Articles tagged with Cholesterol
A randomized trial found that a fixed-dose combination medication for blood pressure, cholesterol, and platelet control resulted in significantly improved medication adherence after 15 months. The study also showed modest but significant improvements in systolic blood pressure and low-density lipoprotein cholesterol levels.
A variant of FGF21, LY2405319, has been shown to improve metabolism in obese humans with type 2 diabetes by reducing LDL cholesterol and triglycerides while increasing HDL cholesterol levels. The hormone also reduced body weight and fasting insulin, and increased adiponectin.
A study of 2,238 CAD patients found that statin treatment reduced the risk of major cardiovascular events across all three groups: very low, low, and high LDL-C levels. Statins also showed significant benefits regardless of LDL-C level, suggesting their potential to reduce cardiovascular risk for all CAD patients.
A study found significant differences in LDL-cholesterol target achievement between Germany and the UK, with UK patients receiving more potent statins and higher doses. The UK system's incentive-based reimbursement may drive aggressive treatment, while Germany's restrictive system leads to conservative treatment.
A recent study found that intensive lifestyle changes and metformin treatment reduced cholesterol levels and improved triglyceride profiles, lowering the risk of heart disease. The Diabetes Prevention Program analyzed over 1,600 participants, showing positive changes in blood particle distribution.
Researchers discovered a new genome-wide significant locus associated with infantile hypertrophic pyloric stenosis, a serious gastrointestinal condition. The study also found an inverse relationship between low cholesterol levels at birth and increased risk of IHPS in infants.
A new study found that middle-aged men are at a greater risk for having a first heart attack due to high cholesterol levels, unlike women who are also at risk but to a lesser extent. The study suggests that men with high cholesterol should be treated more aggressively to prevent infarctions and save lives.
Researchers at Boston University's National Emerging Infectious Diseases Laboratories have generated a map of the cellular circuitry of Mycobacterium tuberculosis, shedding light on its ability to survive inactive in the human body for decades and resist treatment. The study provides new insight into the bacterium's survival mechanisms...
Researchers found that simultaneously controlling high blood pressure and cholesterol can significantly reduce the risk of heart disease. The study suggests that prescribing medications and regular doctor visits can greatly benefit certain populations, including older adults and Hispanic-Americans.
A Loyola University Medical Center study found that statin-intolerant patients who received specialized lipid clinic care had significantly reduced total and LDL cholesterol levels. In contrast, those not referred to a lipid clinic showed minimal improvement in their cholesterol levels.
A study of 1076 preschool children aged 3-5 years found associations between unhealthy eating behaviors and serum non-HDL cholesterol levels, indicating a potential early link to cardiovascular disease. The research suggests that promoting responsive feeding and healthy eating habits may help reduce the risk.
A randomized clinical trial of flaxseed supplementation in children with hypercholesterolemia found no significant effects on total and low-density lipoprotein cholesterol levels. The study concluded that flaxseed remains an unverified strategy for managing cardiovascular risk factors in youth.
Researchers at UC San Diego identified apoA-I binding protein as a key player in regulating blood vessel growth by removing excess cholesterol from endothelial cells. This process inhibits angiogenesis and can help prevent tumor growth.
A healthy Nordic diet is shown to lower cholesterol levels and reduce inflammation associated with pre-diabetes. The diet's emphasis on local produce, whole grains, and lean protein sources contributes to its benefits.
Researchers found that job stress is associated with an altered lipid profile, leading to higher rates of 'bad' cholesterol and lower levels of 'good' cholesterol. This can increase the risk of cardiovascular disease. The study analyzed data from over 90,000 workers and found a significant link between job stress and dyslipidemia.
Researchers found that breathing motor vehicle emissions alters high-density lipoprotein (HDL) cholesterol, making it contribute to clogged arteries. The inhalation of emissions activates components of oxidation, leading to inflammation and hardening of the arteries.
A new study found that consumers are more likely to endorse certain responses on agreement scales when labels are familiar to them. This can lead to biased survey results if the labels are not equivalent across languages. Researchers recommend paying closer attention to response category labels to avoid such biases.
A team of researchers led by Professor Jean Gruenberg has identified an exit in the cellular garbage truck, a structure responsible for sorting molecules and ensuring inter-cell digestion and regulation. The study reveals how Alix protein uses this route to avoid cellular digestion and how vesicular stomatitis uses it to infect cells.
Researchers found that whole walnuts and their extracted oil improve cardiovascular disease risk by favorably affecting vascular health and enhancing the functionality of good cholesterol, HDL. The study suggests that simple dietary changes incorporating walnuts or their oil in a heart-healthy diet may reduce the risk of heart disease.
