Articles tagged with Cholesterol
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Scientists have identified low cholesterol levels in immune cells as a key factor in slowing HIV progression in some individuals. This discovery could lead to the development of new therapeutic strategies for preventing HIV disease progression.
Scientists at Johns Hopkins Medicine have found a way to block abnormal cholesterol production, transport and breakdown, preventing the development of atherosclerosis in mice and rabbits. The treatment, using an existing compound called D-PDMP, successfully prevented the formation of fatty plaque and calcium deposits inside blood vessels.
Researchers found that activating a receptor, Gpr109a, can inhibit inflammation in the retina and prevent vision damage in diabetes. The new grant will enable long-term studies to evaluate the therapeutic potential of this approach.
Researchers found that pharmacist-led interventions show a significant improvement in blood pressure and cholesterol levels compared to current standard of care. Nurse-led care saw a 30% improvement, while pharmacist-led care achieved a 43% improvement in improving patient outcomes.
A randomized controlled trial found that pharmacists significantly improved blood pressure and cholesterol levels in stroke patients, with a 43% absolute improvement compared to the control group. Pharmacists' active medication adjustment contributed to this effect, despite already taking antihypertensive or lipid-lowering medications.
A daily serving of pulses can significantly lower LDL 'bad' cholesterol by five per cent, translating to a five to six per cent reduction in the risk of cardiovascular disease. North Americans would need to more than double their current pulse intake to achieve this benefit.
A study published in the Canadian Medical Association Journal found that eating just 1 serving of legumes daily can significantly reduce LDL cholesterol by 5%. This reduction may lead to a 5% lower risk of major vascular events. The authors suggest that increasing pulse intake is a reasonable and beneficial dietary change.
Researchers found high-density lipoprotein (HDL) cholesterol and remnant lipoprotein (RLP) cholesterol levels are linked to CHD risk. HDL3 subfractions, not traditional HDL cholesterol, were more predictive in assessing and reducing CHD risk.
The study found that aleglitazar did not decrease the time to cardiovascular death, nonfatal heart attack, or nonfatal stroke among patients with type 2 diabetes. The drug was associated with increased risks of kidney abnormalities, bone fractures, gastrointestinal bleeding, and hypoglycemia.
Researchers analyzed electronic health records to identify individuals at risk of familial hypercholesterolaemia. Only 4.3% of those identified were diagnosed, highlighting the need for improved provider recognition and treatment.
In a phase III study, evolocumab was shown to effectively lower LDL-C levels, with fewer side effects compared to ezetimibe. The results suggest that evolocumab may be a promising alternative for patients who cannot tolerate statins due to intolerable side effects.
The LAPLACE-2 study shows evolocumab produces highly significant reductions in LDL cholesterol when added to statins, with 93% of patients achieving an LDL level below 70mg/dL. Evolocumab also reduces non-HDL cholesterol, apolipoprotein B and lipoprotein (a) levels without liver damage or muscle problems.
A study comparing US and European cholesterol guidelines found substantial differences in statin use recommendations for men and women. The application of these guidelines to a European population resulted in varying proportions of individuals eligible for statins.
A study of 12,712 children found that 30% had borderline or elevated total cholesterol, underscoring the importance of universal pediatric cholesterol screening. The findings suggest that adopting healthy lifestyle choices and regular screening can potentially stall vascular changes and reduce future disease risk.
A large-scale study found that cholesterol levels tend to be worse in the colder months compared to warmer months, with significant variations in lipid profiles. The researchers speculate that behaviors such as reduced sun exposure and lower vitamin D levels during winter may contribute to these seasonal fluctuations.
Scientists have solved the high-resolution structure of the molecular transporter TSPO, which introduces cholesterol into mitochondria. The detailed knowledge of its three-dimensional shape and function opens up new diagnostic and therapeutic perspectives.
A rare metabolic disease causing liver failure and autistic behavior showed significant improvements after a liver transplant, suggesting an unexpected link between metabolic conditions and some forms of autism. The patient's normalization of cholesterol levels after transplantation halted the progression of neurological damage.
A new study from the Women's Health Initiative found that calcium and vitamin D supplements can lower LDL cholesterol levels and raise HDL cholesterol in postmenopausal women. Vitamin D levels also played a significant role, with higher levels associated with improved cholesterol profiles.
A recent study at the University of Eastern Finland found that increasing fatty fish intake can increase large HDL particles in the blood, which protect against cardiovascular diseases. Regular consumption of fish, especially fatty fish like salmon and rainbow trout, may help improve lipid metabolism and reduce cholesterol levels.
Researchers found that early but not advanced forms of atherosclerotic plaques in mice regress when 'bad' cholesterol is lowered. The study suggests that preventative cholesterol-lowering treatment could prevent more advanced plaque development and reduce the risk of stroke or heart attack.
