A multi-institutional team has discovered a novel immune regulatory mechanism mediated by antibodies that selectively shut down overactive immune responses. The 'immune-induced TCR-like antibody' (iTab) can reduce disease severity and delay its onset in a mouse model of autoimmune disease.
Researchers have identified a new immune function of human M cells, which can process and present gluten antigens, suggesting a potential link to celiac disease. This discovery sheds light on gut immunity and may support future research into celiac disease diagnosis or treatment.
Moffitt Cancer Center researchers have made a significant discovery about LAG3, a protein that suppresses the antitumor immune response. By understanding how LAG3 interacts with other proteins, they hope to develop more effective immune checkpoint inhibitors.
Researchers have developed a new organoid model to study the thymus and its function in training T cells. The model enables long-term culture of TECs, which could lead to new insights into treating patients with impaired thymus function.
A new study found that the antibody-drug conjugate STRO-001 showed nanomolar cytotoxicity in 88% of cancer cell lines tested, with potent efficacy against proliferating B cells. The research supports ongoing clinical studies for patients with B-cell non-Hodgkin lymphoma.
Researchers have discovered an ancient category of MHC molecules, MHC-W, which represent a missing link for explaining how class I molecules evolved from a class II-like origin. This finding resolves a long-standing puzzle in immunogenetics.
A study at University of Texas M.D. Anderson Cancer Center showed a potential new approach to treating follicular lymphoma and DLBCL through manipulation of molecular programs controlled by CREBBP. Inhibition of HDAC3 restores immune programs lost as a result of CREBBP mutations, paving the way for immunotherapy approaches.
Scientists have identified a novel infection route for influenza A viruses, utilizing MHC class II proteins to infect human and animal cells. This discovery raises questions about the risk of spill-over infections to other species and the evolutionary genesis of influenza viruses.
A new study reveals that autophagy, a cellular process, enhances vaccine effectiveness by presenting antigens on MHC class II molecules to helper T cells. This process is more widespread than previously thought, affecting 50-80% of certain immune cells.
The study reveals the role of Map in promoting S. aureus persistence and survival in infected mice by interfering with T cell function. Researchers warn that the increasing prevalence of multidrug-resistant strains poses a significant threat to public health.