A heart-healthy Mediterranean diet helped men at high risk for heart disease reduce their bad cholesterol levels by 9%, regardless of whether they lost weight. This finding suggests that the Mediterranean-style diet may be recommended for effective management of metabolic syndrome and related cardiovascular risks.
Exposure to secondhand smoke at home has been linked to lower levels of 'good' cholesterol in teenage girls, increasing their risk of heart disease. The study found that 17-year-old girls exposed to passive smoking had declined HDL cholesterol levels, making them more vulnerable to cardiovascular disease.
Researchers discovered a naturally occurring protein that disrupts cholesterol levels in cell membranes, blocking virus entry. The findings have potential for developing anti-viral therapies targeting the endosome compartment.
Researchers discovered that high cholesterol levels can cause defective cell division, leading to Alzheimer's disease and atherosclerosis. Cholesterol disrupts the process of cell division, resulting in cells with incorrect numbers of chromosomes and genes.
Researchers at the University of Michigan identified a new potential therapeutic target for lowering cholesterol, inhibiting a gene responsible for transporting a protein that interferes with liver cell function. This approach preserved the liver's capacity to clear plasma cholesterol from the blood without affecting overall health.
African-Americans with a variant of the ABCA7 gene have nearly double the risk of developing late-onset Alzheimer's disease compared to those without the variant. The study, led by Columbia University Medical Center, suggests that lipid metabolism may play a more important role in Alzheimer's disease among African-Americans.
A new study finds that walking briskly can lower the risk of high blood pressure, high cholesterol, and diabetes as much as running can. Researchers analyzed data from over 33,000 runners and 15,000 walkers to find similar reductions in risk for these conditions.
A study published in Cell Metabolism suggests that macrophage cholesterol accumulation contributes to macular degeneration. Researchers found that eye drops could reduce blood vessel growth and prevent blindness by targeting cholesterol regulators.
Researchers found that age-related macular degeneration shares a common link with atherosclerosis due to impaired cholesterol efflux in macrophages. The study suggests that cholesterol-lowering eye drops or other medications could prevent vision loss caused by macular degeneration.
A study published in Cell Metabolism suggests that targeting cholesterol metabolism in the eye may prevent severe age-related macular degeneration. Researchers found that macrophages play a key role in clearing cholesterol from the eye, and that with aging, these cells become less efficient at this task.
Researchers at the University of Colorado Cancer Center have developed a new technology that uses cholesterol rafts to deliver genetic payloads into cancer cells. This innovative approach overcomes the long-standing challenge of delivering nucleic acids across cell membranes.
A new study found that the standard formula used to calculate LDL cholesterol levels often underestimates accuracy, especially in desirable ranges. Researchers suggest using non-HDL cholesterol as an alternative to assess risk and determine treatment.
Researchers characterized SUDEP in a mouse model of DS, finding that treatment with drugs reducing parasympathetic activity reduced incidence. Lymphatic vasculature also plays crucial role in cholesterol removal from arteries, with impaired lymphatic growth leading to increased cholesterol retention. A new therapeutic target is identif...
Researchers have found that the lymphatic system is crucial for removing cholesterol from peripheral tissues, including artery walls. The study suggests that therapies supporting lymphatic transport could enhance cholesterol clearance and potentially treat atherosclerotic vascular disease.
Researchers genetically engineered tomatoes to produce a peptide that mimics the action of good cholesterol, reducing inflammation and plaque build-up in mice. The study suggests that targeting the small intestine may be a new strategy to prevent diet-induced atherosclerosis.
Researchers have identified a new alternative to statins for patients who can't tolerate the side effects of cholesterol-lowering drugs. Pitavastatin was shown to lower bad cholesterol by an average of 34% and reduce the risk of heart attack, stroke, and death in up to 68% of patients with high cholesterol.
The HPS2-THRIVE study found that niacin therapy provides no benefit and may even be harmful for patients with vascular disease. The study showed a higher incidence of bleeding, infections, new onset diabetes, and gastrointestinal problems among those receiving the drug.
Exposure to statin TV ads was linked to higher rates of high cholesterol diagnosis and statin use, especially among those at low risk for heart disease
Researchers found that LDL cholesterol increases by an average of 7mg/dL in winter compared to summer, resulting in a 8% overall increase in high cholesterol prevalence. Seasonal variations in metabolism and behavior may contribute to these changes.
A study by 98-year-old researcher Fred Kummerow found that oxidized lipids contribute to heart disease by increasing calcium deposition on the arterial wall and interrupting blood flow. Oxidized cholesterol was also linked to an increased synthesis of a blood-clotting agent, thromboxane.
Researchers at LSU Health Sciences Center have identified a new gene mutation causing Schnyder corneal dystrophy, a rare hereditary eye disease. The mutation is linked to vitamin K metabolism and may lead to the development of a new treatment using vitamin K supplements.
