Articles tagged with Cancer Cells
Researchers found that chronic lactate exposure can lead to cellular disruptions, decreased fatty acid transport, and alterations of mitochondrial membranes, which may contribute to the development of heart failure and type 2 diabetes. The study suggests that lactate accumulation could be a major player in disease progression.
Scientists discovered that ants can differentiate healthy from cancerous human cells based on distinct smell signatures. The insects, trained to recognize volatile organic compounds, show high potential for cancer detection with lower costs and efficiency.
A study published in eLife reveals that cancer cells undergoing confined migration become more resistant to anoikis and exhibit increased invasiveness. This process may boost survival in cancer cells and make them more prone to forming deadly metastases.
A new fluorescent DNA label has been developed to visualize disrupted DNA architecture in cancer cells, with promising results for improved cancer diagnoses and risk stratification. The study showed that the label can distinguish normal tissue from precancerous and cancerous lesions.
Researchers found that some painkillers and fever medications may help fight infection, while others can weaken the immune system. The review highlights the need for more studies on the impact of these medicines on infectious diseases.
Scientists have discovered a new therapeutic approach to aid the immune system in fighting cancer, offering hope for better solutions for patients. Researchers found that blocking the EP4 molecule can 'free' the immune system and restore its cancer-fighting functions.
Scientists at the Princess Máxima Center for Pediatric Oncology discovered a new combination treatment strategy for childhood T-cell acute lymphoblastic leukemia (T-ALL) by analyzing protein activity. The study found that blocking specific proteins, such as LCK and SRC, in combination with an overactive chain reaction of INSR/IGF-1R, k...
Researchers at University of Cincinnati develop a new probe and imaging technique to study lysosomes, aiding in cancer and neurodegenerative disease research. The probe, known as EC Green, enables multidimensional analysis of lysosome dynamics and provides stable tracking capabilities.
A new study from Karolinska Institutet shows how certain RNA molecules control the repair of damaged DNA in cancer cells. The researchers discovered two molecule types that interact to regulate an enzyme involved in DNA-repair mechanisms, leading to faulty DNA repair in cancer cells.
Researchers at the University of Helsinki found that a cellular stress state predicts a poor chemotherapy response in ovarian cancer patients. High-stress tumours with an inflammatory microenvironment may resist chemotherapy, making combination therapies a potential solution.
A recent review highlights the effects of different intestinal bacteria on colorectal cancer, exploring new therapies for disease prevention and treatment. Beneficial probiotics, such as Akkermansia muciniphila and Lactobacillus rhamnosus GG, exhibit anticancer properties and reduce CRC cell proliferation.
A new imaging method, combining optimal imaging and machine learning, can determine cell viability without chemical staining. The approach achieved a 95% accuracy rate and has the potential to be applied in hospitals and research labs.
Researchers from National Cancer Centre Singapore have found a potential new strategy to treat peritoneal carcinomatosis, a metastatic form of intra-abdominal cancer. The team identified targeting ascites, excess fluid in the abdomen, as a way to remove fuel that drives cancer growth.
Researchers at Tokyo University of Science have developed bionanoparticles derived from corn that selectively target and inhibit the growth of cancer cells, inducing tumor necrosis factor-α release. These findings suggest a novel, economical, and safe anti-cancer therapy approach.
Patients with severe coronary artery calcium have a significantly increased risk of major adverse cardiovascular events during thoracic radiation therapy for non-small cell lung cancer. The study found that patients with severe coronary artery calcium had a 21.4 times increased risk compared to those with no coronary artery calcium.
Researchers have developed a rapid and affordable test to identify specific genetic mutations in cancer cells using SuperSelective PCR primers. This assay can detect rare mutations, enabling targeted therapy and monitoring minimal residual disease. The study demonstrates the potential of this approach for personalized cancer treatment.
A team of researchers has identified over 250 gene activators in human cells, expanding our understanding of transcriptional regulation and its role in cancer. The study also reveals new insights into how proteins interact with each other to regulate gene expression, potentially leading to the development of targeted therapies.
A novel immune-profiling method can return detailed immune cell type proportions using only DNA from blood, potentially allowing for individualized prediction of outcomes in immunotherapy patients. This approach offers the opportunity to ask and answer questions about the immune system in health and disease.
Researchers have developed a new therapeutic approach to block mutated RAS proteins, which are frequently found in cancers. The method, using small molecules, has the potential to work with multiple mutant forms of RAS in various types of cancers, including pancreatic, lung, and colorectal cancers.
Pulmonary lymphangioleiomyomatosis (LAM) is a rare cancer affecting up to 1 in 1 million women worldwide, characterized by uncontrolled tumor cell growth. Researchers aim to identify new therapeutic targets using extracellular vesicles, with the goal of developing new therapies for LAM patients.
