Research on enzymes and the reactions they drive. Covers enzyme evolution, plastic-degrading enzymes, brain immune cells, and molecular imaging.
Scientists at Northwestern University have developed a lightweight, porous crystal with unprecedented structural complexity using uranium and organic linkers. The new material has a high surface area, pore volume, and water stability, making it suitable for separating small molecules and enzymes.
A Scripps Institution of Oceanography research team discovered bacteria in marine sponges produce toxic compounds nearly identical to man-made fire retardants. The study uses genome mining and environmental DNA sequencing to identify specific genes and enzymes involved in the production of these compounds.
A team of scientists has found that bacteria living in marine sponges can produce toxic compounds nearly identical to man-made fire retardants, also known as polybrominated diphenyl ethers (PBDEs). The discovery could help understand the human health implications of these additives.
Scientists discovered that salicylic acid can improve a crop's ability to deal with drought by increasing the levels of three enzymes involved in the stress response. The treatment allows for more selective planting of drought-tolerant cowpea varieties, enabling them to grow in areas with limited water.
Researchers have discovered an enzyme that can break down small amounts of gluten within the digestive system, reducing symptoms in gluten-sensitive patients. The study found that taking the enzyme tablet while consuming gluten-containing foods prevented a significant amount of it from entering the small intestine.
The KAIST team discovered a new molecular signal triggered by IPMK enzyme in mediating innate immune response to sepsis. This finding suggests a potential therapeutic target for treating serious medical conditions like neuroinflammation and polymicrobial sepsis.
Researchers at Sandia National Laboratories have made a breakthrough in converting lignin, plant waste from biofuel production, into useful products like renewable plastics and fabrics. The discovery of LigM enzyme has opened a path toward new molecules and marketable products, potentially making biofuels competitive with petroleum.
Researchers identified DNA-dependent protein kinase, an enzyme that promotes fat accumulation and exercise capacity loss with age. The study's findings suggest a genetic program driving mid-life weight gain and lower fitness levels.
Researchers found a genetic explanation for how smoking contributes to coronary heart disease, revealing a single gene variant that loses its protective effect in smokers. This discovery opens doors to new therapeutic targets and personalized approaches to preventing CHD.
Researchers found that knocking out a key enzyme improved post-heart attack healing and reduced chronic inflammation. The study suggests that a short-term dietary excess of polyunsaturated fatty acids may also play a role in promoting healing.
The University of Konstanz's biological chemistry working group has decoded a molecular mechanism that inhibits bacterial populations' swarming motility. This mechanism enables bacteria to produce various natural substances using minimal resources, which may aid in combating infectious diseases and antibiotic resistance.
Scientists at Joslin Diabetes Center have found that healthy individuals with diabetes develop protective enzymes against damage from high blood sugar levels. The researchers identified an enzyme called PKM2 and showed that activating it can stop abnormalities in mouse podocytes and delay diabetic kidney disease progression.
Researchers have created a promising mouse model for the devastating genetic disorder NGLY1 deficiency. The double-deletion mice survive and exhibit symptoms analogous to humans with the condition, making them useful for testing potential therapies.
When an insect touches the Venus flytrap's sensory hairs, it triggers a chain reaction involving calcium and hormone jasmonate. The plant's glands then produce acidic vesicles filled with hydrochloric acid to decompose the prey.
Researchers at UCSF discovered a specialized enzyme that destroys chitin, a tough natural material found in the environment, which accumulates in the lungs and triggers inflammatory lung disease. Mice with this enzyme deficiency developed severe lung disease, but restoring its activity cleared up symptoms.
A Washington State University researcher has found that the uterus in female mice contains enzymes that break down semen, making it less gel-like and easier to swim. The study highlights an underappreciated complication in semen liquefaction and could lead to diagnostic tools for unexplained infertility.
Researchers have synthesized and evaluated three novel aldose reductase inhibitors, showcasing a spirobenzopyran scaffold that inhibits the target enzyme without affecting ARL1. These results suggest a promising tool for developing effective ARIs to treat diabetic complications.
A group of giant viruses, called Klosneuviruses, were identified as acquiring components from many other viruses and proteins in an evolutionarily recent timeframe. The analysis suggests that these whopper viruses did not evolve from a cellular ancestor but rather are derived from a much smaller virus through extensive gene gain.
Researchers have successfully tested a new drug that considerably weakens the recollection of a negative experience in humans. In the study, participants who received doxycycline beforehand showed a reduction of two thirds in their emotional responses to traumatic stimuli.
Scientists uncover a potent genetic element in microorganisms that enable them to self-mutate, expanding the diversity of the tree of life. The discovery reveals how rapid evolution happens in some of Earth's smallest and most common microbes.
