Articles tagged with Molecular Targets
Researchers used generative AI to design a lead molecule for treating fibrosis, a biological process associated with aging. The compound, INS018_055, demonstrated significant efficacy in preclinical studies and showed promising results in clinical trials, accelerating drug discovery and providing new therapeutic options.
Researchers have developed a powerful platform to design molecules targeting helicases involved in COVID and certain cancers. The new approach uses electrophilic small molecules to scout out weak points in the enzyme, providing chemical starting points for developing drugs.
Scientists from the University of Cologne developed threofuranosyl nucleic acid (TNA) with a new base pair, offering improved stability and function compared to natural DNA and RNA. This breakthrough could enable targeted drug delivery, diagnostics, and recognition of viral proteins or biomarkers.
Researchers identified genes controlling sorghum flowering and found that overexpressing one gene can delay flowering, increasing plant growth and biomass. The study provides new insights into optimizing sorghum for bioenergy goals.
Researchers investigated the impact of senolytic treatments on DNA methylation clocks and epigenetic age. Results showed significant increases in epigenetic age acceleration with Dasatinib and Quercetin treatment, but not with Fisetin addition.
A new study reveals that MAGE family proteins bind to RAD18 using a groove, preventing its degradation and contributing to cancer progression. The findings also suggest that blocking this interaction could lead to re-sensitization of cancer cells to chemotherapy and radiotherapy.
Researchers have designed a candidate drug to target the K-Ras G12D mutation, responsible for nearly half of all pancreatic cancer cases. The molecule permanently modifies the mutation, stopping tumor growth in cancer cell lines and animal models.
Researchers deciphered the male breast cancer genome, identifying gene mutations and molecular profiles that could impact diagnosis and treatment. The study found mutations in genes known to drive cancer growth and structural variants impacting other cancer-associated genes.
UCSF scientists discover delivering therapeutic molecules to amniotic fluid can effectively treat Angelman syndrome and other neurological conditions. The treatment uses antisense oligonucleotides, which can alter gene expression, and has shown improved motor function and learning outcomes in mice.
Researchers found that KSHV manipulates human enzymes CDK6 and CAD to reshape cellular metabolism and proliferation, leading to tumor formation. Inhibiting this process with existing FDA-approved breast cancer drugs reduced viral replication and shrunk tumors in preclinical models.
Researchers found that faulty mtDNA replication causes mitochondria to leak genetic material, triggering an immune response and leading to disease. By targeting this process, doctors may develop therapies to prevent harmful inflammation.
Researchers at Martin-Luther-Universität Halle-Wittenberg developed novel RNA- or DNA-based substances that reliably fight off viral infections in plants. The new approach uses antisense oligonucleotides to target specific viral RNA molecules, achieving an impressive up to 90% success rate against a common virus.
A new study found that MERRICAL, a long non-coding RNA sequence, is involved in recruiting macrophages to the arterial wall and promotes atherosclerosis progression. Reducing MERRICAL expression levels using inhibitors significantly reduced atherosclerosis and aortic lesion formation.
Researchers at University at Buffalo propose a new approach to developing cancer drugs by determining the optimal placement of molecular linkers earlier in the process, reducing trial and error and increasing potency, according to a study published in Communications Chemistry.
The study investigates how different genes related to autism spectrum disorders affect the brain's neural circuits, resulting in heightened sensitivity to sounds. The researchers aim to identify a potential biomarker for sensory hypersensitivity and develop treatments using optogenetics and minocycline.
Researchers at Aarhus University discovered that RNA modification N4-acetylcytidine (ac4C) plays a key role in stress granule formation and function. Acetylated transcripts are localized to stress granules, regulating their assembly and dispersal.
PandaOmics uses advanced AI algorithms to process vast quantities of diverse data, performing gene and pathway analysis and target predictions. The platform has been extensively validated in multiple therapeutic areas, including oncology, inflammation, and immunology.
Groundbreaking research reveals changes in pancreatic beta cells at the onset of Type 1 Diabetes, identifying a novel mechanism for protection and a promising therapeutic target in mice and humans. Boosting levels of METTL3 enzyme may slow disease progression.
Researchers highlight difficulties in targeting metastatic tumors and propose two- and three-drug combinations to achieve effective tumor control. They also emphasize the need for simultaneous blocking of primary driving oncogene, evolving resistance mechanism, and secondary survival pathway.
A new study from the Stowers Institute for Medical Research has discovered that sea lampreys and humans share an remarkably similar molecular and genetic toolkit in their hindbrain development. The research found a crucial molecular cue, retinoic acid, to be involved in both species' brain stem formation.
