Articles tagged with Cholesterol
A team of University of Alberta researchers has identified a protein that blocks the body's ability to clear low-density lipoprotein (LDL) cholesterol from the blood. This discovery paves the way for developing a new drug to boost existing statin drugs and prevent heart disease.
Researchers have identified a genetic link to clogged arteries, finding that a specific gene variant increases the risk of coronary artery disease, high blood pressure, and diabetes. The discovery provides new insights into the causes of cardiovascular disease and offers potential therapeutic targets for treatment.
A new approach has led to the discovery of a small molecule that may help regulate cholesterol levels in the brain, making it a potential therapeutic target for Alzheimer's disease. Increasing the activity of ABCA1 is expected to positively influence insulin signaling and reduce inflammation in the brain.
The study found that phospholipid PtdIns4P and cholesterol play a critical role in G-protein coupling and ligand recognition, stabilizing the receptor's basal activity. Water molecules also mimic polar functionalities of serotonin, sustaining basal activity.
Researchers at VCU Massey Cancer Center have identified a crucial link between the development and growth of glioblastoma multiforme, the most aggressive type of brain cancer. The gene YTHDF2 drives increased cholesterol levels in GBM cells, paving the way for potential new treatments targeting this gene.
Researchers at Greenwood Genetic Center have identified cholesterol accumulation as a key contributor to the symptoms of genetic movement disorders, including seizures and balance issues. The study provides new hope for treatments targeting cholesterol accumulation, such as the drug 2-hydroxypropyl-beta-cyclodextrin, which showed signi...
Researchers at Tufts University use lipid nanoparticles to deliver CRISPR machinery specifically to the liver, reducing blood cholesterol levels by up to 57% in mice. The treatment may provide a long-term solution for high cholesterol, which affects over 29 million Americans.
Researchers at Aarhus University and hospital have identified the fundamental step linking hypertension to atherosclerosis, finding that hypertension causes increased accumulation of bad cholesterol in arterial walls. This discovery may aid in developing new treatments targeting disease mechanisms.
A new study published in eLife found that combining healthy lifestyle interventions with cholesterol-lowering medications yields the greatest benefits to heart health. Healthy lifestyles, including exercise and a balanced diet, can lower LDL cholesterol and increase HDL cholesterol, reducing the risk of heart disease.
A study found that maternal cardiovascular health during pregnancy is associated with the later cardiovascular health of their offspring in adolescence. The research examined various factors such as body mass index, blood pressure, and cholesterol levels.
A new research program, led by health coaches at primary care clinics, has shown that lifestyle interventions can significantly improve heart disease risk factors. Participants experienced lower blood sugar levels, increased good cholesterol, and improved overall cardiometabolic risk scores.
A new study published in PLOS Medicine found that whole egg consumption was positively associated with increased all-cause mortality, while egg whites or substitutes were negatively associated. Replacing half a whole egg with egg whites/substitutes reduced cardiovascular disease mortality by 3%.
A new study found that a vegan diet is more effective than the Mediterranean diet for improving health markers and boosting weight loss. Participants who followed a low-fat vegan diet lost an average of 6 kg and had significant reductions in visceral fat, total and LDL cholesterol levels.
A new study from the University of Bristol suggests that vitamins D, K, and A could help combat COVID-19 by binding to the viral Spike protein. This reduces SARS-CoV-2 infectivity, while high cholesterol may enable the virus. Researchers identified potential antiviral drug candidates among approved pharmaceuticals and dietary components.
Researchers at Northwestern University have developed a novel therapy that uses synthetic nanoparticles to trigger the destruction of lymphoma cells by depriving them of cholesterol. This approach has potential for targeting other cancers with an appetite for cholesterol, such as kidney and ovarian cancer.
A new model explains why saturated fats increase blood cholesterol and why this should be dangerous. The 'Homeoviscous Adaptation to Dietary Lipids' (HADL) model suggests that cells adjust membrane fluidity according to changes in diet, leading to a decrease in blood cholesterol levels when consuming polyunsaturated fats.
Cholesterol crystals are identified as a primary cause of preeclampsia, triggering an inflammatory response that affects the communication between mother and foetus. This discovery may lead to more effective treatment options, including cholesterol-lowering medications.
Researchers at Nagoya University found that blood pressure, hematocrit, and serum cholesterol levels change in patients with Parkinson's disease long before the onset of motor symptoms. These biomarkers may help detect early signs of developing Parkinson's disease.
Researchers discovered that gamma-delta T cells require glucose to eliminate tumor cells but consume cholesterol, promoting pro-tumor functions. This dichotomy in energy resources has implications for cancer immunotherapy and diet's impact on its effectiveness.
