Articles tagged with Cholesterol
Patients with high levels of cholesterol absorption derive significant benefit from intensive treatment, while those without show no improvement. A new direction for personalized cholesterol treatment strategies is suggested.
The new guidelines recommend individual LDL cholesterol targets based on risk, aiming for at least 50% reduction. Lifestyle and nutrition are emphasized, with goals for body mass index and food preferences.
A Johns Hopkins study of over 13,000 participants found that severe obesity is a standalone high-risk factor for heart failure, but not other types of heart disease. Morbidly obese individuals were nearly fourfold more likely to develop heart failure even after controlling for risk factors such as high blood pressure and diabetes.
A large-scale study found that both high and low levels of HDL cholesterol are associated with an increased risk of premature death. Intermediate levels, however, may increase longevity. The research used data from over 1.7 million male veterans and showed a U-shaped curve relationship between HDL cholesterol levels and mortality.
A large study found that maintaining intermediate levels of high-density lipoprotein (HDL) cholesterol may help people live longer. The study, which included 1.7 million US male veterans, discovered a U-shaped relationship between HDL-C and mortality risk, with low and high levels being associated with higher risks.
Researchers in Jerusalem found that small and medium-sized HDL particles were more closely associated with protection against coronary atherosclerosis. The study, led by Dr. Chobufo Ditah, suggests that these particles may be better markers of coronary heart disease risk than traditional HDL-C.
Increased LDL-C levels increase CAD risk, while increased HDL-C and TG levels lower diabetes risk. This study uses genetics to investigate lipid associations, providing insights for drug development and potential effects on dysglycemia.
Researchers found that adding anti-PCSK9 antibodies to existing treatments can significantly reduce LDL cholesterol levels in patients. The studies demonstrated a reduction in LDL cholesterol and achieved high response rates for both alirocumab and evolocumab.
New research suggests that greater fluctuations in 'bad' cholesterol levels may be associated with lower cognitive performance in elderly adults. The study found that participants with the highest LDL cholesterol variability took longer to complete a cognitive test, indicating poorer brain health.
Researchers found that inhibiting Apolipoprotein C-III (ApoC-III) decreases triglyceride levels in blood by targeting similar pathways as LDL cholesterol. Treating mice with an ApoC-III inhibitor lowered triglycerides, but the effect was blocked in mice lacking key components of the LDL signaling pathway.
Researchers estimate that heterozygous familial hypercholesterolemia affects up to 1.5 million people in the US. Patients with this condition are at five times higher risk for coronary heart disease over the long term compared to those with average LDL cholesterol levels.
Researchers propose using small amounts of efavirenz to increase CYP46A1 enzyme activity, leading to improved memory and reduced plaque development. Studies suggest a 40% increase in cholesterol breakdown in mouse models, with potential benefits for human Alzheimer's patients.
A systematic review of over 68,000 elderly people found no association between 'bad cholesterol' and cardiovascular deaths. High levels of low-density lipoprotein (LDL-C) were often linked to longer life, contradicting the long-held cholesterol hypothesis.
A review of clinical trials found that barley lowers levels of both low-density lipoprotein (LDL) and non-high-density lipoprotein (non-HDL), two types of 'bad cholesterol'. The study suggests that barley has similar cholesterol-lowering effects as oats, making it a valuable alternative for those looking to reduce cardiovascular risk.
A new study found that one-third of children with a strong family history of CVD and/or type 2 diabetes have higher total cholesterol and unfavorable cardiometabolic markers. This group is at a higher risk of heart attacks and strokes in adulthood.
Researchers from the University Freiburg have developed a new model of T cell activation, demonstrating that cholesterol prevents an immune response even when no antigen is present. The study reveals a specific interaction between cholesterol and inactive T cell receptors, regulating their conformation and activity.
Researchers at UT Southwestern Medical Center have determined the 3D atomic structure of a human sterol transporter that helps maintain cholesterol balance. This knowledge could lead to finding highly targeted therapies to treat or prevent diseases related to sterol imbalance.
A new study found that air pollution exposure can worsen blood sugar levels, cholesterol and other risk factors for heart disease. Participants with diabetes experienced higher changes in blood glucose and cholesterol levels when exposed to higher levels of particulate matter.
A recent study published in the New England Journal of Medicine identified a rare genetic mutation that protects against chronic coronary artery diseases. Individuals with this deletion (0.8%) have lower cholesterol levels and a reduced risk of arteriosclerosis, a key factor in heart disease.
Researchers found that HDL is not uniformly predictive of cardiovascular risk, with triglycerides and LDL modifying the incidence of CVD in both low- and high-level HDL. High levels of LDL or TG can increase cardiovascular risk by 30-60% compared to isolated low HDL.
