Articles tagged with Molecular Targets
Researchers developed a liver-targeting drug that reversed obesity and lowered cholesterol in obese mice by delivering the drug via nanogel. The treatment, which was administered intraperitoneally, effectively normalized weight and reduced cholesterol levels despite continued high-fat diet consumption.
Researchers have identified a key protein in SARS-CoV-2 that, when targeted, elicits a robust immune response. A live-attenuated vaccine based on this protein shows promise in preventing disease and offering long-lasting immunity. The approach could target areas of the genome less likely to change with variants.
Researchers identified common bladder cancer-related mutations across species, including TP53, FAT1, and NRAS in cats, and ARID1A and KDM6A in dogs. This study provides insights into human MIBC and aids understanding of bladder cancer biology across species.
Scientists have successfully measured the speed of molecular charge migration in a carbon-chain molecule, revealing a movement of several angstroms per femtosecond. The study used a two-color high harmonic spectroscopy scheme with machine learning reconstruction to achieve a temporal resolution of 50 as.
Researchers discovered a unique optical signature in magnetic beads, which can be used to detect pathogens like Salmonella. This technique enables quick detection within less than an hour, potentially revolutionizing food and water testing.
A new gene-editing technique combines peptide nucleic acids and prokaryotic Argonautes to introduce targeted breaks in the genome. The approach, called PNP editing, offers advantages over CRISPR-based methods, including improved specificity and targeting.
A team of KAUST researchers has found a critical protein that regulates cell division and proliferation in breast cancer and leukemia. Their work clears the way for the development of targeted drugs by refuting recent challenges to their approach.
A new immune-infiltrated human kidney organoid-on-chip model enables the assessment of on-target, off-tumor effects of immunotherapeutic T cell bispecific antibody drugs. The study's findings provide important insights into which cells are targeted by a given TCB and what, if any, off-target damage arises.
Scientists have identified a molecule that regulates nerve cell sensors, which could lead to new therapeutics for obesity, osteoporosis, and inflammatory diseases. The molecule can be modified into peptide-based therapeutics to boost the activity of channels involved in bone strength and satiety.
A new study found that high-stress caregivers had higher klotho levels and longer telomeres in specific immune cells, which may provide protection against aging. In contrast, low-stress caregivers showed no significant associations between klotho levels and telomere length.
Scientists have identified platelet factor 4 (PF4) as a common messenger for the cognitive benefits of young blood transfusion, exercise, and the longevity hormone klotho. Studies show that PF4 calms down the aged immune system, reducing inflammation and promoting brain plasticity and cognition.
Researchers at Sylvester Comprehensive Cancer Center will investigate signaling mechanisms between myeloid-derived suppressor cells and pro-inflammatory cancer-associated fibroblasts in pancreatic cancer. The goal is to develop a nanoengineered immunotherapy that selectively disrupts these interactions to target treatment resistance.
Scientists have discovered a potential new treatment approach for non-alcoholic fatty liver disease by targeting a receptor called Adgrf1. Overexpressing Adgrf1 improved insulin sensitivity and reduced lipid accumulation in liver cells, suggesting its role in fat metabolism.
Researchers found an abnormal imbalance of excitatory cortical neurons in people with autism spectrum disorder, depending on their head size. The study used human 'mini-brain' models called organoids to recreate the brain development alteration that occurred in patients during fetal development.
Researchers have identified a protein called Hmga1 that may help prevent bone loss associated with postmenopausal osteoporosis. Increasing the expression of this protein in rats partially reversed bone loss in ovariectomized animals, suggesting its potential as a therapeutic target.
Researchers at the University of Missouri have developed a new method using nanopores to advance discoveries in neuroscience and medical applications. The technique allows for real-time detection of dynamic aptamer-small molecule interactions, which can aid in understanding DNA and RNA diseases and drug discovery.
Dr. McKay will investigate the chemical composition of chromophores in DOM using advanced analytical tools and conduct measurements at the National High Magnetic Field Laboratory. His research aims to enhance predictions regarding DOM behavior and reactivity in the environment.
Researchers at TUM develop an RNA agent for a lung spray that slows macrophage activity, reducing lung inflammation and fibrosis. The active substance RCS-21 is delivered via an inhaler through a special sugar molecule, showing promise in treating acute inflammatory lung damage.
Researchers at Weill Cornell Medicine developed a non-opioid designer molecule to calm hyperactive pain-sensing neurons, showing promising results in preclinical studies. The novel drug effectively reversed neuropathic pain signs without cardiac side effects or sedation.
Researchers at Insilico Medicine discovered novel inhibitors for salt-inducible kinase 2 (SIK2), a potential target for anti-inflammation and anti-cancer therapy. The findings were published in the July 13 edition of Bioorganic & Medicinal Chemistry, demonstrating the power of Insilico's Pharma.AI platform.
