Research on enzymes and the reactions they drive. Covers enzyme evolution, plastic-degrading enzymes, brain immune cells, and molecular imaging.
Researchers at LMU München have developed a synthetic DNA sequence that can inhibit the activities of several DNA-processing enzymes, including HIV integrase. The artificial DNA mimic successfully competes with its natural counterpart, demonstrating potential for new treatments of retroviral diseases.
Stanford researchers engineered yeast to produce noscapine, a promising cancer drug with less toxicity than current treatments. The breakthrough involves introducing 25 foreign genes into yeast, achieving an 18,000-fold improvement in noscapine output.
Researchers have engineered brewer's yeast to produce noscapine, a potential cancer drug with fewer side effects than conventional chemotherapy. The engineered yeast strain produced 2.2 mg/L noscapine after optimization, paving the way for large-scale commercial production.
Researchers developed a process to observe lipid-flipping enzymes' activity in conjunction with membrane deformation. They found that ATP10A enzyme flips phosphatidylcholine lipids, causing curvature changes that trigger tubule formation, enhancing endocytosis and membrane dynamics.
Scientists at Lawrence Berkeley National Laboratory and JBEI have discovered a new enzyme that enables microbial production of toluene, an aromatic biofuel. The discovery is a major breakthrough in biotechnology, expanding the known catalytic range of glycyl radical enzymes and opening up new possibilities for renewable energy.
A recent study reveals that differences in metabolic enzyme activity break down pesticide chemicals, explaining bee sensitivity. Researchers found specific enzymes like CYP9Q3 and CYP9Q4 responsible for tolerance to thiacloprid and imidacloprid, respectively.
Researchers found that restoring SIRT1 reverses vascular aging, increasing capillaries and endurance by up to 80%. The study shows promise for preventing age-related diseases like cardiovascular disease and frailty.
A joint study by the University of Exeter and Bayer AG has identified key enzymes in honeybees and bumblebees responsible for their sensitivity to neonicotinoid pesticides. This breakthrough provides valuable tools to screen new pesticides early in development, potentially avoiding costly restrictions on their use.
Cytokinins have been found to play a vital role in the communication mechanisms of bacteria, plants and animals, regulating growth, development and disease resistance. The research has also uncovered new details on how cytokinins evolve and activate enzymes, challenging previous assumptions.
A novel enzyme with GNA1 function has been identified as a key player in the survival and infectivity of Apicomplexan parasites. The discovery paves the way for the development of targeted therapies against malaria and other parasitic diseases.
A new study from the University of Bristol and the University of Waikato reveals how enzymes 'choreograph' their atomic movements to work optimally at specific temperatures. This finding provides insights into enzyme structure and function, which can inform the design of better biocatalysts for industrial processes.
Researchers have successfully fused living and non-living cells to harness the natural ability of biological cells to process chemicals while protecting them from the environment. This system can lead to applications such as cellular 'batteries' powered by photosynthesis, synthesis of drugs inside the body, and biological sensors that ...
Researchers at McGill University have developed a new technique for measuring enzyme inhibition, offering a universal approach to drug discovery. The method uses isothermal titration calorimetry (ITC) to measure heat generated by enzyme activity, providing a direct window into the mechanisms of enzyme inhibition.
Researchers at Ohio State University have discovered a new CRISPR mechanism that can help prevent gene-editing errors. The discovery reveals how the Cas9 enzyme determines where and when to cut DNA strands, allowing for more precise control over gene editing.
Researchers at Stanford have discovered how a disease-associated protein gets inactivated, potentially paving the way for new treatments for celiac disease. The discovery of ERp57, an enzyme that re-forms a disulfide bond to turn off TG2, raises questions about its functions in healthy people and could lead to targeted therapies.
A study of ancient insects has provided new insights into future biofuel production. The firebrats' unique digestive system has revealed the presence of lytic polysaccharide monooxygenases (LPMOs), a new class of enzyme that efficiently digests cellulose. This discovery could lead to the development of sustainable low-carbon fuels.
A team of international researchers has successfully stopped the growth of malignant melanoma by targeting epigenetic marks on DNA. By blocking enzymes responsible for erasing these marks, they reactivate a natural protective mechanism called cellular senescence, which prevents mutated cells from dividing and forming tumors.
Scientists at Ecole Polytechnique Fédérale de Lausanne have created a method for tracking specific enzymes in cell compartments, helping identify their roles in various cancers. The biosensors reveal compartment-specific distributions of bioactive enzymes, which may aid the development of targeted cancer treatments.
In a groundbreaking study, researchers from the Cleveland Clinic Lerner Research Institute successfully reversed the formation of amyloid plaques in mice with Alzheimer's disease by gradually depleting the enzyme BACE1. This approach improved cognitive function and had significant benefits for the animals' health.