Preliminary research finds that weight loss surgery increases HDL 'good' cholesterol and improves its heart-protecting actions in severely obese teens. The study shows improved metabolic health measured by HDL function after surgery, despite remaining obesity.
Researchers at Purdue University have discovered a link between cholesterol metabolism and pancreatic cancer spread, pointing to potential new treatment using drugs for atherosclerosis. Controlling cholesterol metabolism reduces tumor growth and metastasis in mice.
A study of over 300,000 individuals suggests that cholesterol levels are similar whether patients fast or not. This new guideline eliminates the need for fasting before cholesterol testing, benefiting patients and healthcare providers alike.
A large case-control study suggests that high cholesterol levels, rather than statin use, may influence the risk of colorectal cancer. The study found an inverse relationship between blood cholesterol levels and colorectal cancer risk, with higher cholesterol levels associated with lower risk.
A large case-control study found that statin use is associated with a reduced risk of colorectal cancer, but the difference in risk between statin users and non-users was not significant. Increased serum cholesterol levels were also independently linked to decreased risk of colorectal cancer.
Researchers found that sleep loss reduces gene expression involved in cholesterol transport, leading to lower levels of good cholesterol. The study also discovered that sleep-deprived individuals have fewer high-density HDL lipoproteins, which increases the risk of cardiovascular disease.
Researchers from Sanford Research successfully modeled Smith-Lemli-Opitz syndrome using induced pluripotent stem cells, highlighting the role of Wnt/β-catenin defects in cholesterol synthesis. The study provides new insights into the underlying cellular mechanisms of this rare developmental disorder.
A study at Oregon State University has identified a specific intake level of xanthohumol that significantly improves metabolic syndrome markers and reduces weight gain in laboratory animals. The findings suggest a possible new approach to addressing obesity, high cholesterol and elevated glucose.
Researchers analyzed previously unpublished data from a large controlled trial and found that using vegetable oils high in linoleic acid may not decrease the risk of heart disease. In contrast, using butter did lower cholesterol levels without affecting heart attacks or deaths.
A recent study published in The BMJ found that replacing saturated fats with vegetable oils rich in linoleic acid does not curb heart disease risk or help people live longer. Despite lowering cholesterol levels, participants who had greater reductions in blood cholesterol actually had higher risks of death.
Researchers have developed a highly-sensitive detection method to monitor HDL kinetics, revealing new lipid biology and potential therapeutic targets. The technique allows for the identification of HDL subfractions and their unique proteomes, which may help pharmaceutical companies design more effective drugs.
Researchers found that cyclodextrin reduces atherosclerotic plaques by reprogramming macrophages and dissolving cholesterol crystals. The treatment prevents plaque formation and reduces existing plaques in mice and human carotid arteries, pointing to cholesterol crystals as a target for atherosclerosis treatment.
Researchers found that cancer cells can regulate the body's lipid metabolism to increase production of lipids. Minimizing liver production of LDL can deprive tumors of their constant supply and reduce growth. The study aims to test existing medications for hypercholesterolemia on patients undergoing cancer treatment.
Researchers at the University of Bonn discovered that cyclodextrin promotes the breakdown of cholesterol deposits in arteries, reducing inflammation and plaque formation. The ring-shaped sugar increases natural mechanisms for cholesterol breakdown and reduces inflammatory response, offering a potential new treatment for atherosclerosis.
Scientists have discovered a new way to inhibit the growth of Mycobacterium tuberculosis by using modified cholesterol as an energy source. This breakthrough holds promise for the development of new treatments for tuberculosis, a highly infectious lung disease that kills one person every 21 seconds.
The Walnuts and Healthy Aging (WAHA) study found that daily walnut consumption reduces LDL cholesterol levels and has no adverse effects on body weight among older adults. This research suggests walnuts may benefit the nutritional well-being of aging adults, particularly in terms of cardiovascular health.
A study found that only 2% of people with very high cholesterol have a familial hypercholesterolemia mutation, but those with the mutation face a six times higher risk of early-onset coronary artery disease. Genetic screening could help identify and ward off cardiovascular disease in affected individuals.
A recent clinical trial provides objective evidence of muscle-related side effects associated with statins. Evolocumab was found to be superior to ezetimibe in reducing low-density lipoprotein cholesterol levels. The study's findings have significant implications for treating patients with statin intolerance.
A new study by the Cleveland Clinic has identified statin intolerance objectively, showing that evolocumab is a more effective option for lowering cholesterol in patients who are intolerant to multiple statins. The PCSK9 inhibitor reduced cholesterol levels by 52.8%, while ezetimibe had a smaller reduction of 16.7%.
A large clinical trial of evacetrapib, a CETP inhibitor, showed no reduction in major adverse cardiovascular events, despite significant increases in HDL and decreases in LDL cholesterol levels. The study's findings challenge conventional thinking on the benefits of high-density lipoprotein (HDL) cholesterol.
