Articles tagged with Cholesterol
Researchers at Tel Aviv University develop a groundbreaking method to eradicate glioblastoma brain tumors by targeting astrocytes and starving them of energy. The study found that in the absence of these brain cells, tumor cells die and are eliminated, offering a promising basis for developing effective medications.
A new study published in the Journal of the American Heart Association found that low physical function after age 65 is associated with a greater risk of developing heart attack, heart failure, and stroke. The study used the Short Physical Performance Battery (SPPB) test to assess physical function in 5,570 adults over 75 years old.
Researchers analyzed 306-million-year-old fossilized animal feces and found biomolecular information about long-extinct diets. The study revealed that an unidentifiable extinct animal was a meat-eater or on a predominantly carnivorous diet, with high proportions of cholesterol-derived molecules and a lack of plant-derived biomarkers.
African American adults with higher levels of religiosity and spirituality may be more likely to meet key cardiovascular health metrics. The study found associations between religious behavior, spirituality, and improved health outcomes in terms of diet, physical activity, and smoking.
Researchers found that statins, commonly prescribed lipid-lowering drugs, provide a protective immune function in females. Women taking statins were 75% less likely to be ANA+, suggesting a sex-specific difference in the relationship between lipid metabolism and immunity.
A recent study published in JAMA found that despite overall improvements in cholesterol levels since 2008, sex, racial, and ethnic disparities persist in lipid control. The research team analyzed data from over 33,000 US adults and discovered significant variations in trends by race and ethnicity.
A West Virginia University study explores the link between pregnancy, sedentary behavior, and cardiovascular disease risk in women. The research aims to investigate whether physical activity can reduce or eliminate this accelerated risk development in women.
Combining sauna and exercise for eight weeks improves cardiorespiratory fitness, lowers systolic blood pressure and total cholesterol levels compared to regular exercise alone. The study found the sauna-exercise combination to be superior in reducing cardiovascular disease risk factors.
Researchers found that daily consumption of small portions of Jarlsberg cheese increased osteocalcin, a hormone associated with strong bones and teeth, without boosting harmful cholesterol levels. The effects were specific to Jarlsberg and not seen in other cheeses.
Research suggests that chemicals produced by gut microbes after eating red meat may contribute to cardiovascular disease. The study found a 22% higher risk of atherosclerotic cardiovascular disease associated with increased red meat consumption, which was partly attributed to elevated levels of TMAO and related metabolites in the blood.
A new analysis from the Family Heart Foundation shows that only 31.3% of individuals with familial hypercholesterolemia (FH) in its database had been diagnosed as of June 2020. This represents a significant increase since 2016, but highlights the ongoing challenge of diagnosing and managing the condition.
A study published in the European Heart Journal found that making small behavioral changes can significantly reduce cardiovascular risk. Participants who received a lifestyle intervention showed improvements in physical activity, diet, and sedentary time, leading to decreased blood pressure and cholesterol levels.
A new study found that consuming green tea extract for four weeks can lower blood sugar levels, improve gut health, and decrease inflammation in healthy individuals and those with metabolic syndrome. Researchers observed a significant reduction in fasting blood glucose levels and decreased gut permeability.
A new study published in the Journal of the American Heart Association found that people with high genetic risk for stroke can reduce their risk by 30-45% by adopting a healthy cardiovascular lifestyle. The study followed 11,568 adults over 28 years and showed that modifying lifestyle risk factors can offset genetic risk.
Researchers found wearable activity trackers encourage users to walk up to 40 minutes more each day, resulting in a significant weight loss of 1kg over five months. The study, which reviewed almost 400 studies involving 164,000 people, also found benefits for blood pressure and cholesterol levels.
Researchers developed a risk algorithm specific to the region, incorporating factors such as age, cholesterol level, and blood pressure. The new score aims to provide greater accuracy in identifying people at high risk of cardiovascular disease in clinical practice.
A world-first study has confirmed the link between Alzheimer's Disease and multiple gut disorders, revealing shared genetic architecture. The study suggests that abnormal cholesterol levels play a key role in both conditions, and may lead to new potential treatments for Alzheimer's and gut disorders.
A study of 6,335 American adults with a history of cardiovascular disease found that risk factor profiles have not improved over the last two decades. Despite advancements in therapies and guideline recommendations, blood glucose, blood pressure, cholesterol levels, body mass index, smoking, physical activity, and diet all showed worse...
Researchers have created a noninvasive method to identify tumors causing hypertension by reducing radiation exposure. The new fluorine-based agent replaces an iodine-based agent and may allow for screening of patients with hypertension-linked aldosterone adenomas.
A new Mount Sinai study reveals that young Black adults are twice as likely to have atherosclerosis as their Hispanic counterparts. Researchers used comprehensive questionnaires and 3D vascular ultrasounds to determine cardiovascular risk scores, finding significant discrepancies between the groups.
