Articles tagged with Cholesterol
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A 'keto-like' diet, characterized by low carbohydrates and high fat intake, has been linked to higher levels of LDL cholesterol and a twofold increased risk of cardiovascular events. Regular consumption of this diet was associated with an average increase in blood LDL cholesterol levels over 11.8 years.
Testing for ApoB protein, which carries LDL cholesterol, may be a more accurate way to test for heart disease risk. Researchers found that ApoB levels positively correlated with LDL cholesterol but showed an increased risk in patients with normal or low LDL levels.
A new study found that walking an additional 500 steps per day was associated with a 14% lower risk of heart disease, stroke or heart failure. This benefit is significant for older adults, as most studies have focused on early-to-midlife adults.
Researchers have identified a new marker that indicates when skin cancer cells are preparing to metastasise. The study shows that tumour cells alter their metabolism to feed on bad cholesterol molecules, allowing them to survive migration and proliferation in other organs.
A new study by Brigham and Women's Hospital found that over 20% of patients at high risk of cardiovascular disease refused statin medications. Women were more likely than men to refuse statin therapy, with a 50% higher rate of never accepting the recommendation.
Research suggests that oleic acid in olive oil has antioxidant properties, inhibiting the expression of proteins associated with cholesterol transport, and reducing atherosclerosis. Additionally, oleic acid is recognized as an anti-cancer molecule, which also displays hypocholesterolaemic effects and may influence epigenetic mechanisms.
A large-scale observational study from China demonstrates a strong link between ideal cardiovascular health and lower mortality rates. Individuals with higher scores on behavioral and medical factors had approximately a 50% lower risk of all-cause, CVD, and respiratory mortality compared to those with lower scores.
Adults living in neighborhoods with dense fast food and unhealthy food environments, known as
A recent study found that consuming soy flour rich in B-conglycinin can reduce LDL cholesterol levels and lower the risk of metabolic diseases. The protein inhibits HMGCR, a liver enzyme involved in triglyceride and low-density lipoprotein metabolism.
A Canadian-led research team has discovered how the protein PCSK9 degrades LDL receptors, leading to increased cholesterol levels. HLA-C plays a critical role in this process, which could lead to new treatments for cardiovascular diseases and certain cancers.
A new study found that teenagers who reported feeling optimistic, happy, and loved had better cardiometabolic health outcomes in adulthood. Despite this, racial disparities remained apparent, with Black teens facing increased health risks due to structural racism.
A school-based gardening, nutrition, and cooking intervention improved glucose control and reduced low-density lipoprotein cholesterol in high-risk youth. Elementary schools can incorporate garden-based interventions to improve metabolic parameters in children.
A cluster randomized controlled trial found that Texas Sprouts, a gardening, nutrition, and cooking intervention, improved glucose control and reduced bad cholesterol in high-risk youth. The results showed a 0.02% reduction in mean blood sugar levels and a 6.4 mg/dL reduction in bad cholesterol.
A UMass Amherst study reveals that 61% of wellness visits for reproductive-age women (15-49) were with OB-GYNs, while chronic condition patients also relied heavily on these specialists. Key preventive services like pap tests and pelvic exams were more common in OB-GYN settings, whereas lipid testing was rare.
Researchers at Kyoto University have discovered a vital role of two proteins, ABCA1 and Aster-A, in maintaining the asymmetric distribution of cholesterol within cells. This process allows for selective control over substances entering and leaving cells.
A recent study discovered a link between soluble urokinase plasminogen activator receptor (suPAR) and the development of atherosclerosis, a hardening of arteries that affects over a billion people worldwide. SuPAR was found to cause inflammation in blood vessels, leading to cardiovascular events and increasing risk of heart disease.
A new study published in Hypertension suggests that lipoprotein(a) cholesterol may affect the relationship between hypertension and cardiovascular disease risk. The study found that people with high levels of lipoprotein(a) and hypertension had a 24% higher risk of cardiovascular disease compared to those without hypertension.
A new study identifies anti-Müllerian hormone (AMH) as a key factor in regulating cholesterol levels during the menopause transition. High AMH levels are associated with lower HDL-C, or good cholesterol, which may indicate cardiovascular risk despite its traditionally protective effects.
Researchers found that dietary saturated/trans fats, but not cholesterol, can trigger hepatic angiogenesis and lymphangiogenesis in mice, leading to the promotion of hepatic tumors. This process is driven by the JNK-HIF1α-VEGF-C axis.
A study of over 1000 Australian adults found that people with trouble sleeping were more likely to have indicators of poor cardiometabolic health, including inflammatory markers, cholesterol, and body weight. Prioritizing a good night's sleep is crucial for maintaining good health, according to researcher Dr Lisa Matricciani.
