Articles tagged with Cholesterol
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Researchers found a link between the APOE e4 allele and increased risk of cardiovascular disease, as well as lower HDL cholesterol levels. Higher cholesterol in older adults may be associated with longevity, challenging current cholesterol-lowering medication practices.
Researchers from UT Southwestern Medical Center found a strong, protective relationship between cholesterol efflux and cardiovascular risk. The study revealed that measuring cholesterol efflux provides significantly different information than traditional HDL cholesterol levels.
Researchers found that a diet rich in plant-based flavonoids can help regulate the body's immune system response to fine particles in polluted air, potentially reducing the risk of heart disease. Additionally, a low-cost vaccine targeting PCSK9 has been shown to safely lower bad cholesterol levels in animal studies.
A study published in the American Journal of Managed Care found that automated reminders improved medication adherence by 2 percentage points, with significant reductions in cholesterol levels. The study, which included over 21,000 participants, suggests that even small changes can have a big impact on public health.
Adding ezetimibe to statin therapy lowered cholesterol levels and reduced cardiovascular events by 6.4% in patients following heart attack, according to the IMPROVE-IT trial. The study found that adding ezetimibe resulted in a significant reduction in cardiovascular events, including heart attacks and strokes.
A study in a rural Midwestern community found that the new cholesterol guidelines substantially increased the number of individuals who qualify for a statin. The biggest driver of this increase was that a larger number of older individuals without known heart disease qualified for a statin under the new guidelines.
Two cholesterol management guidelines agree that nearly all patients with chronic kidney disease should receive statins, but 50% of those recommended are not taking them. The study found the Pooled Cohort risk equations to be accurate among people with CKD, indicating a valid tool for estimating heart disease risk.
Researchers found that people with one inactive copy of the NPC1L1 gene had lower LDL cholesterol levels and a 50% reduced risk of coronary heart disease. The study suggests that targeting this gene may provide protection against heart attack, but further research is needed to confirm its effectiveness.
A study published in Alcohol found that moderate drinking has a protective effect among only 15% of the general population with a specific genotype, which affects HDL cholesterol levels. This suggests that sweeping advice about moderate alcohol consumption may not be suitable for everyone.
A new experimental drug, obeticholic acid, has improved liver health in people with nonalcoholic steatohepatitis (NASH) by reducing inflammation and fat. However, the treatment was associated with increased total cholesterol levels, a potential risk factor for cardiovascular disease.
The review highlights oats' role in improving satiety, with a higher viscosity of oatmeal beta-glucan compared to ready-to-eat cereals. Oats also show potential benefits for digestive health, with resistant starch boosting beneficial bacteria in the gut.
A study of 35,000 participants found that genetic predisposition to elevated LDL-C was associated with aortic valve calcium and narrowing, supporting a causal association. Lowering cholesterol early in the disease process may provide protection from developing aortic valve disease.
A large study of over 35,000 participants found that genetic risk scores for elevated plasma lipids are associated with increased aortic valve calcium and new cases of aortic stenosis. The study suggests a causal link between high LDL-C levels and early stages of aortic valve disease.
A study found that American consumers consume more than 1% of their daily calories from trans fats, exceeding the American Heart Association's recommendation. Omega-3 fatty acids have not changed significantly over the past thirty years and may help improve cardiovascular disease risk.
A new study has uncovered a gene that affects blood cholesterol levels through the generation of a compound from omega-6 polyunsaturated fatty acids, called lipoxins. Aspirin is also found to promote lipoxin production, leading to lower LDL cholesterol and increased HDL cholesterol.
Researchers found that eating muffins made with polyunsaturated oils improved blood cholesterol profiles and reduced the risk of cardiovascular disease. In contrast, those who ate muffins with saturated oils experienced increased bad cholesterol levels and insulin resistance.
Researchers have gained new insight into the complex molecular process of cholesterol production by mapping the structure of a key enzyme involved in the process. The study revealed two pockets within the enzyme's architecture that help spark the synthesis of cholesterol, with potential implications for the treatment of high cholesterol.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that men with high cholesterol and triglyceride levels after prostate cancer surgery had a higher risk of disease recurrence. Normalizing lipid levels may reduce this risk.
Researchers at The Scripps Research Institute have created a synthetic molecule that mimics 'good' cholesterol, reducing plaque buildup in animal models. After two weeks, the molecule improved cholesterol levels, pointing toward a new method for treating atherosclerosis.
Evolocumab, a new PCSK9 inhibitor, has been shown to significantly lower LDL cholesterol levels in patients with familial hypercholesterolaemia (FH) by an average of 60% more than placebo. The treatment was well-tolerated and achieved recommended LDL cholesterol targets in over 60% of patients.
