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Unraveling the reward behavior: mechanisms underlying the dopamine signaling pathway

A team of researchers identified a protein kinase substrate downstream of the dopamine signaling pathway regulating brain reward behavior. The study found that phosphorylation of potassium voltage-gated channel subfamily Q member 2 (KCNQ2) decreases its channel activity, increasing neuronal excitability and promoting reward behavior.

SourceFujita Health University·JournalCell Reports·TypeExperimental study·DateSep 29, 2022
Sky-Watcher EQ6-R Pro Equatorial Mount

Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.

Long-term memories a matter of order—not just repetition

A study by neuroscientists at New York University reveals that the brain's machinery interacts in nuanced ways to form long-term memories. The researchers found that neurons can sense not only repetition but also the order of repeated experiences, allowing them to discriminate between different patterns and build memories.

SourceNew York University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateSep 26, 2022

A new dimension in Stem Cell Signaling

Researchers around Christian Schröter and Luis Morelli have discovered that ERK activity pulses every six to seven minutes in living stem cells, encoding differentiation information. This intermittent oscillation is believed to be a morse code-like mechanism that helps stem cells make decisions about fate.

SourceMax Planck Institute of Molecular Physiology·JournalDevelopment·TypeExperimental study·DateFeb 24, 2022