A study using a nonhuman primate model identified key features of SARS-CoV-2 causing COVID-19, including immunosuppressive effects. The research team also observed rapid viral multiplication in the upper and lower respiratory tracts, followed by a decrease in viral load.
A new study by Max-Planck-Gesellschaft scientists has identified a region of the thalamus as a key source of signals encoding past experiences in the neocortex. This discovery sheds light on how the brain forms sensory memories, which are essential for perceiving our environment and interacting with it.
A phase 2 study found that evinacumab reduced LDL cholesterol by 50% in patients with severe hypercholesterolemia resistant to standard treatments. The therapy works through a different mechanism than existing drugs and shows promise for treating refractory hypercholesterolemia.
Researchers found that RNA from repetitive elements activates RIG-I-like receptors, inducing inflammation and increasing hematopoietic stem cell numbers. The RIG-I-like receptor family plays a crucial role in regulating hematopoiesis, with different members having opposing effects on developmental hematopoiesis.
A new method developed at KAUST uses laser beams to produce uniform, three-dimensional graphene electrodes with high porosity and surface area. The electrodes exhibit excellent electrocatalytic activity and distinguish paracetamol and other compounds. Researchers plan to optimize the fabrication of sensors and expand their applications.
Over the past 50 years, cannabis strength has soared, with THC concentrations increasing by 14% in herbal cannabis and 24% in cannabis resin. This rise in potency is linked to an increased risk of problems such as addiction and psychotic disorders.
A daily dose of omega-3 fatty acids failed to reduce cardiac events, including secondary heart attacks and strokes, among elderly people who survived a recent heart attack. The OMEMI Trial found no significant difference in the rate of cardiac events between the two groups after 2 years of follow-up.
A new fish oil-based medication, omega-3 carboxylic acids, did not decrease the risk of cardiac events compared to a placebo in a large phase III international study. The study found no significant differences in cardiovascular death or heart attack rates between the two groups.
A randomized trial investigated carboxylic acid formulation of EPA and DHA, reducing cardiovascular outcomes in patients with atherogenic dyslipidemia. The study found omega-3 CA to be more effective than corn oil in reducing major adverse cardiovascular events in high-risk patients.
Researchers found that 90% of symptoms reported by statin users were also experienced when taking a placebo. This suggests a psychological rather than pharmacological effect of statins. Despite concerns about side effects, half of participants restarted taking a statin medication six months after the trial.
In a new study, patients taking statins reported experiencing symptoms that were identical to those experienced while taking placebo pills. Researchers suggest that the nocebo effect may be the cause of these side effects, rather than an actual pharmacological effect of the drug.