A new study found that genomic data can explain around 15% of patients' responses to cholesterol-lowering statins. The research used data from a clinical trial and identified genetic signatures associated with improved or poor responses to the medication.
A new study found that rosuvastatin is more effective in reducing low-density lipoprotein subfractions in prediabetic patients than those with normal glucose levels. The medication led to a greater decrease in small dense lipoproteins, considered particularly harmful.
The report emphasizes the need for a more individualized approach to treating cardiovascular disease, focusing on reducing cholesterol levels to specific targets based on a patient's unique health profile. This approach includes lifestyle changes, non-lipid risk factor management, and medication tailored to the patient's needs.
A University of Kentucky research team has made a surprising discovery about oxidized LDL's role in cholesterol transport. The findings indicate that mildly oxidized LDL may actually prevent increases in cholesterol accumulation in arterial walls, potentially leading to new treatments for heart disease.
Scientists at the University of Ottawa Heart Institute have discovered a connection between elevated PCSK9 levels and acute heart attacks in patients. Elevated PCSK9 levels were found in blood samples from patients who had experienced a heart attack, but not in those who had never had one or had recovered from a previous attack.
A new study found that moderate wine consumption is protective against cardiovascular disease in people who exercise regularly. However, the study did not find any benefits for people with no exercise habits.
A new study suggests rosuvastatin has an initially more favourable effect on glucose levels compared to atorvastatin in type 2 diabetes patients. This makes rosuvastatin a wiser choice, especially for those struggling to control their glucose levels.
Researchers at the University of Warwick discovered that methylglyoxal damages 'good' HDL cholesterol, reducing its protective function against heart disease. Low levels of HDL are linked to increased risk of heart disease, and MG levels can be managed through diet and supplements.
The ODYSSEY COMBO II trial shows that alirocumab, a PCSK9 inhibitor, lowers LDL-C levels significantly more than ezetimibe when added to regular statin therapy. By week 24 and 52, alirocumab achieved 50.6% and 49.5% reductions in LDL-C, respectively.
The ODYSSEY LONG TERM trial demonstrates alirocumab's efficacy in lowering LDL-C and reducing cardiovascular events. The study showed a significant reduction in major cardiovascular events and improved lipid profiles, suggesting a useful addition to statin therapy for high-risk patients.
A study found sex-specific associations between socioeconomic factors and cholesterol levels, with women having higher total cholesterol and LDL-cholesterol levels. Men's cholesterol levels were linked to their occupation, while women's were more closely tied to education level.
A Yale University study found that new national guidelines can accurately prescribe statins to patients at risk for cardiovascular disease. The research shows the new guidelines produce a modest increase in patient treatment, with only 92% of those with heavy plaque being assigned to statin therapy under the new method.
Researchers have discovered a key enzyme involved in O-glycosylation of LDLR, a receptor protein responsible for absorbing bad cholesterol. The study provides new insights into the functional impact of glycosylation on cholesterol levels.
A Mayo Clinic task force challenges recommendations in the updated ACC/AHA cholesterol treatment guideline, suggesting an individualized treatment approach with emphasis on lifestyle changes before prescribing statins. The task force also recommends considering additional tests to refine cardiovascular risk estimates.
Research highlights the effectiveness of blood pressure-lowering treatment based on cardiovascular risk, as well as the importance of predicted baseline risk equations. Additionally, studies investigate the use of bivalirudin versus heparin in percutaneous coronary intervention and implant-based multiparameter telemonitoring for heart ...
Exposure to pesticide DDT before birth is linked to increased risk of metabolic syndrome in female mice, characterized by obesity, high cholesterol, and diabetes. The study also found sex differences, with females more susceptible to these conditions.
A new study suggests that niacin should no longer be prescribed for most patients due to potential increased risk of death and dangerous side effects. The therapy was found to have no benefit in reducing heart attacks and strokes, despite raising HDL cholesterol levels.
Researchers discovered cholesterol's activation of a signaling pathway linked to cancer growth and division. Elevated cholesterol levels may selectively promote cancerous pathways, providing a new mechanism for cancer risk.
A study of over 1 million patients in the UK found an association between high blood cholesterol and increased breast cancer risk. The researchers suggest that lowering cholesterol with statins may help prevent or treat breast cancer, warranting further investigation.
Researchers at the University of Pittsburgh found that midlife sex hormone changes are associated with lower quality cholesterol carriers, which predict higher risk of heart disease. The study suggests that advanced testing methods may be needed to evaluate menopause-related dynamic changes in women.
A new MIT study provides direct evidence of plants in the Neanderthal diet, suggesting a more varied diet than previously thought. The researchers analyzed fecal remains from El Salt, Spain, finding metabolized versions of animal-derived cholesterol and phytosterol, a compound found in plants.
