Researchers discovered that reducing cholesterol levels in mice with advanced atherosclerosis leads to a decrease in the number of smooth muscle-derived cells causing plaque growth, while preserving stabilizing cell types. This finding opens up new opportunities for targeted therapies.
A team of scientists has found that 7-dehydrocholesterol (7-DHC) integrates into cell membranes and prevents ferroptosis, increasing cellular fitness and potentially promoting aggressive cancer behavior. This discovery could lead to the development of new cancer treatments targeting cholesterol biosynthesis.
A new review suggests that female reproductive characteristics, such as early menstruation and polycystic ovary syndrome, may contribute to later metabolic dysfunction. The study highlights the importance of screening for reproductive risk factors to aid in prevention or treatment of chronic metabolic diseases.
Research found that having high cholesterol and blood pressure before age 55 significantly increases the risk of heart disease in later life. The study's results show a lasting impact on cardiovascular health, even if levels are lowered subsequently.
Researchers at the University of New Mexico have developed a new vaccine that can lower LDL cholesterol levels by up to 30% and reduce the risk of heart disease. The vaccine is based on a non-infectious virus particle and has shown promising results in animal trials.
A new study found that increased childhood sedentary time significantly increases cholesterol levels in young adulthood. However, light physical activity (LPA) has been shown to completely reverse this effect, while moderate-to-vigorous physical activity (MVPA) may also reduce cholesterol levels but with diminished impact due to body f...
Research suggests that childhood sedentariness contributes to elevated cholesterol levels and premature heart attack or stroke in mid-life. Engaging in light physical activity for 3-4 hours/day may be effective in reducing high cholesterol.
A new study found that increased sedentary time in childhood can raise cholesterol levels by two thirds as an adult, leading to heart problems. However, light physical activity was shown to be up to five times more effective than moderate-to-vigorous physical activity at promoting healthy hearts and lowering inflammation.
Researchers found that blocking cholesterol production prevented progression of serrated-type intestinal tumors in mice, suggesting a potential new strategy for treating these aggressive cancers. The study's findings support the use of cholesterol-lowering drugs to prevent or treat these tumors.
Researchers at Michigan Medicine found that telemedicine patients with hyperlipidemia experienced significant decreases in LDL and non-HDL cholesterol levels. Virtual appointments were shown to be as effective as in-person visits in improving cholesterol levels, overcoming barriers to access for patients.
The UTHealth Houston School of Public Health offers a 12-month lifestyle program combining evidence-based nutrition education with culinary learning to support behavior change. Participants will attend in-person and virtual classes, including hands-on cooking lessons, physical activity guidance, and mindfulness education.
A new study found that very high levels of HDL-C, known as 'good cholesterol', are associated with an increased risk of dementia in older adults. Researchers observed a 27% higher risk of dementia among participants with very high HDL-C levels compared to those with optimal levels.
A new study published in Gut found that higher HDL-C levels are associated with a reduced risk of gallstone formation, while lower LDL-C levels also show an inverse association. The study suggests that these findings could inform personalized risk assessment strategies and potential therapeutic interventions for cholelithiasis prevention.
Researchers have found that lowering a form of brain cholesterol known as cholesteryl esters helps prevent brain damage and behavioral changes in mice with Alzheimer's-like tau deposits. The study suggests that reducing cholesteryl ester levels could be a promising candidate to test in neurodegenerative diseases.
A new study published in Nutrients demonstrates that incorporating pulses into the American diet can significantly improve its nutritional profile. By replacing small amounts of protein sources with pulses, individuals can increase their fiber intake by more than 10% and decrease their cholesterol levels.
A new study reveals that younger people are more vulnerable to the effects of high blood cholesterol and hypertension, atherosclerosis can be reversed if risk factors are controlled early enough. The study suggests aggressive control of cardiovascular risk factors at younger ages.
Researchers investigate nanoparticles for cancer treatment, hoping to reduce side effects and improve efficacy. La-Beck's lab aims to understand the body's interaction with nanoparticles and their impact on tumor growth and immune responses.
Scientists at the University of Leicester have made a groundbreaking discovery about how cholesterol in our diet is absorbed into our cells. The research, published in Science, highlights the role of two proteins called Aster B and Aster C in transporting cholesterol from the intestine to the bloodstream.
The Genes & Health study has enrolled its 10th participant in a gene-editing clinical trial for heart disease, specifically familial hypercholesterolemia. This milestone marks an important step towards improving health outcomes for people of Pakistani and Bangladeshi descent.
A phase 1 trial shows that a single dose of lepodisiran can reduce blood levels of lipoprotein(a) by up to 96%, a key driver of heart disease risk. The therapy, which blocks the production of lipoprotein(a), is well-tolerated and has long-lasting effects.
