Articles tagged with Molecular Targets
Researchers at Oak Ridge National Laboratory used quantum biology and artificial intelligence to sharpen the CRISPR Cas9 genome editing tool, improving its efficiency on microbes. The new model revealed key features about nucleotides that enable better guide RNA selection.
A COVID Moonshot Consortium has made history by developing a potent SARS-CoV-2 antiviral lead compound through an unprecedented, crowdsourced approach. The project leveraged machine learning and high-throughput structural biology to identify novel compounds with excellent antiviral activity.
Scientists have identified a previously unknown pathway for dietary cholesterol absorption in the gut, which could lead to new treatments for managing cholesterol levels. An experimental drug has been found to specifically target this pathway, offering a potential new approach to controlling cholesterol levels.
A recent study found that transient inflammatory pain causes persistent mitochondrial and metabolic disturbances in sensory neurons, leading to failure in pain resolution. Targeting the cellular redox balance prevents and treats chronic inflammatory pain in rodents.
A recent study has provided significant genomic insight into tar spot of corn, a destructive disease causing $1.2 billion in yield loss. The researchers identified over 100 novel effectors that play a crucial role during infection, warranting further investigation.
A phase 1 trial of the radiopharmaceutical 225AC-J591 demonstrated promising antitumor activity against advanced metastatic prostate cancer, reducing PSA levels by at least half for 47% of patients. The treatment was well-tolerated, with only temporary low blood cell count side effects.
Researchers at Weill Cornell Medicine have discovered a new mechanism that makes some cancers treatment-resistant, involving the shuttling of messenger RNAs from the nucleus to the cytoplasm. The approach targets this mechanism with a combination of approved chemotherapies, showing promise in treating persistent cases.
Researchers at St. Jude Children's Research Hospital have determined the structure of vesicular monoamine transporter 2 (VMAT2), a protein crucial for packaging and releasing neurotransmitters in neurons. The study provides critical information for drug development to treat hyperkinetic disorders like Tourette syndrome.
Researchers at the University of California San Diego have created modular nanoparticles that can be tailored for various applications, including targeted drug delivery and neutralizing biological agents. By leveraging a plug-and-play approach, scientists can rapidly modify functional biological nanoparticles with ease.
The Cusack group at EMBL Grenoble has provided insights into the interactions of XIAP and RIPK2 molecules involved in gut signalling pathways. This research sheds light on how these molecules interact, revealing a promising drug target for treating inflammatory bowel diseases.
A collaborative study has identified key epigenetic targets for treating hepatoblastoma, the most common childhood liver cancer. The research found that the enzyme histone-lysine methyltransferase G9a plays a crucial role in epigenetic regulation and is a promising therapeutic target.
Cleveland Clinic is selected by Wellcome Leap to lead two quantum computing research projects in collaboration with IBM Quantum and Algorithmiq. The projects aim to accelerate the development of quantum computing applications for healthcare, with a focus on protein structure prediction and photon-drug interactions in cancer treatment.
Researchers identify cytotoxic CD4+ tissue-resident memory T cells as potential asthma triggers, particularly in older male patients. These cells can cause severe inflammatory responses and make treatment challenging.
Researchers at Tufts University developed a genome-scale metabolic model to identify potential new treatment targets for Lyme disease. The model successfully predicted two compounds that selectively target Lyme bacteria while leaving other helpful bacteria untouched.
U of I researchers have developed organic nanozymes that mimic the properties of natural enzymes, exhibiting peroxidase-like activities and detecting glyphosate with adequate accuracy. The OC nanozyme is quicker to produce, cost-effective, non-toxic, and environmentally friendly.
A Brazilian physicist has developed an alternative method that reduces calculation time for simulating light absorption by molecules from two days to a few hours. This allows for high-resolution microscopy and the creation of precise 3D structures for data storage, with potential applications in medicinal treatments.
Researchers discovered a new role for extracellular signal-regulated kinase (ERK) in a pathway activated by interferon-gamma that leads to cancer cell death. Hyperactivation of ERK causes stress in cells, triggering cell death through specific proteins DR5 and NOXA.
The study developed a highly accurate AI model for fully automated cancer detection, including small and difficult-to-detect tumors. The model could detect visually imperceptible cancer from normal-appearing pancreases substantially early before clinical diagnosis, with a median of 438 days.
Researchers discovered PRMT1 promotes gastric cancer cell proliferation and metastasis through β-catenin signaling. The study identified a novel mechanism involving MLXIP recruitment to activate the β-catenin pathway.
Researchers developed a novel approach to predict therapeutic targets for aging and age-related diseases. They trained a domain-specific BioGPT model on biomedical literature, which improved its performance in identifying prospective targets.
