Articles tagged with Hormones
Researchers found that excess growth hormone disrupts liver metabolism, leading to molecular and cellular patterns similar to those in naturally aged livers. Reducing glycation stress can reverse these negative effects, improving liver health and physical function.
Researchers have identified the cells and connections underlying a fish's ability to dynamically change color to match its surroundings. The study found that specialized skin cells called melanophores control the color change, which helps the zebrafish evade predators by lightening its skin over tens of minutes.
Research on leptin reveals its multifaceted roles in MAFLD, including regulation of energy balance and metabolism. Leptin therapy shows promise in rare cases of leptin deficiency but is largely ineffective in obesity-associated hyperleptinemia.
The European Society of Endocrinology has published a revised clinical practice guideline for the treatment of chronic hypoparathyroidism in adults, featuring a new definition and treatment algorithm. The guidelines aim to provide practical guidance for healthcare providers involved in diagnosing and managing the condition.
A study found that intimate physical contact reduces cortisol responses, while oxytocin administration promotes wound healing. This integration of relationship dynamics and neurohormonal modulation may lead to future interventions for improved health and recovery.
A recent study published in Nature Neuroscience has made significant breakthroughs in understanding how hormones like estrogen impact brain function, particularly in learning and decision-making. The research found that estrogen boosts dopamine activity, leading to enhanced learning capabilities and a potential connection to neuropsych...
Researchers at University of Miami Miller School of Medicine have developed a new combination therapy that shrinks tumors, reduces cancer stem cells and reprograms immune environment to combat hormone-resistant breast cancer. The triple therapy approach targets tumor-associated macrophages, which act like bodyguards for cancer cells.
A study published in Nature found that hunger can trigger aggression in female mice towards pups, especially when their reproductive cycle is in a certain stage. The researchers discovered that hunger information from the hypothalamus affects the brain's medial preoptic area, stimulating pup-directed aggression.
The European Society of Endocrinology has released the EndoCompass Research Roadmap, a major new initiative to align research efforts and improve funding strategies for hormone-related health challenges. The roadmap identifies specific research needs across eight endocrine specialties and five cross-cutting areas.
The review synthesizes clinical evidence on MDMA-assisted psychotherapy for posttraumatic stress disorder (PTSD), autism spectrum disorder, eating disorders, and existential distress. It identifies consistent patterns across diverse clinical applications and highlights the therapeutic potential of MDMA, including its oxytocin-mediated ...
The ASPIRE trial is a Phase III clinical study investigating whether adding chemotherapy to standard treatments can extend survival in men with advanced prostate cancer. The trial aims to determine the effectiveness of combining docetaxel with hormone therapy and apalutamide.
Research reveals that Bifidobacterium breve in pregnant mothers regulates the placenta's hormone production, reducing complications and improving fetal growth. The study opens up a new approach to assessing pregnancy health through gut microbiome analysis.
Researchers found that breast milk components like melatonin and cortisol vary over the course of the day. Labeling expressed milk as 'morning,' 'afternoon,' or 'evening' could help align feeding times with circadian signals, supporting infant sleep and immune development.
Researchers found 22 previously unknown genetic variants associated with type 2 diabetes by considering participants' hormone levels. The analysis suggests that sex hormone levels interact with genes to increase the risk of developing the disease.
A study by Mount Sinai-Duke University identifies specific DNA variants in the DENND1A gene that increase testosterone production in PCOS patients. This finding could lead to new therapies targeting the genetic source of elevated testosterone levels in PCOS, which is a common condition affecting reproductive-age women.
Researchers at Mass General Brigham identified seven metabolites in the blood associated with excessive daytime sleepiness (EDS), a condition linked to increased risk of cardiovascular disease, obesity, and diabetes. The study also found that dietary changes or supplements may help reduce EDS risk.
Researchers at Cornell University developed an implant system that can treat Type 1 diabetes by supplying extra oxygen to densely packed insulin-secreting cells, enabling long-term treatment for chronic diseases. The system could also potentially provide treatment for other autoimmune diseases.
A study by Steve Chang explores how oxytocin influences brain activity to shape social behavior in rhesus monkeys. The researchers found that oxytocin increased activity in the basolateral amygdala and anterior cingulate cortex when monkeys were socially motivated, maintaining beneficial decisions and social task behavior.
A new analysis published in The Journal of Clinical Investigation reveals how leptin affects the brain and its potential use in future therapeutics for type 1 diabetes. Leptin helps regulate appetite and body weight, and insufficient levels lead the brain to activate circuits that mobilize energy sources, including glucose and ketones.