Researchers discover that chemotherapy triggers the secretion of mucins in colorectal cancer cells, forming a physical barrier that prevents drugs from reaching their intended target. The study found potential new biomarkers for disease prognosis and a promising treatment strategy using NCX blockers like SN-6.
Researchers developed a new personalized test for monitoring cancer recurrence in acute lymphoblastic leukemia (ALL) patients. The MP PCR uses multiple genomic markers to detect disease recurrence sooner, improving treatment strategies and patient stratification.
Researchers developed a method called 6mASCOPE that measures DNA tagging system accuracy and distinguishes bacterial from human DNA. The study found high levels of methylation in plant, fly, mouse, and human cells, but mostly attributed to contamination.
The Purdue Research Foundation Office of Technology Commercialization has awarded more than $143,000 to three projects led by researchers in the College of Agriculture, Engineering and Veterinary Medicine. Guri Johal is developing a corn variant that could impact worldwide corn production with Trask funds supporting his project on clon...
Scientists at University College London have developed a novel cancer therapy using magnetic seeds guided by an MRI scanner to heat and destroy tumours. The therapy, called MINIMA, has the potential to precisely treat hard-to-reach cancers with minimal side effects.
A study led by RCSI researchers found that almost half of tumours with metastatic breast cancer in the brain have changes in DNA repair pathways, making them vulnerable to PARP inhibitor drugs. This discovery opens up potential novel treatment strategies for patients with limited targeted therapy options.
Researchers found that macrophages feed on lactic acid produced by cancer cells, paralyzing killer immune cells and weakening tumour immunity. This discovery highlights the need to curb lactic acid production in tumours to improve immunotherapy outcomes.
Researchers found that hyaluronic acid is not only present in pancreatic tumors but also serves as a nutrient source for cancer cells. This discovery indicates potential new treatments for pancreatic cancer by targeting the sugar scavenging pathway.
A research team has developed a new cancer treatment that targets lymph nodes using a prodrug that selectively reacts with glutathione to release nitric oxide. In a metastasis mouse model, the mice treated with the drug showed significantly reduced weight of metastatic cancer cells and improved survival rates.
Researchers used optical imaging to study the metabolic interactions between pancreatic cancer cells and surrounding non-cancer cells. They found that cancer cells can hijack the metabolic activity of these non-cancer cells to fuel tumor growth. This discovery could lead to new therapies targeting the tumor microenvironment.
Researchers have identified nine new factors involved in DNA repair, a critical process for human cell health. The findings can help develop new cancer drugs and improve existing therapies.
Sophie Paczesny's research aims to validate biomarker panels that help doctors predict chronic GVHD risk and adjust immune suppression treatments accordingly. The study uses machine learning algorithms to analyze stored plasma and blood cell samples from over 1,300 BMT recipients.
Researchers developed a multifunctional microfiber probe for real-time monitoring of cellular molecules and changes in cell morphology. The nanowire probe enabled sensitive detection of refractive index distribution in single living cells during apoptosis.
Researchers discovered that IgA and IgG antibodies regulate immune responses against endometrial cancer, improving outcomes when tumor cells express the antibody receptor pIgR. The study suggests new therapies targeting B cells or combinations with T-cell immunotherapies for enhanced efficacy.
Researchers at UTA have discovered commonalities among caspases 3, 6, and 7 that could allow for the isolated activation of proteins in tumor cells without disrupting healthy cells. By understanding how effector caspases work in healthy conditions, they hope to develop methods to destroy abnormal cells while preserving healthy ones.
Researchers at Cold Spring Harbor Laboratory discovered a previously unknown protein called SCP4 that plays a crucial role in the survival of acute myeloid leukemia cells. The study found that SCP4 can pair with specific kinases to regulate cell activity, and targeting this pathway may lead to effective treatment options.
The new technology can reliably distinguish between cancerous and healthy liver tissue, aiding diagnosis and potentially reducing errors in biopsies. The researchers plan to continue measuring fluorescence lifetime parameters in patients with different types of tumors to generate real-time diagnostic classifiers.
Researchers developed a color-coded test that quickly signals whether medical nanoparticles deliver their cargo into target cells. The tool, tested in mouse cells and living mice, assesses nanoparticle formulations on their ability to escape cellular defenses and reach the cell's interior.
Researchers discovered that aberrant splicing of CD22 mRNA leads to decreased protein expression in pediatric B-lymphoblastic leukemia cells. This results in resistance to CD22-directed immunotherapies, making it challenging for oncologists to identify patients who may not respond to these treatments.
