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Science News for November 19, 2002


Ovarian cancer detected in blood samples

Researchers used digital SNP analysis to detect ovarian cancer in 87% of early-stage and 95% of late-stage patients, with high total DNA amounts found in most cancer cases. The test holds promise for improved detection in a wide range of cancers.

SourceJohns Hopkins Medicine·JournalJNCI Journal of the National Cancer Institute·DateNov 19, 2002

The growing Staphylococcus aureus arsenal

The study reveals the role of Map in promoting S. aureus persistence and survival in infected mice by interfering with T cell function. Researchers warn that the increasing prevalence of multidrug-resistant strains poses a significant threat to public health.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateNov 19, 2002

Targeting bone metastasis and hypercalcemia

Researchers have identified two compounds that inhibit PTHrP production, reducing metastatic bone breakdown and tumor burden. The findings suggest potential therapeutic benefits for treating both bone metastasis and hypercalcemia in breast cancer patients.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateNov 19, 2002

Genotyping targets individuals at high risk for H. pylori-associated stomach cancer

A study has identified specific combinations of H. pylori bacterial strain and host genetic variations that increase the risk of stomach cancer in infected individuals. These findings suggest that personalized genotyping can help identify high-risk individuals, who may benefit from targeted H. pylori eradication treatment.

SourceJournal of the National Cancer Institute·JournalJNCI Journal of the National Cancer Institute·DateNov 19, 2002

Other highlights in the November 20 issue of JNCI

Two new studies published in the Journal of the National Cancer Institute identified key risk factors for classical Kaposi's sarcoma and found that smoking may decrease the risk of this disease. Meanwhile, research on leptin suggests it controls breast cancer cell proliferation. Additionally, a potential screening tool for ovarian canc...

SourceJournal of the National Cancer Institute·JournalJNCI Journal of the National Cancer Institute·DateNov 19, 2002

JCI Table of Contents, November 18, 2002

Researchers discover two compounds that inhibit parathyroid hormone-related protein production in human breast cancer cells, reducing metastatic bone breakdown and calcium levels. The findings suggest a novel therapeutic approach to treating bone metastasis and hypercalcemia in breast cancer patients.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateNov 19, 2002

Researchers create DNA 'nanocircles' to probe the mystery of aging in human cells

Scientists at Stanford University have created synthetic DNA nanocircles that can lengthen telomeres in test tube cells, a key factor in determining cell lifespan. This breakthrough could lead to the development of new methods for studying aging and cancer, as well as alternative approaches to transplantation medicine.

SourceStanford University·JournalProceedings of the National Academy of Sciences·DateNov 19, 2002