Articles tagged with Cancer Cells
A faulty version of the RHBDF2 gene is responsible for tylosis with oesophageal cancer, a rare inherited condition. The study reveals that this gene malfunction leads to uncontrolled cell growth and division, causing cancer.
Researchers at UCSF have found that neutrophils use mechanical force to transmit tension across their membrane, restricting activity to the leading edge and enabling them to attack invaders. This discovery could lead to new therapies for conditions such as spinal cord injury and cancer.
A new imaging platform has been developed by Lawson researchers to study the moment when cancer cells turn deadly. The approach uses a shell-less chick embryo model implanted with human cancer cells, allowing scientists to modulate and monitor protein effects in real-time.
A study published in Leukemia identifies a molecular braking process that acute myeloid leukemia (AML) cells use to evade chemotherapy, allowing them to survive treatment. When this brake is removed, AML cells die, providing hope for improved survival rates for patients with the disease.
A new study has found that stomach cells from the cardia region may give rise to esophageal adenocarcinoma, a particularly lethal form of esophageal cancer. The research suggests a link between chronic inflammation and bile acid reflux in the development of this disease.
The study reveals that Raf-1 regulates cell adhesion, enabling cells to form new bonds and new blood vessels. The discovery may lead to cancer treatment approaches by targeting Raf-1 and disrupting tumor environments.
A new study has discovered that medications targeting the protein Mcl-1 can rapidly kill aggressive AML cells without harming non-cancerous blood cells. This finding provides hope for improved treatment options and potentially better patient outcomes for AML patients.
Researchers at UH Case Medical Center have discovered a novel treatment approach for cutaneous T-Cell lymphoma, which is a chronic and progressive disease affecting the skin. The new study finds that adding O6-benzylguanine to carmustine enhances topical chemotherapy efficacy, reducing toxicity and improving treatment outcomes.
MDC researchers found that both forms of therapy are highly effective against large tumors, but T-cell therapy also destroys the tumor blood vessel system, impeding nutrient supply and eradicating resistant tumor cells. This breakthrough may improve future clinical trials and cancer treatment
Scientists have discovered a new mechanism to identify Barrett's dysplasia cells using fluorescent probes and sugar molecules. This technology has the potential to monitor patients with pre-cancerous conditions and prevent the development of esophageal cancer.
Researchers created three-dimensional lab-made tissue models to study oral cancer, revealing the importance of epigenetic mechanisms in cancer development and progression. The findings support the need for more complex tissue-like systems in cancer drug screening, replacing conventional petri dish cultures.
A Stanford study found that a well-known protein complex controls DNA expression and prevents pancreatic cancer. The researchers discovered genetic changes in the protein complex were present in nearly a third of human pancreatic cancers, suggesting its role in tumor suppression.
Researchers at Brigham and Women's Hospital create drug delivery system that effectively targets prostate cancer cells, delivering high amounts of chemotherapeutic drugs. The innovative approach simplifies targeted nanoparticle development and broadens applications in cancer therapy.
Researchers identify PDHK enzyme as a key player in cancer cell metabolism, enabling targeted anti-cancer therapy. Inhibiting PDHK activity slows tumor growth and reduces glucose uptake by cancer cells.
Scientists at Albert Einstein College of Medicine have discovered a mechanism that controls the survival of messenger RNA in cells, which could lead to new treatments for cancer. The study found that mRNAs made from specific genes are born with molecular self-destruct timers that ultimately destroy them.
Researchers at the University of Southampton are working on enhanced MRI scans that can detect cancerous cells before they cause health problems. The new technology uses hyperpolarization to create incredibly strong NMR signals that last long enough for scans, allowing for earlier detection of abnormalities.
Researchers at Queen's University identified a new mechanism that could explain immune resistance in cancer cells, suggesting nitroglycerin may boost the body's natural immune response to cancer. The discovery sheds light on the role of hypoxia and ADAM10 enzyme production in cancer cell resistance.
Researchers at Moffitt Cancer Center have identified a chemical disrupter of the Rb-Raf-1 interaction, which may be vulnerable to targeting to prevent cancer cell proliferation and tumor growth. The study found that this disruption can limit metastasis in test mice, suggesting a potential new approach for combating metastatic disease.
Researchers at UWE Bristol and University of Bristol discovered that mutations in one specific cancer gene can control splicing balance, allowing a master switch to be turned on. This enables the growth of cancer cells and blood vessels, but new drugs targeting this process may block tumour growth.
A new drug, KPT-SINE, targets CRM1 protein to restore normal cell death pathways in cancer cells. This study provides proof-of-concept data for phase I clinical testing of KPT-SINE in patients with chronic lymphocytic leukemia (CLL) and related diseases.
