A recent study discovered that brain cells cannot maintain the myelin sheath in the absence of the TDP-43 protein. Restoring cholesterol levels has been proposed as a potential therapeutic strategy for neurodegenerative diseases associated with TDP-43. The research found that oligodendrocytes, responsible for producing myelin, have def...
Researchers identified bioactive substances that modulate cholesterol homeostasis, a common feature among many compounds. These findings suggest potential side effects of active substances and provide new insights into targeting cholesterol homeostasis, which may also impact SARS-CoV-2 infections.
Researchers identified an immune component, STING, linked to Niemann-Pick disease type C, a condition with no effective treatments. The discovery suggests a new therapeutic target for the disease and offers hope for treatment with immune inhibitors.
A new study has identified key pathways linking high-fat diets to atherosclerosis in mice, shedding light on the role of neutrophils and citrullination in inflammation. Researchers found that blocking this process could lead to reduced neutrophil adhesion and potentially prevent blocked arteries.
Researchers found that eating 50 grams of prunes daily for six months improved CVD risk biomarkers, raised 'good' cholesterol, and lowered inflammation. The study suggests that prunes may be a promising addition to the diet to reduce CVD risk and inflammation.
A new statewide study in Michigan found that smokers needed their blocked arteries fixed nearly a decade earlier than non-smokers, with patients with obesity undergoing procedures four years earlier than non-obese patients. The study suggests that preventing smoking and obesity could delay the onset of heart disease.
A nationwide study found that blood sugar control among US adults with diabetes declined significantly between 2007-2010 and 2015-2018. The proportion of adults achieving glycemic control dropped from 57.4% to 50.5%, while blood pressure control decreased, but cholesterol control levels remained stable.
A new study found that consuming mangos can help lower chronic disease risk by improving fasting glucose levels and reducing inflammation. Researchers also discovered that adding herbs and spices to the diet may help lower blood pressure, while ginger, cinnamon, and turmeric supplements were linked with improved cholesterol benefits.
The American Heart Association recommends increasing physical activity as the first treatment choice for mild to moderately elevated blood pressure and cholesterol. Regular exercise can lower blood pressure and cholesterol, with benefits extending to other health areas.
Researchers found that disturbances in cholesterol catabolism are associated with increased risk of Alzheimer's disease and vascular dementia. The study also suggests that bile acid synthesis may impact brain signaling pathways, leading to sex-specific effects on dementia progression. Further studies are needed to confirm these findings.
A new study of over 2 million people found no link between regular milk consumption and increased cholesterol levels. Those who regularly drank high amounts of milk had lower levels of both good and bad cholesterol, as well as a reduced risk of coronary heart disease.
Researchers used base editing to introduce a single point mutation in the PCSK9 gene, reducing LDL cholesterol levels by up to two-thirds. This precision technology holds promise for treating inherited metabolic liver diseases.
Scientists at UCL have identified a new immunotherapy that targets acyl-CoA:cholesterol acyltransferase (ACAT), an enzyme helping to manage cholesterol levels in cells. Boosting ACAT inhibition boosts specific immune cells fighting both the virus and cancerous tumours, demonstrating its effectiveness as an immunotherapy.
Researchers at University of California San Diego School found that controlling cholesterol in microglia can alleviate chronic pain, a common side effect of chemotherapy. They developed a novel therapeutic approach using a modified version of apoA-I binding protein to reverse the harmful effects of excessive cholesterol.
Cholestenone inhibits H. pylori cell wall biosynthesis by suppressing CGL production, effective against clarithromycin-resistant strains and eradicating bacteria in mice fed with cholestenone-containing diets.
Researchers at University of Utah Health found a strong association between preeclampsia and stroke risk in women who had the condition during pregnancy. Over an average follow-up period of 32 years, women with preeclampsia were 3.8 times more likely to have strokes compared to those without the condition.
A study published in PNAS found that zebra finches have a low-density lipoprotein receptor gene with key domains missing, allowing them to carry high levels of good cholesterol while avoiding high cholesterol-related diseases. This genetic adaptation may hold clues for improving cardiovascular disease treatment.
Recent advances in understanding atherosclerosis have shifted traditional views on who is at risk for heart attacks and strokes, highlighting the importance of HDL cholesterol, triglycerides, and inflammation. This review paper explores these changes and their implications for treatment and prevention.
Research found that shift workers with a deviated body clock had higher cardiovascular risk, even after adjusting for sociodemographic and lifestyle factors. The study's findings suggest that staff with atypical work schedules may need closer monitoring for heart health.
A randomized controlled study found that a Mediterranean diet combined with small portions of lean beef helped lower LDL cholesterol and non-HDL cholesterol levels. The study suggests that healthy diets can include a wide variety of foods, including red meat, while still being heart-friendly.