A new therapeutic, lepodisiran, has shown promising results in reducing lipoprotein(a) levels to undetectable levels for nearly one year. The study found that the medication is safe and effective in lowering Lp(a) levels by more than 94%.
A new study suggests that a PCSK9 inhibitor given every 1-3 months may effectively lower bad cholesterol levels in people with non-genetic hypercholesterolemia. The medication, recaticimab, showed similar effectiveness and safety as other PCSK9 inhibitors when administered less frequently.
A new study from Intermountain Health reveals that genetic screening can effectively identify individuals with familial hypercholesteremia (FH), a condition affecting about 1 in 250 people. By targeting these patients with treatment, researchers aim to prevent heart attacks, strokes, and death.
A single infusion of CRISPR-based gene-editing therapy significantly reduced LDL cholesterol levels in people with heterozygous familial hypercholesterolemia, a condition that increases heart attack risk. The treatment has shown potential as a long-term or permanent option for high LDL-C control.
Scientists have identified a previously unknown pathway for dietary cholesterol absorption in the gut, which could lead to new treatments for managing cholesterol levels. An experimental drug has been found to specifically target this pathway, offering a potential new approach to controlling cholesterol levels.
Researchers are conducting a four-year study to investigate the effectiveness of acupuncture in reducing stable angina-related chest pain. The study will enroll 112 participants and compare acupuncture treatment to watching TED Talk videos for symptom relief.
Despite declining prevalence of severely elevated LDL cholesterol, approximately 1 in 17 U.S. adults still have levels between 160-189 mg/dL, and 1 in 48 have levels above 190 mg/dL. Non-Hispanic Black, Hispanic, and socioeconomically disadvantaged individuals are disproportionately affected, contributing to disparities in outcomes.
A new study from the University of Copenhagen demonstrates that 10-20-30 interval training is effective for improving running times and overall fitness, even at 80% sprint intensity. This type of training benefits both blood pressure and cholesterol levels.
A new study analyzing English primary care records found that hypertension, obesity, diabetes, and low HDL cholesterol confer a higher risk of dementia in South Asian and Black people compared to White individuals. The results suggest tailored dementia prevention efforts should be targeted towards minority ethnic groups.
A new study found that pre-pregnancy obesity is a primary driver of future cardiovascular disease risk, rather than pregnancy complications. The research followed 4,216 individuals from early pregnancy to postpartum and found those with overweight or obese BMI had a higher risk of developing hypertensive disorders during pregnancy.
Scientists at Temple University's Alzheimer's Center have identified a promising new therapeutic target for Alzheimer's disease: the protein ABCA7. The study found that cholesterol depletion and inflammation suppress ABCA7 levels in human brain cells, potentially contributing to disease onset.
A large cohort study found that both high and low levels of high-density lipoprotein (HDL) cholesterol are associated with a small increased risk of dementia. The study included over 184,000 participants and followed them for an average of nine years.
A study published in Diabetes Care found that obesity, hypertension, and dyslipidemia alter cardiac energy production by interfering with metabolic substrate uptake. The research reveals early changes in apparently healthy middle-aged individuals, highlighting the importance of identifying mechanisms involved in heart disease onset.
A real-world study confirms the reliability and effectiveness of the Pooled Cohort Equation (PCE) in assessing cardiovascular risk, regardless of statin use. The PCE performed well across different demographics and retained accuracy with measurement factors outside its original risk profile range.
A new study by Northumbria University found that consuming Quorn protein for two weeks reduced 'bad' LDL cholesterol levels by 12% and waist circumference by almost 1cm. This could lead to a 9% lower risk of dying from a stroke or coronary heart disease, according to the research.
Researchers identified key proteins regulating cholesterol distribution within cells, including OSBP1, ORP92, and GRAMD1s. This discovery sheds light on the critical mechanisms underlying cellular cholesterol distribution, offering insights into various health conditions.
Researchers at Nagoya University developed a unique supramolecule to remove cholesterol from macrophages, stopping the development of non-alcoholic steatohepatitis (NASH) in mice. Cholesterol crystals are also found in human patients, suggesting a potential therapeutic strategy.
Researchers found that almond-supplemented diets resulted in significant weight loss and improved cardiometabolic outcomes. The study demonstrated the benefits of nuts as part of a balanced weight loss diet, with almonds providing unsaturated fats that can improve blood cholesterol levels and contribute to a healthy heart.
A Geisinger-led study found that knowing the genetic cause of high cholesterol increases heart disease risk more than having high cholesterol levels alone. The study used UK Biobank data and observed distinct differences in heart disease rates among participants with different genetic causes.
This study investigates the effects of dietary cholesterol and fruit tannins on kidney stone formation in male mice. The results show that combinations of these substances lead to increased urinary sediment particles and crystal formation, particularly in the renal papilla. Microscopic analysis reveals inflammatory responses and vascul...
