Articles tagged with Microrna
Researchers found a potential therapeutic candidate, miR-506, which blocks epithelial-to-mesenchymal transition and inhibits mesenchymal markers in ovarian cancer cells. Higher miR-506 expression is associated with longer overall survival.
Researchers have identified a microRNA liver gene, miR-27b, which regulates lipid (cholesterol or fat) levels in the blood. The study found that miR-27b is sensitive to high triglycerides and is involved in lipid metabolism.
A large-scale study found that abnormal microRNA levels can be used to classify triple-negative breast cancer into four subtypes. The findings could lead to more effective therapies and personalized treatments for individual patients.
A new study by Scripps Research Institute scientists confirms a critical role for microRNA-182 in the development of emotional memory in the amygdala. MicroRNA-182 was found to promote local protein synthesis and support synapse-specificity of memories.
Researchers discovered a new way to regulate calcium signaling in worms, revealing the crucial role of microRNA-786 in dictating when and where the primary calcium spike occurs. This finding may have significant implications for understanding calcium signaling processes in humans.
A new study challenges previous views on miR-205's function in breast cancer. Research found that miR-205 is overexpressed in transformed cells and contributes to the abnormal morphology of acini. The findings suggest miR-205 can act as an oncogene, promoting cell growth or inhibiting apoptosis.
Researchers found that microRNA-26a suppresses melanoma cell growth while leaving healthy cells unharmed. Reintroducing microRNA-26a to melanoma cell lines led to a marked decrease in cancer cell survival, suggesting it as a potential therapeutic target for melanoma treatment.
Researchers report on the therapeutic potential of microRNAs in cancer therapy and their role as potential biomarkers for early cancer detection. The stability of miRNAs in body fluids makes them suitable for non-invasive malignancy detection methods, offering exciting opportunities for revolutionizing diagnostics and screening.
Researchers at UNC discovered that the hepatitis C virus binds with microRNA miR-122 to protect itself, promoting viral replication. This interaction presents a promising target for new drugs to treat the infection.
Researchers identified microRNAs associated with oligometastatic progression, which differ from those associated with widespread metastatic disease. These findings suggest a biological basis for oligometastasis and potential use in identifying patients suitable for curative interventions.
Sanford-Burnham researchers found that two microRNA families, let-7 and miR-18, regulate germ layer formation by dampening the TGFβ signaling pathway. This discovery provides a paradigm for whole-genome screening and its use in identifying molecular signals controlling complex biological processes.
Researchers identified a group of microRNAs that work together to suppress the spread of cancer by repressing epithelial-to-mesenchymal transition. This discovery offers potential therapeutic targets and diagnostic tools for predicting and inhibiting cancer metastasis.
Researchers discovered that microRNA-223 regulates the brain's response to oxygen deprivation and glutamate signals, offering a potential protective mechanism against stroke-induced brain damage. The molecule's broad regulatory effects raise questions about its therapeutic application.
A new DNA sensor has been invented that can detect genetic material in minutes, potentially revolutionizing disease diagnosis. The Silver Nano Cluster DNA probe uses a luminous molecule to bind to specific targets, emitting light only when the target is present.
Researchers at the University of Texas Health Science Center San Antonio have discovered a potential cure for triple-negative breast cancer. They found that microRNAs can sensitize drug-resistant tumors to chemotherapy drugs like paclitaxel, reducing side effects and improving treatment outcomes.
Researchers at Stanford University School of Medicine discovered that blocking the action of a specific protein called DUSP6 can restore an important class of immune cells' response to vaccines. This finding holds long-term therapeutic ramifications and could potentially counter aging's effects on the immune system.
Researchers at Joslin Diabetes Center have identified a key molecular process in fat cells that affects aging and stress resistance. The study found that reducing microRNA processing in fat tissue promotes longevity and stress resistance, providing potential new avenues for treatment.
Scientists at Virginia Tech and the University of Texas Southwestern Medical Center found that two mini-molecules called microRNAs can help stem the nation's obesity epidemic. The discovery suggests that treatments targeting these two specific microRNAs may help regulate cellular metabolism and increase energy expenditure, leading to r...
A study by UC San Diego researchers identified LIN28 protein binding sites in 25% of human transcripts, causing widespread alternative splicing changes that can result in cancer or other diseases. The discovery suggests that LIN28 itself should be a therapeutic target for diseases.
Researchers at Northwestern University have found that the influenza virus reduces immune system-regulating protein production in human cells by activating specific microRNAs. This discovery sheds light on a new mechanism of viral immune evasion and may lead to the development of therapeutics to preserve the immune response.