Researchers have discovered a molecule sent by fat cells to the fly brain that signals when energy stores are sufficient, inhibiting feeding behavior. This finding suggests a potential appetite-suppression mechanism in humans and may lead to new weight management strategies.
A new fluorescent probe developed by Michigan Technological University researchers has the potential to improve cancer surgery outcomes. The probe uses a near-infrared fluorescence that can penetrate deep tissues, reducing background noise and increasing precision for surgeons.
Scientists developed a unique type of wheat that can increase the digestibility of phosphorus and other minerals, improving health for undernourished populations. The new wheat, HIGHPHY, was tested in broilers and demonstrated improved digestion coefficients for calcium and phosphorus.
Researchers at EPFL develop synthetic methods to introduce chemical modifications on huntingtin, reducing its toxicity and aggregation. The study reveals key findings on the relationship between post-translational modifications and huntingtin structure, function, and toxicity.
Scientists at WashU Medicine have implicated SARM1 in the self-destruction of axons, a process that leads to nerve cell damage in neurodegenerative diseases. The study suggests that blocking this pathway could slow or prevent disease progression and has implications for treating peripheral neuropathy.
A team of scientists has identified a new way that gut bacteria can break down complex sugars, revealing novel enzymes with potential applications in developing pre- and probiotic products to improve human health.
Researchers at TU Graz have found that superoxide dismutase enzyme function can prevent ageing in non-aqueous batteries by eliminating singlet oxygen. This discovery could lead to the development of more efficient and sustainable battery systems.
Researchers discovered a mechanism to block amyloid-beta fragments in Alzheimer's disease, reducing levels of enzyme BACE-1. A type of nucleic acid found in healthy brains promotes its degradation, offering hope for treatment.
A novel combination of two antibiotics, ceftazidime/avibactam and aztreonam, has been shown to be effective against a high percentage of carbapenem-resistant enterobacteriaceae (CRE) specimens. The therapy works by blocking different types of enzymes that bacteria use to destroy antibiotics.
The SETD8 enzyme regulates cellular senescence, a process where cells stop proliferating due to age or stress. Lowering SETD8 increases protein synthesis and growth arrest in senescent cells, promoting metabolic activities.
Researchers discover that a small GTP-hydrolysis enzyme called Rab4 is essential for the assembly of synapses and corresponding brain functions. Reduced supply of Rab4 increases synapse formation in fruit fly neurons, which may have implications for treating Alzheimer's Disease.
A study by Indiana University researchers has identified 24 compounds with the potential to boost an enzyme in the brain that protects against dementia. Caffeine was found to increase production of this enzyme, which also shows promise in reducing the impact of harmful proteins in the brain.
Scientists at Lomonosov Moscow State University have developed nanozymes, which can degrade toxic organophosphorous compounds with high efficiency. The new technology uses an enzyme encapsulated in a biodegradable polymer coat, reducing immune responses and increasing storage stability.
A study published in Science Immunology reveals that a variant of the SP140 protein, an essential epigenetic reader protein, is lacking in patients with Crohn's disease. This deficiency triggers intestinal inflammation and impairs the immune system's response to microbial signals. The researchers found that patients with reduced SP140 ...
Researchers identified an enzyme called CYP46A1 that eliminates both cholesterol and cholestanol from the brain, reducing the formation of debilitating brain lesions. The discovery could inform clinical trials to test the enzyme's potential as a therapeutic target for these diseases.
Scientists at Tokyo Institute of Technology have identified the key enzymes responsible for oil synthesis in microalgae. The research reveals that four lysophosphatidic acid acyltransferases (LPATs) play a crucial role in the formation and growth of lipid droplets, where TAG biosynthesis occurs.
Researchers have used gene therapy to treat Fabry disease, a rare inherited enzyme deficiency that can damage major organs and shorten lifespan. The treatment involves transplanted altered stem cells with copies of the fully functional gene responsible for the missing enzyme.
Researchers have developed a new tool to accurately identify enzymes present in microbiomes and quantify their relative abundances. This breakthrough may uncover novel chemistry in the gut microbiome and provide insights into its impact on human health.
A team of researchers at Johns Hopkins Medicine has identified a crucial enzyme, RAG-2, that enables precise DNA rearrangement during white blood cell development. This process is essential for producing novel antibodies that recognize and combat viruses and bacteria.
A team of scientists led by Anandasankar Ray have identified Histone Deacetylase Inhibitor 6 (HDAC6) as a regulator of learning in fruit flies. The enzyme acts like a 'dimmer switch' to increase or decrease signal across synapses, and its role in healthy neurons is less understood.