Eating one avocado a day for six months improved overall diet quality by eight points and slightly decreased LDL cholesterol levels. However, avocados had no effect on belly fat or weight gain in participants with overweight or obesity.
The American Heart Association has revised its cardiovascular health checklist to include sleep duration as a key factor in ideal heart and brain health. The new Life's Essential 8 score replaces the previous Life's Simple 7 and assesses factors such as diet, physical activity, nicotine exposure, and blood pressure.
Researchers found that 67.7% of stroke patients with previously undiagnosed major risk factors had one underlying condition, with dyslipidaemia being the most common detected vascular risk factor. The study suggests that identifying and treating these conditions can help prevent future strokes.
Research found a link between genetic variants that mimic statin medication effects and increased risk of developing cataracts. Genetic analysis revealed carriers of rare mutations in the HMGCR gene have almost complete protein inhibition, similar to taking statins.
A randomized controlled trial found that spinal anesthesia was associated with worse pain immediately after surgery, but differences diminished over time. Researchers also found higher rates of pain reliever prescriptions at 60 days in the spinal anesthesia group.
A genetic variant in nearly 30% of Greenlanders is linked to high cholesterol and an increased risk of cardiovascular disease. The variant, p.G137S, has a marked population-level impact, increasing the risk of high cholesterol and cardiovascular disease for up to 30% of the Greenlandic population.
Researchers found that the effectiveness of exercise depends on the time of day, with morning exercise reducing belly fat and blood pressure in women, while evening exercise increasing muscular performance. For men, evening exercise lowers blood pressure, burns more fat, and improves heart disease risk.
Researchers at West Virginia University are studying the mechanisms behind Alzheimer's disease and PTSD, using animal models to investigate how stressful events affect brain cells. They aim to understand the role of estrogen and high-cholesterol diet in developing the disease.
A study published in Nature Cardiovascular Research reveals that rare T cells targeting apolipoprotein B can contribute to inflammation and atherosclerosis progression. Researchers discovered these cells resemble regulatory T cells but develop a new identity as heart disease develops.
A randomized controlled trial found that consuming cranberries for 12 weeks improved participants' memory of everyday events and neural functioning. The study also showed a significant decrease in LDL or 'bad' cholesterol levels, contributing to improved vascular health and brain perfusion.
Researchers linked dietary cholesterol to exacerbation of viral infections in mice, showing that high levels of cholesterol made mice sicker when infected with influenza. The study found that dietary cholesterol increased the number of cytokine-producing immune cells in the lungs, contributing to excessive inflammation.
A study found that colchicine significantly improved survival rates for patients hospitalized with worsening heart failure. Colchicine may also reduce the risk of heart attack and stroke in patients with a buildup of cholesterol in their arteries.
A study estimates that more than 1 million U.S. adults carry a gene for familial hypercholesterolemia, a genetic disorder causing high cholesterol and potentially leading to premature heart attack or death. Genetic testing may help identify those at risk, but its affordability is a concern.
Women's metabolism alters during menopause due to changes in sex hormone levels. Metabolite profiles show increased lipid and cholesterol levels, especially triglycerides and LDL particles, which can lead to atherosclerosis.
A study by researchers from the University of Chicago reveals that maternal octopuses undergo a massive shift in cholesterol metabolism, resulting in dramatic changes in steroid hormones produced. This phenomenon is linked to a life cycle process and has serious consequences on longevity and behavior across different animals.
Adding pickled cucumbers to sour cream significantly increases antioxidant activity and reduces cholesterol oxidation products. The addition also improves the bioaccessibility of antioxidants, making it a promising strategy for enhancing the health-promoting activities of sour cream.
A study published in Med found that the human microbiome's variation explains different patient responses to statins. The researchers discovered a Bacteroides enriched microbiome with lower diversity was associated with stronger LDL-lowering effects but greater disruption of blood glucose levels.
A study of 21,083 adults found that coffee consumption is associated with raised cholesterol levels, with brewing methods such as espresso showing the widest gender difference. Drinking 3-5 daily cups of espresso was linked to increased serum total cholesterol, particularly among men.
The BMJ recommends offering additional cholesterol-lowering drugs to adults at high heart disease risk, particularly those with 'bad' LDL cholesterol levels above 70 mg/dl. Ezetimibe and PCSK9 inhibitors are recommended for the high and very high risk group, but not for those in the low risk category.
A new study found that adults who experienced childhood abuse were more likely to develop high cholesterol and Type 2 diabetes. In contrast, healthy childhood experiences may increase the likelihood of heart-healthy behaviors that decrease cardiovascular disease risks.