Researchers discovered that higher levels of HDL cholesterol with improved anti-inflammatory capacity are associated with lower risk of cardiovascular events. The study suggests that adding this measure to risk scores may improve heart disease prediction and patient protection.
New research suggests that HDL particles' anti-inflammatory properties may predict future cardiovascular events, improving risk assessment and prediction. The study found that individuals with lower anti-inflammatory activity in their HDL particles were more likely to experience cardiovascular events.
Researchers found that almonds contain approximately 20% unabsorbed calories after digestion, which can result in reduced energy absorption and potential weight loss. This finding could alleviate concerns about nuts contributing to weight gain, allowing for healthier snacking options.
A team of University of Alberta researchers has identified a protein that blocks the body's ability to clear low-density lipoprotein (LDL) cholesterol from the blood. This discovery paves the way for developing a new drug to boost existing statin drugs and prevent heart disease.
Researchers have identified a genetic link to clogged arteries, finding that a specific gene variant increases the risk of coronary artery disease, high blood pressure, and diabetes. The discovery provides new insights into the causes of cardiovascular disease and offers potential therapeutic targets for treatment.
A new approach has led to the discovery of a small molecule that may help regulate cholesterol levels in the brain, making it a potential therapeutic target for Alzheimer's disease. Increasing the activity of ABCA1 is expected to positively influence insulin signaling and reduce inflammation in the brain.
The study found that phospholipid PtdIns4P and cholesterol play a critical role in G-protein coupling and ligand recognition, stabilizing the receptor's basal activity. Water molecules also mimic polar functionalities of serotonin, sustaining basal activity.
Researchers at VCU Massey Cancer Center have identified a crucial link between the development and growth of glioblastoma multiforme, the most aggressive type of brain cancer. The gene YTHDF2 drives increased cholesterol levels in GBM cells, paving the way for potential new treatments targeting this gene.
Researchers at Greenwood Genetic Center have identified cholesterol accumulation as a key contributor to the symptoms of genetic movement disorders, including seizures and balance issues. The study provides new hope for treatments targeting cholesterol accumulation, such as the drug 2-hydroxypropyl-beta-cyclodextrin, which showed signi...
Researchers at Tufts University use lipid nanoparticles to deliver CRISPR machinery specifically to the liver, reducing blood cholesterol levels by up to 57% in mice. The treatment may provide a long-term solution for high cholesterol, which affects over 29 million Americans.
Researchers at Aarhus University and hospital have identified the fundamental step linking hypertension to atherosclerosis, finding that hypertension causes increased accumulation of bad cholesterol in arterial walls. This discovery may aid in developing new treatments targeting disease mechanisms.
A new study published in eLife found that combining healthy lifestyle interventions with cholesterol-lowering medications yields the greatest benefits to heart health. Healthy lifestyles, including exercise and a balanced diet, can lower LDL cholesterol and increase HDL cholesterol, reducing the risk of heart disease.
A study found that maternal cardiovascular health during pregnancy is associated with the later cardiovascular health of their offspring in adolescence. The research examined various factors such as body mass index, blood pressure, and cholesterol levels.
A new study published in PLOS Medicine found that whole egg consumption was positively associated with increased all-cause mortality, while egg whites or substitutes were negatively associated. Replacing half a whole egg with egg whites/substitutes reduced cardiovascular disease mortality by 3%.
A new research program, led by health coaches at primary care clinics, has shown that lifestyle interventions can significantly improve heart disease risk factors. Participants experienced lower blood sugar levels, increased good cholesterol, and improved overall cardiometabolic risk scores.
A new study found that a vegan diet is more effective than the Mediterranean diet for improving health markers and boosting weight loss. Participants who followed a low-fat vegan diet lost an average of 6 kg and had significant reductions in visceral fat, total and LDL cholesterol levels.
A new study from the University of Bristol suggests that vitamins D, K, and A could help combat COVID-19 by binding to the viral Spike protein. This reduces SARS-CoV-2 infectivity, while high cholesterol may enable the virus. Researchers identified potential antiviral drug candidates among approved pharmaceuticals and dietary components.
Researchers at Northwestern University have developed a novel therapy that uses synthetic nanoparticles to trigger the destruction of lymphoma cells by depriving them of cholesterol. This approach has potential for targeting other cancers with an appetite for cholesterol, such as kidney and ovarian cancer.
A new model explains why saturated fats increase blood cholesterol and why this should be dangerous. The 'Homeoviscous Adaptation to Dietary Lipids' (HADL) model suggests that cells adjust membrane fluidity according to changes in diet, leading to a decrease in blood cholesterol levels when consuming polyunsaturated fats.
Cholesterol crystals are identified as a primary cause of preeclampsia, triggering an inflammatory response that affects the communication between mother and foetus. This discovery may lead to more effective treatment options, including cholesterol-lowering medications.