A research team has developed a technology that selectively targets and eliminates aging cells, contributing to various inflammatory conditions. This approach represents a new paradigm for treating age-related diseases with minimal toxicity concerns.
Researchers classify UGDH as a molecular indicator of tumor progression in multiple cancer types, describing its involvement in key canonical cancer signaling pathways. Methods to inhibit UGDH and its downstream products are also identified.
Researchers identified a circulating tumor DNA (ctDNA) biomarker that can predict disease recurrence and response to treatment in patients with BRAF-negative melanoma. The study found that measuring ctDNA levels and variants can help tailor therapy and improve patient outcomes.
Researchers found that brain circuits in 'deep-blind' zebrafish are fully functional and can drive normal visual behavior through direct stimulation. This study challenges the long-held assumption that neural development depends on visual experience.
Researchers discovered protein p53's role in regulating sociability, repetitive behavior, and hippocampus-related learning and memory in mice. Lowering p53 levels led to changes in gene expressions related to behavior, while elevated p53 levels were linked to positive learning outcomes.
Insilico Medicine has identified 9 potential dual-purpose targets against aging and 14 major age-related diseases using Microsoft BioGPT. The proposed genes include CCR5 and PTH, which have not been previously correlated to the aging process.
A small molecule drug improved the fitness of hematopoietic stem cells used in cell transplants, potentially enhancing the success of procedures like ex vivo gene therapy. The study found that targeting extracellular vesicles relieved stress on cells outside the body, improving their performance when transplanted back in.
Researchers identified potential therapeutic targets for Alzheimer's disease and other conditions using a new approach combining AI-driven target identification with protein phase separation analysis. The study provides insights into the role of protein phase separation in human disease and its potential as a therapeutic target.
Researchers at Mayo Clinic discovered that senescent macrophages in the lung promote tumor growth by blocking the immune system's response to abnormal cell growth. Eliminating these senescent cells delays tumor formation, suggesting a potential therapeutic target for cancer treatment.
Researchers explore kinase inhibitors as targeted therapies for specific CRC subsets, offering hope for improved treatment options. Key findings suggest that uncovering essential kinases for tumor growth can lead to more effective treatment strategies in metastatic or later-stage CRC patients.
Researchers developed a novel material that self-assembles into micelle structures targeting cancer cell lysosomes, specifically interacting with Cathepsin B. This leads to dysfunctional lysosomes and apoptotic death of cancer cells. The technology promises a new approach to combat drug resistance in cancer treatment.
A new study from the University of Cincinnati explores the molecular mechanism of psychological loss through enrichment removal, identifying a key area of the brain that plays a role in this experience. The research highlights the importance of understanding how loss affects mental health and may lead to novel therapeutic targets.
Researchers have developed a new method to detect microRNA targets at the level of single cells, allowing for detailed study of gene regulation. This breakthrough enables researchers to follow microRNA targeting of thousands of RNAs during biological processes, revealing surprising complexity in each cell.
Scientists at OHSU elucidated the structure of Type A GABA receptors targeted by antidepressants and other pharmaceutical drugs, shedding light on their role in brain function and development. The study reveals dominant assemblies and states of the receptor, paving the way for the development of new compounds with improved efficacy.
Researchers developed a DNA damage-induced senescence model in osteoarthritic chondrocytes, which reliably induces cellular senescence and accumulates senescent cells in OA joint tissues. The study provides a useful model to develop therapeutic approaches targeting senescence in osteoarthritis.
A study comparing PI-RADS 2.0 and 2.1 found no significant differences in upgrade (29% vs. 22%) or downgrade (19% vs. 21%) rates from targeted biopsy to radical prostatectomy, suggesting no improvement in prostate cancer grade assessment with the latest PI-RADS update.
A new nuclear medicine treatment has been shown to cure a highly lethal form of advanced intraperitoneal ovarian cancer in a preclinical setting. The therapy targets the HER2 protein and achieved high potency while maintaining an acceptable safety profile.
Researchers developed a personalized combination treatment that turned on an immunometabolic switch to effectively control aggressive prostate cancer. The treatment showed complete tumor control and long-lasting survival without side effects in a mouse model of advanced prostate cancer.
A study by researchers at the University of Tokyo found that the presynaptic Ube3a E3 ligase molecule plays a key role in eliminating neural synapses. This discovery offers insights into developmental disorders such as Angelman syndrome and autism spectrum disorders.
The Beckman Institute has received a $3.6 million NSF grant to acquire an automated system for designing and analyzing polymers. The system will accelerate the discovery of useful materials, especially in combination with artificial intelligence.