Researchers used time-resolved spectroscopy to study the mechanism of light-dependent hydrogenation of protochlorophyllide. They found evidence of partially stepwise hydride transfer involving three discrete intermediates. This discovery sheds light on how light energy can be harnessed for chemical reactions.
The study reveals the importance of sugary appendages on protein surfaces, which differ in composition and branching. The researchers discovered the three-dimensional structure of oligosaccharyltransferase, providing insight into eukaryotic N-glycosylation.
Scientists identified a calcineurin variant CnAβ1 that reduces cardiac hypertrophy and improves heart function by preserving mitochondrial ATP production. This study may lead to new treatment strategies for conditions like aortic stenosis.
Researchers at KAIST have identified a novel molecular mechanism for polyethylene terephthalate (PET) degradation, revealing superior degradability of PET. A new variant with enhanced PET-degrading activity was also developed using structural-based protein engineering.
Researchers identified an enzyme that is absent in healthy colon tissue but abundant in colon cancer cells. The enzyme, GalNAc-T6, attaches sugar molecules to proteins, affecting cell-cell adhesion and leading to abnormal tissue formation. This discovery may lead to new therapies for colon cancer.
A Rutgers study reveals that most primates can digest insect exoskeletons due to the presence of a stomach enzyme called CHIA. Insects have been an essential food source for early primate ancestors, and their nutritional value is comparable to other protein sources.
Researchers created synthetic neurons from a readily available cell line to investigate purine synthesis in the human brain. The study found that the core enzyme FGAMS is expressed throughout neurons and non-neuronal cells, with infection by herpes simplex virus affecting its expression and clustering.
Researchers at Uppsala University have discovered a new strategy to shut down specific enzymes that can help fight cancer. By studying the native structures and mechanisms of dehydroorotate dehydrogenase, they found that lipids play a crucial role in binding drugs to this enzyme.
A new study proposes a double mechanism of inhibition of the NF-κB pathway linked to SirT6's action on chromatin. This regulation is associated with cellular stress levels and promotes genome stability and metabolic balance.
A team of scientists at Princeton University has successfully created a protein that can catalyze biological reactions, functioning as a genuine enzyme. The artificial protein, Syn-F4, was designed entirely from scratch and can sustain life in E. coli bacteria by replacing the natural enzyme Fes.
Researchers at KAUST and TUM have successfully identified and characterized an enzyme from a brine pool in the Red Sea, which shows promising characteristics for commercial use. The study uses single-amplified genomes to produce proteins and provides a roadmap for mining molecular riches of extreme environments.
Scientists at the University of Washington have developed a new biomaterial-based delivery system that releases therapeutics in response to specific physiological conditions. The system uses 'logic gates' programmed with Boolean logic to open and release cargo only when certain environmental cues are met.
A new study found that genetic variations in the CYP2C19 enzyme affect escitalopram levels, leading to improved therapeutic outcomes when doses are adjusted accordingly. The research identified a significant difference between patients with high and low enzyme expression, highlighting the potential for personalized medicine.
The study's findings offer a blueprint for designing therapeutic drugs against common forms of lung and breast cancer. Understanding the structure of DHHC20 may aid in treatment of EGFR-driven cancers.
Researchers found that SOBER1, a plant protein, removes acetyl groups added by bacterial proteins, preventing the plant's immune response. This discovery could lead to strategies to boost plants' natural immunity or contain infections threatening agricultural crops.
Scientists at Bielefeld University confirm the presence of a previously unknown genetic defect 'MPS III-E' causing progressive blindness and inner ear hearing impairment in patients. Biochemical studies revealed that the disorder is caused by an enzyme deficiency, which can be treated with biotechnological enzyme replacement therapy.
Researchers have discovered a way to prevent the Ebola virus from spreading by inhibiting a specific enzyme that allows it to copy itself. By blocking this enzyme, the virus's ability to produce more infection is reduced, suggesting potential breakthrough in treatment.
A novel biochemical assay has been developed to rapidly and sensitively screen for antagonist compounds targeting aldolase A (ALDOA), a key enzyme in cancer cell metabolism. The optimized assay is high-throughput friendly, cost- and labor-efficient, and suitable for analysis of multiple NADH-dependent enzymes.
A team of MGH investigators has developed an approach to convert autoantibodies into anti-inflammatory antibodies using enzymes, which showed promise in treating two autoimmune diseases. The researchers hope this method will provide a more effective and efficient alternative to IVIG treatment.
Researchers found that bacteria navigate randomly but are biased towards nutrient sources, unlike enzymes which move towards areas with less substrate. The study used super-resolution microscopy and discovered run-and-tumble dynamics in enzyme motion.
Glycans are complex structures composed of sugar molecules that play vital roles in cell communication, immunity, and inflammation. Researchers have created a library of enzymes to study glycans' functions, revealing their importance in health and disease. This discovery may lead to new diagnostics and therapeutics for various conditions.
