Articles tagged with Cholesterol
Researchers discovered that an enzyme called squalene monooxygenase (SM) responds to increased cholesterol levels by being destroyed, reducing cholesterol production. This finding could lead to new treatments targeting SM, potentially decreasing cholesterol levels.
Researchers at MIT found that two cholesterol molecules bind to a flu protein called M2, creating a wedge shape in the cell membrane that severs the viral buds. This discovery sheds light on how many other proteins interact with membrane cholesterol.
Research findings emphasize the importance of measuring and maintaining aerobic fitness to reduce CHD risk. Moderate to high levels of cardiorespiratory fitness provide significant protection against CHD death, regardless of blood TG:HDL ratio.
Researchers at Harvard T.H. Chan School of Public Health discovered Nrf1 protein's role in maintaining cholesterol balance within cells. The protein senses and responds to excess cholesterol, promoting protective countermeasures and potentially treating diseases where cholesterol metabolism is disrupted.
A research team from the University of Cincinnati has developed a consensus model of human apolipoprotein A-I, a key component of HDL, which could lead to new strategies for increasing good cholesterol. This breakthrough was achieved through collaborative effort and innovative use of indirect experimental techniques.
A study of over 60,000 patients with known heart disease found that follow-up LDL cholesterol tests significantly reduce the risk of reoccurring heart attacks and strokes. Patients who didn't receive these tests were more likely to experience major adverse outcomes.
A large observational study of nearly 49,000 Malaysian heart attack patients found a significant 10-year decline in blood cholesterol levels. This trend is opposite to the national average and suggests that statins may be responsible for the decrease in cholesterol levels among ACS patients.
Researchers at Houston Methodist discovered a new pathway in cholesterol elimination, revealing that it is eliminated from the body in just two minutes, challenging the current 40-year model. This finding has significant implications for developing new drugs to lower cholesterol and improving cardiovascular health.
Researchers discovered that high levels of cholesterol metabolism's byproduct 27HC facilitates breast cancer metastasis by hijacking specific immune cells. The study identifies 27HC as a potential drug target to inhibit its creation or actions, offering hope for effective therapies against this aggressive form of cancer.
A team of researchers, led by Tony Kim, has developed an innovative lab chip called the human-coronary-artery-on-a-chip to explore new treatments for atherosclerosis. The study aims to improve understanding of high-density lipoprotein (HDL) interactions with proinflammatory proteins and vascular tissues.
A study published in JAMA Cardiology found that only 30.9% of patients prescribed PCSK9 inhibitors ever received therapy, largely due to copay costs and prior authorization processes. Patients with governmental insurance and those filled at specialty pharmacies were more likely to be approved.
Researchers found that drinking alcohol induces changes to a cholesterol-regulating gene, PCSK9, leading to differences in how cholesterol is processed. Higher methylation and gene expression of PCSK9 were associated with chronic heavy alcohol use, which can lead to lower PCSK9 protein levels due to liver damage.
Researchers developed a quality control method to evaluate pharmacological activity and effectiveness of different MβCD preparations. The new method identified differences in average molecular weight and side chain methylation among MβCD samples from different vendors and batches.
Researchers at Aarhus University have uncovered how PCSK9 breaks down LDL receptors, leading to higher LDL cholesterol and increased risk of blood clots. The new knowledge enables the development of more efficient and cheaper PCSK9-inhibiting medicine.
A new study suggests that metabolically healthy obese adults consuming a diet high in unsaturated fats may be able to decrease their total cholesterol by 10 points. However, replacing saturated fats with unsaturated fats does not aid in weight loss.
A large study found that high carbohydrate intake is linked to increased total mortality and non-cardiovascular mortality outcomes, while high fat intake is associated with lower risk. The study suggests that limiting total fat consumption may not improve health in populations.
A meta-analysis of over 68,000 patients found that PCSK9 inhibitors did not increase the short-term risk of developing type 2 diabetes. However, exploratory analyses suggested a trend towards increased risk in patients with intense LDL cholesterol reduction and long-term treatment.
A Japanese study questioned the benefit of treat-to-target intensive statin therapy in patients with diabetic retinopathy, finding no significant reduction in cardiovascular events. However, subanalysis showed that reaching an LDL cholesterol target of less than 70 mg/dL significantly reduced primary endpoint incidence.
The REVEAL trial found that anacetrapib significantly reduces the incidence of major coronary events and improves HDL cholesterol levels, while also reducing LDL cholesterol by at least 20%
A recent study found that the clinical benefit of LDL cholesterol lowering therapies depends on how it is lowered, with apoB particles playing a key role. The study used genetically randomized participants and found that reducing apoB levels had a greater impact on cardiovascular risk than reducing LDL cholesterol.
