Articles tagged with Cholesterol
Daniel J. Rader, MD, has been awarded the American Heart Association's (AHA) Clinical Research Prize for developing new methods to identify factors regulating fat particle metabolism and testing their impact on atherosclerosis. His research focuses on genetic and pharmacologic regulation of lipoprotein metabolism and atherosclerosis.
A study by researchers at the University of Pennsylvania School of Medicine found that apolipoprotein E (apoE) plays a key role in maintaining arterial softness. The protein is associated with the production of collagen and other extracellular matrix proteins, which contribute to cardiovascular disease risk.
Researchers at the University of Pennsylvania developed a new medicine to treat patients suffering from homozygous familial hypercholesterolemia, a rare and deadly cholesterol disorder. Lomitapide substantially reduced LDL cholesterol in patients by up to 50% and improved therapeutic goals for some patients.
A new study from the University of Copenhagen reveals that high blood cholesterol is far more prevalent in Denmark and globally than previously recognized. The research found 40,000 Danes with hereditary high blood cholesterol, a significant underdiagnosis and undertreatment of this serious disease.
A new study reveals that resistin, secreted by fat tissue, increases 'bad' cholesterol levels and accelerates artery plaque buildup. The discovery could lead to revolutionary new therapeutic drugs targeting resistin, improving statin effectiveness.
A new review suggests that intensive treatment with high doses of certain statin drugs is usually the best approach for treating high cholesterol and other blood lipid problems. Increasing statin doses can reduce cardiovascular problems by up to 30% in patients who need them.
A survey of 677 supplement users found that nearly half are concerned about heart health and 75% prefer natural ways to lower cholesterol. The new probiotic supplement Cardioviva aims to fill this gap with a safe and natural addition to a heart-healthy diet and lifestyle.
A large international study has identified 21 new gene variants associated with risks of heart disease and metabolic disorders. The findings expand the list of potential targets for drugs and other treatments for lipid-related cardiovascular disease, a leading global cause of death and disability.
Long-term survivors of hematopoietic cell transplants are at higher risk of developing high blood pressure, diabetes, and high cholesterol compared to the general population. Exposure to pre-transplant chemotherapy and radiation, as well as transplant type, contribute to this increased risk.
A Kaiser Permanente study found that using electronic health records improved drug-treatment intensification, monitoring, and risk-factor control among patients with diabetes. The study also noted greater improvements among patients with poorer diabetes control.
Researchers have upended assumptions on how high cholesterol leads to inflammation and atherosclerosis. Desmosterol, a precursor to cholesterol, has been found to suppress inflammatory response genes and regulate cholesterol balance.
A new study found that cooking with a blend of sesame and rice bran oils significantly lowers blood pressure and improves cholesterol levels. The researchers discovered that the oil blend works nearly as well as a commonly prescribed high blood pressure medication, with even more impressive results when used in combination.
Researchers at URMC found that defective cholesterol exportation appears to be a key component in various cancers. They demonstrated that re-establishing the cholesterol export function in human colon cancer cells inhibited tumor growth.
Vitamin D supplements did not improve cholesterol levels, according to a new study conducted at The Rockefeller University Hospital. Researchers found that correcting vitamin D deficiencies with high doses of oral vitamin D supplements had no effect on cholesterol levels in the short term.
Researchers in India have developed a non-invasive approach to determine total cholesterol levels using image processing and a database of known cholesterol levels. The test uses a digital camera to capture the back of a patient's hand and compares it with images in a database for accurate cholesterol readings.
Regular egg yolk consumption accelerates atherosclerosis in a manner similar to smoking cigarettes, according to a new study published in the journal Atherosclerosis. The research found that those eating three or more yolks per week had significantly more plaque area than those who ate two or fewer yolks per week.
A recent study found that average total cholesterol levels among US children and adolescents decreased between 1988-1994 and 2007-2010. Additionally, there was a decrease in prevalence of elevated non-HDL-C, LDL-C, and triglycerides among this age group.
Researchers found that activation of A2b-type adenosine receptor reduces insulin and glucose levels and improves symptoms of high-fat diet-induced type 2 diabetes. The study identified a novel link between A2bAR and insulin signaling, providing new insights into the regulation of glucose and insulin homeostasis.
The trial found large reductions in blood pressure and LDL cholesterol, with estimated benefits of avoiding or delaying a heart attack or stroke by 28% among participants. The Polypill is a four-component tablet that contains three blood pressure-lowering medicines and a statin for lowering cholesterol.
A German study found that focusing on high blood pressure, smoking, high cholesterol, diabetes, irregular heartbeat, and depression reduced the need for long-term care by 10% in women and 9.6% in men. The study also showed a decrease in death rates, with 2,112 expected deaths vs. 1,939 actual deaths.
