A study published in the Journal of Clinical Investigation reveals a mechanism to reverse disease in arteries by targeting an immune reaction. Researchers at NYU Langone Health discovered that certain immune cells can switch from promoting inflammation to healing, which can lead to reduced plaque growth and improved cardiovascular health.
A study led by the University of Nottingham has uncovered new clues on the connection between pre-eclampsia and an increased risk of heart disease in later life. The research suggests that the body's normal defence mechanism for flushing out cholesterol from the blood may be disrupted by the illness.
A study published in the European Heart Journal shows a vaccine that lowers cholesterol may be effective in preventing cardiovascular disease. The AT04A vaccine, administered to genetically modified mice, reduced cholesterol levels by 53% and induced long-lasting antibodies against PCSK9, an enzyme contributing to high cholesterol.
Researchers at Lund University found that cholesterol impacts the molecular structure of the alveoli's surfactant film, influencing its mechanical properties and substance transport. The study provides new insights into the significance of cholesterol for lung surface properties.
Researchers found that blocking ANGPTL3 activity with an injectable antibody reduced triglycerides by up to 76 percent and lowered LDL cholesterol 23 percent in human study participants. Carriers of mutations disabling ANGPTL3 had nearly 40 percent fewer incidents of coronary artery disease compared to non-carriers.
Researchers developed a 'good heart' muffin to help reduce the risk of heart disease through soluble fibre, meeting food standard guidelines for cholesterol-lowering properties. The muffins contain three grams of beta glucans, a healthy ingredient found in oats and cereals.
More than half of eligible US travelers fail to receive a pre-trip measles vaccine, despite clinical recommendations. This increases the risk of endemic measles outbreaks in the US. Researchers urge improved provider and traveler knowledge of measles as a travel-related illness and increased vaccination rates.
Research suggests that exosomes derived from very obese patients' fat can accelerate biological processes leading to atherosclerosis. In contrast, those from lean patients promote cholesterol efflux and reduce 'bad' cholesterol buildup. This discovery holds promise for early detection of chronic diseases in children.
A large study of over 39,000 participants found that social smokers face the same high blood pressure and cholesterol risks as everyday smokers. The researchers advise clinicians to ask about social smoking in different ways to identify and help these individuals quit.
A new study found that childhood and adolescent cardiovascular risk factors are associated with worse midlife cognition, regardless of adulthood exposure. High blood pressure and high cholesterol in childhood, adolescence, and young adulthood, as well as smoking in adolescence and young adulthood, were linked to impaired cognitive perf...
Coronary artery disease is a chronic inflammatory condition that responds to a Mediterranean-style diet rich in anti-inflammatory compounds, experts claim. A brisk daily walk of just 22 minutes can also significantly reduce biological risk factors for sedentary adults.
Research suggests that high levels of traffic-related air pollution can lead to lower levels of high-density lipoprotein (HDL) cholesterol, also known as "good" cholesterol. This can increase the risk of cardiovascular disease by reducing the number and functionality of HDL particles.
A Minneapolis Heart Institute study found that over half of patients who suffered major heart attacks had not seen a doctor in two years prior to their attack. The new guidelines are more likely to treat these individuals before their heart attacks occur.
The American Heart Association's new initiative aims to raise awareness and empower patients to better manage their high cholesterol. Survey findings show a lack of knowledge among patients with high cholesterol and cardiovascular disease risk factors, leading to missed testing opportunities.
Researchers found that cardiac glycosides, a class of heart failure drugs, can reduce LDL cholesterol levels in patients who don't respond to statins. The study used liver-like cells generated from patient stem cells and showed significant reductions in ApoB levels, indicating potential for a new treatment option.
A clinical study published in New England Journal of Medicine shows that a single dose of siRNA can significantly reduce LDL cholesterol levels by up to 52.6% after two doses, offering long-lasting protection for high-risk patients.
Researchers found a link between partial loss of the ANGPTL3 gene and lower cholesterol levels, as well as a reduced risk of coronary artery disease and heart attack. The study suggests that inhibiting ANGPTL3 could lead to new therapies for preventing heart attacks.
A new study links protein c-Fos to liver carcinogenesis, highlighting the importance of maintaining healthy cholesterol levels in preventing liver cancer. The research suggests that statins may also prevent deleterious changes in hepatocytes caused by hypercholesterolemia and reduce inflammation.
A new review suggests that augmenting the function of HDL cholesterol rather than increasing its concentration is crucial for protecting against cardiovascular disease. The study highlights the importance of addressing adipose tissue-associated inflammation to support the atheroprotective role of HDL.
Researchers developed a new way to visualize cholesterol distribution on cells and tissues using NanoSIMS imaging. The study found that accessible cholesterol is highly enriched on microvilli, supporting the idea that they play a role in regulating cholesterol production and unload surplus cholesterol.
