Articles tagged with Cancer Cells
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Scientists at VCU Massey Cancer Center have developed a novel treatment strategy for multiple myeloma that pairs two targeted agents to kill cancer cells. The combination regimen of Src inhibitors and Chk1 inhibitors induces cell death in multiple myeloma cells while sparing healthy cells.
Researchers propose cancer cells employ ancient genetic pathways, a 'toolkit' from 1 billion years ago, to evade control and develop resistance. This concept offers new hope for personalized medicine and potentially reveals clues about life's history.
Scientists discovered how stressed cells boost thrombin production, a key blood-clotting factor, which may be taken advantage by cancer cells. This process could explain why cancer patients are more likely to suffer from blood clots and septicaemia.
Scientists at Georgia Institute of Technology have found a regulatory RNA called miR-429 that can induce metastatic cancer cells to convert back into less invasive forms. This discovery may allow physicians to treat ovarian cancer more effectively with traditional chemotherapy.
Five scientists with novel approaches to fighting cancer have been awarded the Damon Runyon-Rachleff Innovation Award, receiving a total of $2.25 million over three years. The recipients aim to significantly impact cancer prevention, diagnosis, and treatment through their pioneering ideas.
Researchers at Duke University Medical Center discovered that genetic mutations in brain tumors can alter their metabolism. This study found over 100 metabolites with altered concentrations in cells with the defective IDH1 or IDH2 genes, providing promising avenues for future research into new treatments.
Researchers are developing a new method to identify cell abnormalities, including cancer, by analyzing the shape and behavior of individual cells. They have created mathematical equations that describe cell appearance and motion, which could be used to gauge future stages of a disease.
Researchers have identified a link between mitochondrial fusion and a cell death pathway, with implications for treating heart disease and stroke. The study found that the proteins MFN1 and MFN2 regulate mitochondrial behavior, promoting or preventing apoptosis, depending on their combination.
Researchers found that endothelial cells lining blood vessels secrete molecules suppressing tumor growth and invasion. The discovery could lead to a new way to treat cancer by implanting these cells adjacent to the tumor.
A team of researchers has made a discovery about how the Ras oncogene chooses a signaling pathway and its consequences in cellular development, a key issue in cancer. The study used a common roundworm, C. elegans, to identify the critical events leading to pancreatic cancer.
Researchers identified a chaperone enzyme, Rad18, that plays a key role in accurate DNA repair, and a signaling protein, Cdc7, that ensures error-free repair. This discovery offers a promising new target for cancer therapies, potentially overcoming resistance to DNA-damaging treatments.
Scientists discover a pro-survival mechanism in skin cancer cells, which may lead to new therapeutic targets. Researchers also develop a method to generate hyaline cartilage using adult skin cells.
Researchers discover that PML limits cancer cell division, and its absence allows tumors to grow uncontrollably. The presence of PML molecules can be detected, enabling diagnosis of malignant tumors.
Researchers developed a device using angle-resolved low coherence interferometry to detect pre-cancerous cells in the esophagus lining. The technology holds promise for earlier detection and targeted biopsies, potentially improving treatment outcomes for esophageal cancer.
Researchers found that estrogen induces the expression of CYP1B1 enzyme in precancerous cells, which promotes their movement and division. Depleting CYP1B1 reduces cell mobility and death in precancerous cells.
Researchers at Duke Cancer Institute discover a way to prevent the development of invadopodia structures that enable cancer cells to spread. By blocking Abl and Arg kinases, they also eliminate protein function that burns through tissue, allowing cancer cells to enter new cells.
Researchers used zebrafish to track the behavior of cancer cells and immune cells, discovering that cancer cells produce hydrogen peroxide to attract immune cells. This co-option of the immune system allows tumors to grow and spread, but blocking this interaction can prevent tumor formation.
Researchers at TUM have developed a new mechanism for reversible proteasome inhibition, which could lead to improved treatments for cancer and immune reactions. By targeting the immuno-proteasome specifically, they aim to minimize damage caused by side effects.
Researchers identified pomegranate juice components that inhibit the movement of cancer cells and weaken their attraction to a chemical signal. The effects of these components on prostate cancer progression are still controversial and require further testing.
Researchers found that adding ipilimumab to paclitaxel/carboplatin improved progression-free survival rates for stage IIIb/IV non-small cell lung cancer patients. The study suggests that ipilimumab may be a valuable addition to standard treatments, potentially leading to better patient outcomes.
