Articles tagged with Cholesterol
Researchers used urine-derived induced pluripotent stem cells (iPSCs) to model hypercholesterolemia and predict patient responses to cholesterol-lowering drugs. The study shows that these models can be used to test the efficacy of PCSK9 inhibitors, potentially paving the way for personalized treatment.
A liver pathway controlled by BAF60a stimulates the production of bile, leading to increased cholesterol absorption. Mice with disabled BAF60a had lower cholesterol levels, suggesting a potential therapeutic target for reducing atherosclerosis.
A new vaccine has shown promise in reducing 'bad' LDL cholesterol levels in mice and macaques, suggesting potential as an alternative to statins. The vaccine targets the PCSK9 protein, which regulates cholesterol levels in the blood, offering a more powerful treatment with fewer side effects.
According to a study of 16,415 U.S. Hispanic/Latino adults, only one-third to one-half are eligible for and receiving statin therapy, highlighting a significant undertreatment gap.
Disclosing genetic risk information for coronary heart disease results in lower low-density lipoprotein (bad) cholesterol levels. Participants who received genetic risk information showed nearly 10 milligrams per deciliter of blood lower LDL levels six months after risk disclosure.
Researchers at the University of Pennsylvania School of Medicine found that paying both physicians and patients financial incentives leads to a greater reduction in low-density lipoprotein (LDL) cholesterol. The study enrolled 340 primary care physicians and over 1500 of their patients, dividing them into four groups: physician-only in...
The portfolio diet, which includes mixed nuts, soy protein, and viscous fiber, was found to reduce both cholesterol and blood pressure by an average of 2% compared to the DASH diet. This study adds to the existing evidence connecting diet with health outcomes.
A study in New England Journal of Medicine found that suPAR, a circulating protein, can reliably predict chronic kidney disease up to five years before symptoms appear. High suPAR levels are associated with an increased risk of developing the disease, which affects over 15% of people in the US.
Researchers have identified four microRNAs that play critical roles in controlling cholesterol and triglyceride levels, including miR-128-1 and miR-148a. These microRNAs regulate genes involved in lipid metabolism and may hold promise for treating cardiovascular disease.
A new study shows that increasing caveolin-1 levels in nerve cells improves learning and memory in aged mice. The researchers believe this could be a path toward treating age-related memory loss and other conditions such as Alzheimer's disease.
A pooled analysis of available evidence suggests that high levels of total cholesterol are associated with an increased risk of tendon abnormalities and pain. Chronic low-level inflammation, prompted by cholesterol build-up in immune cells, may be a key factor contributing to this link.
A two-year randomized controlled trial found that moderate wine consumption, especially red wine, can modestly decrease cardio-metabolic risk and improve sugar control. The study also found that slow alcohol-metabolizers who drank red wine achieved an improvement in blood sugar control.
A new study reveals that menopause diminishes the impact of high-density lipoprotein (HDL) in preventing plaque buildup and artery hardening. The research found a positive association between increases in HDL levels and greater plaque buildup among women transitioning through menopause.
A new study reveals a direct relationship between Alzheimer's disease and brain cholesterol levels. Increasing the enzyme CYP46A1 may help eliminate excess cholesterol from the brain, correcting amyloid plaques and degenerated tau protein. This discovery opens up a new line of research for Alzheimer's treatment.
Research found that gut bacteria contribute to differences in body fat (BMI), blood lipids such as triglycerides and HDL, but have little relationship with bad cholesterol. The study used deep sequencing technology to identify 34 types of bacteria associated with these changes.
Two studies published in Age and the British Journal of Nutrition show that consuming cocoa flavanols improves cardiovascular function, lowers blood pressure, and reduces the risk of developing cardiovascular disease. Flavanol intake is particularly beneficial for maintaining healthy blood vessels and reducing arterial stiffness.
A new study found that people with health insurance are more likely to have their chronic conditions correctly diagnosed and under control. If half of nonelderly uninsured Americans gain health insurance, an estimated 1.5 million newly insured individuals will be diagnosed with one or more conditions.
A subgroup analysis of the IMPROVE-IT trial found that ezetimibe significantly reduced the chances of future major cardiac or vascular events in patients with diabetes by 14% compared to placebo. Ezetimibe added to a statin lowered LDL cholesterol at 1 year, resulting in lower risks of cardiovascular events.
Johns Hopkins and Mayo experts suggest upgrades to current heart disease prevention guideline, focusing on improved risk prediction and personalized treatment. The new guidelines aim to clarify key points of confusion related to risk prediction and treatment of heart attacks and strokes, promoting more precise and tailored care.
Researchers at Helmholtz Zentrum München found that Metformin decreases LDL cholesterol levels in Type 2 diabetes patients by regulating genes and metabolites involved in the AMPK pathway. The study suggests a potential additional beneficial effect of Metformin on cardiovascular diseases.