Researchers at Kyoto University's Institute for Integrated Cell-Material Sciences have identified a possible link between a large cholesterol transport protein and schizophrenia. Mice with disrupted ABCA13 protein showed abnormal behaviour, including impaired prepulse inhibition, suggesting a potential role in the pathophysiology of ps...
Researchers propose that a family of transporter proteins, including ABCA1, enabled vertebrates to thrive on land and develop complex body structures. The protein regulated cholesterol levels, allowing for the development of sophisticated biological processes.
CREB3L3 protects against atherosclerosis by inhibiting SREBP's expression. Absence or overexpression of CREB3L3 exacerbates high blood lipid levels and atherosclerosis. The study provides insight into the molecular basis of atherosclerosis and its potential therapeutic targets.
A study by University of Illinois researchers found that beta-carotene's full health benefits require an active enzyme to produce vitamin A. The active enzyme BCO1 converts beta-carotene into vitamin A, which helps lower bad cholesterol and protect against atherosclerosis.
A study from the University of East Anglia found that blood biomarkers such as cholesterol, inflammation, and liver function can predict future disability and healthcare demand. The researchers also discovered a pro-rich inequity in health care use, where people with higher incomes are more likely to seek medical attention.
A team of researchers identified critical molecular processes in human cells that coronaviruses use to survive. Targeting these processes with drugs may treat not only COVID-19 infections but also other existing and future coronaviruses, including common cold viruses and more severe viruses.
Researchers identified 10 metabolites associated with the risk of stroke, including a lower risk for ischemic stroke and higher risk for hemorrhagic stroke. Histidine and high-density lipoprotein cholesterols were found to have protective effects, while pyruvate increased the risk of ischemic stroke.
Researchers have developed microfiber- and nanofiber-based wearables that can track vital signs like blood pressure and cholesterol levels. These technologies could lead to non-invasive health monitoring for chronic illnesses.
New data from the CASCADE FH Registry highlights gaps in care for children with familial hypercholesterolemia. Children are typically diagnosed at age 9, seven years after cholesterol screening guidelines recommend it. Early treatment intervention can prevent cardiovascular disease.
A remote disease management program improved clinical outcomes for 3,939 patients with uncontrolled LDL cholesterol and 1,437 patients with high blood pressure. The program achieved significant reductions in LDL cholesterol (42%) and blood pressure levels (14/6mmHg) in participants.
A remotely-delivered, algorithm-driven program improved patients' cholesterol and blood pressure levels by identifying those with uncontrolled LDL-C and/or high blood pressure. The study used electronic health records and clinical algorithms to initiate and titrate medications at preset intervals until treatment goals were achieved.
Researchers from Queen Mary University of London used Mendelian Randomization to investigate cardiovascular risk factors and COVID-19 infection. Individuals with high BMI and low-density lipoprotein (LDL) cholesterol are at increased risk of getting COVID-19, according to the study.
A phase 2 study found that evinacumab reduced LDL cholesterol by 50% in patients with severe hypercholesterolemia resistant to standard treatments. The therapy works through a different mechanism than existing drugs and shows promise for treating refractory hypercholesterolemia.
A single daily pill combining blood pressure and cholesterol medications with or without aspirin reduced cardiovascular disease events in people at intermediate risk for heart disease. The polypill plus aspirin combination lowered cardiovascular disease by 31%, compared to the polypill alone, which reduced it by 21%.
Two studies suggest that older adults aged 70 and over with elevated LDL cholesterol levels have the highest incidence of heart attacks and cardiovascular diseases. Cholesterol-lowering therapies, including statins, are as effective at reducing cardiovascular events in this age group as they are in younger people.
A study found that DSCR-1 suppresses oxidized LDL cholesterol production and angiogenic signaling, protecting against corneal opacity. High DSCR-1 expression also reduced vascular diseases such as atherosclerosis and hypertension.
The Endocrine Society's Clinical Practice Guideline emphasizes the importance of evaluating high cholesterol and triglycerides in adults with endocrine disorders. The guideline provides recommendations for managing lipid abnormalities and cardiovascular risk in patients with hypothyroidism, menopause, and Cushing's syndrome.
Researchers at Gruthan Bioscience aim to develop a new class of cholesterol-lowering drugs for patients with familial hypercholesterolemia, a rare form of high cholesterol. The startup plans to use its novel cell platform to identify and test promising compounds.
Researchers found that having elevated cholesterol during teens or early twenties increases risk of heart attack, stroke or cardiovascular event in middle age. Regular cholesterol screenings starting in early adulthood may help reduce this risk.
A study by UT Southwestern Medical Center found that switching from brand-name to generic cholesterol medications between 2014 and 2018 saved Medicare billions of dollars. The total costs on these drugs went down despite an increase in prescriptions for LDL-lowering drugs, with the number of generic prescriptions rising by 35%.
