Articles tagged with Microrna
Researchers found that MET gene overexpression leads to deregulation of microRNAs, causing gefitinib resistance in lung cancer. Combining targeted drugs with microRNA blockers may improve treatment efficacy.
Researchers discovered that increased production of microRNA miR-21 stimulates progressive muscle deterioration in a mouse model of Duchenne muscular dystrophy. Inhibiting miR-21 reduced collagen levels and prevented fibrogenesis in diseased animals, suggesting it as a potential therapeutic target.
Researchers have discovered a microRNA, miR-520, that suppresses NFkappaB and TGF-b signaling pathways in breast cancer cells. This finding suggests that miR-520 may act as a tumor suppressor and could lead to new treatment options for ER-negative breast cancer.
Nikolaus Rajewsky, a Professor at the Max Delbrück Center for Molecular Medicine (MDC), will receive Germany's most prestigious research award, the Gottfried Wilhelm Leibniz Prize. His work on microRNAs and gene regulation has led to significant advances in understanding complex biological processes.
A new study provides clear procedures for collecting and analyzing microRNAs, significantly improving diagnostic accuracy. Researchers developed measures to overcome interfering activities and improved the sensitivity of miRNA detection by up to 30-fold, enabling faithful quantitation of miRNA abundance in body fluids.
A study co-authored by University of Leicester expert identifies key genetic mechanisms controlling blood pressure, including two microRNAs that regulate renin hormone production. This breakthrough could lead to innovative new treatments for high blood pressure.
Researchers found that specific microRNAs are up-regulated in obese individuals with healthy periodontium and non-obese subjects with periodontal disease. The study suggests microRNA modulation may play a role in modulating inflammatory pathways within periodontal tissues.
Researchers have discovered a vast new gene regulatory network in mammalian cells that could explain genetic variability in cancer. The mPR network allows mRNAs to communicate through small RNA molecules called microRNAs, influencing the expression of other genes.
Scientists have uncovered evidence of a powerful new genetic network that drives cancer development and normal growth, involving RNA molecules interacting with each other. The discovery may lead to new therapeutic possibilities by rewiring the crosstalk between RNAs for cancer prevention and therapy.
New research suggests that women's stronger immune systems are linked to the X chromosome, with MicroRNAs encoded on this chromosome playing a key role. This discovery may help explain why women live longer than men and are less likely to develop cancer.
Researchers have identified micro-RNA 34c as a key regulator of learning and Alzheimer's disease. Elevated levels of miRNA 34c are associated with memory impairment, while lowering its levels can restore learning ability in mouse models of Alzheimer's disease.
A new study reveals that plant miRNAs acquired through food intake can regulate human physiology by targeting specific genes. This discovery expands the functions of microRNAs and has significant implications for human health, metabolism, and disease treatment.
Researchers at the University of Missouri have developed a nanotechnology sensor that can detect lung cancer in blood plasma with high sensitivity and selectivity. This technology could provide an earlier warning signal, potentially saving lives. The sensor detects changes in a specific microRNA molecule associated with lung cancer.
A Henry Ford Hospital study has identified 23 microRNAs specific to laryngeal squamous cell carcinoma, a form of head and neck cancer. The discovery could lead to a better understanding of what causes certain cells to grow and become cancerous tumors.
Zachary A. Klase has been awarded the ICAAC Young Investigator Award for his groundbreaking research on HIV-1 pathogenesis and RNA interference mechanisms in mammalian cells. His work focuses on understanding HIV transcription regulation, microRNA processing, and innate immune signaling.
Researchers found that inhibiting microRNA-100, a regulatory RNA molecule, can stimulate the growth of new blood vessels in animals with peripheral artery disease. This could lead to potential therapeutic applications for cardiovascular diseases.
Researchers at the University of Illinois have identified 25 microRNAs associated with glioblastoma survival and discovered 20 new microRNAs linked to initiation or growth of other cancer types. These findings suggest common pathways that can be targeted with similar drugs, offering hope for improved treatment options.
Researchers have developed a new resource, mirKO, to investigate the role of microRNAs in human health. The resource provides tools to delete specific microRNA genes in mice or cells, allowing researchers to study their significance and biological function.
A new technique using microRNA analysis resolves an old issue in turtle evolution, placing turtles closer to lizards than crocodiles. The study identified 77 new microRNA families and found evidence of turtle-microRNA similarity with painted turtles.
Researchers from Stanford University School of Medicine successfully converted skin cells into fully functional neurons using two specific gene snippets, known as microRNAs. This breakthrough finding opens up new avenues for studying neuronal development, modeling disease processes, and testing treatments.
