Articles tagged with Hormones
Research reveals oestrogen's protective role in preventing fatty liver disease by targeting the TEAD1 protein. The discovery could lead to a new treatment for fatty liver and liver cancer, as well as earlier detection methods.
A recent study published in Hypertension reveals that aldosterone-producing adenomas are composed of multiple cell types that work together to promote tumor growth. The research identified two distinct cell fates involved in hormone production, with cells expressing genes associated with aldosterone synthesis and cortisol production.
Researchers found that synthetic PIC gel can stimulate cell growth and increase collagen production, potentially improving wound healing after pelvic organ prolapse surgery. The study also showed a mild immune response to the gel when tested on laboratory animals.
Research reveals oxytocin neurons in mouse brain modulate object recognition memory, with activation boosting long-term memory and implicating Alzheimer's disease. Oxytocin's role in social memory also highlighted, suggesting a potential link to loneliness or limited social engagement.
A study by Washington State University researchers found a potential link between high maternal cortisol levels and unpredictable birth complications. Cortisol measurements in hair samples revealed elevated stress hormone levels among women who later experienced unexpected birth problems, such as early births or hemorrhaging.
Middle-aged women exposed to toxic metals have fewer eggs in their ovaries as they approach menopause, according to a new study. The researchers found that higher levels of heavy metals such as arsenic and cadmium are associated with lower Anti-Müllerian hormone levels, indicating diminished ovarian reserve.
Researchers from Osaka University and University of Hawaii found that environmental microorganisms boost fruit fly reproduction by modifying hormone levels and increasing the production of germline stem cells. This discovery could lead to new avenues for improving reproductive health and fertility treatments.
A study published in Environmental Health Perspectives found that exposure to phthalates can lower the odds of getting pregnant, but not lead to pregnancy loss. The researchers also discovered associations between preconception phthalate exposure and changes in women's reproductive hormones, inflammation, and oxidative stress.
A recent study published in Lancet Oncology has found that measuring blood hormone levels can identify post-menopausal women who are most likely to benefit from anastrozole, a medication used to prevent breast cancer. The study suggests that inexpensive blood tests could be used to personalize preventive therapy for these women.
A study by UNICAMP researchers found high concentrations of contaminants in the Piracicaba, Capivari and Jundiaí River Basin, including PFAS compounds, pesticides, and industrial chemicals. The study highlights the severity of pollution in the region, which supplies water for drinking, irrigation, and industry.
Researchers at University College London found that a hunger hormone produced in the gut directly impacts activity of the brain's hippocampus when considering food. The study showed that ghrelin receptors play a crucial role in controlling an animal's instinct to eat, with implications for understanding eating disorders and human health.
A study found that women using oral contraceptives had a thinner ventromedial prefrontal cortex than men, which is thought to sustain emotion regulation. The effects of COCs on brain development and emotional regulation are still not well understood, highlighting the need for further research.
Researchers found that thyroid hormones of the mother during pregnancy affect the later activity of brown adipose tissue in offspring. High maternal thyroid hormone levels were associated with more active brown fat in offspring.
A new study reveals female sex hormones play a crucial role in how Alzheimer's manifests in the brain, with estradiol contributing to variation in beta-amyloid protein regulation. This understanding is necessary for developing targeted therapies.
A recent study discovered two subgroups of people with idiopathic generalized epilepsy, one experiencing highest incidence during sleep and the other during daytime. The researchers found that either dynamics of cortisol or sleep stage transition explained most of the observed distributions of epileptiform discharges.
A University of Cincinnati study found that exposure to PFAS may delay the onset of puberty in girls by an average of five or six months. The researchers also discovered decreased hormone levels consistent with the delay, raising concerns about negative long-term health outcomes such as breast cancer and renal disease.
Websites selling direct-to-consumer AMH tests frequently include misleading information, potentially causing anxiety or reassurance among consumers. The study found that these claims can lead to misplaced decisions on conception or contraceptive plans, highlighting the need for accurate and transparent fertility testing.
Research shows that wild birds in vineyards are highly susceptible to triazole fungicide contamination, disrupting hormones and metabolism, impacting reproduction and survival. Vineyards use significantly more fungicides than other crops, posing a unique threat to bird populations.
Inflammatory breast cancer is a rare and aggressive form of breast cancer with poor outcomes. Research highlights the role of ERβ as a mediator of estrogen signaling, demonstrating its tumor suppressive effects in preclinical models. ERβ's antimetastatic activity may hold promise for improving treatment options for IBC.