A 14-year study found that statins reduce breast cancer risk by 45% and mortality risk by 40%. Women with high cholesterol had significantly lower breast cancer rates and improved survival rates compared to those without high cholesterol.
Researchers used gene therapy with LeXis, a 'junk DNA' suppressor of cholesterol, to reduce plaque in mice with familial hypercholesterolemia. The treatment lowered cholesterol and blockages in arteries, and appeared to reduce fat build-up in liver cells.
Researchers found that ultra-low LDL cholesterol levels (below 10 mg/dL) significantly reduced cardiovascular event risk by over 40%. No adverse effects on cognition or safety endpoints were reported. The study suggests achieving low LDL cholesterol levels beyond current treatment targets may further reduce cardiovascular risk.
The ORION 1 trial shows inclisiran lowers LDL cholesterol by -31.6% and -46.8% at one year with single and two dose regimens, respectively. The two dose regimen produced the greatest reductions in LDL cholesterol without side effects.
Research suggests PCSK9 plays a role in platelet activation and aggregation, with higher levels linked to increased platelet reactivity. PCSK9 inhibitors may also reduce thrombosis by interfering with platelet function.
A recent study found that women at high risk of cardiovascular events are more likely to receive lower doses and less potent statin treatments, which can increase the risk of preventable events. According to the DYSIS study, women were 32% less likely to reach the recommended LDL cholesterol target compared to men.
Researchers found that extremely high HDL levels are associated with a higher mortality rate than normal levels. Men with extremely high levels had a 106% higher mortality rate, while women had a 68% higher mortality rate. The study suggests that the focus on HDL as an important health indicator may need to be revised.
A new meta-analysis finds that plant-based vegetarian diets are linked to lower total cholesterol and reduced risk of heart disease. The study highlights the benefits of a well-planned vegan diet, which can lead to weight loss, lower blood pressure, and improved cardiovascular health.
Duke scientists discovered a gene variant linked to susceptibility to typhoid fever and found that cholesterol-lowering drug ezetimibe protected zebrafish against Salmonella Typhi. The study provides insight into human susceptibility to infectious disease and potential avenues for protection.
A study by Helmholtz Munich researchers found that liver inflammation leads to increased cholesterol levels in people with diabetes, promoting vascular diseases. This mechanism is crucial as it explains why some individuals with well-controlled blood sugar levels still experience long-term complications.
A recent study found that consuming almonds regularly can improve HDL cholesterol levels and function in people with elevated LDL cholesterol. The almond diet resulted in a 19% increase in large HDL particles and improved HDL function by 6.4%, suggesting potential benefits for heart health.
Researchers found that healthy LDL particles become more flexible under pressure, while disease-prone particles lose flexibility. This difference in behavior may be attributed to varying lipid compositions.
Researchers found that stopping statin drugs after a first ischemic stroke increases the risk of having another stroke within a year and death. The study suggests that statins should be a lifelong therapy for ischemic stroke patients if needed to lower cholesterol levels.
The latest issue of Cardiovascular Innovations and Applications (CVIA) brings together a diverse set of papers on various cardiovascular topics. The journal features original articles, reviews, commentaries, and case reports on topics such as telemedicine, heart failure, and cholesterol crystals.
Scientists at UAlberta and McGill University have discovered a direct link between calcium and cholesterol, finding that a lack of calcium can hide cholesterol from the cell's machinery. This discovery could pave the way for new treatments for high blood cholesterol and heart disease.
Researchers at Oregon State University found nearly half of dogs with osteosarcoma had elevated total serum cholesterol levels, leading to longer survival times. Dogs with high cholesterol had a median survival time of 455 days, compared to 345 days for those with normal cholesterol.
Scientists have discovered how a compound activates an enzyme to reduce cholesterol and other accumulated fats in the brains and livers of Niemann-Pick type C1 patients. The study may lead to new treatments for NPC1 and other neurodegenerative diseases.
A study published in the Journal of Clinical Investigation reveals a mechanism to reverse disease in arteries by targeting an immune reaction. Researchers at NYU Langone Health discovered that certain immune cells can switch from promoting inflammation to healing, which can lead to reduced plaque growth and improved cardiovascular health.
A study led by the University of Nottingham has uncovered new clues on the connection between pre-eclampsia and an increased risk of heart disease in later life. The research suggests that the body's normal defence mechanism for flushing out cholesterol from the blood may be disrupted by the illness.
A study published in the European Heart Journal shows a vaccine that lowers cholesterol may be effective in preventing cardiovascular disease. The AT04A vaccine, administered to genetically modified mice, reduced cholesterol levels by 53% and induced long-lasting antibodies against PCSK9, an enzyme contributing to high cholesterol.