New research shows that evolocumab, a PCSK9 inhibitor, effectively lowers LDL cholesterol levels beyond current targets and reduces adverse cardiovascular events. In contrast to previous studies, this study found no association between evolocumab use and decline in memory or cognitive function.
The EBBINGHAUS study, the largest and most rigorous study on the topic, found no significant cognitive effects from adding evolocumab to statin therapy. The study enrolled 1,974 patients and used validated neurocognitive tests to assess executive function, working memory, and reaction time.
A Phase 2 trial found that synthetic high-density lipoprotein cholesterol (HDL-C) injections had no effect on reducing fatty deposits in arteries, despite being well-tolerated. The study's findings suggest that low-dose CER-001 may not be a promising agent for treating patients with acute coronary syndrome.
Researchers found that inclisiran significantly reduced LDL cholesterol levels by up to 51% just one month after treatment. The study also showed sustained lowering of cholesterol levels for at least eight months with no extra side effects.
In the FOURIER trial, evolocumab reduced LDL cholesterol by 59 percent and major cardiovascular events by 15 percent. The therapy showed greater benefit over time, with a 25% reduction in risk after one year.
Bococizumab, a PCSK9 inhibitor, significantly reduced cardiovascular events by 21% in high-risk patients with high LDL cholesterol levels. However, it showed no benefit in patients with lower LDL levels, highlighting the importance of personalized treatment approaches.
Researchers at Intermountain Medical Center Heart Institute identified GlycA as a novel marker of inflammation that predicts heart attack risk. High levels of both GlycA and C-reactive protein independently predict future cardiovascular events, with combined levels being the worst scenario.
The FOURIER trial shows evolocumab reduces the risk of cardiovascular events, including heart attack and stroke, by 15% compared to placebo. The treatment also lowers LDL cholesterol levels, translating to healthier arteries over time.
Bococizumab significantly reduces cardiovascular events in high-risk patients with high LDL cholesterol levels. However, the drug's cholesterol-lowering effect tends to diminish over time in some patients.
A new class of cholesterol-lowering medication has been shown to reduce LDL cholesterol levels by nearly 60% in patients taking statins, resulting in a significant reduction in cardiovascular disease and stroke risk. The study found that this potent drug could provide added benefit for those already on optimal doses of statins.
Patients with high cholesterol levels face increased risk of rotator cuff surgery failure. Statin use prior to surgery reduces this risk, according to a new study. The study found no impact on outcomes from patient triglyceride levels.
Researchers found that activating CARs reduced biliary cholesterol levels, preventing stone formation. The study suggests CARs may play a role in maintaining cholesterol homeostasis, potentially offering a novel approach to prevent or treat cholesterol gallstone disease.
Researchers found that measuring ceramides in the blood can predict major cardiovascular events among patients with and without blockages. Ceramides were linked to a threefold to fourfold greater risk of cardiovascular events compared to those with low ceramide levels.
Researchers found that younger heart attack patients are more likely to have low good cholesterol than elevated bad cholesterol. This suggests that traditional risk factors may not be enough to identify heart attack risk in this age group.
Researchers found that targeting REV-ERB nuclear receptor can suppress cholesterol-related enzyme genes, leading to reduced LDL cholesterol levels. The study suggests that this approach may be an effective method for treating diseases associated with high cholesterol.
Researchers identified an enzyme called CYP46A1 that eliminates both cholesterol and cholestanol from the brain, reducing the formation of debilitating brain lesions. The discovery could inform clinical trials to test the enzyme's potential as a therapeutic target for these diseases.
Researchers have found that cholesterol can regulate the activity of the adenosine receptor by accessing its active site, potentially leading to new treatments for diseases such as Alzheimer's. This discovery could also have implications for other central nervous system diseases where GPCRs play a key role.
Alzheimer's patients have different chemical properties in their 'good' cholesterol, which can lead to inflammation and cognitive impairment. The study found a 5.5 times increase of a dysfunctional HDL subfraction and a decreased protein/lipid ratio, associated with reduced brain function.
Weekly Tai Chi sessions reduced systolic blood pressure by 10.25mmHg and increased high-density lipoprotein (HDL) by 0.16mmol/L in adults with known stroke risk factors. The study suggests that continuing Tai Chi exercise may help prevent strokes.
A new study reveals that high lipoprotein(a), a form of cholesterol, is responsible for 1 in 14 heart attacks and 1 in 7 cases of aortic valve disease. Researchers hope to raise awareness about the risk and stimulate development of new therapies to lower this form of cholesterol.