Duke scientists discovered that genetic material in red blood cells can alter parasite activity via novel gene regulation mechanisms. This finding could lead to greater understanding of host-parasite interaction and eventually develop into a new malaria therapy.
A study published in Oncogene found that progestins regulate miRNA-29, a molecule that helps breast cancer cells revert to a stem-like state marked by proteins CD44 and CK5. This phenomenon makes breast cancers more resistant to treatments targeting hormone dependence.
Scientists are exploring ways to target cancer cells by attacking defective genes before protein production, leveraging micro RNAs (miRNAs) and their interactions with messenger RNAs. miR-7 and miR-128 affected pathways related to cell adhesion, EMT, and cellular replication in ovarian cancer cells.
A mathematical model reveals that multiple mechanisms of microRNA regulation are manifestations of a single biochemical reaction, proposing a simple yet efficient way to control protein production. The findings aim to resolve the decade-long debate and pave the way for future experiments to verify the hypothesis.
A recent study found that miR-122 is involved in modulating fat and cholesterol metabolism in the liver. Additionally, it may have a tumor suppressive function in hepatocytes, suggesting its potential as a therapeutic target for hepatocellular carcinoma. The molecule's role in liver homeostasis has also been highlighted.
Researchers at Ohio State University found that mechanical pressures from hospital ventilators stimulate an innate immune response in lung cells, leading to excessive inflammation. The study identified potential drug targets, including a microRNA and two proteins, that could reduce inflammation.
Researchers at Ohio State University have identified a new mechanism that promotes cancer growth and spread by releasing tiny vesicles containing microRNA, which alter immune cell behavior. The study suggests a new strategy for treating cancer and diseases of the immune system.
Researchers at Oregon State University have linked carcinogens to cancer stem cells and found that spinach can reduce the incidence of colon tumors by almost half.
Researchers identified significant variation in microRNA expression within single tumors, highlighting the importance of sampling multiple tumor zones. This finding may explain conflicting previous results and emphasizes the need for personalized medicine approaches.
Researchers discovered that the Microprocessor complex adjusts its production levels based on available precursor miRNA, reducing the risk of chopping off-target RNAs. This finding has implications for efficiently producing small RNA therapies for diseases.
Researchers identified a genetic marker, microRNA, that differs in expression between African American and Caucasian women with breast cancer. The study found that African American patients overexpressed only six microRNAs, while Caucasian patients expressed 20 microRNAs, suggesting potential connections to treatment outcomes.
Researchers at Brigham and Women's Hospital have identified a microRNA called miR-181b that can reduce the inflammatory response responsible for diseases like sepsis. The findings suggest that higher levels of miR-181b may be protective against sepsis and other inflammatory diseases.
Researchers at Ohio State University Comprehensive Cancer Center identified microRNA-3151 as a new independent prognostic marker in certain patients with acute leukemia. The study found that overexpression of miR-3151 leads to poor treatment responses and shorter survival periods, independent of other gene mutations.
Researchers develop miR-TRAP, a new method to directly identify microRNA targets in cells. This technique allows scientists to understand the roles microRNAs play in human development and disease, bridging a gap in the RNA field.
Researchers have identified biosignatures for tuberculosis and sarcoidosis, but a single signature is insufficient to distinguish between the two diseases. A combination of markers is required to accurately diagnose a specific disease, enabling doctors to distinguish between different diseases with similar clinical appearances.
A new group of regulatory molecules called mirror-microRNAs has been discovered to control multiple aspects of brain function. These microRNA genes are produced from the same piece of DNA but have different functions in regulating protein production and movement, doubling the capacity of regulation.
Researchers have successfully converted scar tissue into heart muscle cells using microRNA, a breakthrough that could lead to new treatments for heart attacks and heart failure. The study uses microRNAs as master switches to regulate gene expression, converting fibroblasts into functional heart muscle cells.
Scientists found that manipulating a genetic pathway in the heart prevents obesity and protects against type 2 diabetes in mice on high-fat diets. The study suggests that MED13, a crucial regulatory molecule, controls whole-body metabolism.
The UCSF project provides a large publicly available resource to help researchers determine the importance of genes in mice. The resource includes 162 gene-disrupting vectors, 64 new stem cell lines, and 46 new strains of mice with missing microRNAs.
Researchers at the University of British Columbia have identified a number of tiny but powerful genetic regulators that are hijacked by avian and swine flu viruses during human infection. The discovery could reveal new targets for broad-spectrum antivirals to combat current and future strains of influenza A viruses.
