Articles tagged with Cholesterol
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Researchers developed a computer model of lipoprotein-associated phospholipase A2, shedding light on its mechanism and substrate specificity. This knowledge creates opportunities for therapeutic interventions against cardiovascular disease.
A genetic variation among some Greenlanders makes sugar healthy by converting it into a short-chain fatty acid called acetate, which boosts the immune system. Adult carriers have lower BMI, weight, and fat percentage, while children may experience negative consequences from consuming sugar.
A recent study published by Queen Mary University of London has found that certain risk factors for heart disease are linked to changes in the structure and appearance of the heart. The research analyzed images from over 30,000 people's heart MRI scans using a new imaging toolkit called radiomics.
Researchers developed an AI-powered system to model disease progression in patients as they age. The model assesses metabolic and cardiovascular biomarkers to calculate health status and disease risks across a patient's lifespan.
Children with autism spectrum disorder should be screened for abnormally high or low cholesterol levels, according to physicians. Research found reduced HDL-C levels in individuals with ASD, indicating a risk factor for cardiovascular disease.
Researchers at Karolinska Institutet found a strong link between the apoB/apoA-1 ratio and cardiovascular disease. Individuals with higher ratios had a greater risk of severe cardiovascular disease, including myocardial infarction and stroke.
A UC Riverside-led study found that dicyclohexyl phthalate, a common plasticizer, increases plasma cholesterol levels by binding to the pregnane X receptor, or PXR. The study suggests that PXR activation contributes to the harmful effects of plastic-associated chemicals on cardiovascular health.
A study conducted at the University of Jyväskylä found that physically active lifestyle mitigates unfavourable changes in metabolic health during menopause. Menopausal transition is associated with increased abdominal fat mass, blood pressure, and blood glucose levels.
A new study from the University of Eastern Finland found that patients with type 2 diabetes often do not receive adequate cholesterol-lowering treatment, despite guidelines recommending statin prescriptions for elevated LDL-C levels. Women tend to have higher average LDL-C levels and receive less statin treatment than men.
The oral PCSK9 inhibitor MK-0616 has been shown to reduce LDL cholesterol levels by up to 65% in patients with high cholesterol, without causing serious side effects. The study's findings suggest that MK-0616 could be a promising new treatment option for lowering bad cholesterol.
A recent study of 17,000 young adults aged 20-39 found that fewer than half were prescribed lipid-lowering therapy despite having persistently high LDL-C levels, highlighting the need for improved management strategies.
A study of 35 low- and middle-income countries found that less than one-third of individuals with high cholesterol received treatment. This highlights the inadequate care for hypercholesterolemia in these regions, a major risk factor for cardiovascular disease.
A new clinical study found that grape consumption increased gut bacterial diversity and reduced cholesterol levels, including total cholesterol by 6.1% and LDL cholesterol by 5.9%. This suggests a potential role for grapes in promoting good gut health and supporting heart health.
Research supports strong relationship between ceramides and diseases in animals and humans. Ceramides are standalone biomarkers of cardiovascular disease, independent of cholesterol.
In chronic damage, new cholesterol production determines the efficiency of repair, with nerve cells contributing to replenishing myelin-forming cells. Treatment with a cholesterol-enriched diet enhances oligodendrocyte progenitor cell proliferation.
A new canine mutant model mimics human cerebrovascular disease by exhibiting severe arteriosclerosis, thrombosis, and stroke. The ApoE knockout dogs show extensive and severe arteriosclerosis plaques and arterial stenosis, consistent with human cerebral arteries and coronary arteries.
A recent Johns Hopkins Medicine-led study suggests that statin use is not beneficial for reducing COVID-19 mortality or severity. Instead, patients taking statins had an increased risk of developing a more severe form of the disease. The researchers found no significant impact on mortality rates.
A small study found that high maternal cholesterol levels during pregnancy are associated with a higher risk of severe heart attacks in young adults. Maternal cholesterol also predicts the development of atherosclerosis in adult offspring.
Researchers at UNSW and University of Sydney develop DNA 'nanostructures' to effectively manipulate synthetic liposomes, leading to potential applications in biosensing and mRNA vaccines. The study also explores the creation of 'mini biological computers' that can sense their environment and respond to signals.
A review of 25 studies on intermittent fasting found that all forms produced mild to moderate weight loss, similar to traditional calorie-restrictive diets. Intermittent fasting regimens also showed benefits in decreasing blood pressure and insulin resistance, and improving appetite regulation.
A new global study found that setting targets for treating diabetes patients with cholesterol or blood pressure medication can significantly improve cardiovascular outcomes. Achieving these targets could save up to 6% of healthy lifetime lost to diabetes over 10 years, mainly due to reduced cardiovascular conditions.
