Researchers identified five immunomodulatory proteins in Borrelia recurrentis that prevent activation of the human complement system, allowing the pathogen to survive in the human body. These Chi proteins also convert plasminogen into active plasmin, giving Borrelia recurrentis a significant advantage in spreading after infection.
SourceGoethe University Frankfurt·JournalNature Communications·TypeExperimental study·DateJun 10, 2026
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Researchers at the University of Göttingen have developed a new method to make biomolecules glow in real-time, eliminating unwanted signals in microscopy. This approach ensures only labelled biological molecules emit fluorescence, making experiments clearer and easier to interpret.
SourceUniversity of Göttingen·JournalAngewandte Chemie·TypeExperimental study·DateMay 22, 2026
Researchers discovered that certain antibodies employ unusual tactics to block bacterial adhesion, including creating molecular wedges and conformational traps. These mechanisms could lead to the development of immune therapies targeting glycan-binding cell-attachment proteins produced by bacteria causing urinary tract infections.
SourceUniversity of Washington School of Medicine/UW Medicine·JournalNature Communications·TypeExperimental study·DateJan 7, 2026
A new study reveals how nymphaeol A, a bioactive compound in propolis, behaves within complex biological membranes. The molecule spontaneously inserts into the membrane, altering its structure and increasing fluidity, which may enhance its therapeutic effectiveness.
SourceUniversidad Miguel Hernandez de Elche·JournalMembranes·TypeComputational simulation/modeling·DateJun 25, 2025
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Scientists create ferritin structures with precisely arranged histidine residues to drive oxidation reactions in a highly effective metal-free peroxidase. This approach eliminates the need for metal cofactors and enhances catalytic activity.
SourceInstitute of Science Tokyo·JournalAngewandte Chemie·TypeExperimental study·DateMay 19, 2025
A team led by Associate Professor Giuseppe Barca has developed software capable of accurately predicting molecular behavior and setting a new benchmark in computational chemistry. This breakthrough enables scientists to simulate drug performance with accuracy rivaling physical experiments, accelerating new therapeutics design.
Scientists from OIST created synthetic droplets to mimic biological processes, finding that pH gradients facilitate Marangoni effect and enabling droplets to detect and migrate towards each other. This study sheds light on the movement of simplest forms of life in primordial soup billions of years ago.
SourceOkinawa Institute of Science and Technology (OIST) Graduate University·JournalJournal of the American Chemical Society·TypeExperimental study·DateApr 25, 2024
Researchers at the University of Bern have determined the structure of the canine distemper virus docking protein, enabling the development of tailor-made active substances to prevent virus entry into host cells. This breakthrough paves the way for novel therapies and antiviral drugs against this highly contagious viral disease.
SourceUniversity of Bern·JournalProceedings of the National Academy of Sciences·DateMar 15, 2023
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