Articles tagged with Hormones
Researchers found that administering nitric oxide to preterm mice after birth can reverse symptoms of congenital hypogonadotropic hypogonadism, including sensory and cognitive disorders. A clinical trial is now underway to test this treatment in human preterm infants.
A recent study published in Acta Oncologica found that young women who have had cancer are at a higher risk of experiencing sexual problems, including loss of libido and intimacy issues. The study, which surveyed nearly 700 women, suggests that the type and intensity of cancer treatment can influence a patient's sex life.
The Leducq Foundation has awarded $7.5 million to UVA researchers, led by Mete Civelek, to investigate sex differences in atherosclerosis and $8 million to Coleen McNamara to advance immunotherapy for cardiovascular disease. These projects aim to improve understanding of heart disease and develop new treatments.
Research from UVA Cancer Center finds that an unhealthy gut microbiome can trigger changes in normal breast tissue, facilitating cancer's spread to other parts of the body. The study suggests that targeting the gut-mast cell relationship could help prevent breast cancer recurrence and metastasis.
A novel fluorescent sensor has been developed to visualize the release of oxytocin, also known as the 'happy hormone', in living animals. The sensor, called MTRIA OT, allows for real-time measurement of extracellular oxytocin dynamics in the brain, revealing variability in OT levels dependent on behavioral and physical conditions.
Researchers found that stressed mice exhibited decreased neuron excitability in the dorsal hippocampus, which may drive social avoidance, while resilient mice showed increased excitability. This difference was linked to changes in stress hormone receptors and HCN1 protein expression.
Children with obesity who lose weight show increased hunger-related brain activity, despite changes in gut hormone levels. This disconnect may underlie why many people regain weight after a strict diet, highlighting the need for targeted treatments.
A cross-sectional study of over 25,000 adults found that approximately 70% of identified adrenal tumors were nonfunctioning, regardless of participant's age. The prevalence of adrenal tumors increased with age, from 0.2% in young adults to 3.2% in older adults.
A study on wild bonobos found that sibling birth causes a five-fold increase in cortisol levels and reduces immune response. This stress reaction lasts up to seven months and is independent of age-related weaning processes.
A study published in Cell Metabolism found that healthy underweight individuals had lower food intakes and lower activity levels, yet surprisingly higher-than-expected resting metabolic rates linked to elevated thyroid hormones. These findings contradict previous assumptions about metabolism in low BMI individuals.
Researchers have created a noninvasive method to identify tumors causing hypertension by reducing radiation exposure. The new fluorine-based agent replaces an iodine-based agent and may allow for screening of patients with hypertension-linked aldosterone adenomas.
Researchers at Kyoto University discovered a unique subpopulation of resident fibroblasts that produce erythropoietin, a hormone critical for oxygen delivery in the kidneys. This 'crack team' of kidney cells has been found to play a crucial role in disease recovery and may hold new avenues for treatment.
Researchers have discovered how sea cucumbers produce defensive chemicals using genome mining techniques. The animals' unique ability to biosynthesize toxins has been found to be linked to the diversion of a sterol-producing enzyme, resulting in the production of valuable medicinal compounds.
Research at Kyoto University found that estradiol suppresses severe skin inflammation in females compared to males, revealing its therapeutic potential. The hormone regulates immune cells and reduces IL-17A and IL-1β cytokines production.
A new study links polycystic ovary syndrome (PCOS) to an increased risk of adverse cardiovascular events and pregnancy outcomes during delivery, including preeclampsia and peripartum cardiomyopathy. Women with PCOS are at a higher risk for heart complications compared to those without the hormone disorder.
A UC Riverside genetic discovery found that mosquitoes lack the primary ecdysone transporter, allowing researchers to develop a mosquito-specific insecticide. This breakthrough could help control Zika, dengue, and other virus-carrying mosquitoes without harming beneficial insects.
Two experimental male contraceptive pills, DMAU and 11β-MNTDC, have shown promising results in lowering testosterone levels without unacceptable side effects. The study found that 75% of men who took the active drug were willing to use it in the future, compared to 46.4% of those taking a placebo.
A new study presented at ENDO 2022 found that inactivated and mRNA COVID-19 vaccines do not cause significant fluctuations in thyroid function or increase the risk of emergency department visits among patients treated for hypothyroidism. The research suggests that these vaccines can be a safe option for this vulnerable population.
A randomized controlled trial shows significant improvements in testosterone replacement therapy for men with poorly-controlled type 2 diabetes and hypogonadism. The treatment improved symptoms, libido, and quality of life, as well as delayed verbal recall, a potential early sign of dementia.