A Cleveland Clinic-led research team found that statistically overweight children who followed a healthy eating pattern significantly improved weight and reduced various cardiovascular disease risks. The study also showed improvements in blood pressure, total cholesterol, and low-density lipoprotein levels.
A new study found that cholesterol produced by astrocytes is required for controlling amyloid beta production, leading to the accumulation of insoluble plaques. Blocking this cholesterol manufacturing reduced amyloid beta production in lab mice, offering a potential strategy against Alzheimer's disease.
A new antioxidant drug, cysteamine, has been found to reverse atherosclerosis by reducing the oxidation of LDL cholesterol. This process reduces inflammation, damage, and clot formation, ultimately lowering the risk of heart attacks and strokes. Cysteamine was shown to decrease plaque size by up to 56% in mice with atherosclerosis.
Researchers found that remnant cholesterol levels above 24 micrograms per deciliter were associated with a 40-50% higher risk of major heart disease or stroke. The study suggests using remnant cholesterol as an additional metric for predicting cardiovascular disease and stroke risk, in addition to LDL cholesterol levels.
A two-year randomized controlled trial found that eating about ½ cup of walnuts daily modestly lowered LDL-cholesterol levels and reduced small LDL particles in healthy, older adults. The study suggests that walnuts can improve cardiovascular health by improving the quality of LDL particles.
Researchers found that astrocytes carrying the AD-associated APOE4 gene released more cholesterol, leading to increased beta-amyloid production in neurons. This study suggests modulating brain cholesterol could be a potential treatment option for Alzheimer's disease.
Researchers at Duke University Medical Center identified a mechanism where breast cancer cells use cholesterol to develop tolerance to stress, allowing them to resist ferroptosis and proliferate. This finding highlights the importance of lowering cholesterol in preventing cancer progression and offers new approaches for treatment.
Researchers identified physical binding sites for cholesterol in GIRK channels, which play a role in neurodegenerative diseases. The study provides structural insights into how cholesterol alters channel function, paving the way for drug development.
A new study found that consuming millets can significantly lower total cholesterol, triglycerides, and BMI, as well as decrease blood pressure in people who were overweight or obese. The study used meta-analysis to analyze data from 19 studies with nearly 900 participants.
Researchers at MUSC identify a type of fat called sphingolipid that could predict the severity of heart disease in African American patients with lupus. Higher levels of Lac-Cer are associated with increased disease activity and may have predictive value for patient progression.
A new study by Staffordshire University found that users of the Heart Age Test (HAT) were more likely to make healthy lifestyle changes. The test aims to provide early warning signs of cardiovascular disease, encouraging users to reduce their heart age through diet and exercise.
A recent study discovered that brain cells cannot maintain the myelin sheath in the absence of the TDP-43 protein. Restoring cholesterol levels has been proposed as a potential therapeutic strategy for neurodegenerative diseases associated with TDP-43. The research found that oligodendrocytes, responsible for producing myelin, have def...
Researchers identified bioactive substances that modulate cholesterol homeostasis, a common feature among many compounds. These findings suggest potential side effects of active substances and provide new insights into targeting cholesterol homeostasis, which may also impact SARS-CoV-2 infections.
Researchers identified an immune component, STING, linked to Niemann-Pick disease type C, a condition with no effective treatments. The discovery suggests a new therapeutic target for the disease and offers hope for treatment with immune inhibitors.
A new study has identified key pathways linking high-fat diets to atherosclerosis in mice, shedding light on the role of neutrophils and citrullination in inflammation. Researchers found that blocking this process could lead to reduced neutrophil adhesion and potentially prevent blocked arteries.
Researchers found that eating 50 grams of prunes daily for six months improved CVD risk biomarkers, raised 'good' cholesterol, and lowered inflammation. The study suggests that prunes may be a promising addition to the diet to reduce CVD risk and inflammation.
A nationwide study found that blood sugar control among US adults with diabetes declined significantly between 2007-2010 and 2015-2018. The proportion of adults achieving glycemic control dropped from 57.4% to 50.5%, while blood pressure control decreased, but cholesterol control levels remained stable.
A new statewide study in Michigan found that smokers needed their blocked arteries fixed nearly a decade earlier than non-smokers, with patients with obesity undergoing procedures four years earlier than non-obese patients. The study suggests that preventing smoking and obesity could delay the onset of heart disease.
A new study found that consuming mangos can help lower chronic disease risk by improving fasting glucose levels and reducing inflammation. Researchers also discovered that adding herbs and spices to the diet may help lower blood pressure, while ginger, cinnamon, and turmeric supplements were linked with improved cholesterol benefits.