Researchers at Brigham and Women's Hospital discovered that analyzing HDL particle count provides stronger cardio-protection than traditional HDL cholesterol measurement. The study suggests that raising HDL levels through other means may be more effective in preventing coronary heart disease.
Researchers discovered that silencing miR-33 reduces bile transporters and improves liver toxicity caused by statins. This breakthrough may lead to treatment options for those with BRIC and statin side effects, including improved bile metabolism and reduced cholestasis.
A Wayne State University researcher has found that ProAlgaZyme, an algae extract, increases high-density lipoprotein (HDL) cholesterol levels in animal models. This increase is associated with improved lipid profiles and reduced risk of cardiovascular disease.
Scientists have created a new laboratory opossum model to study nonalcoholic steatohepatitis (NASH), a common liver disease affecting up to 15 million Americans. The study found that high responders carried a mutated ABCB4 gene, leading to cholesterol accumulation in the liver and potential development of NASH.
Researchers at Carnegie Institution have developed a method to observe lipid metabolism in live zebrafish, revealing new aspects of lipid absorption that could improve human health. The technique enables scientists to study the process by which proteins mediate fatty acid uptake and cholesterol transport.
A study published in the National Lipid Association Annual Scientific Sessions has shown that intensive cholesterol therapy involving a combination of drugs can be more effective over the long run than taking a single statin medication. After 20 years, patients on combination therapy had lower LDL and triglyceride levels, higher HDL, a...
Scientists have discovered that zebrafish can only absorb cholesterol when fed a high-fat diet, and certain long-chain fatty acids enhance this process. The study sheds light on the complex biological mechanisms of cholesterol processing and its regulation by dietary fat.
Researchers found that adding certain apolipoproteins and lipoproteins to risk scores improved cardiovascular disease prediction in individuals without known CVD. However, the addition of these markers did not improve discrimination beyond conventional risk factors, and the clinical benefits remain uncertain.
University of Minnesota researchers found that patients with high levels of good cholesterol but low levels of the GPx3 enzyme were six times less likely to develop cardiovascular disease. The study suggests that measuring this enzyme may become a common blood test to determine risk for cardiovascular disease.
A 25-year study in Northern Sweden found that a switch to low-carbohydrate diets after reducing fat intake led to an increase in cholesterol levels, indicating a higher cardiovascular risk. Despite initial success in reducing cholesterol levels through dietary changes, the population's BMI continued to rise over time.
A new study from VCU School of Medicine has identified molecular changes that may explain the severity of liver disease and risks to heart health in patients with fatty liver. The findings suggest increased cholesterol production and decreased expression of a receptor that takes up cholesterol, leading to cardiovascular disease.
Researchers at Vanderbilt University discovered a new therapeutic strategy to reduce amyloid-beta production in Alzheimer's disease. By understanding how cholesterol binds to the amyloid precursor protein, they found that blocking this interaction could prevent amyloid-beta generation and treatment of dementia.
Recent studies using mendelian randomization have failed to support a causal association between higher concentrations of high-density lipoprotein (HDL) cholesterol and lower risk of heart attack. Instead, findings suggest that raising HDL cholesterol may not uniformly reduce the risk of myocardial infarction in humans.
Researchers at UF will study glycogen storage disease type III and its potential link to high blood pressure and other common conditions on the Faroe Islands. The center aims to provide insights into a rare genetic disorder and potentially change treatment approaches.
Researchers found two subclasses of HDL cholesterol: one with apolipoprotein C-III increases heart disease risk, while the other without it is protective. Measuring HDL-apoC-III may be a better gauge of heart disease risk than total HDL.
Research suggests that whole egg consumption can improve markers of metabolic syndrome, including HDL metabolism and inflammation. Higher-protein breakfasts also lead to increased feelings of satiety and reduced high-fat snacking.
Researchers at Simon Fraser University found that cholesterol-binding proteins called ORPs can control cell growth, potentially slowing down cancer cells. Genetic changes blocked the ability of these proteins to bind cholesterol, but altered ORPs actually stimulated cell growth by activating regulator proteins.
Researchers have made significant advancements in treating autoimmune diabetes by harnessing the power of gut bacteria. Additionally, studies on cancer treatment and tumor growth have revealed that vascular normalization can prevent dangerous side effects while enhancing anti-tumor effects. Furthermore, scientists have discovered a coo...
Researchers at Thomas Jefferson University found that eliminating the 'good cholesterol' receptor SR-BI can decrease breast cancer cell growth and tumor formation in mice. This study suggests a potential new approach to fighting breast cancer, with further research needed to fully characterize its role.
Researchers discovered a novel signaling pathway involving SIX1 and VEGF-C that plays a crucial role in breast cancer metastasis. The study showed that this pathway can be targeted to develop new anti-cancer therapies.
