Articles tagged with Cholesterol
In the FOURIER trial, evolocumab reduced LDL cholesterol by 59 percent and major cardiovascular events by 15 percent. The therapy showed greater benefit over time, with a 25% reduction in risk after one year.
Bococizumab, a PCSK9 inhibitor, significantly reduced cardiovascular events by 21% in high-risk patients with high LDL cholesterol levels. However, it showed no benefit in patients with lower LDL levels, highlighting the importance of personalized treatment approaches.
Researchers at Intermountain Medical Center Heart Institute identified GlycA as a novel marker of inflammation that predicts heart attack risk. High levels of both GlycA and C-reactive protein independently predict future cardiovascular events, with combined levels being the worst scenario.
The FOURIER trial shows evolocumab reduces the risk of cardiovascular events, including heart attack and stroke, by 15% compared to placebo. The treatment also lowers LDL cholesterol levels, translating to healthier arteries over time.
Bococizumab significantly reduces cardiovascular events in high-risk patients with high LDL cholesterol levels. However, the drug's cholesterol-lowering effect tends to diminish over time in some patients.
A new class of cholesterol-lowering medication has been shown to reduce LDL cholesterol levels by nearly 60% in patients taking statins, resulting in a significant reduction in cardiovascular disease and stroke risk. The study found that this potent drug could provide added benefit for those already on optimal doses of statins.
Researchers found that inclisiran significantly reduced LDL cholesterol levels by up to 51% just one month after treatment. The study also showed sustained lowering of cholesterol levels for at least eight months with no extra side effects.
Patients with high cholesterol levels face increased risk of rotator cuff surgery failure. Statin use prior to surgery reduces this risk, according to a new study. The study found no impact on outcomes from patient triglyceride levels.
Researchers found that activating CARs reduced biliary cholesterol levels, preventing stone formation. The study suggests CARs may play a role in maintaining cholesterol homeostasis, potentially offering a novel approach to prevent or treat cholesterol gallstone disease.
Researchers found that measuring ceramides in the blood can predict major cardiovascular events among patients with and without blockages. Ceramides were linked to a threefold to fourfold greater risk of cardiovascular events compared to those with low ceramide levels.
Researchers found that younger heart attack patients are more likely to have low good cholesterol than elevated bad cholesterol. This suggests that traditional risk factors may not be enough to identify heart attack risk in this age group.
Researchers found that targeting REV-ERB nuclear receptor can suppress cholesterol-related enzyme genes, leading to reduced LDL cholesterol levels. The study suggests that this approach may be an effective method for treating diseases associated with high cholesterol.
Researchers identified an enzyme called CYP46A1 that eliminates both cholesterol and cholestanol from the brain, reducing the formation of debilitating brain lesions. The discovery could inform clinical trials to test the enzyme's potential as a therapeutic target for these diseases.
Researchers have found that cholesterol can regulate the activity of the adenosine receptor by accessing its active site, potentially leading to new treatments for diseases such as Alzheimer's. This discovery could also have implications for other central nervous system diseases where GPCRs play a key role.
Weekly Tai Chi sessions reduced systolic blood pressure by 10.25mmHg and increased high-density lipoprotein (HDL) by 0.16mmol/L in adults with known stroke risk factors. The study suggests that continuing Tai Chi exercise may help prevent strokes.
A new study reveals that high lipoprotein(a), a form of cholesterol, is responsible for 1 in 14 heart attacks and 1 in 7 cases of aortic valve disease. Researchers hope to raise awareness about the risk and stimulate development of new therapies to lower this form of cholesterol.
Alzheimer's patients have different chemical properties in their 'good' cholesterol, which can lead to inflammation and cognitive impairment. The study found a 5.5 times increase of a dysfunctional HDL subfraction and a decreased protein/lipid ratio, associated with reduced brain function.
Prostate cancer cells grow with malfunction of cholesterol control in cells, a process that allows them to accumulate fat and stimulate uncontrolled growth. Identifying this process could inform the development of better ways to control cholesterol accumulation in tumors.
Researchers found that statin specific side effects were the main reason patients failed to meet LDL cholesterol targets. Patients prescribed low-intensity statins were more likely to miss the target than those on high-intensity statins.
A Mediterranean diet rich in virgin olive oil improves HDL function, including reverse cholesterol transport, antioxidant protection, and vasodilator capacity. Only the control diet reduced total and LDL cholesterol levels, while the Mediterranean diets had no significant impact on HDL levels but improved overall cardiovascular health.
