A study published in the Journal of the American College of Cardiology found that higher levels of cardiorespiratory fitness can delay the onset of high cholesterol by up to 15 years. Men with lower fitness levels were more likely to develop high cholesterol in their early 30s, while those with higher fitness did not experience this un...
UTHealth researchers have sequenced exomes of 8,554 individuals to identify naturally occurring mutations that inactivate certain genes. The study found eight new relationships between genes and diseases, including a link between TXNDC5 and Type 1 Diabetes progression.
A new class of PCSK9 antibodies has been shown to reduce mortality, lower LDL-cholesterol, and improve cardiovascular outcomes in patients with dyslipidemia. The treatment was well-tolerated and proved safe, providing a promising alternative for those who do not respond to statins.
A new variety of broccoli, enriched with glucoraphanin, has been shown to reduce blood LDL-cholesterol levels by an average of 6%. The compound is converted into sulphuraphane in the body, which activates genes that help balance metabolism and reduce cholesterol production.
Patients taking evolocumab, a new class of cholesterol-lowering medications, were half as likely to die or experience a heart attack/stroke compared to those on standard care. The study found that patients treated with evolocumab had significantly lower rates of cardiovascular events and adverse effects.
A recent study published in the American Journal of Clinical Nutrition found that high levels of blood lipids can prevent vitamin E from reaching body tissues. The research suggests that measuring only blood levels may be misleading and that past methods of estimating tissue levels are flawed.
The study provides high-resolution pictures of two closely related enzymes, lysosomal phospholipase A2 (LPLA2) and lecithin-cholesterol acyltransferase (LCAT), which play crucial roles in metabolizing cholesterol and other lipids. The findings offer new insights into the mechanisms underlying these disorders and suggest potential thera...
A new study published in Neurology found that people who sleep more than eight hours a night have an increased risk of stroke. Those who shifted from sleeping less than six hours a night to more than eight hours were nearly four times as likely to have a stroke.
A recent study suggests that statins may not protect against Parkinson's disease, despite previous reports of a potential link. The research found no evidence that statin use lowered the risk of PD, and may even increase it over time.
A recent study by Cleveland Clinic found that a plant-based vegan diet can significantly improve cardiovascular risks in obese children, including lower BMI, blood pressure, and cholesterol levels. The study suggests that such diets may be more effective than the American Heart Association diet in reducing heart disease risk.
Scientists have discovered the crystal structure of a key protein associated with anxiety disorders, providing clues for new anti-anxiety treatments. The TSPO protein's unique structure and interactions with cholesterol could lead to improved medications with zero side effects.
A recent study published in the Journal of Clinical Lipidology found that corn oil significantly reduces cholesterol levels compared to extra virgin olive oil. The study showed a 10.9% reduction in LDL (bad) cholesterol and an 8.2% decrease in total cholesterol with corn oil.
A new study published in Circulation reveals that long-term exposure to elevated cholesterol levels substantially increases lifetime risk for heart disease. Adults with longstanding mild to moderately elevated cholesterol levels may benefit from more aggressive prevention strategies earlier, according to the study's lead author.
Researchers found that high cholesterol in young adults between 35-55 years increases heart disease risk by 39% each decade, even among those with normal blood pressure and weight. The study suggests that healthy individuals in this age group should consider cholesterol control earlier.
Joining a walking group improves lung power, physical functioning, and general fitness, with few side effects, according to an analysis of available evidence published in the British Journal of Sports Medicine. The study found wide-ranging benefits for adults with various long-term conditions.
A 40-year study found sustained community-wide programs in rural Maine reduced hospitalizations and death rates by targeting cardiovascular risk factors. Improvements were seen in hypertension control, cholesterol management, and smoking cessation.
A comprehensive cardiovascular risk reduction program in Franklin County, Maine, demonstrated significant improvements in hypertension control, cholesterol management, and smoking cessation rates. The program resulted in substantial reductions in hospitalization and death rates, as well as $5,450,362 in annual savings in hospital charges.
A study found that optimistic individuals have significantly better blood sugar and total cholesterol levels, are more physically active, and have healthier body mass indexes. They were also less likely to smoke and had a stronger association with cardiovascular health when socio-demographic characteristics were factored in.
A new study published in the Journal of the American Heart Association found that a moderate fat diet incorporating one fresh avocado daily improved certain blood lipid markers, including total cholesterol to HDL and LDL-cholesterol ratios. The avocado diet achieved greater reductions in bad cholesterol levels compared to low-fat diets.
Researchers found that eating one avocado a day as part of a moderate-fat diet can improve bad cholesterol levels in overweight and obese individuals. The study also showed favorable results for total cholesterol, triglycerides, small dense LDL, non-HDL cholesterol, and other cardio-metabolic risk factors.
