About The Study: In this cohort study of 10,634 participants, childhood risk factors were found to be associated both directly and indirectly to adult cardiovascular disease (CVD), with the largest direct effect seen for body mass index (BMI) and low-density lipoprotein cholesterol. These findings suggest that intervention for childhood risk factors, in particular BMI, is warranted to reduce incidence of adult CVD as it cannot be fully mitigated by risk factor management in adulthood.
Corresponding Author: To contact the corresponding author, Terence Dwyer, M.D., email terence.dwyer@wrh.ox.ac.uk .
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(doi:10.1001/jamanetworkopen.2024.18148)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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