Articles tagged with Phosphodiesterases
Researchers found females with a history of binge eating start drinking alcohol quicker than males. Increased levels of phosphodiesterase 4B (PDE4B) prevent cooccurrence of binging in both sexes of mice.
Researchers identified a crucial molecular process involving gene expression in neurons that contributes to early memory loss and Alzheimer's disease. Genetic alterations in mice showed that lack of phosphorylation on beta-2 adrenergic receptors led to poor memory, while PDE inhibitors improved memory function.
A new study found that a specific genetic mutation can protect the heart from the damaging effects of high blood pressure, unlike in other individuals. The researchers discovered that this mutation leads to overactive phosphodiesterase 3A enzyme production, but unexpectedly does not cause cardiac hypertrophy or heart failure.
A cohort study found an increased risk of serous retinal detachment, retinal vascular occlusion, and ischemic optic neuropathy among men taking phosphodiesterase type 5 inhibitors. The study suggests a potential link between erectile dysfunction medication use and vision impairment.
A study by John Scott found that the mAKAP signaling system is perturbed in cases of heart disease, leading to cardiomyocyte hypertrophy. Researchers have identified a potential therapeutic target for treating this condition by suppressing the enzyme phosphodiesterase with drugs such as growth hormone.