Researchers have visualized telomerase molecules in living cells using advanced microscopy techniques, revealing that they cluster on specific telomeres and elongate them during cell division. This breakthrough provides new insights into the regulation of telomerase activity, a key factor in cancer development.
A new molecular imaging probe using ghrelin exploits the hunger hormone's unique consumption pattern by malignant prostate cancer cells. The test showed the signal was almost 5 times stronger in malignant cancer cells than in normal or benign cells.
Researchers found distinct binding patterns of tumor suppressor protein p53 with the entire genome in normal human cells compared to cancer cells. The study reveals a link between p53 function and human epigenome.
A study by NTU researchers found that nano-sized Zinc Oxide particles may cause DNA damage, activate p53 protein and lead to cancerous cells. The team's findings suggest reassessment of the health impact of these particles in everyday products.
Researchers have developed a system to measure the mechanical properties of living cells, which could lead to new ways to diagnose diseases and understand biological processes. The technique uses an atomic force microscope to study three types of cells, including bacteria, human red blood cells, and rat fibroblasts.
A new method for counting molecules has been developed by researchers at Karolinska Institutet, allowing for the accurate measurement of RNA and DNA molecules in cells. This breakthrough enables the counting of absolute numbers of molecules, rather than just relative differences between samples.
A new mathematical model predicts individual patient responses to therapy and identifies optimal treatments for advanced prostate cancer. The model incorporates personalized data, including tumor cell characteristics, to provide more accurate treatment decisions.
Researchers at Albert Einstein College of Medicine discovered that cancer cells use autophagy, a natural recycling process, to obtain energy. By blocking this process, the study found that tumor growth and metastasis can be stopped, providing potential new strategy for cancer treatments.
Researchers at VTT Technical Research Centre of Finland have discovered the SHARPIN protein, which regulates human cell activity and movement. The study's findings may have significant implications for conditions such as Crohn's disease, psoriasis, rheumatism and multiple sclerosis.
Professor Andreas Strasser has been awarded the 2011 Victoria Prize for his groundbreaking research into programmed cell death, which has shown that defects in apoptosis can lead to cancer and autoimmune disease. His work aims to improve anti-cancer treatments by increasing cancer cells' propensity to die.
A new method visualizes mechanical forces on cell surfaces in real-time, providing detailed view of forces as they occur. The technique has potential to diagnose and treat diseases related to cellular mechanics.
Researchers have found a novel mechanism by which cancer cells can continue to divide without the help of telomerase, a key enzyme involved in cell aging. The discovery identifies a special protein complex called APBs as a potential target for cancer therapy.
A new study identifies PKM2 as a critical enzyme for cancer cell survival under oxidative stress. Researchers found that activating PKM2 can sensitize cancer cells to ROS-induced death, opening up potential therapeutic avenues for cancer treatment. The study suggests that manipulating PKM2 activity could be a way to disrupt tumor growth.
Researchers discovered signals within exons 9 and 10 of the PK-M gene that determine mutually exclusive splicing, promoting PK-M2 production in cancer cells. This finding has implications for developing therapies to reverse the Warburg effect.
Researchers at Mayo Clinic found that eliminating senescent cells can prevent or delay the onset of age-related disorders and disabilities. The study showed that lifelong elimination of these cells delayed age-related disorders such as cataracts and muscle loss, and slowed their progression in already established diseases.
Scientists have developed a technique using scanning transmission electron microscopy (STEM) to view proteins tagged with gold nanoparticles in whole, intact cells. This method offers ten times better resolution than optical microscopes and could help study cancer processes and understand how viruses hijack healthy cells.
Scientists at University of Warwick discover mechanism for cell division ensuring correct chromosome number, a key factor in cancer development. The study found that the 'spindle checkpoint' is conserved from yeast to human cells and can be targeted by drugs to prevent cancer.
Patterns formed by a new DNA letter, 5-hydroxymethylcytosine (5-hmC), suggest it has specific functions in stem cells and brain. The study's findings indicate that 5-hmC may poise genes to be turned on after being repressed.
Scientists at Dana-Farber Cancer Institute have developed a test that can predict how effective chemotherapy agents will be against a patient's tumor cells. By measuring the proximity of cancer cells to self-destruction, researchers found that tumors with higher mitochondrial priming are more susceptible to chemotherapy.
Researchers have developed a potent compound that selectively kills cancer cells while leaving healthy ones intact. This breakthrough has the potential to revolutionize leukemia treatment and could be a game-changer for patients with this life-threatening disease.