Scientists used fluorescent tagging to track movement of two enzymes in glycolytic pathway, revealing that aldolase chemotaxed up the reactant gradient produced by the functioning of the first three enzymes. This suggests a possible role for chemotaxis in enzyme cluster assembly, such as metabolons.
A new homogeneous assay detects succinate using luminescence, enabling the investigation of a large number of structurally conserved enzymes belonging to the Fe(II)/2-oxoglutarate-dependent dioxygenase superfamily. This method has significant applications in dioxygenase research and has the potential to impact human diseases.
Researchers at Goethe University Frankfurt have successfully designed non-ribosomal peptide synthetases to produce completely new natural products. This breakthrough enables the creation of novel therapeutics and peptides with improved yields and modified structures, offering new avenues for biotechnology and drug development.
Researchers at NREL discovered distinct roles of small sugars in cellulase activity and stability, shedding light on the functions of glycans attached to proteins. This knowledge can be used to improve enzyme performance for biomass conversion to renewable fuels and products.
Scientists have discovered a vital quality control mechanism in mitochondria, crucial for constructing a functional respiratory chain. A faulty enzyme can attach incorrect amino acids to transfer RNA, leading to protein synthesis errors and hereditary diseases.
A study published in Molecular Cell sheds light on the molecular mechanisms controlling Amplified in Liver Cancer 1 (ALC1) enzyme activity. Researchers found that ALC1's 'macro domain' interacts with its ATPase motor, switching off activity when not needed.
Researchers found that high ADAR1 levels correlate with reduced survival rates and disease recurrence in multiple myeloma. Inhibiting ADAR1 in experimental models suggests a potential approach to detect the disease earlier and address its root cause.
A research team has quantified blind spots in protein function, revealing that 30% of proteins with unknown functions are enzymes. This discovery has significant implications for understanding rare genetic diseases and could lead to a better insight into the onset and triggers of inherited metabolic diseases.
A University of Missouri researcher has identified a potential target for therapeutics in treating Lou Gehrig's disease (ALS), which may also help recover patients from strokes and other disorders. The study found that an enzyme called NAMPT plays a crucial role in ALS pathogenesis.
A new drug delivery system uses a synthetic-biological hybrid nanocapsule to target and correct diseased cells at the genetic level, reducing side effects. The platform is programmable, modular, and can integrate diverse peptide sequences for tailored treatment.
Three new studies have identified key proteins in microbes found in extremely salty environments, enabling them to survive in cold, dry conditions. These findings have applications in green biotechnology and could lead to the removal of toxic contaminants like perchlorate from groundwater.
A recent study published in Nature Medicine has identified a critical trigger for the damaging inflammation that causes macular degeneration. The enzyme cGAS plays a key role in detecting foreign DNA and is activated in the dry form of age-related macular degeneration, leading to vision loss.
A research team led by Whitehead Institute reveals how a key protein in plants can act imprecisely and how it can be successfully re-engineered to enhance specificity. The new study raises standards for bioengineering in the 21st century, using cutting-edge techniques like metabolomics.
A Berkeley Lab-led study discovers new types of cellulases from a microbiome, which can break down plant biomass into glucose at high temperatures. The enzymes were cultivated from a cluster of uncultivated bacteria in municipal compost, offering a scalable source for biofuel production.
Researchers have developed enzymes that can perform complex chemical reactions with improved selectivity and efficiency. These catalysts show promise for building molecules with important biological activity and reducing waste in the process. The discovery opens up new practices for chemists to create more powerful tools.
A new study uses neutron analysis to understand the molecular mechanism of an oxygen-generating enzyme that breaks down chlorite, a industrial pollutant found in groundwater and drinking water. The research opens possibilities for future applications in bioremediation and biotechnology.
Researchers have identified enzymes that regulate the speed of protein cargo trucks on cellular highways, a discovery with implications for spinal cord and nerve injuries as well as neurodegenerative diseases. The study found that these enzymes, TTLL-11 and CCPP-1, work together to control traffic flow on microtubule highways.
Researchers at UNC and Auckland University propose a new 'peptide-RNA' theory, suggesting genetic instructions (nucleic acids) and small proteins (peptides) interacted to form life. The theory contradicts the widely-held 'RNA-world' hypothesis, which states nucleic acids gave rise to life.
Researchers identified an improved form of the enzyme Rubisco, which can enhance carbon dioxide-fixation kinetics. The new screening strategy enabled the discovery of 11 mutations that increased efficiency, with potential applications in crops and sustainable food production.
Researchers identified a sulfur metabolite with antioxidant activity that supports mitochondrial energy metabolism, a crucial process for cellular function. This finding highlights the potential of enzymes involved in sulfur respiration to treat diseases such as diabetes and cardiovascular disease.