A small study suggests that vaginal progesterone treatment can increase the chances of conception in couples with unexplained infertility. The treatment, which is safe and low-cost, showed more than double the birth rate among treated women, but further research is needed to confirm these results.
A randomized clinical trial found that rapid access to testosterone therapy significantly reduced feelings of gender dysphoria and depression among transgender adults. The study also showed a 50% reduction in suicidal ideation compared to those on a standard waiting list.
The Endocrine Society's new scientific statement distinguishes between normal aging and endocrine disease in older adults. Menopausal symptoms and osteoporosis are often undertreated despite being treatable.
The use of alternative thyroid hormone treatments is on the rise for hypothyroidism patients. A study found that desiccated thyroid extract (DTE) prescriptions have doubled over a decade, while T3 therapy has seen a significant increase in rural areas. Access to endocrine care may contribute to these disparities.
A new study from the Stowers Institute for Medical Research reveals the placenta's polyploid cells play a vital role in supporting healthy embryonic development. The modified cell cycle controlling polyploidy is governed by the regulatory gene Myc, which supports DNA replication and prevents premature cellular aging.
In a breakthrough study, researchers discovered that the neuropeptide DH31 regulates reproductive dormancy in insects, controlling juvenile hormone production. This finding could lead to the development of new technologies to control agricultural pests and infectious disease vectors.
Researchers found that dietary fructose is necessary for increased germline stem cells after mating, which leads to enhanced post-mating egg production. The study reveals that circulating fructose stimulates the fructose-specific taste receptor in insects.
Researchers at the Max Planck Institute found that ghrelin activates specialized nerve cells in the amygdala, promoting food consumption and conveying hunger feelings. The study uncovers the physiological processes behind feeding behavior, which may lead to novel therapeutic approaches for eating disorders.
A systematic review of research on gender-affirming hormone therapy among transgender people found that the therapy reduces depressive symptoms and psychological distress. The study analyzed data from 46 relevant journal articles and identified inconsistent findings across other areas, warranting further investigation.
Women with short or long menstrual cycles are at increased risk of cardiovascular disease events such as heart attack or AFib. The study analyzed data from over 58,000 women and found that irregular menstrual cycle length was associated with higher risks of CVD, independent of other factors.
Researchers found that four weeks of shift work-like patterns in female mice disrupted their biological clock and reduced fertility. The study suggests that circadian disturbances impact female fertility and may lead to future prevention strategies.
High levels of cortisol during the third trimester of pregnancy have been linked to improved speech and language skills in young children. Research found that boys exposed to high cortisol had better word-saying abilities, while girls showed enhanced understanding skills.
Researchers have observed beta-arrestin molecules directly controlling receptor-mediated signals in living cells using advanced microscopy. The study reveals a new mechanism of how these proteins interact with receptors on the plasma membrane, enabling efficient control of signal flow and desensitization.
A recent study published in Brain found that stress increases Alzheimer's risk in female mice by elevating amyloid beta levels, while male mice do not exhibit this effect. The researchers identified a cellular stress response pathway in brain cells that is active in females but not males.
A Rutgers University study finds that inhaling plastic particles can disrupt sex hormones in female lab rats, leading to impaired vascular function and decreased reproductive hormone levels. The researchers used a commercially available food-grade nylon powder and aerosolized it for the rats to breathe in.
The study revealed lower age-standardized rate of NENs incidence in China (1.14 per 100,000) compared to the USA (6.26 per 100,000). The most common sites for primary NEN tumors progressed were found to be the pancreas, stomach, lungs, and rectum.
Researchers at MIT developed an ingestible capsule that delivers electrical stimulation to the stomach, boosting ghrelin production and potentially alleviating nausea and appetite loss. The device uses a grooved surface to create a drier environment for electrodes to contact stomach tissue.
A new study finds that pet rabbits require daily freedom to exercise outside their home enclosure, even in larger hutches with access to an exercise area. The research highlights the importance of allowing pairs of rabbits to move freely throughout the day.
A recent study found that males on reduced calorie diets showed greater fat loss and improvements in blood sugar levels compared to females in young adulthood. However, when dieting began at older ages, there was no significant difference in fat loss between sexes.
Researchers have found that the subfornical organ senses circulating parathyroid hormone (PTH) and modulates its peripheral level. PTH then alters bone metabolism and remodeling, highlighting a critical role of the brain-parathyroid-bone axis in maintaining bone homeostasis.
Researchers found that a neuropeptide called GLWamide regulates feeding in jellyfish, while myoinhibitory peptide (MIP) does the same in fruit flies. The discovery highlights the deep evolutionary origins of a conserved satiety signal.