A new study published in the American Journal of Cardiology found that a healthy diet can reduce the risk of cardiovascular disease by up to 10%. The Dietary Approaches to Stop Hypertension (DASH) diet, which emphasizes whole grains, lean proteins, and fruits and vegetables, showed additional benefits for women and black adults compare...
Scientists at Medical College of Georgia discover a new target to intervene in coronary artery disease, the most common type of heart disease. The target is ATIC, a gene essential for purine production, which increases in response to arterial disease.
A new study from Northwestern University found that vitamin D supplements do not significantly reduce statin-associated muscle symptoms, contradicting previous non-randomized studies. The trial involved 2,083 participants and was the first placebo-controlled, randomized clinical trial to examine this effect.
A study found that lower levels of HDL cholesterol increased the risk of heart attacks in white but not Black adults. Higher levels of HDL cholesterol did not provide protective benefits for either group. The research tested long-held assumptions about the role of HDL in cardiovascular health.
A new study from Mount Sinai Hospital finds a strong association between age-related macular degeneration and severe forms of heart disease, including heart failure, heart attacks, and stroke. The study highlights the importance of increased screening for eye disorders to diagnose undetected heart disease.
Researchers at University Hospitals and Case Western Reserve University have discovered a small-molecule oral drug that reduces PCSK9 levels and lowers cholesterol by 70% in animal models. This breakthrough could also improve the efficacy of cancer immunotherapies.
Researchers found that raw honey from single floral sources lowers fasting blood glucose, total and LDL cholesterol, triglycerides, and inflammation. Honey's health benefits depend on processing, floral source, and quantity.
The APOE4 gene variant increases the risk of Alzheimer's disease by disrupting the insulation of brain wiring. Research found that oligodendrocytes mismanage cholesterol, failing to transport fat molecules to myelinate axons. This deficiency may contribute to the pathology and symptoms of Alzheimer's.
A study of 1779 adolescents found that early-life elevated lipids and dyslipidemia are linked to worsening subclinical atherosclerosis. Conversely, treatment at age 17 effectively halted progression and even reversed it. This critical evidence emphasizes the need for early-life screening and prevention.
Researchers found two Korean native plants' saponins inhibit SARS-CoV-2 entry into cells by blocking membrane fusion. These compounds show promise in treating COVID-19, especially for asymptomatic cases.
The Mass General Brigham remote healthcare delivery program lowered blood pressure and LDL-cholesterol significantly in a study of over 10,000 participants. The program provided convenient care from home using digital solutions, improving health outcomes for traditionally underserved populations.
A remote hypertension, lipid program across a diverse health care network found that it may help optimize guideline-directed therapy at scale. The study results indicate a potential reduction in cardiovascular risk among patients with elevated blood pressure and cholesterol levels.
Scientists at Ural Federal University have developed a sensor device that determines cholesterol levels without using enzymes. The system uses copper chloride, making the process cheaper, easier, and faster than traditional methods.
A large international clinical trial found that fenofibrate had no significant effect on COVID-19 outcomes, including disease severity and death. The study included 701 participants and was led by Penn Medicine scientists.
Regular use of cholesterol-lowering and diabetes-control drugs may lessen the risk of age-related macular degeneration (AMD) in European populations. The pooled data analysis involved 38,694 participants and showed a 15% lower prevalence of any type of AMD with these medications.
A study published in the American Heart Association found that six common dietary supplements did not lower LDL cholesterol levels when compared to a low-dose statin medication or placebo. The research suggests that these supplements are unlikely to offer meaningful impact on cholesterol levels, and a heart-healthy lifestyle is still t...
A new study by Intermountain Healthcare found that following up a cardiac event with a statin prescription and cholesterol measuring blood test prevents 94% of patients from having or dying from a second cardiovascular event. Patients without follow-up care were at a 60% risk, compared to just 6% for those who received treatment.
A new medication, pemafibrate, lowered triglyceride levels among adults with Type 2 diabetes, but did not decrease their cardiovascular risk. The study found that lowering triglyceride levels may not protect against cardiovascular disease in people with Type 2 diabetes.
Researchers at Brigham and Women's Hospital found that olpasiran, a small interfering RNA drug, significantly reduces lipoprotein(a) levels in patients with established cardiovascular disease. The treatment was associated with minimal serious side effects apart from injection site reactions.
Neighborhood walkability is associated with lower cardiovascular disease burden and risk, according to two preliminary studies. The analysis found that even after considering other factors, walkability alone was linked to a 0.1% decrease in cardiovascular disease for each one-point increase in walkability score.