Researchers discovered that specific microRNAs play a crucial role in melanoma metastasis by suppressing the immune system and promoting cell invasion. The study found that these miRNAs can serve as biomarkers for more aggressive tumors, suggesting new therapeutic targets for battling the deadliest form of skin cancer.
A multi-institutional study published in Nature reveals the genetic overview of ovarian cancer, showing mutations in one gene and frequent structural changes that contribute to its development. The findings could lead to better treatments for this aggressive form of cancer.
Researchers found that alpha-tocotrienol triggers production of a protein in the brain that clears toxins from nerve cells after a stroke. The study also identified two other mechanisms: blocking an enzyme's release of toxic fatty acids and inhibiting neuron death gene activity.
Researchers discovered that microRNA levels increase or decrease in the zebra finch brain after hearing a new song. This finding suggests that microRNAs play a regulatory role in fine-tuning the brain's response to social information.
Xuemei Chen, a leading plant scientist at UC Riverside, has been awarded an HHMI-GBMF Investigator grant for her groundbreaking research on small RNA and microRNA. The grant will support high-risk projects aimed at uncovering fundamental mechanisms in biology with potential applications to agriculture and medicine.
Robert Blelloch's groundbreaking research on microRNAs in embryonic stem cells and cancer has shed light on the molecular mechanisms regulating cell fate transitions. His work holds promise for developing new therapeutic strategies, including inducing adult cells to de-differentiate into pluripotent stem cells.
U-M researchers found that attacking specific microRNA molecules can reduce deaths from sepsis. The approach also holds promise for other inflammatory diseases like juvenile rheumatoid arthritis and graft-vs.-host disease.
Research reveals how fragile X protein, FMRP, hooks up with microRNAs to switch the production of other proteins on and off. This process is crucial for learning and memory, as neurons need to make new proteins at specific synapses.
UT Southwestern Medical Center researchers have found that blocking two specific RNA molecules can suppress abnormal blood vessel growth in degenerative eye disorders. This finding suggests a potential strategy to treat age-related macular degeneration, a leading cause of blindness among older people.
Researchers at Texas AgriLife Research have identified a key molecular mechanism regulating plant stem cell development, which could lead to increased fruit, seed, and leaf production. By understanding how microRNAs interact with RNA silencing proteins, scientists can engineer plants to produce more biomass.
Researchers identified characteristic patterns of molecules called microRNA (miRNA) in the blood of people with lung cancer that may reveal its presence and aggressiveness. These patterns could potentially lead to a blood test for early detection, even up to two years before tumor formation.
The study identified a microRNA that may elucidate the biological mechanism behind obesity-related traits in individuals carrying the PLIN4 gene variant. Higher omega-3 fatty acid intakes were associated with lower body mass index and weight in carriers of the gene variant.
Researchers identified networks of genes crucial for healthy heart formation, shedding light on congenital heart disease. MicroRNAs regulate gene expression and dosage, and the study provides insights into the genetic mechanisms underlying fetal-heart development.
Researchers have developed a new method to generate induced pluripotent stem cells (iPSCs) using microRNAs, increasing efficiency by 100-fold compared to traditional methods. This breakthrough has the potential to revolutionize regenerative medicine and tissue engineering.
Researchers at Fox Chase Cancer Center have discovered two novel genetic markers associated with earlier time to prostate cancer diagnosis among African American men. Genetic variations in miRNA binding sites, particularly in genes IL-16 and IL-18, were found to increase the risk of early diagnosis.
New research explores the role of microRNAs in understanding immunoregulation, inflammation, and autoimmune diseases. MicroRNAs are also being investigated as therapeutic targets in cancer and potential biomarkers for various diseases.
Tiny LNA-based compounds developed by Santaris Pharma A/S successfully inhibit entire microRNA families, targeting cancer, viral infections, and cardiovascular diseases. The high affinity and target specificity of these compounds enable functional inhibition without off-target effects.
Researchers have developed a novel method for measuring microRNA expression in specific tissues of developing zebrafish embryos. This technique uses digoxigenin-labeled riboprobes for in situ hybridization, enabling the study of miRNA's role in embryonic development and disease mechanisms.
Researchers have found that tumor microvesicles contain segments of tumor DNA, including retrotransposons, which can transfer between cells. This discovery may help understand tumor progression and monitor treatment response.
A team at Sanford-Burnham identified specific microRNAs that enhance the reprogramming process from skin cells to induced pluripotent stem (iPS) cells. Adding these miRNAs increases cell survival and improves iPS cell generation.