Researchers at the University of Gothenburg have made significant findings on the link between gut bacteria and cholesterol metabolism. The study reveals that gut bacteria can reduce bile acid synthesis in the liver by signaling through a specific protein, which could lead to new treatments for cardiovascular disease.
Researchers have found a gene associated with an unusual type of cholesterol that increases the risk of developing aortic stenosis, the most common form of heart valve disease. High levels of Lipoprotein (a) cholesterol are predicted primarily by an individual's genetic make-up.
A new study by University of Illinois researchers reveals that lipids in the cell membrane form larger domains than previously thought, with cholesterol playing a key role in their organization. The findings challenge current understanding of cell membrane structure and function.
Researchers discovered that sphingolipids form larger domains than expected, clustering together to create micrometer-sized patches in the membrane. The presence of cholesterol affects lipid aggregation, but its role is more complex than initially thought.
A new study of 73,000 Danes found that 'ugly' cholesterol, a type of remnant-like particle cholesterol, is the direct cause of arteriosclerosis and ischaemic heart disease. High levels of ugly cholesterol triple the risk of heart disease, emphasizing the need for preventive treatment and lifestyle changes.
Researchers at Northwestern University discovered a new nanoparticle that kills B-cell lymphoma cells by depriving them of natural HDL cholesterol. The nanoparticle, which mimics the size and shape of HDL particles, blocks cholesterol from entering cancer cells, leading to cell death.
A study published in Neurology found that smoking and poor blood pressure and cholesterol levels significantly increase the risk of death for patients who have survived subarachnoid hemorrhage. The research, which followed over 64,000 Finns, revealed that lifestyle changes can help prevent early deaths among SAH survivors.
Researchers at the University of Copenhagen have identified a mechanism underlying statin-induced muscle pain, which may be related to low energy production in muscles due to Q10 depletion. Statins, commonly used to treat high cholesterol levels, can affect skeletal muscle function and lead to muscle weakness and pain.
Researchers at Karolinska Institutet have identified two molecules that stimulate liver X receptors in the midbrain, promoting the production of new dopamine-producing neurons. These findings may lead to the development of regenerative medicine treatments for Parkinson's disease.
A study published in Nature Communications reveals that cholesterol regulates key signaling proteins in cells, challenging existing views on its role in heart disease. The research found that cholesterol interacts with a scaffolding protein to activate its partner, shedding light on the importance of cholesterol in cellular processes.
Scientists from Scripps Research Institute have developed a synthetic compound that reverses the effects of fatty liver disease by suppressing lipid production in the liver. The compound, SR9238, also significantly lowered total cholesterol levels and reduced markers for liver damage.
A study published in Applied and Environmental Microbiology found that changes in dietary cholesterol can alter the gut flora, leading to a shift in bacterial populations. The researchers discovered that this change triggered an increase in cholesterol excretion into the gut, which in turn affected the abundance of certain bacterial taxa.
A recent study suggests that consuming whole eggs can improve lipid profiles in individuals with metabolic syndrome, reducing triglycerides and increasing HDL cholesterol levels. Egg yolks are also a rich source of antioxidants and nutrients like vitamin D, choline, and lutein.
A recent study published in The Lancet found that combining better physical fitness and statins significantly improves survival in people with unhealthy blood fat or cholesterol levels. Moderate intensity physical activity can be achieved through walking, gardening, and gym classes, making it a feasible option for many middle-aged adul...
A new study found that using electronic health records (EHRs) can identify patients at high risk for cardiovascular disease and encourage them to receive cholesterol-lowering medication. The study showed that patients who received personalized risk assessments via mail were twice as likely to receive a prescription for lipid-lowering m...
Research found that people with diabetes who have adequate vitamin D are less likely to develop clogged arteries. In contrast, insufficient vitamin D leads to immune cells binding to blood vessels and trapping cholesterol.
A large community-based cohort study found that fasting duration showed little association with lipid subclass levels, including total cholesterol and HDL. The authors conclude that fasting for routine lipid level determinations is largely unnecessary.
Daniel J. Rader, MD, has been awarded the American Heart Association's (AHA) Clinical Research Prize for developing new methods to identify factors regulating fat particle metabolism and testing their impact on atherosclerosis. His research focuses on genetic and pharmacologic regulation of lipoprotein metabolism and atherosclerosis.
A study by researchers at the University of Pennsylvania School of Medicine found that apolipoprotein E (apoE) plays a key role in maintaining arterial softness. The protein is associated with the production of collagen and other extracellular matrix proteins, which contribute to cardiovascular disease risk.
Researchers at the University of Pennsylvania developed a new medicine to treat patients suffering from homozygous familial hypercholesterolemia, a rare and deadly cholesterol disorder. Lomitapide substantially reduced LDL cholesterol in patients by up to 50% and improved therapeutic goals for some patients.