Articles tagged with Cholesterol
Researchers discovered that high cholesterol levels at a young age can be a significant risk factor for atherosclerosis. Fluctuating levels of cholesterol were found to cause the most damage and may increase the risk of heart attack even in those taking statin medication.
Very intensive lipid-lowering therapy significantly regresses atheroma volume at the lesion level compared to statin therapy alone. This study found greater enlargement of the minimum lumen area and more frequent transition to stable plaque phenotypes with alirocumab treatment.
A blood test that measures three modifiable factors together can better predict cardiovascular risk than any marker used alone. The study found that inflammation is at least as important as cholesterol in predicting cardiovascular events.
Inflammation in RA leads to altered lipid and lipoprotein profiles, with elevated triglycerides, total cholesterol, and LDL-cholesterol levels. Proinflammatory HDL complexes contribute to the proatherogenic phenotype.
Researchers at Edith Cowan University have uncovered a significant genetic connection between Alzheimer's disease and several coronary artery disease-related disorders, offering opportunities to improve health outcomes. The study found that some of the same genes played a role in or are associated across these conditions.
A new study published in Cell Reports Medicine found that a ketogenic diet can reduce beneficial gut bacteria and increase unfavorable fats in the blood. The diet, which is high in fat and low in carbohydrates, may have long-term health implications such as increased risk of heart disease and stroke.
A randomized crossover clinical trial reveals that swapping refined corn flour for a blend of refined corn flour and corn bran lowers LDL cholesterol concentrations by 5-13.3%. The study found significant reductions in LDL cholesterol among 70% of participants who consumed the blend, while whole-grain corn meal had no impact.
A new study found that taking fish oil supplements can lower blood lipid levels in individuals with a genetic predisposition to high cholesterol. The research used genetic data from over 441,000 participants and found that fish oil supplementation can counteract the genetic risk of developing high cholesterol.
The Lancet Commission on dementia prevention recommends addressing 14 modifiable risk factors to prevent or delay nearly half of dementia cases. The report identifies two new risks: high LDL cholesterol and vision loss, which are associated with 9% of all dementia cases.
A study of non-statin cholesterol-lowering medications found that cholesterol absorption inhibitors were associated with a 31% lower odds of liver cancer risk. Statin use was also linked with a 35% lower risk. Fibrates, omega-3 fatty acids, and niacin showed no association.
A new University of Michigan study found that over 82% of Americans aged 50-80 take one or more prescription medications, with 80% open to stopping certain drugs. However, researchers stress the importance of personalized guidance for deprescribing older adults, particularly those taking medication for cardiovascular disease or diabetes.
A systematic review published in Nutrients highlights the positive health outcomes associated with pulse consumption. The study found that eating more pulses reduces the risk of type 2 diabetes and heart disease.
A cohort study of 10,634 participants reveals that childhood risk factors are associated with adult cardiovascular disease. The study highlights the importance of intervening in childhood to reduce the incidence of adult CVD, particularly for body mass index (BMI) and low-density lipoprotein cholesterol.
Researchers have discovered a better way to identify those at high risk of potential heart attacks and strokes by adding genetic information to health checks. The study found that combining clinical risk scores with polygenic risk scores significantly improves identification rates, especially among younger people.
A clinical trial led by Mount Sinai researchers shows zodasiran, an RNA inhibitor targeting ANGPTL3, significantly reduces various types of cholesterol and triglycerides. The therapy also lowers apolipoprotein B, a lipid-transporting protein linked to heart disease.
Research finds insulin levels correlate with triglycerides, ApoB, non-HDL cholesterol, and free cholesterol in women with atherosclerotic coronary disease. The study suggests these laboratory-associated flags indicate early coronary atherosclerosis in both diabetic and non-diabetic women.
A recent analysis of WHI findings indicates that MetS and obesity each have different associations with breast cancer subtypes and mortality risk. Women with higher MetS scores are at a higher risk of poor-prognosis, estrogen receptor-positive, progesterone receptor-negative breast cancers.
Three FAU researchers have received $1M in FDOH grants to develop innovative approaches against Alzheimer's disease. Mare Cudic aims to explore the link between glycosylation and neuroinflammation, while Ruth Tappen develops an online screening tool for older drivers with cognitive decline.
A study published in PLOS ONE found that combining time-restricted eating with high-intensity functional training improves body composition and cardiometabolic health more than either alone. The research, conducted on inactive women with obesity, showed significant weight loss and favorable changes in lipid and glucose levels.
Researchers at Aarhus University have identified a way to regulate cholesterol levels to improve immunotherapies for cancer and other illnesses. By manipulating STING protein activity, they aim to bolster the body's natural defences against disease.