A low-fat diet with fish oil supplements slowed the growth of prostate cancer cells in human tissue compared to a traditional Western diet. The men on the low-fat diet also showed changes in cell membrane composition, increasing omega-3 fatty acids and decreasing omega-6 fatty acids.
Researchers found that recombination, a key DNA repair process, has a self-correcting mechanism allowing DNA to make a virtual u-turn and start over. This discovery contributes new understanding to basic cancer biology and may improve the efficacy of cancer treatments.
Scientists propose 'Lance Armstrong effect' to overcome resistance in pancreatic and other cancers, with promising results in testicular cancer patients who beat metastatic disease despite low survival rates elsewhere. Researchers explore nanoparticle therapies to target tumors with high temperatures.
Researchers at the University of Gothenburg have discovered a modified aquaporin, AQP10, which is more stable due to its carbohydrate structure. This stability makes it potentially useful for treating diseases such as eczema and cancer.
Researchers at Sanford-Burnham Medical Research Institute have identified a new component of the cellular machinery that senses dietary amino acids, which is essential for mTORC1 activation. This finding provides new information about mTORC1 and its role in cellular metabolism in both normal cells and cancer cells.
Researchers are utilizing Office of Naval Research's FARSIGHT to identify and classify cancer-related cells. The technology, originally developed for mine hunting, improves accuracy and consistency in cell identification, potentially saving lives in the future.
A new study uses the Tilman model of competition between invasive species to understand how prostate cells invade bone marrow and take over the microenvironment. The research reveals that cancer cells follow a similar path to ecological invasions, highlighting the potential for ecological modeling to understand metastasis.
Researchers found that later-stage prostate cancer cells lack Pten, a tumor-suppressor gene, leading to rapid cell division and mutations. Plk1 inhibitor BI 2356 showed promise in killing cancer cells without Pten.
A team of researchers at McGill University developed a new device that can float over cell surfaces without touching them, allowing for the study of cellular processes such as cancer cell formation and neuron alignment. The device uses quadrupoles to create force fields and deliver molecules selectively to cells.
A new multispectral fluorescence imaging system has been developed to localize cancer cells during surgery, enabling surgeons to detect small clusters of tumor cells that might otherwise go undetected. In a study on nine patients with ovarian cancer, the system successfully detected and removed all cancer cells in eight cases.
A team of researchers at UC Santa Barbara has developed a novel technique using laser spectroscopy and silver nanoparticles to discriminate between cancerous and non-cancerous cells. The technology can help identify unique tumor cells that may spread to other parts of the body, improving diagnosis and treatment outcomes.
A study by University of Texas Medical Branch researchers has identified fortilin as a key protein that promotes the growth of cancer cells by inhibiting p53, a tumor suppressor. This finding may lead to new treatments for cancers and atherosclerosis.
Researchers at Vanderbilt University School of Medicine found that BVES regulates EMT in human colon cancer cells and is silenced via promoter methylation in human colorectal carcinoma. Restoring BVES expression decreased cancer cell characteristics.
Researchers have successfully delivered chemotherapy to cancer cells inside tiny microparticles, reducing ovarian cancer tumours by 65 times more than traditional methods. The 'Trojan Horse' approach uses a special protein called CD95 to hijack cancer cells and deliver the chemotherapy cargo.
Researchers have discovered how p53 binds to Hsp90, revealing new insights into cancer development and potential therapeutic targets. The study found that p53 binds to both the middle and C-terminal domains of Hsp90, with negatively charged amino acids playing a crucial role in stabilizing the bond.
Cells can switch between sender and receiver mode, inhibiting their own signals while allowing them to receive information from other cells. This mechanism could lead to the development of cancer drugs that target specific cell communications, potentially stopping uncontrollable proliferation.
Researchers developed a diagnostic biological 'computer' network in human cells that recognizes cancer cells and triggers their destruction. The network uses a combination of five specific miRNAs to identify HeLa cancer cells and destroy them, while leaving healthy cells intact.
New research from Brown University finds that nickel nanoparticles can activate a cellular pathway that contributes to cancer in human lung cells. The study shows that smaller nanoscale particles are more harmful and potentially cancer-causing than larger microscale particles.
Researchers successfully created a computerized model of cancer cell metabolism, predicting which drugs are lethal to cancer cells' function and demonstrating efficacy in kidney cancer models. The approach holds promise for future investigations aimed at effective drug therapies for other types of cancer.
Researchers at the University of Pittsburgh Cancer Institute have identified the small tumor protein (sT) as the oncoprotein that triggers Merkel Cell Carcinoma (MCC), a rare but deadly skin cancer. The discovery could improve diagnosis and understanding of MCC, potentially shedding light on other cancers.