Researchers found that very low levels of LDL cholesterol did not lead to adverse events like memory impairment or nervous system disorders in heart disease patients taking PCSK9 inhibitors. However, there was an increased incidence of cataracts in patients with LDL levels below 25mg/dL.
Researchers at Joslin Diabetes Center found that mice with reduced brain cholesterol suffer neurological damage and behavioral abnormalities. The study suggests that cholesterol may play a role in the development of Alzheimer's disease in people with diabetes.
Researchers have identified an endogenous peptide that reduces cholesterol levels in mice, inhibiting the development of atherosclerosis. The protein, human neutrophil peptide 1 (HNP1), binds to LDL in the bloodstream and induces rapid uptake by the liver, reducing hypercholesterolemia.
Cholesterol is found predominantly in the outer layer of cell membranes, where it transmits signals across the membrane. In cancer cells, high levels of cholesterol are associated with suppressed growth activity, suggesting a new way to treat cancer through pharmacological modulation.
A new study found that dietary supplements containing red yeast rice may carry both benefits and risks associated with statins. The beneficial effects of RYR are attributed to monacolins, which are chemically related to statins.
A new study published in the American Journal of Clinical Nutrition found that a high-cholesterol diet or frequent consumption of eggs do not increase the risk of memory disorders. In fact, egg consumption was associated with better cognitive performance in certain tests.
The National Commission on Prevention Priorities has released updated rankings for clinical preventive services, highlighting the most effective and cost-effective options. The top three services include immunizing children, tobacco-use screening, and alcohol misuse screening, with scores of 10 out of a possible 10.
A new study found that fenofibrate therapy may be beneficial in reducing cardiovascular events in patients with type 2 diabetes who take statins but still have high triglyceride levels and low HDL cholesterol levels. The study suggests a potential benefit of combining fenofibrate with statin treatment for this specific patient population.
A Geisinger-Regeneron genomics study found that Familial Hypercholesterolemia (FH) is more common than thought, with 1 in every 256 people carrying a disease-causing mutation. The study identified 35 mutations causing FH and found many patients were undertreated due to lack of genetic confirmation.
Researchers found that dropping cholesterol to very low levels, comparable to those of a newborn baby, reduced the risk of heart attack, stroke, and fatal heart disease by around one-third. The study suggests that very low cholesterol levels are both safe and beneficial.
A recent study published by the American Chemical Society found that red cabbage microgreens can help lower LDL, or 'bad', cholesterol and liver triglyceride levels in mice on high-fat diets. The microgreens contained more polyphenols and glucosinolates than mature red cabbage, making them a promising source of health benefits.
A new discovery by researchers at the University of Queensland reveals that beta glucans in oats actually reduce circulating bile, leading to lower and slower absorption of fat. This finding could lead to ways of boosting the cholesterol-fighting properties of other cereals like wheat.
A Norwegian diet intervention study found similar health effects of diets high in carbohydrates or fats, with substantial improvements in cardiometabolic risk factors. The study suggests that the quality of food is more important than the quantity of fat or carbohydrates, and that most healthy people can tolerate a high intake of satur...
A study found that genetic variants in PCSK9 and HMGCR genes associated with lower LDL cholesterol lowered the risk of cardiovascular events and diabetes, suggesting a protective effect. The risk of diabetes was increased, but only in individuals with impaired glucose metabolism, called pre-diabetes.
A study published in JAMA Cardiology found that average total cholesterol, triglyceride, and LDL-C levels among US adults have decreased over the past two decades. The decline, which began between 1999 and 2010, continued through 2013/2014, with significant drops in triglycerides and LDL-C levels.
Researchers at Iowa State University found a gene mutation linked to an accelerated onset of Parkinson's disease in Caucasians, with those under 50 experiencing symptoms 5 years earlier and a 45% increased risk. The study also highlights the importance of blood cholesterol levels, which are directly related to dopamine production.
A recent study published in Molecular Metabolism has found that cholesterol from animal sources helps mice burn fat, while plant-based fats hinder it. The research suggests a critical link between gut bacteria and energy metabolism, challenging the conventional wisdom on dietary fats and obesity.
Researchers found stroke rates declining in people 55 and older, but doubling in those between 35 and 39. The study also revealed that younger people are more likely to experience debilitating strokes, which can lead to long-term physical disabilities.
A Yale-led research team identified a protein called ALK1 that binds to LDL cholesterol, facilitating its transport into cells. This finding could lead to a new therapeutic approach for reducing atherosclerosis and slowing heart disease.
A recent study suggests that high-density lipoprotein (HDL) cholesterol may not always protect against heart disease as previously thought. HDL can actually enhance the inflammatory response of immune cells called macrophages, which counteracts its established anti-inflammatory effect in other cell types.