Scientists at Scripps Research Institute created compounds that dramatically alter the biological clock, resulting in weight loss and improved metabolic markers in diet-induced obese mice. The study suggests potential effectiveness in treating obesity, diabetes, high cholesterol, and sleep disorders.
A study published in the American Chemical Society found that capsaicinoids, a compound in chili peppers, can lower cholesterol levels and increase blood flow to the heart. The compounds may also reduce the formation of atherosclerotic plaques in blood vessels.
A meta-analysis found that non-HDL-C levels are strongly associated with the risk of major cardiovascular events in patients taking statins, more so than LDL-C. Non-HDL-C was also shown to explain a larger proportion of the atheroprotective effect of statin therapy.
Helen Hobbs, UT Southwestern researcher, receives prestigious award for identifying genetic factors that contribute to variations in cholesterol levels. Her work has led to a 28% reduction in LDL cholesterol levels and an 88% reduction in risk of coronary heart disease.
A novel monoclonal antibody, SAR236553/REGN727, has been shown to dramatically lower circulating LDL cholesterol by 40-72% in patients, providing a potential new treatment option for those resistant to statins. The study's results demonstrate a dose-response effect, with higher doses resulting in greater reductions in LDL cholesterol.
A study of 1018 adults found that those who consumed chocolate more frequently had a lower body mass index (BMI) compared to those who ate it less often. The researchers also found a positive association between chocolate consumption and improved metabolic health, including lower blood pressure and insulin sensitivity.
New research shows that lowering LDL cholesterol beginning early in life can lead to a significant reduction in the risk of coronary heart disease. The study found that a consistent 50-60% reduction in CHD risk was associated with each 1 mmol/L lower lifetime exposure to LDL cholesterol.
A study found that participants who met six or more cardiovascular health metrics had a significantly lower risk of all-cause, CVD, and ischemic heart disease mortality. Meeting a greater number of these metrics was associated with a graded lower risk of total and CVD mortality.
A study published in European Journal of Nutrition found that serum taurine intake was associated with significantly lower coronary heart disease risk among women with high total cholesterol levels. Higher taurine intake was linked to a 60% lower risk of developing or dying from CHD.
Researchers are taking a new approach to developing medications that boost levels of good cholesterol, removing it from the body. Three new versions of CETP blockers show promise as viable new heart drugs, but final judgment may be years away.
Researchers at Berkeley Lab found structural images of CETP interacting with HDLs and LDLs, revealing a tunnel mechanism that facilitates cholesterol transfer. This discovery supports the design of next generation CETP inhibitors to prevent heart disease.
Higher amounts of moderate-to-vigorous physical activity (MVPA) were associated with lower waist circumference, systolic blood pressure, fasting insulin, and higher HDL cholesterol levels. Increasing daily MVPA by 20 minutes can improve cardiometabolic health in children.
Researchers at MDC Berlin-Buch have identified a receptor for cholesterol that plays a key role in forebrain development. The study found that defective binding sites can lead to severe anomalies, highlighting the crucial importance of cholesterol metabolism in embryonic development.
Patients with low levels of anti-PC in connection with acute coronary syndromes are at a greater risk of complications and premature death. Inhibiting inflammation and cell death may have a protective effect on cardiovascular disease.
A recent study published in Stroke journal found that high triglyceride levels are a stronger predictor of stroke risk in postmenopausal women than previously thought. Researchers analyzed data from over 90,000 women and discovered that those with the highest triglyceride levels were nearly twice as likely to suffer an ischemic stroke.
Researchers found high triglyceride levels strongly predict ischemic stroke in postmenopausal women, exceeding the risk associated with cholesterol levels. The study analyzed data from over 900 women who experienced strokes, revealing a nearly two-fold increased risk for those in the highest triglyceride quartile.
A Northwestern University study reveals that individuals with low short-term risk may face very high lifetime risk of heart disease if they have just one or two risk factors, such as high cholesterol or blood pressure. The study found significant variations in risk by age, sex and race.
Researchers at the University of Illinois College of Medicine have identified a molecule embedded in liver cells that enables hepatitis C virus entry. Ezetimibe, an FDA-approved cholesterol drug, has been shown to inhibit HCV infection and may provide a new treatment option for patients.
A large-scale study found that lifestyle counseling significantly reduces time to reach treatment goals for people with diabetes, with those receiving regular counseling achieving lower blood glucose, blood pressure, and cholesterol levels. The study suggests that incorporating counseling into routine care can be an effective strategy ...
Researchers found that minuscule amounts of ethanol double the life span of a tiny worm, while higher concentrations are harmful. The discovery raises intriguing possibilities for human health benefits, but more research is needed to understand the mechanism behind this effect.