Researchers have discovered a previously unknown mechanism behind immune tolerance, where B cells teach T cells to ignore the body's own proteins. This failure can lead to autoimmune diseases such as Multiple Sclerosis-like Neuromyelitis optica.
A new study aims to enhance and prolong vaccine effectiveness by delivering adjuvants to white blood cells using lipid nanoparticles. The research, led by WVU professor Sharan Bobbala, has the potential to provide broader protection against evolving viruses and multiple diseases.
Scientists at CeMM Research Center have discovered a new method to mark proteins for destruction, potentially treating diseases like cancer. The technique uses 'intramolecular bivalent glues' to alter the protein's surface, triggering targeted protein degradation via ubiquitin ligases.
Researchers at UCSF used clinical data and a precision medicine approach to identify early risk factors for Alzheimer’s disease, predicting its onset with 72% accuracy. High cholesterol, osteoporosis, and erectile dysfunction were found to be predictive factors in both men and women.
A team of researchers from the National University of Singapore has found a potential way to treat conditions like depression and anxiety with fewer side effects. They modified the relaxin-3 molecule to selectively activate specific signalling pathways in the brain, reducing unwanted side effects.
Researchers at Tohoku University have developed a novel monoclonal antibody targeting HER2-positive breast cancer cells, providing a new tool for treating this aggressive subtype. The antibody disrupts cell growth and proliferation while minimizing harm to surrounding healthy tissue.
Recent research by scientists at Boyce Thompson Institute reveals that a specific fatty acid produced by gut bacteria directly influences fat metabolism in animals. This discovery sheds light on the complex interplay between diet, gut microbiota, and host metabolic health.
Researchers developed a framework for standardizing biomarker development and validation to improve the prediction of age-related health outcomes. The study highlights the need for expanded focus on functional decline, frailty, chronic disease, and disability, and calls for harmonization of omic data to enhance reliability.
Researchers at Harvard University have developed a new antibiotic compound, cresomycin, that effectively targets and kills multiple strains of drug-resistant bacteria. The breakthrough demonstrates improved ability to bind to bacterial ribosomes, overcoming resistance mechanisms.
Researchers found that dysregulation of RNA transfer between cells in different tissues shortens lifespan in roundworms. They demonstrated that this phenomenon, termed Intercellular/Extracellular Systemic RNA imbalance (InExS), can be caused by an increase in RNA uptake from the environment, leading to a reduction in organism's lifespan.
Recent advances in permeating the brain-blood barrier hold promise for using radiopharmaceuticals to treat brain tumors. Theranostic approaches show encouraging preliminary results, particularly for meningiomas and pediatric brain tumors.
Researchers develop nanovector nanogels that selectively target glial cells involved in spinal cord injury inflammation, reducing damage and improving recovery. The treatment demonstrates potential for modulating glial cells in neurodegenerative diseases like Alzheimer's.
A study published in Nature Communications reports the discovery of a wound-homing molecule called CAR peptide, which accelerates tissue repair by activating natural healing pathways. The treatment shows promise for treating various injuries, including muscle ruptures and bone fractures, without forming less functional scar tissue.
Scientists at the University of California, Riverside, have identified 898 RNA-dependent proteins in the deadliest human malaria parasite, Plasmodium falciparum. These findings could lead to novel therapeutic targets against malaria and highlight the importance of RNAs in biological pathways in the parasite.
Researchers developed a novel assay that integrates data from four fusion callers to identify disease-related gene fusions in pediatric tumors with high accuracy and efficiency. The new bioinformatics platform detected fusions, prioritized them, and custom curated downstream processes for consensus fusion calling.
Researchers found significantly higher levels of IL-18 expression in osteoarthritis patients and cells compared to healthy controls. IL-17 promoted IL-18 production through the MEK/ERK/miR-4492 axis, indicating potential therapeutic targets for OA treatment.
Researchers created an additional means for therapy to find and eliminate cancer cells using a small peptide, demonstrating better efficacy in lab tests and in vitro experiments. The study used computational analysis and predicted protein models to understand how structure impacts antigen recognition and therapy efficacy.
Researchers developed a faster test for mpox using CRISPR and nanopore sensing technology, which can detect the virus in 32-55 minutes, compared to hours of current lab testing. The test is specific to mpox and was confirmed not to detect other viruses.
Researchers discovered that VISTA induces immune suppressor cells called myeloid-derived suppressor cells (MDSCs) through a feedback loop involving STAT3 and polyamines. This pathway has high translational impact for several human cancers, offering promising drug targets.
Researchers at Weill Cornell Medicine have developed a mouse model that illuminates the process of histological transformation, where adenocarcinoma transforms into aggressive small cell lung cancer. The study suggests targeting Myc proteins as potential therapeutic approaches for this deadly type of cancer.