Researchers at FAU discovered that cholesterol strongly influences CXCR4 dimerization and signal transmission in human cells. Their computer simulations revealed that cholesterol is required for the correct formation of GPCR pairs, which affects their function.
Using statin drugs provided wide-ranging prevention benefits, reducing risk of death, heart attacks, and strokes. Statins were effective in people at highest risk for heart attacks and strokes, as well as those at lower risk, with no significant harmful effects found.
Researchers tested an injectable biologic drug therapy that inhibits Angiopoietin-like 3 (ANGPTL3) to lower triglyceride levels. The study showed a profound drop in triglyceride levels, with reductions of up to 73%, and dose-dependent reductions in cholesterol levels.
A study of 80,000 healthy adults found that moderate drinking was associated with slower declines in high-density lipoprotein (HDL) levels over time. Moderate drinkers had the slowest decline in HDL levels, with heavy drinking nearly eliminating this benefit.
Researchers found that patients with high cholesterol who take statins have a 20% increased risk of developing Type 2 diabetes. However, those in the fit and highly fit categories had significantly lower diabetes risk, with reductions of 22% and 42%, respectively.
A new study reveals that cholesterol selectively binds to specific regions of GPCR proteins, enabling them to form paired structures and sense external signals. This discovery could open up new avenues for drug discovery and understanding cancer metastasis and AIDS.
Researchers found that consuming high oleic canola oil enriched with Omega-3 significantly reduced triglyceride levels and PCSK9 protein concentration in plasma, suggesting a potential role for dietary fat in preventing cardiovascular diseases.
A systematic review of studies suggests a 12% lower risk of stroke associated with moderate egg consumption, likely due to the high-quality protein and antioxidants present. Eggs are an affordable source of essential nutrients, supporting heart health and overall well-being.
Two studies published in American Heart Association journals found that regular leisure and commuter biking reduces heart attack risk by 11-18% over 20 years. Habitual biking as little as half an hour per week provides some protection against coronary artery disease.
A study published in the Journal of the American College of Cardiology found that low and very high levels of 'good cholesterol' are associated with an increased risk of dying from heart disease, cancer, and other causes. Raising HDL levels does not appear to reduce a person's risk of heart disease.
A new genetic testing method, LipidSeq, has been developed to identify a genetic basis for high-cholesterol in almost 70% of targeted patient populations. The method uses next-generation sequencing technology to pinpoint specific areas of a person's DNA and provides a more cost-effective way to diagnose genetic forms of high-cholesterol.
Research suggests that high cholesterol levels trigger mitochondrial oxidative stress on cartilage cells, causing them to die and ultimately leading to the development of osteoarthritis. Mitochondria targeting antioxidants have shown promise as a viable treatment strategy.
A study by Ludwig Cancer Research identified a metabolic vulnerability in glioblastoma cells that can be exploited for therapy. GBM cells are extremely dependent on imported cholesterol and shutting down their import controls leads to dramatic cancer cell death and tumor shrinkage.
Nearly one in three Myanmar citizens have hypertension, while half have high cholesterol. Experts warn that poor lifestyle choices are contributing to a surge in heart disease.
Researchers found that depriving brain tumor cells of cholesterol specifically kills them and causes tumor regression. This alternative method targets glioblastomas, the most aggressive form of brain cancer, which are difficult to treat due to their biochemical composition and blood-brain barrier.
The Canadian Cardiovascular Society has published new guidelines for managing dyslipidemia, a major risk factor for cardiovascular disease. The guidelines recommend shared decision-making between physician and patient, with a focus on patient involvement in lipid target setting.
A systematic review and meta-analysis found that oat fibre can reduce LDL cholesterol, non-HDL cholesterol, and apolipoprotein B, providing an accurate assessment of cardiovascular risk. The study suggests increasing oat consumption, particularly oat bran, as a healthy dietary option.
Researchers found that mice can maintain learning and memory when virtually all ApoE is removed from the brain, as long as it remains present in the liver to filter cholesterol. This study supports the belief that reducing ApoE in the brain could be a viable therapeutic option for treating Alzheimer's.
A new study demonstrates that lowering LDL cholesterol and systolic blood pressure can have independent, multiplicative, and cumulative causal effects on cardiovascular disease risk. By reducing both by modest amounts, individuals may see a significant reduction in their lifetime risk of cardiovascular disease.
Patients with high levels of cholesterol absorption derive significant benefit from intensive treatment, while those without show no improvement. A new direction for personalized cholesterol treatment strategies is suggested.