Articles tagged with Cholesterol
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Researchers developed a new technology to monitor cholesterol in brain tissue, revealing major locations of cholesterol and its metabolites. This breakthrough could lead to the discovery of new therapies for neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's disease.
A diet rich in fish omega-3 fatty acids modulates lipoprotein particles, reducing triglycerides transported by any type of lipoprotein. The study found that increased consumption of LDL cholesterol from fish is associated with larger, less atherogenic LDL particles.
Research shows low-income adults are less likely to receive preventive heart disease care, including cholesterol and blood pressure screenings. Socioeconomic disparities worsen during crises like COVID-19, highlighting the need for city-level interventions and public health policies to address these gaps.
Researchers developed open-source software PCAlipids to analyze individual lipid molecules, highlighting the effects of temperature and cholesterol on their behavior. The study aims to better understand the mechanisms behind these interactions.
Researchers have discovered a new gene, Sestrin1, that regulates cholesterol levels by shutting off cholesterol production in the liver when food provides enough essential nutrients. The study combines fine-grained detail from animal studies with statistical power of genetic studies involving hundreds of thousands of human genomes.
Regular dietary counselling from infancy leads to improved cardiovascular health and reduced risk factors, such as lower serum cholesterol levels and better insulin sensitivity. The intervention group continued to have a heart-healthy diet even after the counselling ended.
People with type 2 diabetes and heart disease may benefit from newer therapies that combine glucose control with cardiovascular benefits. These treatments, such as SGLT2 inhibitors and GLP-1 receptor agonists, have been shown to reduce the risk of major cardiovascular events and improve outcomes for patients.
Cells in vulnerable entry routes to bacterial infection buffer themselves when immune system detects danger by reorganizing surface cholesterol. This defense mechanism, identified by UTSW researchers, could offer new strategies for fighting infections without antibiotics.
A U-shaped relationship was found between egg consumption and the risks of incident CVD and total death among general Chinese. Consumption of 3-6 eggs/week was associated with the lowest risk. Higher or lower egg intake was linked to increased cardiovascular disease and mortality risks, respectively.
A phase three clinical trial found alirocumab to substantially reduce low-density lipoprotein (LDL) cholesterol levels in adult patients with HoFH, with an average relative reduction of 35.6%. The drug also reduced other harmful lipids typically elevated in people with FH.
Researchers found evinacumab, a monoclonal antibody, reduced LDL cholesterol to near-normal levels among patients with HoFH, meeting the primary endpoint. Patients achieved an average relative reduction of 49% and nearly half had LDL cholesterol below 100mg/dL.
A new study found that middle-aged and older adults who consumed sugary beverages daily had a higher risk of developing abnormal cholesterol and triglyceride levels compared to those who rarely drank them. The study suggests that limiting sugary drink intake may help maintain healthier blood cholesterol and triglyceride levels.
A new observational study published in the Journal of the American Heart Association found that drinking 12 ounces of sugary drinks more than once per day is linked to lower levels of HDL-C and higher levels of triglycerides. The study also found that regularly consuming sugar-sweetened beverages increases the risk of cardiovascular di...
Researchers found that using plant-based analogs of cholesterol improves the shape and structure of nanoparticles, allowing them to deliver genes more effectively. This boosts delivery by up to 10-fold and enables patients to be treated with higher efficacy.
Researchers found that high cholesterol levels increase the risk of developing aortic stenosis, a major heart valve disease. The study used Mendelian randomization to determine the causal effect of cholesterol levels on aortic stenosis.
A Finnish study found that patients taking cholesterol or blood pressure-lowering medications were more likely to become obese and reduce their physical activity levels. The research highlights the importance of maintaining healthy habits even when starting prescription medications.
Researchers create new model to study lipid rafts in living cells, revealing the role of cholesterol in their formation and behavior. This breakthrough sheds light on diseases like Parkinson and Alzheimer, where lipid rafts are thought to play a key role.
Researchers develop new model to simulate lipid raft formation on a nanometric scale, confirming high dynamicity and existence of 10 nanoseconds. Cholesterol discovered to destabilize membranes and enable nanotubes to leave cells in milliseconds.
A new study found that quercetin can greatly reduce systolic blood pressure and improve HDL cholesterol levels. Quercetin administration is associated with a 10-20% reduction in cardiovascular risk for heart failure, stroke, and myocardial infarction.
Researchers discovered that DHCR7 inhibitors and intermediate cholesterol metabolite 7-DHC promote IFN-I production and an antiviral response by activating AKT3 and IRF3. This may aid in the development of new drugs to treat viral infections.