Researchers found that coadministering statins with ezetimibe significantly reduced LDL cholesterol levels and plaque buildup in heart disease patients. The study showed a 40% lower cholesterol level and greater plaque regression compared to single-drug therapies.
Replacing time spent sitting with standing can lower blood sugar and cholesterol levels, according to a new study. Standing for two hours a day was associated with improved waist circumference and reduced risk of metabolic disorders.
Researchers found that many older Americans with diabetes are not meeting clinical targets for blood sugar, cholesterol, and blood pressure levels. Despite using less stringent guidelines, the study revealed significant racial disparities in diabetes control, particularly among women.
Research found that enhanced cholesterol metabolism in certain immune cells may help explain why some HIV-infected people naturally control disease progression. The study analyzed gene expression data from immune cells and found higher levels of cholesterol-related genes associated with defective viral transmission.
Researchers found a statistically significant association between higher vitamin D levels and lower non-HDL cholesterol in children aged one to five years. The study suggests that factors leading to cardiovascular disease may start in early childhood, providing an opportunity for early life interventions to reduce risk.
A study examines the cost-effectiveness of new cholesterol guidelines, finding that a more lenient threshold may be cost-effective. The analysis suggests that shifting from a 7.5% ASCVD risk threshold to 3-4% thresholds could avert up to 160,000 cardiovascular events.
A new scoring method, the Healthy Beverage Index (HBI), evaluates overall beverage intake quality and its association with cardiometabolic risk factors. Higher HBI scores are linked to more favorable lipid profiles, decreased hypertension risk, and improved C-reactive protein levels.
A review of 160 clinical trials found exercise improves health outcomes, but effects vary by age, gender, and health status. Intermediate biomarkers like insulin resistance and inflammation may mediate cardioprotective effects.
A study by University of Illinois professor Ruopeng An found that eating at restaurants consumes more calories, fat, and sodium than eating at home. African-Americans who dine out take in more total fat, saturated fat, sodium, and sugar.
Researchers found that hantaviruses are highly dependent on cholesterol in cell membranes to gain access into cells. Disrupting the S1P pathway reduced their ability to infect cells, suggesting potential therapeutic targets. However, further studies are needed to fully understand the viruses' dependence on cholesterol.
Scientists at Johns Hopkins Medicine report a breakthrough in treating atherosclerosis by loading nanoparticles with a chemical that restores normal fat metabolism in rodents. The nanoparticle 'wrapper' improves the drug's potency and ability to stop fatty buildup, offering new hope for treating cardiovascular disease.
A Swedish study found that interventions among healthy people were the key to saving lives, with changes in risk factors such as smoking cessation, diet, and blood pressure levels contributing significantly. The greatest impact was seen in people over 55, highlighting the need for a broader approach to health promotion.
A new study published in Radiology found that non-calcified arterial plaque is associated with diabetes, high systolic blood pressure, and elevated 'bad' cholesterol levels. CT angiography can quantify plaque burden and assess progression or regression of coronary artery disease in low-to-moderate risk individuals.
A new study found that a low protein, high carbohydrate diet can provide similar benefits to calorie restriction in mice. The researchers compared three diets varying in protein-to-carbohydrate ratio and found that the low protein, high carbohydrate diet delivered better metabolic outcomes.
A large prospective study found that individuals with higher HDL function have a lower risk of developing coronary heart disease. Researchers from the University of Pennsylvania analyzed data from over 25,000 participants and discovered a strong correlation between HDL function and reduced heart disease events.
A study found that a common mutation in the SCARB1 gene is associated with an increased risk of heart disease, especially among men and African Americans. The mutation was linked to a 49% higher risk of heart disease in African American males compared to white males.
A study published in the Journal of the American College of Cardiology found that higher levels of cardiorespiratory fitness can delay the onset of high cholesterol by up to 15 years. Men with lower fitness levels were more likely to develop high cholesterol in their early 30s, while those with higher fitness did not experience this un...
A large-scale meta-analysis discovered 10 new genes that tune cholesterol levels in individuals. The study, led by researchers at the University of Helsinki, analyzed DNA data from over 60,000 people and identified genetic variants associated with cholesterol levels.
UTHealth researchers have sequenced exomes of 8,554 individuals to identify naturally occurring mutations that inactivate certain genes. The study found eight new relationships between genes and diseases, including a link between TXNDC5 and Type 1 Diabetes progression.
A new class of PCSK9 antibodies has been shown to reduce mortality, lower LDL-cholesterol, and improve cardiovascular outcomes in patients with dyslipidemia. The treatment was well-tolerated and proved safe, providing a promising alternative for those who do not respond to statins.
