression protocol has significantly reduced the need for anti-rejection medications in intestinal transplant patients, resulting in a 96% one-year survival rate. The study showed that 69% of patients are taking a single dose of immunosuppression, and none experienced chronic rejection.
UT Austin researchers found that fruit fly exposure to benzyl alcohol increases slo gene activity, leading to tolerance and increased resistance. This study provides potential targets for anti-addiction drugs.
Researchers design medication that corrects abnormal brain functions in targeted areas, reducing side effects found in existing medications. The new type of drug could be available within five to 10 years and has the potential to improve treatment options for Canadians affected by psychiatric disorders.
Researchers at NYU discovered a gene mutation, Lmo, that increases sensitivity to cocaine in fruit flies. The mutation affects the fly's internal clock, modulating sensitivity to cocaine within its cells.
Researchers found that ultrasound therapy increased clot clearance by 26% compared to tPA alone, with 70% of patients experiencing complete or partial clearance. The study used a hand-held extracranial ultrasound device to deliver heavy doses of the clot-busting drug tPA directly to blood clots.
Researchers found evidence that HIV co-opts human enzyme DDX3 to transport its genetic material out of the cell nucleus. The discovery provides an attractive target for drug development and could lead to a new type of HIV drug that blocks viral replication without causing harm to human cells.
A study using antibody microarrays measured levels of over 500 proteins in tissue samples from patients with epilepsy and Alzheimer's disease, identifying increased signal transduction proteins as a possible new target for treatment. This discovery could lead to the development of new medications for these conditions.
Researchers found an enzymatic pathway called Rho/ROCK plays a key role in the metabolism of APP, which is associated with Alzheimer's. The discovery may lead to novel anti-amyloid drugs and more specific therapies for Alzheimer's patients.
Basic research on HIV is leading to new therapies that deny initial entry into cells. Fast-moving research on naturally occurring antiviral factors is opening the way for a new class of anti-HIV drugs.
The study found that increasing neuronal activity in the region enhances flinch responses, while decreasing activity reduces sustained defensive movements. This suggests the polysensory zone is a hotspot for processing specific stimuli related to body defense.
The report recommends the development of antiviral drugs against smallpox due to its high lethality and ease of transmission. Research on poxvirus mechanisms and animal models is crucial to understand how the virus kills and develop effective treatments without using antiviral drugs.
Researchers at Rice University have received a four-year, $1.1 million grant to develop a fruit fly model for neurofibromatosis and test key proteins as potential drug targets. The team aims to understand how signaling proteins regulate NF tumor growth.
Researchers have made progress in understanding the mechanisms of HIV drug resistance, particularly with tenofovir and the DAPY compounds. These drugs approach the problem of resistance in different ways, targeting reverse transcriptase enzyme or molecular machine used by the AIDS virus.
Researchers found that platelets can promote diabetic complications and contribute to inflammation in heart disease. They discovered a common Type II diabetes drug can dampen platelet inflammatory activity, potentially leading to new treatments for vascular diseases.
A study by Imperial College London calls for targeted health education campaigns for HCV among injecting drug users, citing a lack of awareness and risk of transmission. The researchers found that many users share paraphernalia, leading to under-reported cases.
A new study finds that cephalosporin drugs are more effective in treating strep throat than penicillin, with a superior bacterial cure rate. First-generation cephalosporin drugs offer the same narrow-spectrum effect as penicillin at comparable costs.
A new study suggests that male circumcision may protect against HIV-1 infection by removing the foreskin's high density of specific cellular targets. The study found a highly significant and specific protective effect of male circumcision on HIV-1 acquisition rates, but no protective effect against other STIs.
The completed genome sequence of Cryptosporidium parvum provides new insights into the parasite's genetic makeup and biochemical pathways. This information can be used to develop early diagnosis, prevention, and treatment strategies for humans and animals affected by the parasite.
Researchers use computer methods and electron microscopy to understand how molecular machines interact and work together in cells. By building assembly plans for individual machines, they can connect them to form a network, providing insights into cellular structures and functions.
A combination of two existing drugs, rapamycin and doxorubicin, was found to be effective in treating cancer by restoring a natural cell death mechanism and triggering programmed cell death. The treatment led to complete remission in mouse models of B-cell lymphoma.
Researchers have identified orlistat as an inhibitor of fatty acid synthase, a key enzyme in cancer cell metabolism. This discovery holds promise for developing new treatments for prostate, breast, and colon cancers by inhibiting the enzyme's activity with orlistat.
A team of biologists has discovered that the parasite relies on salvage enzymes to steal nutrients from its host to survive. This discovery provides new targets for drugs designed to treat victims of this parasitic disease, which causes chronic severe diarrhea and life-threatening complications in AIDS patients.
Researchers developed ultrasound-guided liposomes to boost imaging and target drug/gene therapy. The technique directs liposomes to specific targets, such as atherosclerotic plaques or blood clots, and releases drugs with ultrasonic pulses, improving visualization and diagnosis of arterial conditions.
A Stanford team has developed a simplified method for generating siRNA molecules to disable genes, overcoming the technique's limitations in expense and labor. The new protocol allows researchers to create libraries of siRNA molecules for all known genes, enabling the identification of genes that play critical roles in stem cell function.