Researchers from Boston University School of Medicine have identified a mechanism by which specific viruses acting as oncolytic agents can enter and kill cancer cells. By targeting the AKT signaling pathway, VSV is able to switch off a major cell survival signal, leaving cancer cells vulnerable to attack.
In mouse models, overexpression of microRNA 125b (miR-125b) causes leukemia and accelerates its progression. The study found that miR-125b is a major cancer-causing microRNA, leading to different types of leukemia.
A new study reveals that cannabis triggers unique immune cells called myeloid-derived suppressor cells (MDSCs), which promote cancer growth. MDSCs actively suppress the immune system, making users more susceptible to infections and certain types of cancers.
Researchers found that a simple mechanism of finger-trap tension helps stabilize chromosomes during cell division, ensuring accurate gene distribution. This discovery could lead to new ways to correct defects before they occur or target cells with incorrect chromosome numbers to prevent further division.
Researchers discovered that muscle cells in developing fly embryos send 'finger-like' protrusions into neighboring cells to facilitate fusion. The actin-rich fingers help form a small pore connecting the two cell types, eventually fusing them together.
Researchers have identified key factors in cancer cell development and reconstituted the first step in the process in a test tube. The study, published in Nature Structural & Molecular Biology, found that DNA breaks are a major instigator of cancer cell development.
Researchers at Stanford University School of Medicine have successfully transformed normal human tissue into three-dimensional cancers for the first time. The new technique allows for quick and cheap testing of anti-cancer drugs without laboratory animals, providing insights into how human cancers act in the body.
Researchers used computer models to illuminate protein behavior in crowded cells, revealing enzyme activity was 15 times more active. This discovery can aid in designing efficient therapeutic means for diseases like Alzheimer's and cancer.
Scientists at Johns Hopkins have identified a glutaminase inhibitor that slows cancer cell growth by blocking the sugar-based building blocks. The compound has shown promise in reducing cancer cell growth by 30% and may be used for many types of primary brain tumors.
A study found that targeting HDMX overcomes p53 suppression and resistance to selective HDM2 inhibition, restoring tumor suppressor pathway in cancers expressing both proteins. The research enables new therapeutic strategies for human cancer, including those resistant to current treatments.
University of Illinois researchers developed microsensors that can track individual cells' masses and divisions over time. They found that cells grow faster as they grow heavier, rather than at a fixed rate throughout the cell cycle. The sensors also allow for imaging and tracking of cellular processes in conjunction with changes in mass.
Researchers at the Centenary Institute discovered a new death pathway that can break drug resistance in ovarian cancer. The treatment, FTY720, kills ovarian cancer cells through necrosis, making it resistant to relapse. Further clinical trials are needed to confirm its effectiveness.
Researchers at Thomas Jefferson University have been awarded a $100,000 grant from the W.W. Smith Charitable Trust to investigate why African-Americans respond poorly to common chemotherapeutic agents used to treat pancreatic cancer.
Researchers at UNC identify cellular communicators for cancer virus, revealing a new mechanism by which the Epstein-Barr virus manipulates cells and induces uncontrolled growth. The study shows that infected cells can produce altered exosomes that enter recipient cells, changing their growth patterns.
Researchers at Northwestern University have found that a soy-based drug can prevent the movement of prostate cancer cells from the prostate to the rest of the body. The experimental treatment, genistein, has shown beneficial effects on human subjects with localized prostate cancer in a recent phase II study.
Researchers at Weill Cornell Medical College have found a combination therapy that is more effective than traditional treatments and can kill cancer cells without harming surrounding tissues. By targeting BCL6 and EP300, they were able to suppress and eradicate human DLBCL in mice.
A team of researchers has identified how the protein perforin kills rogue cells, which could lead to new treatments for cancer, malaria, and diabetes. The study reveals that perforin assembles to punch holes in cell membranes, allowing toxic enzymes to destroy infected cells.
Researchers have successfully visualized the human immune system's assassin protein perforin, revealing how it punches holes in cancerous or infected cells. The study provides insights into the protein's structure and function, which could lead to new ways of fighting cancer, malaria, and diabetes.
Researchers found that BAFF interacts with c-MYC gene, promoting aggressive leukemias and lymphomas. High levels of BAFF in CLL microenvironment may lead to improved treatment options by blocking its effects or inhibiting signaling pathways.
Researchers found that the Reaper protein triggers apoptosis by interfering with inhibitor of apoptosis proteins and delivering its death sentence to the mitochondria. By targeting the protein to the mitochondrial membrane, it can be made more effective at killing cells, providing a potential new approach for cancer treatments.