A new variety of broccoli, enriched with glucoraphanin, has been shown to reduce blood LDL-cholesterol levels by an average of 6%. The compound is converted into sulphuraphane in the body, which activates genes that help balance metabolism and reduce cholesterol production.
Patients taking evolocumab, a new class of cholesterol-lowering medications, were half as likely to die or experience a heart attack/stroke compared to those on standard care. The study found that patients treated with evolocumab had significantly lower rates of cardiovascular events and adverse effects.
A recent study published in the American Journal of Clinical Nutrition found that high levels of blood lipids can prevent vitamin E from reaching body tissues. The research suggests that measuring only blood levels may be misleading and that past methods of estimating tissue levels are flawed.
The study provides high-resolution pictures of two closely related enzymes, lysosomal phospholipase A2 (LPLA2) and lecithin-cholesterol acyltransferase (LCAT), which play crucial roles in metabolizing cholesterol and other lipids. The findings offer new insights into the mechanisms underlying these disorders and suggest potential thera...
A new study published in Neurology found that people who sleep more than eight hours a night have an increased risk of stroke. Those who shifted from sleeping less than six hours a night to more than eight hours were nearly four times as likely to have a stroke.
A recent study suggests that statins may not protect against Parkinson's disease, despite previous reports of a potential link. The research found no evidence that statin use lowered the risk of PD, and may even increase it over time.
A recent study by Cleveland Clinic found that a plant-based vegan diet can significantly improve cardiovascular risks in obese children, including lower BMI, blood pressure, and cholesterol levels. The study suggests that such diets may be more effective than the American Heart Association diet in reducing heart disease risk.
Scientists have discovered the crystal structure of a key protein associated with anxiety disorders, providing clues for new anti-anxiety treatments. The TSPO protein's unique structure and interactions with cholesterol could lead to improved medications with zero side effects.
A recent study published in the Journal of Clinical Lipidology found that corn oil significantly reduces cholesterol levels compared to extra virgin olive oil. The study showed a 10.9% reduction in LDL (bad) cholesterol and an 8.2% decrease in total cholesterol with corn oil.
Researchers found that high cholesterol in young adults between 35-55 years increases heart disease risk by 39% each decade, even among those with normal blood pressure and weight. The study suggests that healthy individuals in this age group should consider cholesterol control earlier.
A new study published in Circulation reveals that long-term exposure to elevated cholesterol levels substantially increases lifetime risk for heart disease. Adults with longstanding mild to moderately elevated cholesterol levels may benefit from more aggressive prevention strategies earlier, according to the study's lead author.
Joining a walking group improves lung power, physical functioning, and general fitness, with few side effects, according to an analysis of available evidence published in the British Journal of Sports Medicine. The study found wide-ranging benefits for adults with various long-term conditions.
A comprehensive cardiovascular risk reduction program in Franklin County, Maine, demonstrated significant improvements in hypertension control, cholesterol management, and smoking cessation rates. The program resulted in substantial reductions in hospitalization and death rates, as well as $5,450,362 in annual savings in hospital charges.
A 40-year study found sustained community-wide programs in rural Maine reduced hospitalizations and death rates by targeting cardiovascular risk factors. Improvements were seen in hypertension control, cholesterol management, and smoking cessation.
A study found that optimistic individuals have significantly better blood sugar and total cholesterol levels, are more physically active, and have healthier body mass indexes. They were also less likely to smoke and had a stronger association with cardiovascular health when socio-demographic characteristics were factored in.
A new study published in the Journal of the American Heart Association found that a moderate fat diet incorporating one fresh avocado daily improved certain blood lipid markers, including total cholesterol to HDL and LDL-cholesterol ratios. The avocado diet achieved greater reductions in bad cholesterol levels compared to low-fat diets.
Researchers found that eating one avocado a day as part of a moderate-fat diet can improve bad cholesterol levels in overweight and obese individuals. The study also showed favorable results for total cholesterol, triglycerides, small dense LDL, non-HDL cholesterol, and other cardio-metabolic risk factors.
A recent study found that incorporating one avocado per day into a moderate-fat, cholesterol-lowering diet significantly lowers LDL and total cholesterol levels. The researchers tested three diets, including one with an added avocado, and found the avocado diet to be more effective in reducing bad cholesterol.
A daily snack of 1.5 ounces of almonds significantly improved LDL and total cholesterol levels, reducing central adiposity and improving heart health risk factors. The study also found benefits in reducing abdominal and leg fat mass.
A study published in JAMA found that a low-glycemic index diet did not improve cardiovascular risk factors, such as blood pressure and lipid levels, or insulin sensitivity in overweight adults. The researchers also found that high-glycemic index diets had more negative effects on insulin sensitivity and LDL cholesterol levels