Researchers at Lund University found that cholesterol impacts the molecular structure of the alveoli's surfactant film, influencing its mechanical properties and substance transport. The study provides new insights into the significance of cholesterol for lung surface properties.
Researchers found that blocking ANGPTL3 activity with an injectable antibody reduced triglycerides by up to 76 percent and lowered LDL cholesterol 23 percent in human study participants. Carriers of mutations disabling ANGPTL3 had nearly 40 percent fewer incidents of coronary artery disease compared to non-carriers.
Researchers developed a 'good heart' muffin to help reduce the risk of heart disease through soluble fibre, meeting food standard guidelines for cholesterol-lowering properties. The muffins contain three grams of beta glucans, a healthy ingredient found in oats and cereals.
More than half of eligible US travelers fail to receive a pre-trip measles vaccine, despite clinical recommendations. This increases the risk of endemic measles outbreaks in the US. Researchers urge improved provider and traveler knowledge of measles as a travel-related illness and increased vaccination rates.
Research suggests that exosomes derived from very obese patients' fat can accelerate biological processes leading to atherosclerosis. In contrast, those from lean patients promote cholesterol efflux and reduce 'bad' cholesterol buildup. This discovery holds promise for early detection of chronic diseases in children.
A large study of over 39,000 participants found that social smokers face the same high blood pressure and cholesterol risks as everyday smokers. The researchers advise clinicians to ask about social smoking in different ways to identify and help these individuals quit.
A new study found that childhood and adolescent cardiovascular risk factors are associated with worse midlife cognition, regardless of adulthood exposure. High blood pressure and high cholesterol in childhood, adolescence, and young adulthood, as well as smoking in adolescence and young adulthood, were linked to impaired cognitive perf...
Coronary artery disease is a chronic inflammatory condition that responds to a Mediterranean-style diet rich in anti-inflammatory compounds, experts claim. A brisk daily walk of just 22 minutes can also significantly reduce biological risk factors for sedentary adults.
Research suggests that high levels of traffic-related air pollution can lead to lower levels of high-density lipoprotein (HDL) cholesterol, also known as "good" cholesterol. This can increase the risk of cardiovascular disease by reducing the number and functionality of HDL particles.
A Minneapolis Heart Institute study found that over half of patients who suffered major heart attacks had not seen a doctor in two years prior to their attack. The new guidelines are more likely to treat these individuals before their heart attacks occur.
The American Heart Association's new initiative aims to raise awareness and empower patients to better manage their high cholesterol. Survey findings show a lack of knowledge among patients with high cholesterol and cardiovascular disease risk factors, leading to missed testing opportunities.
Researchers found that cardiac glycosides, a class of heart failure drugs, can reduce LDL cholesterol levels in patients who don't respond to statins. The study used liver-like cells generated from patient stem cells and showed significant reductions in ApoB levels, indicating potential for a new treatment option.
A clinical study published in New England Journal of Medicine shows that a single dose of siRNA can significantly reduce LDL cholesterol levels by up to 52.6% after two doses, offering long-lasting protection for high-risk patients.
Researchers found a link between partial loss of the ANGPTL3 gene and lower cholesterol levels, as well as a reduced risk of coronary artery disease and heart attack. The study suggests that inhibiting ANGPTL3 could lead to new therapies for preventing heart attacks.
A new study links protein c-Fos to liver carcinogenesis, highlighting the importance of maintaining healthy cholesterol levels in preventing liver cancer. The research suggests that statins may also prevent deleterious changes in hepatocytes caused by hypercholesterolemia and reduce inflammation.
A new review suggests that augmenting the function of HDL cholesterol rather than increasing its concentration is crucial for protecting against cardiovascular disease. The study highlights the importance of addressing adipose tissue-associated inflammation to support the atheroprotective role of HDL.
Researchers developed a new way to visualize cholesterol distribution on cells and tissues using NanoSIMS imaging. The study found that accessible cholesterol is highly enriched on microvilli, supporting the idea that they play a role in regulating cholesterol production and unload surplus cholesterol.
A Phase 2 trial found that synthetic high-density lipoprotein cholesterol (HDL-C) injections had no effect on reducing fatty deposits in arteries, despite being well-tolerated. The study's findings suggest that low-dose CER-001 may not be a promising agent for treating patients with acute coronary syndrome.
New research shows that evolocumab, a PCSK9 inhibitor, effectively lowers LDL cholesterol levels beyond current targets and reduces adverse cardiovascular events. In contrast to previous studies, this study found no association between evolocumab use and decline in memory or cognitive function.
The EBBINGHAUS study, the largest and most rigorous study on the topic, found no significant cognitive effects from adding evolocumab to statin therapy. The study enrolled 1,974 patients and used validated neurocognitive tests to assess executive function, working memory, and reaction time.