Prostate cancer cells grow with malfunction of cholesterol control in cells, a process that allows them to accumulate fat and stimulate uncontrolled growth. Identifying this process could inform the development of better ways to control cholesterol accumulation in tumors.
Researchers found that statin specific side effects were the main reason patients failed to meet LDL cholesterol targets. Patients prescribed low-intensity statins were more likely to miss the target than those on high-intensity statins.
A Mediterranean diet rich in virgin olive oil improves HDL function, including reverse cholesterol transport, antioxidant protection, and vasodilator capacity. Only the control diet reduced total and LDL cholesterol levels, while the Mediterranean diets had no significant impact on HDL levels but improved overall cardiovascular health.
Researchers found that very low levels of LDL cholesterol did not lead to adverse events like memory impairment or nervous system disorders in heart disease patients taking PCSK9 inhibitors. However, there was an increased incidence of cataracts in patients with LDL levels below 25mg/dL.
Researchers at Joslin Diabetes Center found that mice with reduced brain cholesterol suffer neurological damage and behavioral abnormalities. The study suggests that cholesterol may play a role in the development of Alzheimer's disease in people with diabetes.
Researchers have identified an endogenous peptide that reduces cholesterol levels in mice, inhibiting the development of atherosclerosis. The protein, human neutrophil peptide 1 (HNP1), binds to LDL in the bloodstream and induces rapid uptake by the liver, reducing hypercholesterolemia.
Cholesterol is found predominantly in the outer layer of cell membranes, where it transmits signals across the membrane. In cancer cells, high levels of cholesterol are associated with suppressed growth activity, suggesting a new way to treat cancer through pharmacological modulation.
A new study found that dietary supplements containing red yeast rice may carry both benefits and risks associated with statins. The beneficial effects of RYR are attributed to monacolins, which are chemically related to statins.
The National Commission on Prevention Priorities has released updated rankings for clinical preventive services, highlighting the most effective and cost-effective options. The top three services include immunizing children, tobacco-use screening, and alcohol misuse screening, with scores of 10 out of a possible 10.
A new study published in the American Journal of Clinical Nutrition found that a high-cholesterol diet or frequent consumption of eggs do not increase the risk of memory disorders. In fact, egg consumption was associated with better cognitive performance in certain tests.
A new study found that fenofibrate therapy may be beneficial in reducing cardiovascular events in patients with type 2 diabetes who take statins but still have high triglyceride levels and low HDL cholesterol levels. The study suggests a potential benefit of combining fenofibrate with statin treatment for this specific patient population.
A Geisinger-Regeneron genomics study found that Familial Hypercholesterolemia (FH) is more common than thought, with 1 in every 256 people carrying a disease-causing mutation. The study identified 35 mutations causing FH and found many patients were undertreated due to lack of genetic confirmation.
Researchers found that dropping cholesterol to very low levels, comparable to those of a newborn baby, reduced the risk of heart attack, stroke, and fatal heart disease by around one-third. The study suggests that very low cholesterol levels are both safe and beneficial.
A recent study published by the American Chemical Society found that red cabbage microgreens can help lower LDL, or 'bad', cholesterol and liver triglyceride levels in mice on high-fat diets. The microgreens contained more polyphenols and glucosinolates than mature red cabbage, making them a promising source of health benefits.
A new discovery by researchers at the University of Queensland reveals that beta glucans in oats actually reduce circulating bile, leading to lower and slower absorption of fat. This finding could lead to ways of boosting the cholesterol-fighting properties of other cereals like wheat.
A Norwegian diet intervention study found similar health effects of diets high in carbohydrates or fats, with substantial improvements in cardiometabolic risk factors. The study suggests that the quality of food is more important than the quantity of fat or carbohydrates, and that most healthy people can tolerate a high intake of satur...
A study found that genetic variants in PCSK9 and HMGCR genes associated with lower LDL cholesterol lowered the risk of cardiovascular events and diabetes, suggesting a protective effect. The risk of diabetes was increased, but only in individuals with impaired glucose metabolism, called pre-diabetes.
A study published in JAMA Cardiology found that average total cholesterol, triglyceride, and LDL-C levels among US adults have decreased over the past two decades. The decline, which began between 1999 and 2010, continued through 2013/2014, with significant drops in triglycerides and LDL-C levels.
Researchers at Iowa State University found a gene mutation linked to an accelerated onset of Parkinson's disease in Caucasians, with those under 50 experiencing symptoms 5 years earlier and a 45% increased risk. The study also highlights the importance of blood cholesterol levels, which are directly related to dopamine production.
A recent study published in Molecular Metabolism has found that cholesterol from animal sources helps mice burn fat, while plant-based fats hinder it. The research suggests a critical link between gut bacteria and energy metabolism, challenging the conventional wisdom on dietary fats and obesity.