A study conducted at a FAPESP-supported research center discovered a link between the protein VAPB and tumor cell proliferation in medulloblastoma, one of the most common and aggressive brain tumors in children. High expression of VAPB correlated with reduced patient survival.
Researchers have engineered T cells with a mutation found in malignant lymphoma cells, making them more than 100 times potent at killing cancer cells. The new approach shows promise against solid tumors and could provide long-term immunity against cancer.
A research team at Helmholtz-Zentrum Dresden-Rossendorf develops a new approach for fast and cost-effective pathogen detection using miniaturized biosensor devices and systems. The system can simultaneously carry out up to thirty-two analyses of one sample, offering significant advantages over traditional electronic FET-based biosensors.
Researchers found that artepillin C interacts intensely with tumor cells, altering their fluidity and triggering autophagy. The study's results contribute to a deeper understanding of the substance's action mechanisms and provide insights for future research.
Researchers found elevated PROX1 levels in advanced colon adenocarcinoma, correlating with poor prognosis. PROX1 modulates CRC cell behavior, influencing invasiveness and survival outcomes. The combined PROX1/α-SMA gene set emerges as a potential CRC prognostic marker.
Researchers at ISTA have discovered the composition of poxviral cores, a key factor in their infectivity. The study's findings could lead to the development of new therapeutics targeting the viral core.
Researchers have discovered a new treatment that enhances the body's natural defences against atherosclerosis in patients with rheumatoid arthritis. Treating arthritic mice with RvT4 reduces blood vessel inflammation by re-programming macrophages to release stored lipids.
A team of scientists from the Beckman Institute has received a $3 million grant to develop diagnostic tools and imaging agents for the early detection of Alzheimer's disease. They will use a combination of PET and MRI scans to target smaller beta-amyloid peptides and other signs of neuroinflammation and oxidative stress.
The lack of synergy between academia and industry in drug discovery hinders the development of effective treatments. Researchers discuss why many therapeutic molecules fail to reach clinical trials despite pre-clinical efficacy.
Researchers developed a molecular predictor of radiation response using cell line data and machine learning-based approaches, capturing a wider range of biological processes. The new gene signature has the potential to aid decision-making, personalize treatments, and improve outcomes for various types of cancers.
Researchers discovered that microRNA-29 can restore normal skin structure rather than producing a scar, promoting faster and more efficient wound healing. The release of microRNA-29 targets, particularly LAMC2, is crucial in this process, suggesting a potential new approach for treating large-area or deep wounds.
Researchers in Italy cultivate four species of microgreens with bespoke nutritional profiles, providing a blueprint for soilless cultivation of nutritionally enriched plants. The study successfully produces microgreens with up to 14 times higher iodine content and 45% reduced potassium levels, catering to specific dietary requirements.
Researchers have uncovered the molecular and ultrastructural features of BCAS1+ cells in diffuse gliomas, highlighting their proliferative capacity and distribution. The study provides a comprehensive characterization of the BCAS1+ cell population within diffuse gliomas, shedding light on its role in tumor malignancy.
Researchers have identified regional biological signatures in invasive brain tumor margins of high-grade glioma, which could lead to improved diagnosis, prognosis, and treatment. Advanced MRI techniques may help distinguish between the genetic and molecular alterations, providing insights into resistance to treatment.
Researchers created a DNA-based vaccine that mimics the structure of a virus, inducing a strong antibody response against SARS-CoV-2. The vaccine uses a DNA scaffold carrying viral proteins, allowing the immune system to focus on the target antigen.
A new CRISPR-based technology, TRED-I, has been developed to increase visibility of cancer cells to the immune system by augmenting MHC class I molecules. This technology has shown promising results in animal cancer models, reducing tumor sizes and enhancing treatment efficacy when used with existing immunotherapy.
A study reveals thyroid cancer's genetic changes contribute to resistance to BRAF inhibitors and can lead to tumor dedifferentiation. Researchers identify potential targets for new therapies, including dual-targeted treatments and immunotherapy combinations.
A pilot study proposes a promising global genomic assay for diagnosing molecular subtypes in pediatric B-ALL, leading to more accurate diagnosis and targeted treatment options. RNA sequencing analysis accurately identified subtypes in all known cases and determined genetic subtype in 79% of previously unknown cases.
A recent study published in Nature Plants reveals that O-glycosylation of the transcription factor SPATULA promotes Arabidopsis style development. The experimental study sheds new light on the mechanisms underlying plant organ symmetry.
La Jolla Institute researchers discovered that prior exposure to a common cold coronavirus partially protects mice from lung damage during a subsequent SARS-CoV-2 infection. Harnessing 'cross-reactive' T cells may lead to novel vaccines with broad, pan-coronavirus protection.