A study from Weill Cornell Medicine and Cornell University reveals that targeting protein ATF4 and its related metabolic protein SIRT3 can trick lymphoma cells into starving themselves, slowing their growth.
Researchers discover a chromatin degrader that blocks cancer-causing genes, offering potential treatment for over 90% of prostate cancers. The study found that blocking the SWI/SNF complex slowed cancer cell growth and induced cell death, especially in tumors driven by FOXA1 or androgen receptor.
Scientists at La Jolla Institute for Immunology have discovered a link between TET enzyme deficiency and the formation of unusual DNA structures, such as G-quadruplexes and R-loops, which contribute to genomic instability. The study suggests that regulating these structures may be key to controlling cancer development.
A marine-dwelling creature, Trichoplax adhaerens, has been found to resist cancer and repair DNA after radiation damage. Researchers are exploring its unique properties to develop new therapies for cancer.
Researchers have identified NDUFS1 and ATP5O as novel markers of aggressive prostate cancer, associated with poorer survival rates. The study's findings provide new insights into the disease's molecular mechanisms and potential targets for therapy.
Researchers analyzed the largest cross-species database to assess species-specific cancer mortality rates and found conclusive proof that cancer risk is largely independent of body mass and life expectancy. The study highlights potent mechanisms of cancer resistance in larger species, contradicting intuitive expectations.
Researchers discover tBID can induce programmed cell death through mitochondrial damage, revealing a new function for a previously thought signal transducer protein. This finding has implications for treating malignant cells and combating infections like Shigella.
Scientists have developed a pioneering new technique to barcode individual cells more accurately and efficiently. The method combines artificial intelligence with microfluidics, allowing for real-time analysis of single cells and enabling the efficient sorting and counting of cells.
A recent study has identified a new mechanism by which oral cancer cells acquire radioresistance through the transfer of microRNA, specifically miR-503-3p. This discovery brings hope for the development of new treatments for radiation-resistant oral cancer.
Researchers have identified a novel immune-like mechanism by which healthy epithelial cells recognize and eliminate precancerous cells through a MHC class I-LILRB3 interaction. This process generates mechanical force to extrude the precancerous cells from the body, offering new hope for cancer prevention and treatment.
Researchers mapped how HTLV-1 transforms T-cells into cancerous cells, revealing the virus over-activates them and makes them more vulnerable to DNA damage. This study provides new directions for potential treatments to prevent cancer development.
Researchers identified specific metabolic vulnerabilities in leukemia cell lines, including sensitivity to PI3K and fatty acid synthase inhibitors. The study highlights the potential for targeted cancer therapy by exploiting these dependencies.
Researchers have discovered that NOR-1 protein can provide broad protection against heart damage following cancer treatment. Administering the protein directly may reduce heart risk, at least in laboratory tests.
Researchers analyzed 140 neuroblastoma samples to understand the genetic changes associated with the disease. They found that mutations can disappear and reappear, occurring in distinct sections or individual cells, making targeted therapy less effective.
Researchers identified three prototypical RNA-expression states in pancreatic cancer cells and found that altering the tumor microenvironment can drive tumor cells to become more susceptible to certain drugs. This discovery opens up new possibilities for personalized medicine and targeting specific drug responses.
Researchers have developed a CRISPR/Cas9 gene editing system to enhance the effectiveness of sonodynamic therapy, allowing tumors to be effectively shrunk in a mouse model of liver cancer. The technology reduces antioxidant defense systems, increasing cancer cell death from the treatment.
A recent study by NTU Singapore and Singapore General Hospital found that mutations in the DDX3X gene are responsible for chemotherapy resistance in some blood cancer patients. The study also discovered that STAT inhibitors can effectively kill lymphoma cells with DDX3X mutations, providing hope for new treatment options.
Researchers discovered a newly defined domain in a protein that regulates gene expression under high-energy conditions. Cells adapt to changing nutrient environments by switching between specialized gene expression programs, which are triggered by different molecular tags on histones.
Researchers identified a mechanism for how genetically defective cells mutate to survive stressful situations, such as drug treatment. Understanding this resistance mechanism could lead to the development of new strategies to delay or prevent cancer drug resistance.
Researchers at Tel-Aviv University have shed light on the Sigma-1 receptor's topology and function in neurodegenerative diseases. The study reveals that the receptor is retained in the endoplasmic reticulum and its amino end faces the cytoplasm, providing a crucial mechanism for therapeutic approaches to alleviate suffering from ALS.
A research team developed an AI framework that analyzes protein interactions to predict effective and low-toxicity cancer drug combinations. The framework, GraphSynergy, outperforms conventional models in identifying synergistic combinations.