Articles tagged with Cholesterol
A study by Brigham and Women's Hospital found that a combination of high levels of dietary cholesterol with specific saturated fats exacerbates retinal damage in a preclinical model of diabetes. The research used an experimental rat model to examine the effects of different dietary fats on early molecular signs of inflammation and damage.
Researchers found that patients taking an additional injection of alirocumab, a PCSK9 inhibitor, had significantly reduced cholesterol levels and lower risk of heart attack. For patients with diabetes, the treatment was found to reduce cardiovascular risk by an average of 2.3%.
Researchers found a consistent cholesterol-lowering effect for soy protein across all 46 trials, contradicting the FDA's proposed revocation of its health claim. The study's findings support the original FDA claim and highlight the benefits of incorporating soy into a plant-based diet.
A recent study by Jae Hee Kang et al., published in JAMA Ophthalmology, initially reported a significant association between long-term statin use and reduced primary open-angle glaucoma risk. However, due to serious coding errors, the findings were later retracted.
Research found associations between serum antibodies against P. gingivalis and A. actinomycetemcomitans with altered metabolite levels, including lipoprotein particles and fatty acids. These findings suggest exposure to periodontal pathogens may contribute to a proatherogenic state.
Researchers have demonstrated a new imaging modality that accurately evaluates plaque-based cholesterol, allowing for more timely treatment of atherosclerosis. The technology combines laser photoacoustics and frequency-domain signal processing to detect cholesterol in arterial plaque.
A recent study found that lowering cholesterol with statins does not decrease the activation of immune cells in patients with high cholesterol levels. This 'trained immunity' allows immune cells to 'remember' previous exposures and maintain hyperactivity despite cholesterol reduction.
Drinking unsalted tomato juice lowered blood pressure and LDL cholesterol in Japanese adults at risk of cardiovascular disease. The study found significant drops in systolic and diastolic blood pressure and LDL cholesterol levels over a year.
A new study found that irregular sleep patterns are associated with a higher risk of metabolic disorders, including obesity and high cholesterol. The research suggests that maintaining a regular sleep schedule has beneficial effects on metabolism.
A large-scale study found that consuming high amounts of cholesterol from eggs is associated with a higher risk of cardiovascular disease and death. The researchers also noted that even healthy diets can have negative effects when eggs are consumed excessively, emphasizing the importance of moderation and balance in daily eating habits.
Researchers discover that cell cannibalism contributes to the concentration of harmful substances, leading to a 'double-whammy' for cell health. This process can perpetuate disease transmission and exacerbate conditions like atherosclerosis.
Researchers at Houston Methodist have identified a new regulatory mechanism in zebrafish models that leads to high levels of LDL cholesterol, increasing the risk of cardiovascular disease. The study suggests targeting this protein using its antagonist could reduce white blood cell counts and bring down the risk of heart disease.
A new study published in the American Journal of Clinical Nutrition finds that red and white meats raise low-density lipoproteins (LDLs) by the same amount, regardless of meat type. Plant proteins show the best cholesterol benefit and should be prioritized for heart health.
Researchers found a link between high LDL cholesterol levels and early-onset Alzheimer's, suggesting LDL may play a causal role in the development of the disease. APOE E4 and other gene variants also explain some cases, but the study suggests cholesterol could be an independent risk factor.
A study published in JAMA Cardiology found that blood donation programs can be used to screen for familial hypercholesterolemia (FH), a genetic cholesterol condition. Researchers identified over 3,000 people with FH in the blood donation records of nearly 1.2 million donors.
Researchers analyzed data from 1.2 million donors to determine if blood donation programs could detect familial hypercholesterolemia, a genetic disorder causing high cholesterol and premature coronary artery disease. The study found that about 1 in every 339 donors met the criteria for the condition.
Nearly one in 10 young adults who had a heart attack met the clinical definition for familial hypercholesterolemia. Many patients continued having elevated cholesterol levels a year after their heart attack, highlighting opportunities for more aggressive treatment.
Cholesterol levels in US children and adolescents decreased over two decades, with favorable changes observed in total cholesterol and triglycerides. However, only half of participants achieved ideal levels for all measures, highlighting the need for continued efforts to address childhood obesity.
According to a study published in JAMA, only half of children and adolescents in the US have ideal cholesterol levels, with 25% having clinically high levels. High cholesterol in childhood is a key risk factor for developing heart disease later in life.
A new Finnish study published in the American Journal of Clinical Nutrition found that dietary cholesterol and moderate egg consumption are not associated with an increased risk of stroke. The study, which followed 1,950 men for 21 years, also found no association between these factors and stroke risk in carriers of the APOE4 phenotype.