A new review study published in the American Journal of Lifestyle Medicine finds that egg-industry funded research tends to skew findings, leading to a neutralized image of eggs as a cholesterol-raising product. Over 85% of studies showed unfavorable effects on blood cholesterol levels.
The American Heart Association suggests focusing on an overall heart-healthy dietary pattern that replaces saturated fats with polyunsaturated fats to maintain healthy LDL cholesterol levels. A nutrient-rich diet emphasizing fruits, vegetables, whole grains, and lean protein sources can help reduce the risk of heart disease.
Aging adults are more likely to develop and die from cardiovascular disease due to narrowed, hardened arteries. The study reveals a novel pathway where mitochondrial dysfunction and pro-inflammatory cytokine IL-6 co-exist with aging to promote atherosclerosis.
The study, published in The Lancet, analyzed data from almost 400,000 people and found a strong link between non-HDL cholesterol levels and long-term cardiovascular disease risk in those under 45. Reducing cholesterol levels by half may lower the risk of heart disease or stroke by up to 60% for some individuals.
Researchers identified Annexin A6 as a key factor in cholesterol regulation and potential therapeutic target for diseases caused by lipid accumulation. The study shows that silencing AnxA6 can redirect cholesterol to other cell compartments, potentially treating conditions like Niemann-Pick type C1 and various cancers.
Research reveals that only one LDL subclass causes significant damage, while others are harmless. Accurate diagnosis using LDL subclass composition could improve cardiovascular disease rates.
The ORION-10 trial shows inclisiran significantly lowers LDL cholesterol in patients taking statin drugs, reducing heart attack and stroke risk. The medication's excellent safety profile and convenient dosing schedule make it a promising treatment option.
A study of 1,369 children found that high levels of good cholesterol and bad fats at birth can predict social and emotional development issues at age 5. Children with high-density lipoprotein (HDL) and low triglycerides showed improved psychological ratings from teachers.
American adults on cholesterol-lowering medications have seen improved overall cholesterol levels since the 2013 ACC/AHA Cholesterol Guideline was implemented. This is largely attributed to a shift towards a risk-based approach over target LDL-based management.
Researchers at American Heart Association Scientific Sessions reveal that e-cigarettes pose significant cardiovascular threats. Contrary to popular belief, e-cigarettes do not appear to be a healthier alternative to traditional cigarettes regarding heart health.
A new study by Lund University researchers has identified a key mechanism in insulin release by a cholesterol metabolite. The receptor GPR183 plays a major role in stimulating insulin secretion in human cells and rats.
A randomized, controlled feeding study found that eating one avocado a day was associated with lower levels of LDL (specifically small, dense LDL particles) and oxidized LDL in adults with overweight or obesity. Avocados also helped reduce oxidized LDL particles and increased antioxidant lutein levels.
A new study found that halving red and processed meat consumption reduces LDL 'bad' cholesterol levels and heart disease risk by an average of 10%. Researchers discovered that even small changes to RPM intake can induce significant changes in LDL cholesterol, potentially reducing the risk of developing heart disease.
A new study finds that increasing levels of 'good' cholesterol reversed disease in the blood vessels of mice with diabetes, reversing atherosclerosis. The study also shows that raising functional HDL levels stopped inflammation and improved cardiovascular disease processes.
The study reveals how cholesterol is incorporated into cells through a previously unknown pathway, providing new understanding of cellular function. The discovery has significant implications for the regulation of cholesterol uptake and potential applications in treating diseases such as cardiovascular disease.
Babies born weighing under 3.6kg are more likely to develop type 2 diabetes by 50.0 years vs 51.3 years, with lower BMI and higher HDL cholesterol at diagnosis. Low birthweight affects risk of developing type 2 diabetes in the same way irrespective of BMI and HDL cholesterol.
A single pill containing low doses of three medications reduced blood pressure and cholesterol levels in a US study, translating to a 25% lower risk of cardiovascular disease. The study enrolled mostly low-income, primarily black adults from Mobile, Alabama, and showed high adherence rates.
Researchers found that a daily polypill with four medications lowered systolic blood pressure and LDL cholesterol by an average of 9 mm Hg and 15 mg per deciliter, respectively. Medication adherence was high in the polypill group, with 86% sticking to their regimen over 12 months.
Researchers identified early metabolic features that can predict susceptibility to type 2 diabetes in children, including low HDL cholesterol and chronic inflammation. These findings may help prevent young people from developing the disease.
A new study found that leisure-time physical activity is associated with a healthier blood lipid profile in postmenopausal women. However, it did not completely offset the unfavorable changes seen during the menopausal transition.
A UK study found that vegetarians and pescetarians have a lower risk of coronary heart disease (CHD) than meat eaters, but a higher risk of stroke. This may be due to low blood levels of total cholesterol or certain vitamins. The study included 48,188 participants over 18 years.