A study led by Richard Isaacson found that individualized, multi-domain interventions improved cognition and reduced Alzheimer's risk in both men and women. Women demonstrated greater improvements in certain risk scores and biomarkers compared to men.
A recent study analyzed data from 421 adults with type 2 diabetes and found that achieving optimal blood pressure, glucose, cholesterol, and body weight levels can significantly improve life expectancy. By targeting these key health metrics, individuals with type 2 diabetes may be able to extend their lifespan.
A new study published in PLOS ONE finds that high and very high cardiovascular risk are associated with depressive symptoms, especially in women. The researchers used data from a Mediterranean Diet trial and found that participants with higher cardiovascular risk had lower depressive status scores after following the diet.
Researchers found a higher number of small HDL particles in cerebrospinal fluid is associated with better cognitive performance and lower risk for Alzheimer's disease. These particles may play a key role in clearing amyloid beta peptides, which contribute to the disease.
Researchers have identified a key protein molecule that plays a major role in the accumulation of brain cholesterol, triggering Alzheimer's disease. The peptide inhibitor ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.
A study tracking children for up to half a century found five childhood risk factors predict fatal and non-fatal cardiovascular events in adulthood. The findings emphasize the importance of preventive strategies starting in childhood.
Vupanorsen, an experimental drug targeting non-HDL cholesterol, showed modest reductions in Non-HDL cholesterol by up to 28%, triglycerides by up to 57%, and angiopoietin-like 3 (ANGPTL3) levels by up to 95% in patients with high cholesterol.
A Cleveland Clinic-led trial found that an experimental 'gene silencing' therapy significantly reduced blood levels of lipoprotein(a), a key driver of heart disease risk, by up to 96%-98%. The therapy targets the gene responsible for Lp(a) production and has shown strong efficacy with no major safety concerns reported.
The study found a twofold regression of coronary atherosclerosis and stabilization of high-risk plaques in patients who received alirocumab, compared to those who received a placebo. Patients treated with alirocumab also needed significantly fewer repeat stenting procedures.
Researchers from NTU Singapore and Waseda University found that fermented soybean waste improves fat metabolism and mitigates the effects of diet-induced obesity. The study, published in Metabolites, showed that mice fed fermented okara gained less body mass and had lower levels of fat and cholesterol.
A comprehensive literature review found that consuming plant-based alpha-linolenic acid (ALA) rich in walnuts and flaxseeds can lower cardiovascular disease risk by 10% and fatal coronary heart disease risk by 20%. ALA may also benefit heart health when combined with other omega-3s.
Scientists at NTU Singapore have developed a method to produce and extract oils from a type of common microalgae, which are edible and have superior properties as those found in palm oil. The newly discovered method would serve as a healthier and greener alternative to palm oil.
A new University of Kentucky study published in Science Signaling suggests that replenishing high-density lipoprotein (HDL) cholesterol could be an effective treatment for sepsis. The research found that a synthetic form of HDL provided protection against sepsis in mice, increasing survival rates and improving kidney function.
A new 3D matrix ultrasound method has been developed to assess cardiovascular risk in healthy individuals, offering a reliable and accurate alternative to traditional methods. The technique shows promise for personalized prevention and treatment strategies by detecting and quantifying an individual's accumulated cardiovascular damage.
A new study published in JAMA Internal Medicine found that the link between high cholesterol and heart disease may not be as strong as previously thought. The research suggests that statins may have a modest benefit for some individuals, but this benefit varies depending on personal risk factors.
The International Lipid Expert Panel recommends a step-by-step approach to diagnosing and managing muscle symptoms caused by statins. The 'nocebo/drucebo' effect, where patients experience side effects due to expectation, affects up to 70% of diagnosed statin intolerance cases.
A new analysis by University of Copenhagen researchers found that a Nordic diet has positive health benefits regardless of weight loss. The diet's unique fat composition, high in omega-3 and omega-6 unsaturated fats, plays a significant role in lowering blood sugar and cholesterol levels.
A team of UTSA researchers has developed an innovative inhibitor that blocks the effects of cytochrome P450 8B1, a key enzyme linked to cholesterol absorption and obesity. The treatment shows promise in reducing glucose levels without affecting body weight, offering potential relief from obesity-associated metabolic disorders.
A new study reveals that simultaneous measurement of dozens of types of fats in the blood can predict the risk of developing type 2 diabetes and cardiovascular disease years in advance. The researchers found that individuals with a certain lipid profile are at increased risk, while those with a different profile have lower risk. This d...
A study published in Science Immunology reveals that a specific neurotransmitter in immune cells plays a crucial role in cholesterol accumulation and sterile inflammation in atherosclerosis. The researchers found that blocking this neurotransmitter may help reduce inflammation and develop effective treatments for the disease.