Researchers investigated H3K27me3 expression patterns in pediatric brain tumors, finding a global loss of this epigenetic mark in diffused midline glioma (DMG). This loss was associated with high relapse rates and poor survival, highlighting the potential for targeting H3K27me3 as an epigenetically guided cancer therapy.
Researchers aim to treat pancreatic ductal adenocarcinoma by targeting amino acid transporter SLC6A14 and compensatory nutrient scavenging mechanisms autophagy and macropinocytosis. Using alpha-methyl-L-tryptophan and hydroxychlorquine, the study seeks to improve therapeutic outcomes in patients with pancreatic cancer.
A team of researchers at Texas A&M University has developed a new model to accurately measure ancient ocean temperatures using clumped isotopes. By understanding the reordering process, they were able to identify the role of water as an accelerator in resetting clumped isotope temperatures.
Researchers at OHSU identified a type of monoclonal antibody that can slow the progression of amyotrophic lateral sclerosis (ALS) by modulating immune cells. The study used a mouse model and confirmed results in human brains affected by ALS, revealing a promising potential treatment for this fatal neurodegenerative disease.
A team of researchers at the University of Oklahoma has made a groundbreaking discovery in overcoming antimicrobial resistance by developing a new class of molecules that inhibit efflux pumps. These inhibitors work as 'molecular wedges' targeting the area between bacterial cell membranes, increasing the effectiveness of antibiotics.
Targeting tiny amounts of hydrogen sulfide to specific areas of cells in adult worms improved health and activity as they aged, according to a University of Exeter study. The research found that H2S improved the integrity of mitochondria, kept muscles active, and extended lifespan.
Scientists have developed a new assay system to target lactate transporters SLC16A1 and SLC16A3, associated with certain cancers and diseases. The method enables the discovery of highly selective inhibitors, providing a potential new approach for cancer treatments.
A team led by Takuro Sato found that the chiral-induced spin selectivity (CISS) effect can filter out electrons and molecules with specific chirality, enabling enantioselectivity without chiral catalysis. This discovery has broader applications in producing safer chemicals and developing advanced electronics across various scales.
The 'survival of the accessible' model provides an alternative explanation for evolutionary changes in flu viruses, highlighting the importance of mutational bias and variant accessibility. The research reveals how specific mutations can gain or lose function, influencing protein activity and potentially driving pandemics.
A new complex-domain neural network enhances large-scale coherent imaging by exploiting latent coupling information between amplitude and phase components. The technique reduces exposure time and data volume significantly while maintaining high-quality reconstructions.
Researchers at the University of Copenhagen have discovered how a bacterium called Vibrio alginolyticus moves using sodium ions, which could lead to new targets for antibiotics. The study provides insights into the flagellum's movement and may help develop novel antibiotics to combat antibiotic resistance.
Researchers have identified KIAA0930 as a key factor causing muscle atrophy in cancer cells, which could lead to the development of new anti-cachexia therapies. The study found that KIAA0930 knockdown cells showed increased muscle mass and weight compared to control cells.
A new study uses machine learning to analyze data from DrugAge, a database of chemical compounds modulating lifespan in model organisms. The researchers create four types of datasets to predict whether or not a compound extends the lifespan of C. elegans, using features such as compound-protein interactions and Gene Ontology terms.
PSMA PET imaging provides prognostic information on cancer recurrence risk before treatment, improving personalized treatments and guiding surgical plans. The tool outperforms current standard tests in predicting biochemical recurrence, a critical factor in determining cancer-specific mortality.
Researchers at the University of Virginia Health System discovered that improper calcium signaling in mitochondria accelerates chronic inflammation, leading to age-related conditions. Increasing calcium uptake in macrophages may help prevent harmful inflammation and its effects on the brain.
Researchers developed a novel technique to measure the refractive index line shape in ultrafast XUV transient absorption spectroscopy. By controlling the phase of the XUV light field, they can manipulate matter response and explore new physical phenomena.
Metalenses have been developed with differentiated design principles to eliminate chromatic aberration. By merging bright spots into a single focusing spot, researchers achieved an efficiency of up to 43% and demonstrated the versatility of their approach for various optical applications.
A study published in Hepatology reveals that abnormal pre-mRNA splicing is associated with liver disease caused by excessive alcohol consumption. The researchers propose targeting specific splicing factors as a novel approach to mitigate the disease.
Researchers develop a new technique to detect circulating tumor cells in blood, overcoming noise issues with existing methods. The dual-ratio approach enhances penetration range and accuracy, paving the way for quicker diagnosis of metastasis.
Researchers at MIT have developed a novel sensor that can detect immune molecule CXCL12, which plays a crucial role in several human diseases including cancer. The device uses receptor proteins found in cell membranes, making it a potential tool for early screening of hard-to-diagnose cancers.