Researchers found that inhibiting intestinal protein NCoR1 breaks down bilirubin, eliminating signs of severe neonatal hyperbilirubinemia in mice. This discovery could lead to new therapeutic approaches for preventing or treating the condition.
Lily and Yuh-Nung Jan receive $100,000 prize for their discoveries on neural development, vision, and hearing; Michaela Gack, Michael Halassa, and Ahmet Yildiz win $50,000 for their innovative work in biomedical science
Researchers used neutron crystallography to visualize the positions and movements of hydrogen atoms in a key enzyme from Helicobacter pylori, which causes stomach cancer. The study provides insights into the enzyme's structure and potential targets for new medications that selectively target H. pylori without harming useful bacteria.
Researchers at Boston Children's Hospital have identified a potential therapeutic solution for age-related fibrosis by pinpointing the gene responsible for the condition. Deletion of the PAD4 gene has been shown to curb fibrosis in mice, reducing organ dysfunction and improving heart function.
A team of researchers at UD has discovered a new function for an enzyme involved in bacterial metabolism. They found that the enzyme plays a major role when generating sugars from non-sugar substrates and facilitates 'back-flow' even when sugar is being consumed.
A new gene therapy has demonstrated effectiveness in clearing glycogen buildup from muscles in mice, potentially replacing enzyme infusions. The therapy uses a modified virus to deliver a gene that produces an enzyme missing in people with Pompe disease.
A recent international multicenter study has identified a molecule that can help personalize treatment for heart failure. Researchers have found that an excess of lysyl oxidase-like 2 produces fibrosis of the cardiac muscle, impeding its normal functioning and stimulating HF development. The elimination of this excess repairs fibrosis ...
A team of researchers from the University of Basel has clarified the role of the enzyme MPO in fighting infections. They found that MPO produces a highly aggressive acid that kills pathogens without damaging surrounding tissue, providing new approaches for immunity strengthening therapies.
Researchers at UT Southwestern Medical Center have identified a novel mechanism by which the stress hormone FGF21 protects the pancreas from damage caused by digestive enzymes. This discovery may lead to new treatments for pancreatitis, a potentially life-threatening inflammation of the pancreas.
A new study uses transgenic organisms and biochemistry to test an evolutionary hypothesis on fruit flies' ability to metabolize alcohol. The research found that the amino acid changes in the ADH protein do not improve the fruit flies' tolerance for alcohol, challenging a previous hypothesis.
Using infrared spectroscopy and computer simulations, researchers at Ruhr-Universität Bochum discovered a magnesium atom contributes significantly to switching G-proteins on and off. This finding has implications for understanding disease mechanisms and developing targeted drugs.
Termite queens have higher antioxidative enzyme levels and lower oxidative damage than other termites, suggesting an anti-aging mechanism that enables their longevity. This efficient antioxidant system allows the queens to live longer despite high fertility.
A study published in Diabetes journal found epigenetic changes in the DPP4 gene are associated with fatty liver development in both mice and humans. These changes, detected at six weeks of age, lead to increased enzyme production and correlate with fat content in the liver.
Researchers at Tufts University have identified over 200 identifiable proteins within firefly nuptial gifts, including structural proteins, enzymes and anti-predator toxins that may influence female reproductive success and paternity rates
Researchers at UConn have developed experimental antibiotics that successfully target and kill MRSA bacteria by blocking the enzyme pathway critical to its survival. By understanding the molecular structure of the enzyme and designing tailored inhibitors, the team created compounds that evade previously resistant strains.
Researchers used neutrons to determine the structure of an important enzyme in Helicobacter pylori, offering a new point of attack for medications. The findings provide insights into the enzyme's mode of action, enabling the development of molecules that can block this process and target the bacterium effectively.
Scientists have discovered metabolons, complex enzyme clusters, for the first time using molecular movie technology. This breakthrough reveals plants' secret medicinal toolbox and unlocks new possibilities for harnessing plant-based medicines.
University of Minnesota researchers have provided unprecedented images of cancer genome-mutating enzymes acting on DNA, offering vital clues into how these enzymes promote tumor evolution. The findings suggest ways to block enzyme activity in cancer, potentially making current anti-cancer therapies more effective.
A recent study discovered that liver cancer drugs fail because the body lacks a balance between two enzymes, Shp2 and Pten. This imbalance activates molecules involved in lipid metabolism, inflammation, and fibrosis, leading to liver disease and cancer.
Researchers at Scripps Research Institute discovered that a human enzyme has evolved to change its shape and function without major architectural changes. This unique ability allows the enzyme to carry out new roles in humans, shedding light on diseases linked to mutations in aminoacyl tRNA synthetases.