A new study led by Assistant Professor Rana Ashkar of Virginia Tech Department of Physics finds that cholesterol actually does adhere to biophysical principles and causes membrane stiffening.
A large European study shows that combining lipid-lowering therapies can further reduce cholesterol levels and improve health outcomes for high-risk patients. Current clinical guidelines are not always followed in practice, highlighting a need for better cholesterol management across Europe.
A new study published in Nutrition and Metabolism found that an eight-week very low-carbohydrate diet improved body composition, fat distribution, and metabolic health in older adults with obesity. The diet also preserved skeletal muscle mass without intentional caloric restriction.
A meta-analysis published in eLife reveals low HDL cholesterol is the most common lipid disorder in Latin America and the Caribbean. The study suggests that efforts to boost HDL cholesterol may provide the greatest heart health benefits to people living in these regions.
A new study published in Circulation: Cardiovascular Imaging found that coronary calcium scores are a better predictor of future heart attacks than strokes, with similar findings across sex and racial groups. The amount of calcified plaque in the heart's arteries was twice as risky for heart attacks as it was for strokes.
Researchers identify a subtype of autism associated with lipid metabolism and brain development, offering potential targets for precision-targeted therapies and earlier diagnosis. The study found notable alterations in cholesterol levels among children with autism and their parents.
A food-based approach using clinically-proven diet interventions can significantly lower cholesterol levels and reduce healthcare costs. The study found that successfully managing hyperlipidemia with Step One Foods could lead to billions of medical savings annually for the entire Medicare privately insured population.
A new study by researchers at Stanford Medicine found that plant-based meat alternatives can improve some cardiovascular risk factors compared to red meat. The study, which used products from Beyond Meat, found lower levels of TMAO in participants who ate plant-based diets.
Researchers at Korea Brain Research Institute used GANs to analyze bulk RNA-seq data, finding that increased Amyloid-beta in the brain alters cholesterol biosynthesis. This study provides a new approach for projecting biological changes and aiding healthcare industry.
Decades of research have failed to show consistent benefit for lowering LDL cholesterol levels in reducing heart disease and death. The approach has been shown to fail in identifying those at high risk while including those at low risk, who don't need treatment.
A six-week course of a PCSK9 inhibitor improved coronary artery function in people living with HIV or high cholesterol, increasing area and blood flow. The study suggests a potential way to limit cardiovascular disease risk in these populations by improving blood vessel function.
A new study analyzed data on over 15,000 people to better understand the association between HDL cholesterol, heart attacks, and strokes. The researchers found that the number of HDL particles is a more reliable predictor of heart attack and stroke risk than the standard HDL cholesterol metric.
A new study reveals that certain T lymphocytes can increase inflammation and worsen atherosclerosis cases, contrary to their usual role as immune system defenders. Researchers at La Jolla Institute for Immunology are working to design a safe anti-atherosclerosis vaccine by harnessing the power of T cells.
A team of researchers has developed a potential approach to overcome anti-VEGF resistance in patients with age-related macular degeneration. By combining apolipoprotein A-I binding protein (AIBP) with anti-VEGF, the strategy effectively suppresses choroidal neovascularization (CNV) and reduces drug resistance.
A new study published in Cell Metabolism found that two daily fasting diets, with eating windows of 4-6 hours, can lead to significant weight loss and improved cardiometabolic risk factors. Participants lost about 3% of their body weight by reducing calorie intake and showed reduced insulin resistance and oxidative stress levels.
Researchers at Cold Spring Harbor Laboratory found that interfering with cholesterol storage can stop pancreatic cancer cell growth in mice and lab-grown pancreas models. The study suggests a new strategy for treating deadly disease by targeting an enzyme called SOAT1.
A new study published in BMJ Evidence-Based Medicine suggests that people with familial hypercholesterolemia should eliminate carbs and focus on a heart-healthy diet low in sugar. The research finds no evidence to support the long-held recommendation to minimize saturated fat intake.
Nieng Yan's research program aims to solve the structure of ion channels and membrane transporters using cryo-EM. Her lab has produced valuable rewards, including structures of proteins involved in diseases such as Niemann-Pick disease type C.
Researchers analyzed data from over 15,000 people to find that the number of HDL particles is a more reliable predictor of heart attack and stroke risk than standard HDL cholesterol metric. In black people, neither HDL measurement was significantly associated with heart attack risk.
Researchers at KAIST designed nanoparticles that significantly reduce cholesterol and macrophage foam cells in arteries, two key triggers of atherosclerotic plaque. The combination drug delivery therapy showed great potential for treating and preventing atherosclerosis with reduced side effects.
A team of researchers has discovered a species of gut bacteria that can affect cholesterol levels in humans. The discovery could lead to new therapeutics, such as probiotics or enzyme delivery to the gut, to help people manage their blood cholesterol levels.