A study published in PLOS ONE reveals a common set of dysregulated miRNAs in murine lupus models, which may lead to the development of molecular markers for early diagnosis and therapeutic interventions. The findings could ultimately improve the treatment and management of autoimmune diseases like lupus.
Research identifies miR-143 and miR-145 as downregulated biomarkers in esophageal squamous cell carcinoma, showing anti-oncogenic activity. These findings suggest that microRNAs may serve as useful biomarkers for early detection and therapeutic targets.
Researchers at UNC Health Care have discovered a molecule, microRNA-29, that can make brain cells resistant to programmed cell death or apoptosis. This breakthrough could lead to new treatments for neurodegenerative illnesses like Alzheimer's disease and Huntington's disease.
Researchers at UT MD Anderson Cancer Center found that a specific microRNA, miR-34a, suppresses prostate cancer stem cells and metastasis by targeting the surface protein CD44. The study provides a strong rationale for developing new treatment options for prostate cancer.
Research found that a specific microRNA (miR-503) can impair the ability of endothelial cells to form new blood vessels, leading to reduced blood flow and increased risk of amputation in diabetic patients. Inhibiting this miRNA improved blood vessel formation.
A study discovered a microRNA-TP53 circuit that explains the link between chromosome deletion and less aggressive forms of CLL. MicroRNAs miR-15a and miR-16-1 inhibit tumor-suppressing gene TP53, while its increased expression leads to indolent CLL. This mechanism may also contribute to chemotherapy resistance.
A recent study published in PLoS ONE found that Longevinex exerts a greater influence on genes than resveratrol, leading to improved heart health outcomes. The research demonstrated that Longevinex reduced the size of heart attacks and protected against cell death, while also improving microRNA activity.
Preethi Gunaratne's research aims to unleash the body's natural cancer-fighting agents using microRNAs, which have been shown to suppress the growth of cancer cells. Gold nanoparticles are being explored as a potential carrier for these molecules, offering a promising treatment for ovarian cancer with minimal side effects.
Researchers at Johns Hopkins Medicine discovered a potential therapy strategy by restoring lost microRNAs in human pancreatic tumor cells. The study found that these microRNAs put brakes on tumors when the KRAS gene is mutated, a common event in pancreatic cancer.
A team of scientists has discovered that microRNA profiles can predict the type of cell, including whether it's cancerous or not. This finding has significant implications for the use of stem cells in repairing damaged body parts, as it highlights the potential risks of creating cancer.
A team of UC Riverside entomologists has identified a microRNA molecule that disrupts the Aedes aegypti mosquito's ability to transmit dengue and yellow fever viruses. The discovery could help control the spread of vector-borne diseases by reducing the mosquito population.
In mouse models, overexpression of microRNA 125b (miR-125b) causes leukemia and accelerates its progression. The study found that miR-125b is a major cancer-causing microRNA, leading to different types of leukemia.
Researchers at UT Southwestern Medical Center have discovered a feedback cycle involving microRNAs, proteins called ZEB1 and ZEB2, and pregnancy-maintaining hormone progesterone. MicroRNA levels increase before labor, enabling uterine contractions.
Paul Kenny, a Scripps Research Institute associate professor, has been awarded the Jacob P. Waletzky Memorial Award for his groundbreaking research on drug addiction and compulsive eating. His work reveals new links between molecular mechanisms that drive both behaviors.
A team of scientists has found that microRNAs, tiny ribonucleic acid molecules, play a crucial role in mammary gland development in mice. The absence of these molecules resulted in the complete failure of duct development in the mammary glands of mice.
Researchers have identified key molecules in multiple myeloma that can trigger expression of the P53 tumor suppressor gene, slowing cell growth and leading to death. The study suggests re-activating these microRNAs could provide a new treatment strategy for the disease.
Researchers have identified a new class of long non-protein-coding RNAs that respond to SARS-CoV and influenza virus infections, suggesting they play a role in determining the outcome of infection. The study found distinct profiles of genetic activity associated with pathogenicity and lethal infection.
Scientists discover how EBV uses microRNA to create an elaborate timing mechanism, allowing it to hide within cells and evade the immune system. Removing this mechanism could enable physicians to flush EBV out of hiding and allow a healthy immune system to rid the body of the virus.
Researchers found a way to shrink tumors in certain cancers by blocking the production of microRNA 380, which disables the P53 gene. This breakthrough provides hope for new treatments and may return cells to normal when blocked.
Tel Aviv University researchers developed miRNAkey software to analyze microRNA patterns in healthy and diseased tissues, improving understanding of human diseases at a genetic level. The software enables scientists to identify relevant microRNAs, determine their levels, and generate statistically valuable information.