A study by Intermountain Medical Center Heart Institute has established a connection between microRNAs and impending heart attacks. Researchers identified six microRNA molecules linked to gene regulation, revealing lower levels in patients who experienced a heart attack within seven days.
A genetic signature has been identified for eosinophilic esophagitis (EoE), a disease causing painful food allergies, inflammation, and swallowing difficulties. The microRNA signature is reversible with steroid treatment, offering an opportunity for non-invasive diagnosis and precise analysis.
Researchers found that BDNF uses microRNA to target the production of specific proteins involved in learning and memory, and that increasing these microRNAs can halt protein production. The study sheds light on how memories are made and offers hope for treating mental disorders and neurodegenerative diseases.
Two tiny molecules, miR-21 and miR-29b, have been found to strengthen the aorta during bulge growth, reducing abdominal aortic aneurysms in mice. The team believes this could lead to a new treatment for the disease.
Researchers at Ohio State University have discovered a pattern of microRNAs that distinguishes early-stage breast tumors from deadly, invasive cancer. The findings suggest a potential biomarker for identifying high-risk DCIS tumors that may become invasive.
Researchers found that MET gene overexpression leads to deregulation of microRNAs, causing gefitinib resistance in lung cancer. Combining targeted drugs with microRNA blockers may improve treatment efficacy.
Researchers discovered that increased production of microRNA miR-21 stimulates progressive muscle deterioration in a mouse model of Duchenne muscular dystrophy. Inhibiting miR-21 reduced collagen levels and prevented fibrogenesis in diseased animals, suggesting it as a potential therapeutic target.
Researchers have discovered a microRNA, miR-520, that suppresses NFkappaB and TGF-b signaling pathways in breast cancer cells. This finding suggests that miR-520 may act as a tumor suppressor and could lead to new treatment options for ER-negative breast cancer.
Nikolaus Rajewsky, a Professor at the Max Delbrück Center for Molecular Medicine (MDC), will receive Germany's most prestigious research award, the Gottfried Wilhelm Leibniz Prize. His work on microRNAs and gene regulation has led to significant advances in understanding complex biological processes.
A new study provides clear procedures for collecting and analyzing microRNAs, significantly improving diagnostic accuracy. Researchers developed measures to overcome interfering activities and improved the sensitivity of miRNA detection by up to 30-fold, enabling faithful quantitation of miRNA abundance in body fluids.
A study co-authored by University of Leicester expert identifies key genetic mechanisms controlling blood pressure, including two microRNAs that regulate renin hormone production. This breakthrough could lead to innovative new treatments for high blood pressure.
Researchers found that specific microRNAs are up-regulated in obese individuals with healthy periodontium and non-obese subjects with periodontal disease. The study suggests microRNA modulation may play a role in modulating inflammatory pathways within periodontal tissues.
Researchers have discovered a vast new gene regulatory network in mammalian cells that could explain genetic variability in cancer. The mPR network allows mRNAs to communicate through small RNA molecules called microRNAs, influencing the expression of other genes.
Scientists have uncovered evidence of a powerful new genetic network that drives cancer development and normal growth, involving RNA molecules interacting with each other. The discovery may lead to new therapeutic possibilities by rewiring the crosstalk between RNAs for cancer prevention and therapy.
New research suggests that women's stronger immune systems are linked to the X chromosome, with MicroRNAs encoded on this chromosome playing a key role. This discovery may help explain why women live longer than men and are less likely to develop cancer.
Researchers have identified micro-RNA 34c as a key regulator of learning and Alzheimer's disease. Elevated levels of miRNA 34c are associated with memory impairment, while lowering its levels can restore learning ability in mouse models of Alzheimer's disease.
A new study reveals that plant miRNAs acquired through food intake can regulate human physiology by targeting specific genes. This discovery expands the functions of microRNAs and has significant implications for human health, metabolism, and disease treatment.
Researchers at the University of Missouri have developed a nanotechnology sensor that can detect lung cancer in blood plasma with high sensitivity and selectivity. This technology could provide an earlier warning signal, potentially saving lives. The sensor detects changes in a specific microRNA molecule associated with lung cancer.
A Henry Ford Hospital study has identified 23 microRNAs specific to laryngeal squamous cell carcinoma, a form of head and neck cancer. The discovery could lead to a better understanding of what causes certain cells to grow and become cancerous tumors.
Zachary A. Klase has been awarded the ICAAC Young Investigator Award for his groundbreaking research on HIV-1 pathogenesis and RNA interference mechanisms in mammalian cells. His work focuses on understanding HIV transcription regulation, microRNA processing, and innate immune signaling.