A recent study found that incorporating one avocado per day into a moderate-fat, cholesterol-lowering diet significantly lowers LDL and total cholesterol levels. The researchers tested three diets, including one with an added avocado, and found the avocado diet to be more effective in reducing bad cholesterol.
A daily snack of 1.5 ounces of almonds significantly improved LDL and total cholesterol levels, reducing central adiposity and improving heart health risk factors. The study also found benefits in reducing abdominal and leg fat mass.
A study published in JAMA found that a low-glycemic index diet did not improve cardiovascular risk factors, such as blood pressure and lipid levels, or insulin sensitivity in overweight adults. The researchers also found that high-glycemic index diets had more negative effects on insulin sensitivity and LDL cholesterol levels
A clinical trial found no clear benefit of low glycemic index diets on key measures of heart disease and diabetes risk. Healthy eating habits focusing on fruits, vegetables, and whole grains are recommended by the study's lead researchers.
A low glycemic diet did not improve insulin sensitivity, lipid levels or blood pressure in a randomized controlled trial of 163 overweight adults. The study found that diets with high-glycemic index carbohydrates, such as the DASH diet, had similar effects on cardiovascular risk factors as those with low-glycemic index carbohydrates.
A new study shows racial disparities in Medicare Advantage persist across the US, except in Western states, where control of key health measures is higher for black seniors. In contrast, Eastern and Midwestern states show significant gaps between white and black seniors.
Researchers create dye-functionalized nanoparticles that selectively deliver siRNA to liver cells, reducing cholesterol production and offering new hope for personalized therapy approaches. The method uses near-infrared fluorescent dyes as address labels and tracking numbers, allowing for non-invasive monitoring of the transport process.
The American College of Cardiology and American Heart Association guidelines now recommend statin therapy for individuals with an elevated estimated risk of a heart attack or stroke in the next 10 years. A study found that 97% of adults aged 66-75 qualify for statin therapy, with 100% of men in this age group being eligible.
Researchers found a link between the APOE e4 allele and increased risk of cardiovascular disease, as well as lower HDL cholesterol levels. Higher cholesterol in older adults may be associated with longevity, challenging current cholesterol-lowering medication practices.
Researchers from UT Southwestern Medical Center found a strong, protective relationship between cholesterol efflux and cardiovascular risk. The study revealed that measuring cholesterol efflux provides significantly different information than traditional HDL cholesterol levels.
A study published in the American Journal of Managed Care found that automated reminders improved medication adherence by 2 percentage points, with significant reductions in cholesterol levels. The study, which included over 21,000 participants, suggests that even small changes can have a big impact on public health.
Adding ezetimibe to statin therapy lowered cholesterol levels and reduced cardiovascular events by 6.4% in patients following heart attack, according to the IMPROVE-IT trial. The study found that adding ezetimibe resulted in a significant reduction in cardiovascular events, including heart attacks and strokes.
A study in a rural Midwestern community found that the new cholesterol guidelines substantially increased the number of individuals who qualify for a statin. The biggest driver of this increase was that a larger number of older individuals without known heart disease qualified for a statin under the new guidelines.
Researchers found that a diet rich in plant-based flavonoids can help regulate the body's immune system response to fine particles in polluted air, potentially reducing the risk of heart disease. Additionally, a low-cost vaccine targeting PCSK9 has been shown to safely lower bad cholesterol levels in animal studies.
Two cholesterol management guidelines agree that nearly all patients with chronic kidney disease should receive statins, but 50% of those recommended are not taking them. The study found the Pooled Cohort risk equations to be accurate among people with CKD, indicating a valid tool for estimating heart disease risk.
Researchers found that people with one inactive copy of the NPC1L1 gene had lower LDL cholesterol levels and a 50% reduced risk of coronary heart disease. The study suggests that targeting this gene may provide protection against heart attack, but further research is needed to confirm its effectiveness.
A study published in Alcohol found that moderate drinking has a protective effect among only 15% of the general population with a specific genotype, which affects HDL cholesterol levels. This suggests that sweeping advice about moderate alcohol consumption may not be suitable for everyone.
A new experimental drug, obeticholic acid, has improved liver health in people with nonalcoholic steatohepatitis (NASH) by reducing inflammation and fat. However, the treatment was associated with increased total cholesterol levels, a potential risk factor for cardiovascular disease.
The review highlights oats' role in improving satiety, with a higher viscosity of oatmeal beta-glucan compared to ready-to-eat cereals. Oats also show potential benefits for digestive health, with resistant starch boosting beneficial bacteria in the gut.
A study of 35,000 participants found that genetic predisposition to elevated LDL-C was associated with aortic valve calcium and narrowing, supporting a causal association. Lowering cholesterol early in the disease process may provide protection from developing aortic valve disease.
