A study published in mAbs reveals that up to one-third of antibody-based drugs exhibit nonspecific binding to unintended targets, a serious concern for patient safety. The Membrane Proteome Array technology helped identify this issue, challenging the long-held belief in absolute antibody specificity.
Researchers at UCSF used cryogenic electron microscopy to study the protein TGF-Beta, which plays a crucial role in development and cancer. They found that TGF-Beta can signal even when bound to a 'straitjacket' within the cell membrane, challenging decades-old dogma on its function.
Researchers develop a new method to track disease-carrying mosquitoes by ingesting harmless DNA particles, providing unique fingerprints of information. This innovative approach has the potential to revolutionize mosquito-borne disease surveillance and tracking, offering insights into mosquito movement and hotspots.
A Purdue University biochemist has created a protein array that can distinguish between glycoproteins, which are indicators of cancer and other diseases. The method, developed by W. Andy Tao, is 17-25 times more accurate than traditional testing procedures.
Researchers are developing protein microarray technology to identify early signs of diseases such as diabetes and cancers. This technique allows for the simultaneous analysis of thousands of proteins, facilitating high specificity and reduced cost.