A recent study published in the Journal of Endocrinology suggests that lowering blood glucose levels can partially restore reproductive hormone levels and ovulation in female mice with obesity. The study used dapagliflozin, a common type 2 diabetes medication, to treat the mice, resulting in improved fertility outcomes.
A study of middle-aged women approaching menopause found increased body fat, particularly in the waist area, but those with healthier lifestyles had lower fat mass. The research suggests that maintaining physical activity and a balanced diet during this life stage may help protect against health risks associated with increased adiposity.
A recent study published in Breast Cancer Research suggests that self-reported male infertility may be associated with an increased risk of invasive breast cancer. The researchers conducted a case-control study among 1,998 males diagnosed with breast cancer, comparing them to 1,597 control males without blood relatives. The study found...
Women's metabolism alters during menopause due to changes in sex hormone levels. Metabolite profiles show increased lipid and cholesterol levels, especially triglycerides and LDL particles, which can lead to atherosclerosis.
Research published in the European Journal of Preventive Cardiology found that menopause is associated with a decline in cardiovascular health due to hormonal changes. Levels of bad cholesterol rise during menopause, and shifts in sex hormones are linked to this increase.
A new study published by The Endocrine Society suggests that exposure to per- and polyfluoroalkyl substances (PFAS) and phthalates may impair bone health in male teenagers. Researchers analyzed urine and blood samples from over 800 adolescents, finding an association between certain PFAS and phthalates and reduced bone mineral density.
A new study reveals that cardiac surgery causes distinct patterns of cortisol secretion, which may reflect individual physiological differences and inflammatory responses. Researchers identified three dynamic phenotypes: single-pulse, two-pulse and multiple-pulse dynamics, suggesting improved diagnostics and personalized interventions ...
A study published in the Endocrine Society's Journal of Clinical Endocrinology and Metabolism found that undertreatment with thyroid hormone replacement can lead to longer hospital stays and higher readmission rates. Patients with high TSH levels before hospitalization had a 49% higher risk of 30-day readmission.
A study published in Scientific Reports found that shelter dog hair cortisol levels increased by one-third after six weeks in the shelter, indicating elevated stress. After adoption, cortisol levels decreased, returning to pre-shelter values. The results suggest that even well-managed shelters can cause stress in dogs.
A new study reveals funding for fertility preservation policies varies across the UK, with Scotland offering the most inclusive approach. The study highlights the need for standardization of policies to ensure equal access to care for patients.
Researchers have developed a new implant that reduces ghrelin levels and body weight gain by half when exposed to laser light, offering a minimally invasive treatment option for obese patients. The implant uses a laser-activated dye to kill cells producing the 'hunger hormone'.
Researchers at UCLA found that premenopausal women with low levels of anti-Mullerian hormone are at a higher risk of experiencing significant bone loss within two to three years. The study suggests that measuring AMH levels could help physicians identify women at risk and provide targeted treatment.
A study of over 3,000 mother-child pairs from six European countries found an association between prenatal bisphenol A exposure and increased risk of asthma and wheezing in school-age girls. The study revealed a high prevalence of BPA in maternal urine during pregnancy.
A new study confirms that abnormalities in the GDF15 gene are involved in hyperemesis gravidarum, a condition causing severe nausea and vomiting during pregnancy. The discovery may lead to targeted treatments and improved care for women with HG.
Researchers discovered that bacteria suppress membrane protein transport in response to stress, using alarm hormones to regulate the process. This allows the microorganisms to slow down their cellular processes and recover when conditions become more favorable.
A study of 104 transgender and nonbinary youths found that gender-affirming care reduces depression and suicidal thoughts over 12 months. The treatment significantly improved mental health outcomes in the participants.
Researchers found that genetic relatedness correlates with hormonal responses and behavioural reactions in fish, allowing for selective breeding of less-stressed fish. This approach could simplify breeding methods for aquaculture and aquariums.
Research published in BMJ Open found that older women with higher oestrogen levels had a lower risk of severe COVID-19 infection and death. Women taking hormone replacement therapy also showed a significantly reduced risk of dying from COVID-19, highlighting the potential benefits of hormonal treatment in reducing infection severity.
Researchers discovered that toxic goiter causes shrinkage in central brain regions, such as the hippocampus and amygdala, which can lead to mental symptoms. The study provides key insights for patients with Graves' disease, a common form of hyperthyroidism.
Researchers discovered a protein called PHR regulates arbuscular mycorrhiza (AM) symbiosis based on phosphate availability. AM promotes phosphate uptake and other nutrient absorption, enhancing plant resistance to stressors.