Research published in the Journal of the American Heart Association found that patients who start taking a combination of statins and ezetimibe after a heart attack are 47% less likely to die within three years. The study suggests that changing treatment guidelines could prevent many thousands of deaths each year.
Researchers found a buildup of cholesterol in the retina contributes to diabetic retinopathy. Non-invasive retina evaluations can detect crystalized deposits, allowing for earlier diagnosis. The study suggests new treatments could be less invasive than current options.
A Medical College of Wisconsin research team has identified a new role for liver protein tPA in influencing blood cholesterol levels. The study found that increased tPA production leads to decreased VLDL assembly in the liver, which may provide a novel target for heart disease treatment.
Researchers developed a liver-targeting drug that reversed obesity and lowered cholesterol in obese mice by delivering the drug via nanogel. The treatment, which was administered intraperitoneally, effectively normalized weight and reduced cholesterol levels despite continued high-fat diet consumption.
Researchers found that phytosterols can reverse age-related hearing loss in mice by replenishing cholesterol in sensory cells. The study suggests that these plant-based compounds could be a convenient way to combat age-related hearing loss.
Researchers investigate how exposure to endocrine-disrupting chemicals in plastics may increase atherosclerosis and CVD risk, particularly in children. The study aims to establish a novel therapeutic target for chemical-induced CVD and explore gene-EDC interactions.
A study published in Liver Research found that glucokinase activators (GKAs) improved glucose tolerance and insulin sensitivity in mice with diet-induced obesity. However, GKAs also induced hepatic lipid accumulation, which activated the PERK-UPR signaling pathway.
Scientists at the University of Pittsburgh Center for Vaccine Research have identified a protein responsible for lethal liver disease in mice infected with Rift Valley fever virus. Removing this protein, Lrp1, from the liver prevented viral replication and extended mouse lifespan.
Researchers at the Medical University of South Carolina have identified a novel class of compounds that effectively lower cholesterol, triglycerides and apoB in human liver-like cells. These molecules work independently of the LDLR pathway and offer a new treatment regimen for patients with familial hypercholesterolemia.
A recent study found that PCSK9 inhibitors may impair lung function in some patients, while statins have a protective effect on the brain, increasing hippocampus volume which may reduce dementia and depression risk. The study used genetic data from 340,000 UK Biobank participants.
Researchers found a strong association between certain gut bacteria and coronary atherosclerotic plaques, which can lead to heart attacks. The study analyzed gut bacteria and cardiac imaging data from over 8,900 participants and identified Streptococcus species as key players.
A novel molecular pathway has been identified, explaining how a mutation in the ACTA2 gene can cause individuals in their 30s with normal cholesterol levels to develop coronary artery disease. The mutation leads to stress in smooth muscle cells, triggering the production of excess cholesterol and driving atherosclerotic plaque formation.
Research found that older adults with fluctuating cholesterol and triglyceride levels have a higher risk of Alzheimer's disease and related dementias compared to those with steady levels. The study identified a link between variations in total cholesterol and triglycerides and an increased risk of dementia.
Research from University of Illinois Chicago found water fasts spur noticeable short-term weight loss, but metabolic benefits disappear soon after fast ends. Participants lost 4-10% of their weight during the fast, and some gained back the lost weight within three months.
A new proposal suggests adopting an 'adolescent cholesterol passport' to prevent atherosclerosis, a leading cause of death worldwide. The tool would involve regular cholesterol screenings starting at age two, with the goal of detecting familial hypercholesterolemia and other genetic conditions early on.
The Martin/Hopkins method has been shown to accurately calculate LDL cholesterol levels in over 89% of patients, surpassing other available equations. This method is particularly beneficial for identifying patients at higher risk of heart disease and strokes.
A recent study unveiled the doorway that SARS-CoV2 uses to slip inside cells undetected. Cholesterol clusters make up this door, allowing the virus to infect human cells. Regular exercise and mechanical force can disrupt these cholesterol aggregates, reducing the risk of infection.
A new analysis of the CLEAR Outcomes Trial found that bempedoic acid lowered LDL cholesterol levels by 21% and reduced cardiovascular events by 13%. This suggests that different classes of cholesterol drugs have similar benefits for cardiovascular health.
A new study found that elevated Lipoprotein(a) levels are a significant predictor of recurrent coronary heart disease (CHD) in people over 60. The study suggests current cholesterol-lowering medications may not be effective in reducing the risk of recurrent CHD, highlighting the need for novel therapeutics to target elevated Lp(a).
Researchers have discovered a new record of protosteroids in Earth's Middle Ages, extending the current molecular record of eukaryotes to 1600 million years ago. This finding provides a rare glimpse into the conditions surrounding the evolution of complex life and may shed light on the competitive demise of ancient eukaryote groups.