Researchers found that mirabegron increases cholesterol synthesis in mouse models of atherosclerosis, leading to accelerated plaque growth and increased cardiovascular risk. The changes were linked to thermogenic fat breakdown induced by mirabegron treatment, raising concerns for patients with LDL receptor mutations.
Researchers found simvastatin helped delay disability worsening and slow brain atrophy in people with secondary progressive MS. The study suggests statins may have independent effects on the disease, beyond cholesterol lowering.
A new study finds that a third of people taking statin medications in Indiana do not reach a safe level of LDL-C, putting them at increased risk for cardiovascular disease events. Reducing their bad cholesterol levels could save $1,455 per person and avoid 1,173 cardiovascular disease events.
A meta-analysis of 46 trials found soy protein reduces LDL cholesterol, supporting its inclusion as a heart-healthy food option. Researchers hope their findings inform the FDA's evaluation of soy protein.
A recent study of over 136,000 adults found that high cholesterol levels are associated with an increased risk for primary open-angle glaucoma. In contrast, longer use of statins was linked to a lower risk of POAG, particularly among those 65 and older.
Researchers found that half of patients prescribed statins failed to achieve 'healthy' cholesterol levels within two years, increasing the risk of cardiovascular disease and stroke. Patients who did not respond well had a 22% higher risk of developing cardiovascular disease compared to those who reached the target.
A new algorithm developed by Stanford researchers can accurately identify individuals at risk of familial hypercholesterolemia (FH), a cholesterol-raising genetic disease that increases the risk of early and fatal heart problems. The algorithm, trained on data from over 200 FH patients, correctly flagged 88% of cases in testing runs.
A new study has found that women with low-density lipoprotein (LDL) cholesterol levels below 70 mg/dL may be at a higher risk of hemorrhagic stroke. The study also found that women with the lowest triglyceride levels had an increased risk of bleeding strokes compared to those with the highest triglyceride levels.
Researchers have unraveled the three-dimensional structure of ATP citrate lyase (ACLY), a central metabolic enzyme crucial for fatty acid and cholesterol production. The study's findings provide new insights into ACLY's role in metabolism, evolution, and potential therapeutic targeting of cancer and metabolic diseases.
A team of scientists has unraveled the three-dimensional structure and molecular mechanism of ATP citrate lyase, a key enzyme in fatty acid and cholesterol production. The findings offer new insights into the origins of cellular respiration and have potential therapeutic implications for metabolic diseases and cancer.
Researchers discovered a novel molecular pathway for PAI-1 inhibition that reversed diet-induced obesity and its related health problems in mice. The investigational drug TM5614 showed significantly improved fasting levels of blood sugar, insulin, and LDL cholesterol, as well as a reduction in fatty liver disease.
A 64-year-old woman developed acute liver injury after taking red yeast rice supplement for six weeks. The supplement contains monacolin K, a chemical found in lovastatin, which carries the same risk of liver damage as statin medication. Doctors warn that more regulation is needed to prevent harmful side effects.
A study found that bempedoic acid significantly reduces LDL cholesterol levels in patients with high-risk cardiovascular disease who are already taking statins. The treatment was durable and had no increase in adverse effects compared to a placebo at one year, suggesting it may be a viable alternative for these patients.
A large study of nearly 30,000 adults found that consuming 300 mg of dietary cholesterol per day increases the risk of cardiovascular disease by 17% and death by 18%. The study also linked eating three to four eggs per week to a 6% higher risk of cardiovascular disease and an 8% higher risk of any cause of death.
A large observational study of over 29,000 people found no significant association between dietary cholesterol and the risk of cardiovascular disease or death. Conversely, egg consumption was linked to a higher risk of CVD, suggesting that other factors may contribute to this association.
A new class of oral cholesterol-lowering drug bempedoic acid has shown effectiveness in reducing LDL cholesterol levels and preventing heart disease. The treatment is well-tolerated, with minimal side effects, making it a potential option for patients unable to take statins.
A study reveals that eight out of ten women of childbearing age have never had their cholesterol levels checked, highlighting gaps in lipid screening. Research suggests that high cholesterol during pregnancy can lead to early birth and low birth weight babies, as well as increase the risk of heart disease and stroke.
A high-fat diet causes thickening of arteries at the cellular level, according to researchers. The study found that even small amounts of oxidized LDL can dramatically change the structure of the cell membrane, leading to increased tension and stiffness.
A new study published in Neurology has found that medications commonly used to lower blood pressure and cholesterol do not slow down cognitive decline in older adults. The study, which involved over 1,600 participants, suggests that longer studies are needed to determine the effects of these medications on brain health.
A recent study found that resistance training improves health in over 65-year-olds, with benefits even when training as little as once per week. The benefits include improved blood values, muscle strength, and mental well-being.
A study of over 30,000 Americans reveals significant differences in managing heart disease risk between women and men. Women have better control of high blood pressure, while both sexes struggle with obesity and cholesterol management.