Researchers at UNC School of Medicine discovered the detailed protein structure of the TAS2R14 bitter taste receptor, revealing how it identifies and activates bitter tastants. The discovery has potential applications in drug development for metabolic diseases like obesity and diabetes.
A study published in PNAS reveals the structure of a protein linked to neurodegenerative disease Niemann-Pick type C, which accumulates cholesterol within cellular compartments. The research sheds light on the complex mechanism of cholesterol distribution and its role in maintaining optimal levels.
A new study suggests that most essential care for cardiovascular health happens in general primary care clinics, but many at high risk don't receive it. The study found that large percentages of people with major cardiovascular risk factors didn't see a primary care provider or cardiologist in the past year.
Studies at the University of Gothenburg found a clear shift in arterial disease risks in diabetes, with decreases in central organ diseases like heart attack and stroke, but increases in peripheral vessel complications. Closer monitoring of long-term blood sugar levels can reduce peripheral arterial disease risk by 30-50%.
A new study suggests that anxiety and depression in younger women may accelerate the development of cardiovascular risk factors, putting them at nearly par with men of the same age. The researchers found that these mental health conditions were associated with a much higher relative risk among young women than seen in other groups.
A recent study found that eating fortified eggs had no adverse effect on blood cholesterol levels and may even have beneficial effects on cardiovascular health. Subgroup analyses revealed potential benefits among older adults and those with diabetes.
A recent study examined cholesteryl esters and found that prolonged inactivity may affect people of different ages differently. The researchers observed changes in middle-aged subjects but not in older adults when comparing pre- and post-bed-rest levels.
A free, weekly home delivery program of fresh fruits and vegetables improved participants' nutrition levels, physical activity levels, and cardiovascular disease risk factors. The 16-week program resulted in significant improvements in food insecurity, diet quality, and indicators of cardiovascular health.
Researchers found that Kupffer cells in liver respond to high cholesterol by removing excess, revealing the liver's role in regulating cholesterol levels. This discovery suggests atherosclerosis is a systemic disease affecting multiple organs.
A new study found that more than half of American Indian teens had high levels of cholesterol, with nearly two-thirds of young adults experiencing the same issue. The study suggests a need for early screening and treatment to prevent premature heart disease.
A study funded by the National Institutes of Health found that more than 70% of American Indian young adults aged 20-39 and 50% of teens have abnormal or high cholesterol. High LDL cholesterol was linked to plaque buildup and cardiovascular events, emphasizing the need for early screenings and culturally relevant education.
A study by the University of Exeter found that substituting meat for Quorn lowers bad cholesterol by 10-percent. This reduction is comparable to switching to a Mediterranean or vegan diet and has significant implications for heart health.
Researchers found that physical pressure on cells reduces pain signals, but excess cholesterol can interfere with this process. The study shows how cell membrane lipids help send electrical pulses into cells after experiencing pressure and force.
Researchers have discovered a new way to target chemotherapy-resistant ovarian cancer cells by depriving them of cholesterol, leading to significant tumor growth reduction. The nanoparticles starve the cells of cholesterol, triggering cell death through oxidation of lipids in the cell membrane.
Researchers at UCSF used clinical data and a precision medicine approach to identify early risk factors for Alzheimer’s disease, predicting its onset with 72% accuracy. High cholesterol, osteoporosis, and erectile dysfunction were found to be predictive factors in both men and women.
A new study reveals that utilization of PCSK9 inhibitors is low among high-risk patients, despite extensive evidence documenting their role in LDL-C reduction and the prevention of heart attacks. The study found that insurance coverage rejection or abandonment leads to significantly more cardiovascular events within 12 months.
A new study suggests that finasteride, a common hair loss and prostate drug, may also lower cholesterol levels and reduce cardiovascular disease risk in men. In mice, the researchers found significant correlations between finasteride use and lower cholesterol levels, as well as reduced inflammation and atherosclerosis progression.
Lung adenocarcinoma cells manipulate macrophage lipid metabolism to drive tumor progression. This exploitation of immune cells' metabolic pathways may be targeted with statins, improving lung cancer treatments.
Researchers have discovered a new treatment that enhances the body's natural defences against atherosclerosis in patients with rheumatoid arthritis. Treating arthritic mice with RvT4 reduces blood vessel inflammation by re-programming macrophages to release stored lipids.
Researchers at Duke-NUS Medical School discovered a novel enzyme, FAXDC2, that plays a pivotal role in cholesterol synthesis and cancer progression. The study highlights the potential vulnerability of cancer cells to targeted therapeutic intervention. Further research is needed to explore the therapeutic potential of targeting FAXDC2 i...