Dr. David Rubinow's research reveals that susceptible women respond differently to normal hormonal fluctuations, leading to breakthrough treatment approaches and FDA-approved medication for postpartum depression. His work validates the experiences of millions of women whose hormone-related mood symptoms were previously misunderstood.
Despite supply shortages and insurance coverage obstacles, patients taking GLP-1 medications achieve clinically significant weight loss when paired with intensive lifestyle interventions. The study found that consistent medication courses combined with lifestyle changes and support remain the most effective weight-loss program option.
A new study found that anti-obesity medications can normalize testosterone levels in men with obesity or type 2 diabetes. This positive effect on reproductive health was observed after a 10% weight loss, with total and free testosterone levels increasing by 24%.
An animal study found that early-life exposure to endocrine-disrupting chemicals can alter the brain's pathways controlling reward preference and eating behavior. Male rats showed a temporary preference for sugary solutions, while female rats gained weight after preferring high-fat food.
A study found that consuming aspartame, sucralose, glycyrrhizin and added sugars may increase the risk of early puberty in children, especially those with genetic traits. This association was strongest for central precocious puberty, a condition linked to emotional distress and metabolic disorders.
A new study found that intermittent energy restriction significantly improved fasting blood glucose and triglycerides, while also increasing insulin sensitivity. The IER group showed the greatest advantages in reducing these markers compared to time-restricted eating and continuous energy restriction groups.
A new study presents preliminary data suggesting that grandparents' exposure to endocrine-disrupting chemicals may impact the age when girls get their first period. The research found that certain chemicals in both mothers and fathers were linked to earlier puberty, with stronger effects seen in granddaughters.
A study presented at the Endocrine Society's annual meeting found that socially isolated older adults are 34% more likely to have diabetes and 75% more likely to have poor blood sugar control. Social isolation is being recognized as a critical social determinant of health, highlighting its importance in caring for older patients.
Research suggests that thyroid hormone treatment can improve gut health in individuals with hypothyroidism, particularly those with autoimmune thyroiditis. The study found a higher prevalence of SIBO in people with hypothyroidism compared to controls, which was mitigated by thyroid medication.
A study by The Endocrine Society reveals that children with growth hormone deficiency experience improved overall health and coping mechanisms when their caregivers report reduced stress, anxiety, and depression. Conversely, caregivers' emotional stability is associated with better outcomes for the child.
A real-world study of 120 postmenopausal women found that using tirzepatide and menopause hormone therapy simultaneously led to superior total body weight loss percentage compared to using tirzepatide alone. This combined treatment also resulted in a higher percentage of participants achieving at least 20% weight loss.
A long-term study of healthy men found that minimally elevated blood sugar levels can lead to declines in sperm movement and erectile function. The study suggests that lifestyle choices and medical interventions can help preserve or revive reproductive health in aging men.
Researchers found that disabling mERα signaling in osteoblast lineage cells reduced cortical bone mass and density, leading to weaker bones. This pathway is essential for maintaining bone strength and density, especially in females.
A new technique allows scientists to inject molecules into coral tissues, revealing thyroxine's positive effect on calcification. The study raises questions about the evolution of animal physiology and how corals utilize thyroxine in their natural habitat.
Researchers found that rats with shorter second digits exhibit stronger sexual behavior, including a preference for female scent and frequent ejaculations. This study reveals the impact of fetal hormone exposure on brain development and highlights the link between body and mind.
Elevated cortisol levels in preterm fetuses disrupt normal heart development, potentially leading to increased cardiovascular disease risk. Cortisol exposure accelerates heart development in ways that may not be beneficial, ultimately compromising heart health.
A multi-center clinical trial found that Duavee, a menopause drug, significantly reduced cell growth in breast tissue and was well-tolerated by participants. The study suggests that Duavee may offer a promising alternative for women at elevated risk of invasive breast cancer due to personal or family history.
Researchers at the University of Oklahoma discovered that FGF21 can reverse fatty liver disease in mice by sending signals to both the brain and liver. The study provides valuable insight into the mechanism of action of FGF21, a target for a new class of highly anticipated drugs.
A large-scale study published in eClinicalMedicine found that transmasculine and gender-diverse individuals who use testosterone for an average of five years do not have an increased risk of gynecological cancer. The research, which followed 1955 participants, suggests that hormone therapy may be safe for this group.
The EndoCompass project aims to guide future studies and funding programs with a research roadmap for better hormone health in Europe. Manuel Heitor will share his perspective on the future of research in Europe, emphasizing the need for greater investment and coordination.