A phase 3 clinical trial showed evacetrapib reduced LDL cholesterol by 37% and HDL cholesterol by 130%, but failed to lower rates of major cardiovascular events. Researchers attribute the lack of benefits to the drug's inability to translate improved cholesterol levels into clinical outcomes.
Researchers discover inhibiting cholesterol esterification enzyme ACAT1 boosts CD8+ T cells' antitumor activity. Avasimibe, a small molecule inhibitor of ACAT1, shows promising results in treating cancer and could be used as a complement to current immunotherapies.
A new study reveals genetically inherited high levels of cholesterol are more prevalent than previously believed, affecting an estimated 834,500 U.S. adults. Researchers found that familial hypercholesterolemia (FH) affects both men and women equally, with varying prevalence rates across racial groups.
A study published in the European Heart Journal found that improved lifestyles led to a significant decrease in cholesterol levels, resulting in reduced cardiovascular disease and cardiac death. The study shows that changes in diet and lifestyle had a more pronounced effect on older individuals and those with high risk of cardiovascula...
Research suggests that moderate drinking poses an immediate higher cardiovascular risk, but this risk lessens and can become protective after 24 hours. Heavy drinking, on the other hand, heightens short- and long-term risks of heart attack and stroke.
A study of 5,566 older workers found that those in sales, office-support and service occupations had more risk factors for heart disease and stroke than management or professional jobs. Workers in these professions had higher rates of smoking, poor eating habits and lower levels of physical activity
A study of over 18,300 U.S. adults found that increasing plain water intake by 1% daily led to significant reductions in calorie intake, saturated fat, sugar, sodium, and cholesterol consumption. The study suggests universal nutrition interventions promoting plain water consumption may be effective across diverse population subgroups.
A recent study published in the journal SLEEP found that people with insomnia do not have higher levels of cholesterol than those without. However, insomniacs who take sleeping pills were found to have significantly higher levels of LDL cholesterol.
A rat study published in the Journal of the Federation of American Societies for Experimental Biology found that exposure to Beijing's polluted air increases weight and metabolic dysfunctions. The study also showed that pregnant rats exposed to polluted air had higher levels of insulin resistance, a precursor to Type 2 diabetes.
A new meta-analysis published in the Journal of Clinical Lipidology found that consuming 1-1.5 avocados per day significantly reduced total cholesterol, LDL-C, and triglycerides when replaced with solid fats. Avocado consumption did not impact HDL levels.
A new study from the University of Eastern Finland found that a high-cholesterol diet and frequent egg consumption are not associated with an elevated risk of coronary heart disease. The study included over 1,000 men aged 42-60 years and found no link between dietary cholesterol or eggs and cardiovascular disease.
A walnut-rich, higher-fat diet resulted in significant weight loss and improved cholesterol levels compared to a lower-fat, higher-carbohydrate diet. The study found that participants on the walnut-rich diet showed comparable weight loss effects as those on the lower fat diet.
Researchers have identified a new drug target that can restore healthier lipid levels in people with type 1 diabetes. By blocking the growth hormone receptor, MIA-602 has been shown to reduce unhealthy lipids and improve vascular function.
Researchers at the Tata Institute of Fundamental Research found that cholesterol-rich domains on phagosome membranes facilitate the transport of pathogens to lysosomes for degradation. This process is disrupted by certain parasites, potentially allowing them to survive and spread infection.
A University of California, San Diego study found that weight loss programs emphasizing healthy fats lower both good and bad cholesterol. The walnut-rich diet had the most impact on cholesterol levels, decreasing low-density lipoprotein and increasing high-density lipoprotein.
A new study published in PLOS ONE found that while a healthier diet can aid weight loss and improve metabolism, it may not fully reverse liver damage caused by the Western diet. Diets high in sugar significantly slow liver recovery, even if overall calorie intake is reduced.
A recent study by the University of California, Irvine found that three-fourths of ER stroke cases had some degree of preventability, highlighting the need for improved stroke prevention strategies. The study's results suggest that resources for acute stroke treatment may be misdirected towards patients whose strokes are more preventable.
Children with common allergies like asthma and hay fever have a higher rate of hypertension and high cholesterol, setting them up for heart disease early on. Inflammation from these conditions may contribute to cardiovascular risks.
Eating a daily handful of walnuts improves blood vessel cell wall function and lowers total and LDL cholesterol in adults at risk of diabetes. The walnut diet also enhances endothelial cell function, regardless of calorie intake.
Researchers used urine-derived induced pluripotent stem cells (iPSCs) to model hypercholesterolemia and predict patient responses to cholesterol-lowering drugs. The study shows that these models can be used to test the efficacy of PCSK9 inhibitors, potentially paving the way for personalized treatment.