Researchers discovered that reducing cholesterol levels in mice with advanced atherosclerosis leads to a decrease in the number of smooth muscle-derived cells causing plaque growth, while preserving stabilizing cell types. This finding opens up new opportunities for targeted therapies.
A team of scientists has found that 7-dehydrocholesterol (7-DHC) integrates into cell membranes and prevents ferroptosis, increasing cellular fitness and potentially promoting aggressive cancer behavior. This discovery could lead to the development of new cancer treatments targeting cholesterol biosynthesis.
A new review suggests that female reproductive characteristics, such as early menstruation and polycystic ovary syndrome, may contribute to later metabolic dysfunction. The study highlights the importance of screening for reproductive risk factors to aid in prevention or treatment of chronic metabolic diseases.
Research found that having high cholesterol and blood pressure before age 55 significantly increases the risk of heart disease in later life. The study's results show a lasting impact on cardiovascular health, even if levels are lowered subsequently.
Researchers at the University of New Mexico have developed a new vaccine that can lower LDL cholesterol levels by up to 30% and reduce the risk of heart disease. The vaccine is based on a non-infectious virus particle and has shown promising results in animal trials.
A new study found that increased childhood sedentary time significantly increases cholesterol levels in young adulthood. However, light physical activity (LPA) has been shown to completely reverse this effect, while moderate-to-vigorous physical activity (MVPA) may also reduce cholesterol levels but with diminished impact due to body f...
Research suggests that childhood sedentariness contributes to elevated cholesterol levels and premature heart attack or stroke in mid-life. Engaging in light physical activity for 3-4 hours/day may be effective in reducing high cholesterol.
A new study found that increased sedentary time in childhood can raise cholesterol levels by two thirds as an adult, leading to heart problems. However, light physical activity was shown to be up to five times more effective than moderate-to-vigorous physical activity at promoting healthy hearts and lowering inflammation.
Researchers found that blocking cholesterol production prevented progression of serrated-type intestinal tumors in mice, suggesting a potential new strategy for treating these aggressive cancers. The study's findings support the use of cholesterol-lowering drugs to prevent or treat these tumors.
Researchers at Michigan Medicine found that telemedicine patients with hyperlipidemia experienced significant decreases in LDL and non-HDL cholesterol levels. Virtual appointments were shown to be as effective as in-person visits in improving cholesterol levels, overcoming barriers to access for patients.
The UTHealth Houston School of Public Health offers a 12-month lifestyle program combining evidence-based nutrition education with culinary learning to support behavior change. Participants will attend in-person and virtual classes, including hands-on cooking lessons, physical activity guidance, and mindfulness education.
A new study found that very high levels of HDL-C, known as 'good cholesterol', are associated with an increased risk of dementia in older adults. Researchers observed a 27% higher risk of dementia among participants with very high HDL-C levels compared to those with optimal levels.
A new study published in Gut found that higher HDL-C levels are associated with a reduced risk of gallstone formation, while lower LDL-C levels also show an inverse association. The study suggests that these findings could inform personalized risk assessment strategies and potential therapeutic interventions for cholelithiasis prevention.
Researchers have found that lowering a form of brain cholesterol known as cholesteryl esters helps prevent brain damage and behavioral changes in mice with Alzheimer's-like tau deposits. The study suggests that reducing cholesteryl ester levels could be a promising candidate to test in neurodegenerative diseases.
A new study published in Nutrients demonstrates that incorporating pulses into the American diet can significantly improve its nutritional profile. By replacing small amounts of protein sources with pulses, individuals can increase their fiber intake by more than 10% and decrease their cholesterol levels.
A new study reveals that younger people are more vulnerable to the effects of high blood cholesterol and hypertension, atherosclerosis can be reversed if risk factors are controlled early enough. The study suggests aggressive control of cardiovascular risk factors at younger ages.
Researchers investigate nanoparticles for cancer treatment, hoping to reduce side effects and improve efficacy. La-Beck's lab aims to understand the body's interaction with nanoparticles and their impact on tumor growth and immune responses.
Scientists at the University of Leicester have made a groundbreaking discovery about how cholesterol in our diet is absorbed into our cells. The research, published in Science, highlights the role of two proteins called Aster B and Aster C in transporting cholesterol from the intestine to the bloodstream.
A new therapeutic, lepodisiran, has shown promising results in reducing lipoprotein(a) levels to undetectable levels for nearly one year. The study found that the medication is safe and effective in lowering Lp(a) levels by more than 94%.
A new study suggests that a PCSK9 inhibitor given every 1-3 months may effectively lower bad cholesterol levels in people with non-genetic hypercholesterolemia. The medication, recaticimab, showed similar effectiveness and safety as other PCSK9 inhibitors when administered less frequently.