Articles tagged with Fc Receptors
Researchers uncover the placenta distinguishes between antibodies and albumin, allowing for the design of long-acting biologic medicines with reduced fetal exposure. Fusion of IgG antibodies to albumin inhibits transport across the placenta, enabling the development of safer treatments during pregnancy.
Researchers from Chiba University found that antibody therapeutics with stronger Fcγ receptor binding are more likely to be recognized as foreign and associated with higher anaphylaxis risk. High affinities for Fcγ receptors critical determinants of anaphylaxis, study suggests.
Scientists from Rockefeller University have developed a powerful upgrade to IVIG therapy, an engineered antibody that delivers the effectiveness of IVIG at a fraction of the dose in mice. The new molecule is synthesized without human plasma and has shown significant improvement over current IVIG treatments.
Researchers at LMU have discovered that inhibition of a specific enzyme can effectively prevent heparin-induced thrombocytopenia (HIT), a potentially life-threatening condition. The study shows that Btk inhibitors can block platelet activation and prevent the formation of harmful clots, offering a new promising therapeutic option for t...
Antibodies recognize viruses and cancer cells via Fab arms, but now researchers know the Fab portion also directly binds to Fc receptors. This discovery opens up a new strategy for developing therapeutic antibodies with enhanced binding properties.
Researchers at Rockefeller University have discovered two antibody-binding receptors on immune cells that work together to kill tumors and create a memory of them. The study found that targeting specific antigens with antibodies can lead to the formation of immunological memory, which can suppress future tumor growth.
Researchers discovered a genetic variant that influences vaccine response and autoimmune disease risk. Individuals with this variant express an additional immune system receptor on their B cells, which activates antibody production, potentially leading to autoimmune diseases.
Researchers studied the molecular mechanisms of successful HIV antibodies and found that Fc receptors play a crucial role in preventing infection. The study's findings may lead to the design of tailor-made vaccines that have never been done before.
Researchers discovered a critical 'gatekeeper' function that prevents auto-antibody accumulation in lupus, which can be restored to reverse the disease. Increasing Fc receptor activity by 40% restored health in animal models of lupus.
Rockefeller University researchers identify a critical link between autoantibodies and inflammation, suggesting novel ways to uncouple this connection. They found that preventing the activation of antibody receptors by autoantibodies is an effective way to treat autoimmune diseases like lupus.