A study of over 1.3 million young Asian American adults hospitalized for atrial fibrillation found a significant increase in obesity and other modifiable cardiovascular disease risk factors. Young adults with at least one cardiovascular risk factor were almost three times more likely to be hospitalized for atrial fibrillation.
A study found that living in a food desert increases the risk of heart attack, stroke, and early death for people with PAD. People with PAD living in food deserts were 17% more likely to experience a major cardiac event compared to those with better nutrition access.
A recent study published in Journal of Science and Medicine in Sport reveals that high aerobic fitness does not protect children from metabolic syndrome. In contrast, a lower risk was observed when considering body size and composition.
A genetic variant associated with low levels of HDL 'good' cholesterol and high triglycerides has been identified in Polynesian people. This discovery provides new insights into the genetic causes of high cholesterol and may lead to the development of more effective treatment options.
Children with homozygous familial hypercholesterolemia are diagnosed earlier and have higher untreated LDL-C levels than adults, while those not identified early miss out on decades of life-saving treatment. This study emphasizes the need for universal screening to identify children with HoFH or heterozygous familial hypercholesterolemia.
A clinical trial conducted by Salk Institute and UC San Diego Health found that time-restricted eating improved measures of health and wellbeing in firefighters. The study showed that a 10-hour eating window reduced VLDL cholesterol, improved mental health, and decreased alcohol intake.
The study found that the interaction between two organelles in the cell, the endoplasmic reticulum and Golgi apparatus, controls the transfer of cholesterol to the plasma membrane. This process is crucial for maintaining proper lipid composition at the cell surface.
Researchers explored how differences in skin composition affect susceptibility to diseases like psoriasis and atopic dermatitis. The study found that body site determines skin structure and function, with specific lipids and proteins playing a crucial role in disease diagnosis.
A new study published in Current Opinion in Endocrinology, Diabetes and Obesity suggests that statin therapy is not justified for healthy individuals with high cholesterol. The research found a very weak association between low-density lipoprotein-cholesterol (LDL) and the risk of heart disease and stroke.
A lab study found that high cholesterol intake worsens fatty liver disease progression by driving inflammation and scarring. The researchers also discovered long-lasting dysfunction in immune cells responsible for fighting liver damage. Moderation is key to maintaining a healthy diet, according to the study's findings.
Researchers found higher total and non-HDL cholesterol levels associated with GenX exposure in a new study. Legacy PFAS chemicals like PFOS and PFNA were most strongly linked to elevated cholesterol, particularly in older participants.
A new study found that young Swiss military personnel with confirmed Covid-19 infections experienced symptoms like fatigue, reduced sense of smell, and psychological problems for up to 180 days. Long-term effects included increased BMI, high cholesterol, and lower physical stamina, suggesting a higher risk of metabolic disorders and ca...
Researchers at Tel Aviv University develop a groundbreaking method to eradicate glioblastoma brain tumors by targeting astrocytes and starving them of energy. The study found that in the absence of these brain cells, tumor cells die and are eliminated, offering a promising basis for developing effective medications.
A new study published in the Journal of the American Heart Association found that low physical function after age 65 is associated with a greater risk of developing heart attack, heart failure, and stroke. The study used the Short Physical Performance Battery (SPPB) test to assess physical function in 5,570 adults over 75 years old.
Researchers analyzed 306-million-year-old fossilized animal feces and found biomolecular information about long-extinct diets. The study revealed that an unidentifiable extinct animal was a meat-eater or on a predominantly carnivorous diet, with high proportions of cholesterol-derived molecules and a lack of plant-derived biomarkers.
African American adults with higher levels of religiosity and spirituality may be more likely to meet key cardiovascular health metrics. The study found associations between religious behavior, spirituality, and improved health outcomes in terms of diet, physical activity, and smoking.
Researchers found that statins, commonly prescribed lipid-lowering drugs, provide a protective immune function in females. Women taking statins were 75% less likely to be ANA+, suggesting a sex-specific difference in the relationship between lipid metabolism and immunity.
A recent study published in JAMA found that despite overall improvements in cholesterol levels since 2008, sex, racial, and ethnic disparities persist in lipid control. The research team analyzed data from over 33,000 US adults and discovered significant variations in trends by race and ethnicity.
A West Virginia University study explores the link between pregnancy, sedentary behavior, and cardiovascular disease risk in women. The research aims to investigate whether physical activity can reduce or eliminate this accelerated risk development in women.
Combining sauna and exercise for eight weeks improves cardiorespiratory fitness, lowers systolic blood pressure and total cholesterol levels compared to regular exercise alone. The study found the sauna-exercise combination to be superior in reducing cardiovascular disease risk factors.