A Spanish Foundation for Science and Technology study found that consuming strawberries reduced total cholesterol, LDL (bad) cholesterol, and triglycerides in healthy volunteers. The antioxidant properties of strawberries were also linked to improved cardiovascular health parameters.
A study by Penn microbiologists found that statins can lower cholesterol levels and make cells less susceptible to hantavirus infection. This could lead to potential treatments for the deadly virus, which causes flu-like symptoms and respiratory distress syndrome.
Researchers suggest lower-intensity statin combination therapy as an alternative to high-intensity monotherapy for certain patients. Meanwhile, a medical author argues that personal genome services lack evidence to support their claims and may overwhelm the healthcare system.
A new study published in Nutrition Reviews found that certain probiotics can significantly reduce LDL-cholesterol and improve other coronary heart disease risk factors. L. reuteri NCIMB 30242 (Cardioviva) was found to be the most effective, with results similar to those of existing therapeutic lifestyle change dietary options.
Researchers at Aarhus University have discovered a new way to treat high cholesterol by targeting the sortilin receptor system, which regulates PCSK9 protein levels. This breakthrough may lead to an alternative to statins for patients who cannot tolerate or benefit from them.
A GW researcher has found a connection between the pathogenesis of prion disease and HIV, discovering that impairment of cellular cholesterol metabolism is key to their development. The study suggests that stimulation of ABCA1, a cellular cholesterol transporter, could inhibit conversion of prions into a pathogenic form.
A new study led by Harvard School of Public Health found that a Mediterranean-style diet was associated with lower risk factors for cardiovascular disease among a group of young, working US adults. The study showed that promoting Mediterranean dietary habits could have significant health benefits for young populations.
Researchers discovered that kinesin KIF13B concentrates at the cell membrane where LDL is taken up, and promotes endocytosis of LRP1 through caveolae. This unexpected role for a motor protein reveals a new mechanism for regulating blood cholesterol levels.
Scientists Jürgen Rehm and David Nutt propose a simple 10-point plan to reduce personal and public costs of alcohol. The plan includes monitoring individual intake, limiting consumption, taking breaks from drinking, and implementing government interventions such as minimum pricing, labeling, and treatment.
Research from UC Davis Health found that high HDL and low LDL cholesterol levels are associated with lower brain amyloid plaque deposits, a hallmark of Alzheimer's disease. This study provides evidence for the importance of cholesterol management in preventing cognitive decline.
A recent study published in the Journal of Nutrition & Metabolism found that algal extracts from Health Enhancement Products, Inc. improved plasma cholesterol profile despite a hypercholesterolemic state induced by a high fat diet. The extracts increased 'good' cholesterol levels and decreased 'bad' cholesterol concentrations.
A new smartphone device employing advanced camera technology can now accurately read a user's cholesterol level in under a minute. The Smartphone Cholesterol Application for Rapid Diagnostics, or smartCARD, uses color analysis to discern results from a drop of blood, sweat or saliva.
Researchers discovered HDL acts upon inflammatory processes by activating ATF3, downregulating chronic inflammation in macrophages. This finding suggests a molecular approach for treating inflammation in diseases like diabetes.
A new study published by Dr. Kevin C Maki of Biofortis found that corn oil significantly reduces cholesterol levels with more favorable changes in total cholesterol and LDL-C than extra virgin olive oil. Corn oil lowered LDL cholesterol by 10.9% compared to extra virgin olive oil's 3.5% reduction.
Researchers found that high cholesterol's metabolite, 27HC, mimics estrogen to drive breast cancer growth. Statins appear to reduce this effect, suggesting a link between dietary changes and breast cancer prevention. Human breast tumors express the enzyme making 27HC, which can promote tumor growth.
A pooled analysis of 97 prospective studies found that controlling these factors can reduce the risk of heart disease and stroke in overweight and obese individuals. High blood pressure poses the biggest risk, accounting for most of the increased risk of heart disease and stroke.
Family members of patients with coronary heart disease improved cholesterol levels, physical activity, and dietary habits after participating in a year-long intervention program. The program included counselling sessions, goal setting, and feedback, resulting in reduced body mass index and waist circumference.
Researchers developed a new system using 180 factors to calculate LDL cholesterol, providing a more accurate assessment for high-risk patients. The Friedewald equation underestimates LDL levels in nearly one out of four samples, leading to potential false reassurance and inadequate treatment.
A novel method to estimate LDL-C levels has been developed, providing more accurate risk classification for heart disease. The new approach uses a larger database of lipid profiles and applies an adjustable factor for triglyceride levels, resulting in improved accuracy, especially for patients with elevated triglyceride concentrations.
Researchers at UCLA found that engineered tomatoes can reduce the negative effects of unsaturated lysophosphatidic acids (LPAs) in mice, which are linked to high cholesterol and inflammation. The tomatoes produce a peptide that mimics HDL ('good') cholesterol, stopping increases in 'bad' cholesterol and inflammation.