A UC Riverside study identifies how a Fragile X gene mutation contributes to premature ovarian failure, leading to early infertility. Researchers found that the mutation affects neurons regulating reproduction in the brain and ovaries, causing an increase in hormone production and faster secretion rates.
A new study from McGill University reveals that every day Canadians are exposed to Bisphenol S (BPS) in fresh foods due to chemical migration from packaging materials. High concentrations of BPS were found on thermal food labels, exceeding the European Union's regulatory limit.
A study published in Nature Immunology found that female mouse and human NK cells have more of a specific epigenetic regulator called UTX, which boosts anti-viral function while repressing NK cell numbers. This suggests that therapies need to be tailored to individual differences, including sex.
Researchers found that Matcha tea powder reduces depression in mice by activating dopaminergic neural circuits and improving mood. The study's results suggest that Matcha's antidepressant-like effects depend on the animal's prior mental state, with stress-susceptible mice showing a significant response.
Researchers examine the effects of gender-affirming androgen therapy on breast tissue in transgender men with single-cell resolution. Gene expression is silenced, and male gene programs are activated. This work has implications for the treatment of breast cancer across all populations.
Researchers discovered a significant increase in serotonin transporter density in the midbrain of patients with PMDD during the periovulatory phase, which was associated with increased depressed mood. The study suggests that taking SSRIs at specific times during the menstrual cycle may help target these changes and alleviate symptoms.
A University of Arizona-led study found that expectant lemur dads see a significant increase in estradiol during their mates' pregnancies, which may help prepare them for parenting. The hormone spike occurs mainly in the third trimester and is associated with increased maternal sensitivity.
A study analyzed gene expression data from 46 different human tissues to understand the impact of circadian and circannual cycles on human health. The research revealed that certain genes have strong diurnal or seasonal preferences, which could inform effective diagnostic and therapeutic strategies.
A recent study at Ruhr-University Bochum found that interactive online teaching can increase students' physiological state of arousal compared to passive online or face-to-face teaching. Students in interactive online classes reported feeling more involved and attentive but also experienced increased anxiety.
A study found that competition preparation temporarily reduces resting energy expenditure in physique athletes, primarily due to reduced energy intake and lower levels of thyroid hormone T3. This reduction can complicate weight loss and make it difficult for athletes to compete.
A new study published in the Journal of Clinical Endocrinology & Metabolism found that phthalate exposure may contribute to a higher incidence of diabetes in women. The research, which studied 1,308 women over six years, showed that White women exposed to high levels of certain phthalates had a 30-63% higher chance of developing diabetes.
A retrospective study found associations between vitamin D levels and fine motor development delays, as well as thyroid hormones with cognitive development. Certain metals were also linked to language, cognitive, or motor skill development.
The study reveals that SWEET13 transporter is necessary for pollen production, highlighting the importance of sucrose transport. Researchers used molecular docking and simulation to understand how SWEET13 selectively transports sucrose over gibberellin.
A recent study by Universitat Oberta de Catalunya reveals that Spanish citizens have lower vitamin D levels compared to Northern European nations. Despite the importance of this hormone for overall health, supplementation is not commonly practiced in Spain.
A new study from the University of South Australia found that eating 30-50 grams of almonds can help people cut back on kilojoules consumed each day. This leads to a reduced energy intake by 300 kilojoules, mostly coming from junk food.
Researchers found that IGF1 gene therapy increases kisspeptin expression and GnRH release, and alters microglial cell numbers, suggesting a potential protective effect against reproductive decline. This could lead to new strategies for optimizing lifespan and combating age-related health problems in women.
New insights into the processing of hormones in the human gut reveal dozens of peptides regulating appetite, bowel movement, and insulin secretion. By studying human intestinal organoids, researchers characterized potentially novel gut hormones, including glucagon, and explored its role in human physiology.
Researchers have successfully isolated parathyroid stem cells and maintained them in lab as organoids for an extended period. These patient-derived parathyroid organoids (PTOs) closely mimic human parathyroid tissue, enabling the study of parathyroid diseases and drug development.
Research from the University of Pittsburgh found that high COVID-19 stress in women is associated with changes in menstrual cycle length, period duration, and spotting. The study suggests that these changes can have economic and health consequences for women, including increased costs for feminine hygiene products.
A new study at the Turku PET Centre discovered that shorter daylight hours increase opioid receptor levels in brown fat of rats. This complements previous findings on day length modulating opioid receptor levels in brain emotional circuits.