A UMass Amherst study found associations between oral contraceptive use and certain tubal ligation methods with lower levels of antimüllerian hormone (AMH), a biomarker for ovarian aging. This may suggest an increased risk for early menopause in women who have used oral contraceptives or undergone specific types of tubal ligation.
A study published in PLOS Medicine found associations between obesity and various female reproductive conditions. Researchers used Mendelian randomization to investigate causal links between body mass index, waist-to-hip ratio, and risk of conditions like uterine fibroids and pre-eclampsia.
UC researchers received a $1.2 million grant to examine the impact of stress hormone receptors on cell degeneration in Parkinson's disease. The study aims to develop a new model that better replicates the progression of the disease, which may lead to treatments targeting stress hormone blockers or next-generation therapeutics.
A study suggests that nearly 60 percent of the risk associated with coronary artery disease may be explained by changes in hundreds of genes working together in networks across several organs. Fat processing hormones may play a central role in coordinating this activity.
A study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that abnormal thyroid hormone levels during pregnancy may predict preschool boys' emotional and behavioral problems. Mothers with high thyroid hormone levels were more likely to have withdrawn, anxious, or depressed sons.
Researchers discovered a new hormone, fabkin, that regulates metabolism and controls insulin production in pancreatic beta cells. Blocking fabkin's activity prevented the development of both forms of diabetes in mice, suggesting its potential as a therapeutic target.
A new study from the University of South Australia found that vitamin D deficiency is associated with a higher risk of heart disease and higher blood pressure. Increasing vitamin D levels in deficient individuals may prevent up to 4.4% of all CVD cases, according to the research.
Researchers at Tel Aviv University conducted a cross-adoption experiment with fruit bat pups to determine whether boldness is genetic or learned. The findings indicate that the pups behave like their adoptive mothers, not biological mothers, suggesting that boldness is an acquired trait passed on through mother's milk.
A new review in the Journal of Dairy Science explores the relationship between serotonin and calcium metabolism in dairy cows, highlighting its importance in maintaining calcium balance. Research shows that mammary serotonin drives hormone production that modulates mammary calcium transport.
Recent clinical and experimental data suggest that vascular calcification and bone loss share common pathophysiological mechanisms. The International Osteoporosis Foundation's new review elucidates the key associations between the two disorders.
A new mobile phone app called GrowthMonitor can accurately measure children's height and detect potential growth disorders, enabling early diagnosis and treatment. The app uses a traffic light system to inform parents of normal, amber, or red growth status, empowering them to take action.
Researchers discovered that a single protein, Kr-h1, responds to socially regulated hormones to orchestrate the complex social transition in Harpegnathos saltator ants. The study reveals important roles for gene regulation and hormone response in controlling animal brains' plasticity.
About 42% of U.S. adults are considered clinically obese due to increased risk of health conditions such as diabetes and heart disease. New weight-loss drugs like Wegovy (semaglutide) show promise in safely aiding weight loss, but long-term side effects and sustainability remain concerns.
A new study found that women whose menstrual cycle length increased two years before menopause had better vascular health than those with stable cycles. Changes in cycle length may predict cardiovascular disease risk, allowing clinicians to recommend preventive strategies.
A study published in The Journal of Sex Research found that higher testosterone levels are associated with having multiple partners in men and solitary sexual activity in women. The research, which analyzed data from nearly 4,000 adults, highlights the complex relationship between hormones and human sexuality.
A study found that meditation training reduced chronic stress by 25% through decreased cortisol levels in hair. The researchers used a 9-month training programme to measure the effect, and the results showed that only sufficiently long training leads to significant stress-reducing effects.
Research suggests that people sensitive to stress hormones are at greater risk of developing cardiovascular disease, with markers indicating increased risk of stroke and heart attack. A novel proteomic signature may help identify these individuals and inform stress management strategies.
Researchers at UT Southwestern Medical Center discovered a gene linked to eczema that regulates sex hormones and skin lipid production. The study suggests that targeting this gene could provide relief for patients with eczema by increasing sebum production.
Chronic light exposure disrupts circadian rhythms in rats, leading to memory deficits and amyloid β accumulation similar to Alzheimer's disease. Fluoxetine treatment prevents these effects, suggesting a potential therapeutic strategy.
Researchers found that a gene called REST is crucial for boosting insulin-producing cells during early pancreas development. Inactivating this gene increased the number of insulin-producing cells, which were maintained into adulthood in mice.
Researchers found that pituitary hormone ß-endorphin and Arg-vasopressin contribute to movement impairments on the opposite side of the body after a brain injury. Blocking these hormones may help treat movement problems following stroke or injury, targeting left and right sides differently.