Researchers from Boston University School of Medicine found that only about half of patients with newly diagnosed high cholesterol were screened for thyroid dysfunction. Current guidelines recommend TSH blood tests to rule out hypothyroidism in these patients.
The new guideline identifies four major groups of patients who will benefit from statin therapy to prevent stroke and heart attacks. Adopting a heart-healthy lifestyle is also crucial in preventing high blood cholesterol.
Analysis suggests replacing saturated fats with polyunsaturated oils like corn and safflower oil may not reduce heart disease risk, but rather increase it. Health Canada should modify health claims to exclude these oils.
A study found that replacing saturated fats with polyunsaturated oils like corn and safflower oil may not reduce heart disease risk. In fact, rates of death from cardiovascular disease increased in the treatment group. Health Canada should modify its health claim for omega-6 oils.
Scientists have created a lab-made high-density lipoprotein (HDL) mimic that can be easily produced in large amounts, offering a potential new treatment for cardiovascular disease. The material is also being explored as a carrier for drug delivery and medical imaging applications.
An observational study found that testosterone treatment reduced total cholesterol, LDL, triglycerides, and increased HDL in hypogonadal men. Testosterone therapy also lowered systolic and diastolic blood pressure, suggesting a reduction in hypertension.
A new consensus report highlights massive underdiagnosis and undertreatment of hereditary high blood cholesterol in virtually all countries, with the exception of Netherlands and Norway. Easy to diagnose through a blood test and family history, the condition can be treated with statins and a low-cholesterol diet.
A study found that mothers with high LDL cholesterol before pregnancy have a 5-fold increase in their children's risk of developing high cholesterol as adults. This risk factor may be influenced by epigenetic changes, highlighting the importance of managing cholesterol levels throughout life.
Regular weight training may improve HDL function and protect against heart disease even in those who remain overweight. The study found that sedentary men had dysfunctional HDL compared to strength-trained men, regardless of body weight status. Fitness is a better measure of who has healthier functioning HDL cholesterol.
A new class of RNAi drugs has shown promising results in lowering cholesterol levels by up to 57% in healthy volunteers. The treatment, ALN-PCS, works by blocking the production of PCSK9, a protein that destroys low-density lipoprotein (LDL) receptors.
Recent studies suggest that moderate habitual coffee consumption is unlikely to adversely affect cardiovascular health. Higher green tea and coffee consumption has been inversely associated with the risk of CVD and stroke in the general population. Moderate coffee consumption may also have a favorable effect on plasma cholesterol levels.
Researchers found that pravastatin impaired learning and recognition memory in rats, while atorvostatin showed no adverse effects. The study suggests chronic treatment with pravastatin may cause cognitive impairment, but further studies are needed to confirm this.
Research reveals that high 'bad' cholesterol levels stimulate production of hematopoietic stem/progenitor cells, which promote inflammation and atherosclerosis. The study opens up a potential new approach to preventing heart attack and stroke by focusing on interactions between cholesterol and these cells.
A large DNA-sequencing study of anorexia nervosa has linked the eating disorder to variants in a gene coding for an enzyme regulating cholesterol metabolism. This finding suggests that anorexia could be caused by disruption in normal cholesterol processing, affecting mood and eating behavior.
Researchers found platelet Golgi apparatus undergoes changes after acute cerebral infarction, influencing CD40L expression and platelet function. This discovery may lead to new therapeutic targets for treating cerebral infarctions.
A randomized trial found that a fixed-dose combination medication for blood pressure, cholesterol, and platelet control resulted in significantly improved medication adherence after 15 months. The study also showed modest but significant improvements in systolic blood pressure and low-density lipoprotein cholesterol levels.
A variant of FGF21, LY2405319, has been shown to improve metabolism in obese humans with type 2 diabetes by reducing LDL cholesterol and triglycerides while increasing HDL cholesterol levels. The hormone also reduced body weight and fasting insulin, and increased adiponectin.
A study of 2,238 CAD patients found that statin treatment reduced the risk of major cardiovascular events across all three groups: very low, low, and high LDL-C levels. Statins also showed significant benefits regardless of LDL-C level, suggesting their potential to reduce cardiovascular risk for all CAD patients.
A study found significant differences in LDL-cholesterol target achievement between Germany and the UK, with UK patients receiving more potent statins and higher doses. The UK system's incentive-based reimbursement may drive aggressive treatment, while Germany's restrictive system leads to conservative treatment.
A recent study found that intensive lifestyle changes and metformin treatment reduced cholesterol levels and improved triglyceride profiles, lowering the risk of heart disease. The Diabetes Prevention Program analyzed over 1,600 participants, showing positive changes in blood particle distribution.