Researchers at Yale School of Medicine have discovered a new pathway involving multiple cell types that contributes to the development of Type 1 Gaucher disease. This knowledge could lead to more effective and less expensive treatments, including a small molecule substrate inhibitor in pill form.
Research suggests a connection between vitamin D levels and skin cancer risk in individuals with basal cell nevus syndrome. Patients with this condition are found to be more likely to have low vitamin D levels, even when taking sun protection measures.
Researchers found that proteins importing structural material and regulating its import determine cell size. By manipulating these proteins, they can make a smaller species' nuclei balloon up to the size of a larger one. This discovery could lead to new insights into nuclear size regulation in cancer cells.
Researchers have uncovered a key mechanism in which leukemia cells trigger a protective response when exposed to histone deacetylase inhibitors. By disrupting this pathway, the cancer-killing capacity of HDACIs can be increased dramatically.
Researchers at Rice University used gold nanoparticles with laser pulses to create tiny vapor bubbles that selectively destroyed cancer cells in zebra fish implanted with live human prostate cancer cells. This technique avoids damaging healthy tissue and demonstrates a new approach to cancer treatment.
A team led by Dana-Farber Cancer Institute scientists created a molecule that prevents cancer genes from 'hearing' instructions, stifling the cancer process at its root. The research targets proteins issuing stop and start commands to a cancer gene, known as epigenetic reader proteins, for future cancer therapies.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have discovered a new cell signaling pathway that controls cell growth and development. This pathway, part of a global DNA damage response, turns off 136 genes that can promote aberrant cell division and cancer.
Weiguo Cao's research aims to understand the mechanisms of DNA repair and its contribution to cancer prevention. The study will investigate two DNA repair pathways and explore how defects in these processes can lead to cancer.
Researchers develop electronic biosensing technology that can detect gene mutations indicative of cancer, potentially leading to faster and more accurate diagnoses. The new platform uses disposable arrays containing thousands of electronic sensors connected to powerful signal processing circuitry.
MIT researchers found cancer cells use an alternative glycolytic pathway to speed up metabolism and build new cells, which could be exploited to develop new anti-cancer treatments. The discovery sheds light on how cancer cells adapt to rapidly proliferate and highlights potential targets for therapy.
Dana-Farber Cancer Institute scientists have identified cells in mice that prevent the immune system from attacking own cells, potentially leading to improved therapies for autoimmune diseases. The discovery highlights the importance of balancing the immune response, with CD8+ Treg cells playing a key role.
Researchers at UT Southwestern Medical Center have found that overexpressing microRNA-21 promotes the formation, growth and survival of new tumors in mice with non-small-cell lung cancer. The study suggests that inhibiting miR-21 could be a therapeutic approach to treating the disease.
A study by Heike Allgayer's team found that micro-RNA miR-200c inhibits the motility and invasive capacity of non-small cell lung cancer cells. Higher miR-200c levels were associated with increased tissue-anchoring molecules and lower metastasis rates.
Researchers have created a new cancer treatment that uses conditional small RNA molecules to selectively kill cancer cells. The approach exploits characteristics of DNA and RNA to separate diagnosis and treatment steps, potentially eliminating unwanted side effects.
Researchers identified thousands of proteins involved in compacting DNA, a crucial process for cell division. This discovery could help explain why cell renewal can go wrong, leading to cancer or miscarriage.
CDX2 is an identity gene that tells a cell it is in the epithelial tissue of the intestine, enabling it to perform its job correctly. Cancer cells deactivate this gene, leading researchers to identify five anti-cancer genes and discover CDX2's role in suppressing colon cancer.
Researchers use fruit flies to study protein modifications that can contribute to cancer development. The study aims to unravel the role of enzyme San in tissue proliferation and cancer growth.
Researchers have discovered a protein called Salt Inducible Kinase 2 (SIK2) that plays a key role in regulating cell division and may be an attractive target for treating ovarian cancer. Combination therapies targeting different phases of the cell cycle are highly desirable for optimal cancer treatment.
A study found that patients with basal cell carcinoma who have multiple lesions are at higher risk of developing more cancers. Red hair and a higher socioeconomic status were associated with an increased risk of multiple lesions.
Researchers discovered that SUMO modifies RPA70, essential for DNA repair by homologous recombination. The connection offers a potential target to short-circuit repair, making cells more vulnerable to chemotherapy and ionizing radiation.