A study of 1,075 patients under 50 found that healthy behaviors such as regular exercise, quitting smoking, and managing cholesterol levels can significantly reduce the risk of premature heart disease. In contrast, genetics played a less significant role in those with multiple modifiable risk factors.
Researchers found that modest decreases in cholesterol and blood pressure can reduce the lifetime risk of developing fatal heart and circulatory diseases, such as heart attack and stroke. A long-term reduction of 1 mmol/L LDL cholesterol and a 10 mmHg decrease in blood pressure led to an 80% lower lifetime risk.
Research presented at ESC Congress 2019 found that genetic high cholesterol is underdiagnosed and undertreated, with a prevalence of 3.6-4.5 million individuals in Europe. Screening for the condition could identify patients and family members affected by heterozygous familial hypercholesterolaemia, allowing for lifestyle changes and tr...
The European Society of Cardiology and European Atherosclerosis Society Guidelines recommend lowering LDL cholesterol levels to prevent cardiovascular disease. Lowering LDL cholesterol reduces risk regardless of the baseline concentration, making it effective even in people at very high risk of heart attack or stroke.
A single cholesterol-derived molecule, 27-hydroxycholesterol (27HC), has been found to increase body fat even without a high-fat diet. The molecule affects white adipose tissue and expands the capacity of existing fat cells.
A University at Buffalo-led study found that a vegetable-rich diet can improve fatigue in multiple sclerosis patients by increasing good cholesterol levels. The results suggest that lipid metabolism plays a crucial role in fatigue and may provide new treatment options for this debilitating symptom.
Researchers discover that sticky meshworks of DNA and proteins extruded by neutrophils act as the glue that binds together calcium and cholesterol crystals during gallstone formation. Inhibiting NETs reduces gallstone growth in mice, offering new strategies for treating gallstone disease.
Research from the University of Copenhagen found that remnant particle cholesterol in the blood is constantly increasing and often remains at a high level for life. Maintaining a normal body weight is key to reducing remnant cholesterol and triglycerides, according to experts.
Research found that extracellular vesicles derived from kids' fat can disrupt cholesterol disposal in various tissues, regardless of weight. The study suggests that fat tissue plays a pivotal role in triggering cardiovascular disease, even before symptoms appear.
Researchers found that high-risk patients who have prescriptions for PCSK9 inhibitors rejected by insurance or not filled by patients are more likely to experience cardiovascular events. The study also identified disparities in prescription rejection rates among different demographics, including women and minorities.
Research found that young adulthood is a critical period for cardiovascular disease prevention. Elevated blood pressure and cholesterol levels in this age group are associated with an increased risk of heart disease later in life. Maintaining optimal levels of these risk factors could yield substantial lifetime benefits.
A large retrospective study found that statins are significantly underutilized in patients with and at risk for atherosclerotic cardiovascular disease. Despite known benefits, only two-thirds of these patients were receiving moderate/high-intensity statins.
A UTSA professor is designing a novel protein blocker to inhibit the activity of P450 8B1, a human enzyme linked to bad cholesterol and obesity. The breakthrough aims to fight rising obesity rates and related health issues like high blood pressure and strokes.
A study by Brigham and Women's Hospital found that a combination of high levels of dietary cholesterol with specific saturated fats exacerbates retinal damage in a preclinical model of diabetes. The research used an experimental rat model to examine the effects of different dietary fats on early molecular signs of inflammation and damage.
A study by Penn State researchers found that low-density lipoprotein cholesterol levels below 70mg/dL increase the risk of hemorrhagic stroke. Participants with LDL levels between 70-99mg/dL had a similar risk, but those below 50mg/dL faced a significantly higher risk of 169%.
Researchers found that patients taking an additional injection of alirocumab, a PCSK9 inhibitor, had significantly reduced cholesterol levels and lower risk of heart attack. For patients with diabetes, the treatment was found to reduce cardiovascular risk by an average of 2.3%.
Researchers found a consistent cholesterol-lowering effect for soy protein across all 46 trials, contradicting the FDA's proposed revocation of its health claim. The study's findings support the original FDA claim and highlight the benefits of incorporating soy into a plant-based diet.
A recent study by Jae Hee Kang et al., published in JAMA Ophthalmology, initially reported a significant association between long-term statin use and reduced primary open-angle glaucoma risk. However, due to serious coding errors, the findings were later retracted.
Research found associations between serum antibodies against P. gingivalis and A. actinomycetemcomitans with altered metabolite levels, including lipoprotein particles and fatty acids. These findings suggest exposure to periodontal pathogens may contribute to a proatherogenic state.