A large study of over 35,000 participants found that genetic risk scores for elevated plasma lipids are associated with increased aortic valve calcium and new cases of aortic stenosis. The study suggests a causal link between high LDL-C levels and early stages of aortic valve disease.
A study found that American consumers consume more than 1% of their daily calories from trans fats, exceeding the American Heart Association's recommendation. Omega-3 fatty acids have not changed significantly over the past thirty years and may help improve cardiovascular disease risk.
A new study has uncovered a gene that affects blood cholesterol levels through the generation of a compound from omega-6 polyunsaturated fatty acids, called lipoxins. Aspirin is also found to promote lipoxin production, leading to lower LDL cholesterol and increased HDL cholesterol.
Researchers found that eating muffins made with polyunsaturated oils improved blood cholesterol profiles and reduced the risk of cardiovascular disease. In contrast, those who ate muffins with saturated oils experienced increased bad cholesterol levels and insulin resistance.
Researchers have gained new insight into the complex molecular process of cholesterol production by mapping the structure of a key enzyme involved in the process. The study revealed two pockets within the enzyme's architecture that help spark the synthesis of cholesterol, with potential implications for the treatment of high cholesterol.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that men with high cholesterol and triglyceride levels after prostate cancer surgery had a higher risk of disease recurrence. Normalizing lipid levels may reduce this risk.
Researchers at The Scripps Research Institute have created a synthetic molecule that mimics 'good' cholesterol, reducing plaque buildup in animal models. After two weeks, the molecule improved cholesterol levels, pointing toward a new method for treating atherosclerosis.
Evolocumab, a new PCSK9 inhibitor, has been shown to significantly lower LDL cholesterol levels in patients with familial hypercholesterolaemia (FH) by an average of 60% more than placebo. The treatment was well-tolerated and achieved recommended LDL cholesterol targets in over 60% of patients.
A new study found that genomic data can explain around 15% of patients' responses to cholesterol-lowering statins. The research used data from a clinical trial and identified genetic signatures associated with improved or poor responses to the medication.
A new study found that rosuvastatin is more effective in reducing low-density lipoprotein subfractions in prediabetic patients than those with normal glucose levels. The medication led to a greater decrease in small dense lipoproteins, considered particularly harmful.
SourceSAGE·JournalJournal of Cardiovascular Pharmacology and Therapeutics·DateSep 18, 2014
The report emphasizes the need for a more individualized approach to treating cardiovascular disease, focusing on reducing cholesterol levels to specific targets based on a patient's unique health profile. This approach includes lifestyle changes, non-lipid risk factor management, and medication tailored to the patient's needs.
A University of Kentucky research team has made a surprising discovery about oxidized LDL's role in cholesterol transport. The findings indicate that mildly oxidized LDL may actually prevent increases in cholesterol accumulation in arterial walls, potentially leading to new treatments for heart disease.
Scientists at the University of Ottawa Heart Institute have discovered a connection between elevated PCSK9 levels and acute heart attacks in patients. Elevated PCSK9 levels were found in blood samples from patients who had experienced a heart attack, but not in those who had never had one or had recovered from a previous attack.
A new study suggests rosuvastatin has an initially more favourable effect on glucose levels compared to atorvastatin in type 2 diabetes patients. This makes rosuvastatin a wiser choice, especially for those struggling to control their glucose levels.
Researchers at the University of Warwick discovered that methylglyoxal damages 'good' HDL cholesterol, reducing its protective function against heart disease. Low levels of HDL are linked to increased risk of heart disease, and MG levels can be managed through diet and supplements.
The ODYSSEY COMBO II trial shows that alirocumab, a PCSK9 inhibitor, lowers LDL-C levels significantly more than ezetimibe when added to regular statin therapy. By week 24 and 52, alirocumab achieved 50.6% and 49.5% reductions in LDL-C, respectively.
The ODYSSEY LONG TERM trial demonstrates alirocumab's efficacy in lowering LDL-C and reducing cardiovascular events. The study showed a significant reduction in major cardiovascular events and improved lipid profiles, suggesting a useful addition to statin therapy for high-risk patients.
A new study found that moderate wine consumption is protective against cardiovascular disease in people who exercise regularly. However, the study did not find any benefits for people with no exercise habits.
A study found sex-specific associations between socioeconomic factors and cholesterol levels, with women having higher total cholesterol and LDL-cholesterol levels. Men's cholesterol levels were linked to their occupation, while women's were more closely tied to education level.
A Yale University study found that new national guidelines can accurately prescribe statins to patients at risk for cardiovascular disease. The research shows the new guidelines produce a modest increase in patient treatment, with only 92% of those with heavy plaque being assigned to statin therapy under the new method.