Research shows women with Type 2 diabetes and high cholesterol have poorer adherence to statin medication, leading to lower LDL cholesterol levels compared to men. The study highlights the need for gender-based evaluation and treatment of cardiovascular risk factors in these patients.
A multicenter study found that liraglutide, a diabetes drug, reduced weight and improved cardiovascular risk factors such as high blood pressure and cholesterol levels. The results showed significant improvements in weight loss and lipid profiles, suggesting a potential lower risk of heart disease.
A Canadian study found that women with type 2 diabetes and high cholesterol have poorer LDL cholesterol levels than men, despite equal access to cholesterol-lowering medication. The researchers suggest a need for gender-based evaluation and treatment of cardiovascular risk factors in these patients to prevent heart disease and stroke.
Researchers at UT Southwestern Medical Center have discovered a new driver of atherosclerosis, a molecule called 27-hydroxycholesterol (27HC), which exacerbates the condition and may be a promising therapeutic target. Blocking 27HC or inhibiting its actions could provide a complementary approach to preventing vascular disease.
Researchers found that people with a specific gene variation have lower blood lipids and a reduced risk of arteriosclerosis. The study, based on two large population studies, suggests that inhibiting apolipoprotein C3 could be an effective target for new drugs to prevent cardiovascular disease.
Researchers at the University of Missouri have discovered a potential cholesterol-lowering drug that can also halt the progression of breast cancer and kill cancerous cells. The compound targets the production of cholesterol in cancer cells, leading to cell death.
Researchers found that periodic fasting can convert bad cholesterol in fat cells to energy, reducing the risk of diabetes and metabolic problems. After 10-12 hours of fasting, the body starts scavenging for other sources of energy, pulling LDL cholesterol from fat cells and using it as energy.
The new ACC/AHA guidelines recommend statin therapy for people with type 2 diabetes, but experts debate its appropriateness. Robert H. Eckel supports the guidelines, while Henry Ginsberg argues they are too narrow and ignore evidence of lower LDL-C levels.
New research links low blood cholesterol to more advanced tumor stages and reduced cancer survival rates in kidney cancer patients. High cholesterol levels are associated with a lower risk of death from the disease, suggesting a potential new prognostic tool for monitoring patient outcomes.
New studies have found that daily intake of monounsaturated fatty acids is an independent predictor of remission in patients with RA, while excessive cholesterol levels increase cartilage damage in OA. The Mediterranean diet has been shown to reduce inflammatory activity and improve function in RA patients.
Researchers at Harvard University have developed a genome-editing approach that permanently reduces cholesterol levels in mice through a single injection. This approach could significantly reduce the risk of heart attacks in humans, translating to a potential 90% reduction in heart attack risk. The technique targets the PCSK9 gene and ...
Researchers found that Siberian hamsters require dietary cholesterol to enter daily torpor during winter. The minimum amount of cholesterol necessary for winter daily torpor is around 0.3%, similar to the amount found in insect larvae.
A recent NIH study found that high cholesterol levels may impair fertility in couples trying to achieve a pregnancy. Couples with the highest cholesterol levels took longer to get pregnant, while those with acceptable cholesterol levels had faster conception rates.
A new study published by The Endocrine Society found that couples with high cholesterol levels took longer to conceive a child. The study examined the rate of pregnancies among 501 heterosexual couples trying to conceive and found that those with high cholesterol levels had significantly lower fecundity rates.
Researchers found high prevalence of hypertension and elevated cholesterol among HIV patients, with low rates of control. The study recommends greater emphasis on cardiology in HIV treatment and research to optimize heart disease risk factor management.
A phase 3 study found that evolocumab, a human monoclonal antibody, added to moderate- or high-intensity statin therapy further lowers LDL-C levels by up to 24 percent. The treatment was well-tolerated and showed similar results across different statin types and doses.
A new Cornell study reveals that tofu lovers perceive it as a convenient and filling source of light protein. However, non-users had misconceptions about its cost and cooking difficulties. Correcting these misconceptions through price information, simple recipes, and 'cooks like chicken' messaging increased the likelihood of purchase.
Abnormal lipid values occur in 1 in 5 U.S. children and adolescents, associated with cardiovascular disease in adulthood. Testing rates increased only slightly from 2.5% in 1995 to 3.4% in 2010, highlighting a low rate of cholesterol testing among children and adolescents.
A recent study found that statin therapy lowers LDL cholesterol and reduces the risk of heart disease and stroke in patients with chronic kidney disease, but has no effect on kidney function or progression. The Study of Heart and Renal Protection (SHARP) included 6,245 patients who received a placebo or cholesterol-lowering treatment w...