Researchers developed tiny human ovary organoids using stem cells to understand gonad development and disease. The models replicate key aspects of ovarian follicles, offering a powerful platform for studying gene function in a controlled environment.
A new study has discovered a link between delayed puberty and an increased risk of developing type 2 diabetes in boys. According to the research, adolescent boys who experience delayed puberty are 37% more likely to develop type 2 diabetes in early adulthood, regardless of their weight or socio-economic status.
A meta-analysis of 21 studies involving over 178,000 women found that those with infertility history have a 14% increased risk of heart or blood vessel conditions, as well as higher risks of heart disease and stroke. Younger women and those undergoing fertility treatments are at greater risk.
Research shows that low phosphate levels in blood are associated with reduced sperm motility and poor semen quality. The findings suggest a potential link between phosphate and male fertility, highlighting the importance of understanding biological factors involved in reproductive health.
The inaugural Joint Congress brings together paediatric and adult endocrine specialists to learn from each other, collaborate, and celebrate endocrinology. Over 7,500 delegates from 100 countries attend the event to experience the latest research and developments.
Research found that early-life growth plays a significant role in determining final adult height, accounting for about 67% of the variation. Childhood growth also accounted for a substantial proportion of the difference in adult height.
Research finds high levels of phthalates in mothers' urine associated with shorter anogenital distances in 3-year-old boys and girls, a marker of reproductive health and hormone disruption. The study emphasizes the need for preventive measures to protect vulnerable groups from endocrine-disrupting chemicals.
Research found that boys born to mothers with polycystic ovary syndrome (PCOS) or higher testosterone levels during pregnancy are less physically active at age 7. Girls exposed to similar levels of testosterone had lower muscle strength, highlighting the role of maternal testosterone and PCOS in future development.
Women who experience menopause before age 50 are at higher risk of developing fatty liver disease and its related metabolic risk factors. The study found that early menopause is associated with increased risks of pre-diabetes, obesity, hypertension, and dyslipidemia.
Research reveals individuals taking oral steroids for over 3 months are 6 times more likely to be diagnosed with adrenal insufficiency than those treated with non-steroidal anti-inflammatory drugs. Long-term users of inhaled steroids also face increased risk without hospitalisations.
Research suggests that antibiotics taken during infancy, especially in the first three months, may lead to earlier onset of puberty in girls. The study, which analyzed data on over 322,000 children in South Korea, found a significant association between early antibiotic exposure and increased risk of central precocious puberty.
The event aims to create a positive scientific and policy legacy from the Congress in Denmark, Europe, and internationally. The conference will focus on key research presented at the Joint Congress and future priorities from the EndoCompass Research Roadmap.
Researchers discovered neuroestrogen's role in regulating food intake and hunger. Neuroestrogen enhances the brain's responsiveness to leptin, a hormone that helps regulate hunger.
The European Society of Endocrinology and the European Hormone and Metabolism Foundation launch a global campaign to raise awareness about hormone balance and its impact on chronic diseases. Small steps can make a big difference in improving hormone health.
Researchers discovered a mechanism that harnesses immune cells to produce opioids, potentially alleviating chronic pain. Estrogen and progesterone drive this process, which could lead to more effective treatments for women experiencing pain after menopause.
Hormonal contraceptives initiated immediately after childbirth may increase the risk of developing depression in new mothers. Researchers found that combined oral contraceptives were associated with a higher risk of depression when started earlier postpartum.
A recent study found that everyday physical activity does not slow bone loss during menopause, contrary to previous studies suggesting exercise can mitigate age-related bone weakening. Despite this, researchers believe more targeted exercise may help slow hormonal bone loss.
A recent study published in Science Advances found that oral contraceptive use in women is associated with changes in steroid hormone levels, while smoking in men is linked to altered levels of nearly every steroid hormone measured. The study also discovered a link between decreased androgens and various diseases in aging men.
Researchers discovered Lepr neurons in the dorsomedial hypothalamus communicate using glutamate and GABA to regulate metabolism, body weight, and energy use. The study sheds light on fundamental neuronal interplay influencing metabolic adjustments.
Media professionals can register for ENDO 2025 to discuss groundbreaking research on obesity, diabetes, and more with world-renowned experts. The event features nearly 2,500 abstracts and over 200 sessions, offering a premier global conference in endocrinology research and clinical care.
The University of Turku researchers have developed a new method to create more accurate sensors for detecting subtle changes in the body, such as hormone fluctuations. By purifying and separating single-wall carbon nanotubes, they achieved precise control over their properties and identified their electrochemical characteristics.