A Chinese national screening project found that only 0.6% and 2.4% of individuals with high cardiovascular risk were using statins and aspirin, respectively. The study highlights the need for increased risk mitigation in China's population.
A recent study published in the Journal of Lipid Research found that the protein makeup of HDL particles plays a crucial role in their ability to predict heart health. The research, led by Nathalie Pamir, identified genetic variants linked to cholesterol efflux capacity and proteins associated with HDL's activity.
A large study of genetic data suggests that statins could prevent the onset of motor neurone disease, as higher levels of LDL cholesterol were causally linked with a greater risk. The condition affects up to 5,000 adults in the UK and is projected to nearly double by 2040 due to ageing of the global population.
Researchers discovered a rare tumor type that can't synthesize cholesterol, leading to its dependence on external nutrients. This vulnerability can be exploited with therapies blocking cholesterol uptake, offering a potential treatment for drug-resistant ALCL cells.
A randomized-controlled clinical trial found that Montmorency tart cherry juice helped lower systolic blood pressure and LDL cholesterol in older adults by reducing inflammation and oxidative stress biomarkers. The participants also showed increased DNA repair activity, suggesting potential health benefits for heart health.
Researchers found that high triglyceride levels were linked to lower risk of cognitive decline, frailty, and death in older adults. Current guidelines for lowering cholesterol may not be beneficial for this age group.
A meta-analysis of 28 randomised controlled trials found that statin therapy reduces the risk of major vascular events in older people by about a fifth per 1 mmol/L reduction in LDL cholesterol. The study showed no adverse effects of statin therapy on non-vascular mortality or cancer across all age groups.
The University of Warwick has identified the enzyme DGAT1, which controls how much fat is added to particles released by the liver. Inhibiting this enzyme allowed scientists to 'slim down' particles and load them with less fat, reducing the amount of 'bad' cholesterol in the blood.
A team of researchers from Illinois Institute of Technology has developed a novel microfluidic device for measuring cholesterol secreted from human hepatocytes in real-time. The device uses bead-based enzymatic assay for cholesterol measurement, which can quantify cholesterol secreted by human hepatocytes in real-time on-chip.
Several studies have shown that reducing LDL-C to levels lower than 50 mg/dl can provide cardiovascular benefits. However, data on the impact of lowering LDL-C below 25 mg/dl is limited, with some evidence suggesting no increased risk of cancer or hemorrhagic stroke.
A new study of 25,000 Danes reveals that cholesterol levels are 20% higher after the Christmas break, increasing the risk of high cholesterol by six times. The research suggests that festive food may contribute to elevated cholesterol readings, highlighting the importance of monitoring cholesterol levels during the holiday season.
Research identifies GM3S and GM3 ganglioside as crucial for intestinal cholesterol uptake, offering a new therapeutic target for reducing high blood cholesterol. A high-cholesterol diet-fed mouse model with deficient GM3S shows lower susceptibility to high blood cholesterol.
A new study by USC researchers reveals that a fatty diet can trigger changes in the immune system leading to non-alcoholic steatohepatitis (NASH), a serious form of non-alcoholic fatty liver disease. The study identified a novel type of reparative macrophage that counteracts inflammation, offering potential pathways for future therapies.
A study by Imperial College London and University of Leicester found that patients taking high-intensity statins and adhering to treatment regimens can avoid 12,000 cardiovascular events. High adherence achieves better long-term cholesterol reductions and outcomes for patients.
Researchers at Boston University have made significant progress in understanding the molecular mechanisms underlying HDL formation. They discovered a crucial interaction between apolipoprotein A-I and ABCA1 proteins, which enables the formation of nascent HDL particles.
Researchers have determined the structure of an enzyme that helps remove excess cholesterol from the body. A small molecule stimulates LCAT enzyme action, showing promise for treating heart and kidney disease. The study paves the way for potential new therapeutics.
Researchers at The Wistar Institute developed novel synthetic DNA-encoded monoclonal antibodies targeting PCSK9, which significantly reduced cholesterol levels in preclinical studies. This approach may provide a less frequent and cost-effective alternative to statins for treating high cholesterol and reducing cardiovascular risk.
Studies in mice with psoriasis-like conditions found that stiff blood vessel walls trapped cholesterol, promoting plaques and increasing cardiovascular risk. Neutralizing a specific immune cell type reduced collagen density and cholesterol deposits, suggesting a preventable link between autoimmune diseases and heart disease.
A large international clinical trial found that alirocumab, a PCSK9 antibody, reduced the chance of additional heart problems or stroke in heart attack survivors. LDL cholesterol levels decreased by 50% with alirocumab treatment, leading to a 15% reduction in risk of death from coronary heart disease, another heart attack, or stroke.