The American Heart Association recommends increasing physical activity as the first treatment choice for mild to moderately elevated blood pressure and cholesterol. Regular exercise can lower blood pressure and cholesterol, with benefits extending to other health areas.
Researchers found that disturbances in cholesterol catabolism are associated with increased risk of Alzheimer's disease and vascular dementia. The study also suggests that bile acid synthesis may impact brain signaling pathways, leading to sex-specific effects on dementia progression. Further studies are needed to confirm these findings.
A new study of over 2 million people found no link between regular milk consumption and increased cholesterol levels. Those who regularly drank high amounts of milk had lower levels of both good and bad cholesterol, as well as a reduced risk of coronary heart disease.
Researchers used base editing to introduce a single point mutation in the PCSK9 gene, reducing LDL cholesterol levels by up to two-thirds. This precision technology holds promise for treating inherited metabolic liver diseases.
Scientists at UCL have identified a new immunotherapy that targets acyl-CoA:cholesterol acyltransferase (ACAT), an enzyme helping to manage cholesterol levels in cells. Boosting ACAT inhibition boosts specific immune cells fighting both the virus and cancerous tumours, demonstrating its effectiveness as an immunotherapy.
Researchers at University of California San Diego School found that controlling cholesterol in microglia can alleviate chronic pain, a common side effect of chemotherapy. They developed a novel therapeutic approach using a modified version of apoA-I binding protein to reverse the harmful effects of excessive cholesterol.
Cholestenone inhibits H. pylori cell wall biosynthesis by suppressing CGL production, effective against clarithromycin-resistant strains and eradicating bacteria in mice fed with cholestenone-containing diets.
A study published in PNAS found that zebra finches have a low-density lipoprotein receptor gene with key domains missing, allowing them to carry high levels of good cholesterol while avoiding high cholesterol-related diseases. This genetic adaptation may hold clues for improving cardiovascular disease treatment.
Researchers at University of Utah Health found a strong association between preeclampsia and stroke risk in women who had the condition during pregnancy. Over an average follow-up period of 32 years, women with preeclampsia were 3.8 times more likely to have strokes compared to those without the condition.
Recent advances in understanding atherosclerosis have shifted traditional views on who is at risk for heart attacks and strokes, highlighting the importance of HDL cholesterol, triglycerides, and inflammation. This review paper explores these changes and their implications for treatment and prevention.
Research found that shift workers with a deviated body clock had higher cardiovascular risk, even after adjusting for sociodemographic and lifestyle factors. The study's findings suggest that staff with atypical work schedules may need closer monitoring for heart health.
A randomized controlled study found that a Mediterranean diet combined with small portions of lean beef helped lower LDL cholesterol and non-HDL cholesterol levels. The study suggests that healthy diets can include a wide variety of foods, including red meat, while still being heart-friendly.
New research suggests that HDL particles' anti-inflammatory properties may predict future cardiovascular events, improving risk assessment and prediction. The study found that individuals with lower anti-inflammatory activity in their HDL particles were more likely to experience cardiovascular events.
Researchers found that almonds contain approximately 20% unabsorbed calories after digestion, which can result in reduced energy absorption and potential weight loss. This finding could alleviate concerns about nuts contributing to weight gain, allowing for healthier snacking options.
Researchers discovered that higher levels of HDL cholesterol with improved anti-inflammatory capacity are associated with lower risk of cardiovascular events. The study suggests that adding this measure to risk scores may improve heart disease prediction and patient protection.
A team of University of Alberta researchers has identified a protein that blocks the body's ability to clear low-density lipoprotein (LDL) cholesterol from the blood. This discovery paves the way for developing a new drug to boost existing statin drugs and prevent heart disease.
Researchers have identified a genetic link to clogged arteries, finding that a specific gene variant increases the risk of coronary artery disease, high blood pressure, and diabetes. The discovery provides new insights into the causes of cardiovascular disease and offers potential therapeutic targets for treatment.
The study found that phospholipid PtdIns4P and cholesterol play a critical role in G-protein coupling and ligand recognition, stabilizing the receptor's basal activity. Water molecules also mimic polar functionalities of serotonin, sustaining basal activity.
A new approach has led to the discovery of a small molecule that may help regulate cholesterol levels in the brain, making it a potential therapeutic target for Alzheimer's disease. Increasing the activity of ABCA1 is expected to positively influence insulin signaling and reduce inflammation in the brain.
Researchers at VCU Massey Cancer Center have identified a crucial link between the development and growth of glioblastoma multiforme, the most aggressive type of brain cancer. The gene YTHDF2 drives increased cholesterol levels in GBM cells, paving the way for potential new treatments targeting this gene.