Researchers at the University of Missouri have identified a way to improve immunological memory produced by T cells in response to influenza infection, potentially leading to more effective vaccines and treatments. The study found that manipulating a molecular signaling pathway can strengthen and prolong the immune response.
Researchers at UTSA are studying the bioactive properties of Sweet Annie, a plant used in traditional Chinese medicine for over 2,000 years. The study reveals that arteannuin B from the plant has anti-COVID and anti-glioblastoma properties, offering new avenues for targeted therapy.
A new study published in eLife reveals the folding speed limit of helical membrane proteins using a robust single-molecule tweezer method. The findings provide unprecedented insights into structural states, kinetics, and energy barrier properties, offering valuable guidance for advancing pharmaceutical research and design.
A team of Chinese and UK researchers has identified superoxide dismutase 1 (SOD1) as a potential target for reversing drug resistance in ovarian cancer. By using nanoparticles to deliver siRNA that reduces SOD1 levels, the study showed reduced growth and decreased resistance to cisplatin in female mice.
Researchers at UCLA Jonsson Comprehensive Cancer Center aim to overcome brain tumor's limited treatment options with ERAS-801, a brain-penetrant inhibitor showing promise in preclinical models. The team is testing the treatment in early clinical trials for patients diagnosed with glioblastoma.
Researchers developed a photoelectrochemical technique to precisely tune the lasing wavelength of microdisk lasers with subnanometric accuracy. The new approach facilitates the fabrication of micro- and nano-laser batches with precise emission wavelengths.
A new study by University of Missouri biochemist Steven Van Doren reveals the fusion peptide's crucial role in virus attachment and cell penetration. This research could inform the development of more effective vaccines capable of fighting all types of coronavirus infections.
Researchers at Weill Cornell Medicine have discovered a unique site on BK channels that allows small molecules to selectively access the channel, potentially leading to the development of targeted drugs. This finding could help treat a range of diseases, including epilepsy and hypertension.
Researchers developed a liver-targeting drug that reversed obesity and lowered cholesterol in obese mice by delivering the drug via nanogel. The treatment, which was administered intraperitoneally, effectively normalized weight and reduced cholesterol levels despite continued high-fat diet consumption.
Researchers have identified a key protein in SARS-CoV-2 that, when targeted, elicits a robust immune response. A live-attenuated vaccine based on this protein shows promise in preventing disease and offering long-lasting immunity. The approach could target areas of the genome less likely to change with variants.
Researchers identified common bladder cancer-related mutations across species, including TP53, FAT1, and NRAS in cats, and ARID1A and KDM6A in dogs. This study provides insights into human MIBC and aids understanding of bladder cancer biology across species.
Scientists have successfully measured the speed of molecular charge migration in a carbon-chain molecule, revealing a movement of several angstroms per femtosecond. The study used a two-color high harmonic spectroscopy scheme with machine learning reconstruction to achieve a temporal resolution of 50 as.
Researchers discovered a unique optical signature in magnetic beads, which can be used to detect pathogens like Salmonella. This technique enables quick detection within less than an hour, potentially revolutionizing food and water testing.
A team of KAUST researchers has found a critical protein that regulates cell division and proliferation in breast cancer and leukemia. Their work clears the way for the development of targeted drugs by refuting recent challenges to their approach.
A new gene-editing technique combines peptide nucleic acids and prokaryotic Argonautes to introduce targeted breaks in the genome. The approach, called PNP editing, offers advantages over CRISPR-based methods, including improved specificity and targeting.
A new immune-infiltrated human kidney organoid-on-chip model enables the assessment of on-target, off-tumor effects of immunotherapeutic T cell bispecific antibody drugs. The study's findings provide important insights into which cells are targeted by a given TCB and what, if any, off-target damage arises.
A new study found that high-stress caregivers had higher klotho levels and longer telomeres in specific immune cells, which may provide protection against aging. In contrast, low-stress caregivers showed no significant associations between klotho levels and telomere length.
Scientists have identified a molecule that regulates nerve cell sensors, which could lead to new therapeutics for obesity, osteoporosis, and inflammatory diseases. The molecule can be modified into peptide-based therapeutics to boost the activity of channels involved in bone strength and satiety.
Researchers at Sylvester Comprehensive Cancer Center will investigate signaling mechanisms between myeloid-derived suppressor cells and pro-inflammatory cancer-associated fibroblasts in pancreatic cancer. The goal is to develop a nanoengineered immunotherapy that selectively disrupts these interactions to target treatment resistance.
Scientists have identified platelet factor 4 (PF4) as a common messenger for the cognitive benefits of young blood transfusion, exercise, and the longevity hormone klotho. Studies show that PF4 calms down the aged immune system, reducing inflammation and promoting brain plasticity and cognition.