A new 'fly-to-bedside' resource has been developed to sort through the complexities of SARS-CoV-2 virus-host interactions. Researchers found that nine out of 10 non-structural proteins resulted in wing defects, providing a basis for understanding how viral proteins affect host proteins.
Researchers at IISc designed a short peptide that targets topoisomerases in disease-causing bacteria, including antibiotic-resistant species. The peptide effectively killed bacterial cells and reduced infection in animal models, providing leads for combination therapy with existing antibiotics.
Researchers propose targeting non-canonical HH/GLI signaling to improve response rate and durability of therapeutic effects exerted by SMO inhibition in melanoma. The findings suggest that combined targeting of hedgehog signaling and BRD4 could provide a novel therapeutic option against melanoma.
Research reveals e-cigarettes carry potential health risks, including increased blood pressure and heart rate. Long-term studies are needed to fully understand the effects of e-cigarette use on the heart and lungs.
The latest Alzheimer's drug, donanemab, has shown encouraging results in slowing cognitive decline by 35% compared to placebo in patients with low-to-intermediate levels of tau. However, its effectiveness is limited for those with more advanced disease, and risks include serious side effects such as amyloid-related imaging abnormalities.
Researchers have made groundbreaking progress in confining light to subnanometer scales using a novel waveguiding scheme. The approach generates an astonishingly efficient and confined optical field with applications in light-matter interactions, super-resolution nanoscopy, and ultrasensitive detection.
Researchers successfully fabricate a microlens on a single-mode polarization-stable VCSEL chip using 2-photon-polymerization 3D printing, reducing beam divergence from 14.4° to 3° and enabling compact optical gas sensors with improved performance.
Researchers at North Carolina State University used CRISPR gene-editing to breed poplar trees with reduced lignin levels, while improving their wood properties. This breakthrough could make fiber production for paper, diapers, and other products more sustainable, efficient, and cost-effective.
New research suggests targeting autoimmune inflammation associated with ALS could be a promising approach. The study found that two drugs, including one already approved for multiple sclerosis, reduced the expression of inflammatory proteins in ALS patients' immune cells.
Amplified Sciences has received a $400,000 NCI grant to develop and validate an assay testing for the detection of pancreatic cancer in patients diagnosed with pancreatic cystic lesions. The company aims to improve the accuracy of diagnoses, reducing unnecessary surgical interventions.
A new study by Yale University reveals that combining pembrolizumab with other treatments reduces tumor size and improves response rates for patients with advanced NSCLC. The treatment regimens resulted in higher survival outcomes, particularly in patients with specific biomarker-defined subgroups.
A recent study by Tokyo Tech researchers explores the structure and electron transport properties of molecular junctions. The findings reveal three distinct structures at the junction, corresponding to high- and low-conductivity states, which hold promise for designing novel electronic devices with unique properties.
Researchers at Nanyang Technological University discover ponatinib, an existing cancer drug, can block key steps in alternative lengthening of telomeres (ALT) mechanism. This could lead to new treatment options for ALT cancers, which currently lack targeted therapies.
A team from the University of Ottawa has developed a comprehensive screening platform and cellular interrogation tool to facilitate novel drug discovery targeting various human diseases. The 'Tango-Trio' platform can identify small molecule modulators for orphan GPCRs, which have significant untapped therapeutic potential.
St. Jude researchers found that supplying glutamine to tumors enhances the immune system's cancer-killing activity, while a molecular pathway identified as a potential drug target could improve anti-cancer therapies. Glutamine helps activate dendritic cells, which then activate T cells that kill cancer cells.
A new special issue of Calcified Tissue International & Musculoskeletal Research explores how the skeleton functions as both a secretory organ and an endocrine target tissue. Researchers discuss key avenues in this area of research, including deciphering hormone messages encoded in bone cell secretory products.
Researchers have developed a new material for single-molecule electronic switches, which can vary current at the nanoscale in response to external stimuli. The ladder-type molecular structure enhances stability and makes it promising for use in single-molecule electronics applications.
Scientists have gained high-res structural insights into a key bacterial enzyme to develop new drugs that target its weaknesses and suppress disease-causing bacteria. The enzyme Lnt is not found in humans and has huge potential as a therapeutic target with fewer side effects for patients.
Researchers investigate MCL-1i-induced Mcl-1 protein accumulation and its implications in B-cell malignancies. The study reveals a complex mechanism contributing to MCL-1 protein stability upon treatment with MCL-1 inhibitors.
A new study demonstrates the potential of generative AI to accelerate the development of new antivirals and drug discovery. Researchers from IBM, Oxford University, and Diamond Light Source have developed an AI model that can generate antiviral molecules for multiple target virus proteins, including SARS-CoV-2.