Researchers at Nagoya University found that blood pressure, hematocrit, and serum cholesterol levels change in patients with Parkinson's disease long before the onset of motor symptoms. These biomarkers may help detect early signs of developing Parkinson's disease.
Researchers discovered that gamma-delta T cells require glucose to eliminate tumor cells but consume cholesterol, promoting pro-tumor functions. This dichotomy in energy resources has implications for cancer immunotherapy and diet's impact on its effectiveness.
Researchers at Kyoto University's Institute for Integrated Cell-Material Sciences have identified a possible link between a large cholesterol transport protein and schizophrenia. Mice with disrupted ABCA13 protein showed abnormal behaviour, including impaired prepulse inhibition, suggesting a potential role in the pathophysiology of ps...
Researchers propose that a family of transporter proteins, including ABCA1, enabled vertebrates to thrive on land and develop complex body structures. The protein regulated cholesterol levels, allowing for the development of sophisticated biological processes.
CREB3L3 protects against atherosclerosis by inhibiting SREBP's expression. Absence or overexpression of CREB3L3 exacerbates high blood lipid levels and atherosclerosis. The study provides insight into the molecular basis of atherosclerosis and its potential therapeutic targets.
A study by University of Illinois researchers found that beta-carotene's full health benefits require an active enzyme to produce vitamin A. The active enzyme BCO1 converts beta-carotene into vitamin A, which helps lower bad cholesterol and protect against atherosclerosis.
A study from the University of East Anglia found that blood biomarkers such as cholesterol, inflammation, and liver function can predict future disability and healthcare demand. The researchers also discovered a pro-rich inequity in health care use, where people with higher incomes are more likely to seek medical attention.
A team of researchers identified critical molecular processes in human cells that coronaviruses use to survive. Targeting these processes with drugs may treat not only COVID-19 infections but also other existing and future coronaviruses, including common cold viruses and more severe viruses.
Researchers identified 10 metabolites associated with the risk of stroke, including a lower risk for ischemic stroke and higher risk for hemorrhagic stroke. Histidine and high-density lipoprotein cholesterols were found to have protective effects, while pyruvate increased the risk of ischemic stroke.
Researchers have developed microfiber- and nanofiber-based wearables that can track vital signs like blood pressure and cholesterol levels. These technologies could lead to non-invasive health monitoring for chronic illnesses.
New data from the CASCADE FH Registry highlights gaps in care for children with familial hypercholesterolemia. Children are typically diagnosed at age 9, seven years after cholesterol screening guidelines recommend it. Early treatment intervention can prevent cardiovascular disease.
A remote disease management program improved clinical outcomes for 3,939 patients with uncontrolled LDL cholesterol and 1,437 patients with high blood pressure. The program achieved significant reductions in LDL cholesterol (42%) and blood pressure levels (14/6mmHg) in participants.
A remotely-delivered, algorithm-driven program improved patients' cholesterol and blood pressure levels by identifying those with uncontrolled LDL-C and/or high blood pressure. The study used electronic health records and clinical algorithms to initiate and titrate medications at preset intervals until treatment goals were achieved.
Researchers from Queen Mary University of London used Mendelian Randomization to investigate cardiovascular risk factors and COVID-19 infection. Individuals with high BMI and low-density lipoprotein (LDL) cholesterol are at increased risk of getting COVID-19, according to the study.
A phase 2 study found that evinacumab reduced LDL cholesterol by 50% in patients with severe hypercholesterolemia resistant to standard treatments. The therapy works through a different mechanism than existing drugs and shows promise for treating refractory hypercholesterolemia.
A single daily pill combining blood pressure and cholesterol medications with or without aspirin reduced cardiovascular disease events in people at intermediate risk for heart disease. The polypill plus aspirin combination lowered cardiovascular disease by 31%, compared to the polypill alone, which reduced it by 21%.
Two studies suggest that older adults aged 70 and over with elevated LDL cholesterol levels have the highest incidence of heart attacks and cardiovascular diseases. Cholesterol-lowering therapies, including statins, are as effective at reducing cardiovascular events in this age group as they are in younger people.
A study found that DSCR-1 suppresses oxidized LDL cholesterol production and angiogenic signaling, protecting against corneal opacity. High DSCR-1 expression also reduced vascular diseases such as atherosclerosis and hypertension.
The Endocrine Society's Clinical Practice Guideline emphasizes the importance of evaluating high cholesterol and triglycerides in adults with endocrine disorders. The guideline provides recommendations for managing lipid abnormalities and cardiovascular risk in patients with hypothyroidism, menopause, and Cushing's syndrome.
Researchers at Gruthan Bioscience aim to develop a new class of cholesterol-lowering drugs for patients with familial hypercholesterolemia, a rare form of high cholesterol. The startup plans to use its novel cell platform to identify and test promising compounds.