Research on the cell biology of tumors. Covers cancer-cell vulnerabilities, tumor spread, nanoreactor therapies, and AI-guided cancer research.
A low-fat diet with fish oil supplements slowed the growth of prostate cancer cells in human tissue compared to a traditional Western diet. The men on the low-fat diet also showed changes in cell membrane composition, increasing omega-3 fatty acids and decreasing omega-6 fatty acids.
Researchers found that recombination, a key DNA repair process, has a self-correcting mechanism allowing DNA to make a virtual u-turn and start over. This discovery contributes new understanding to basic cancer biology and may improve the efficacy of cancer treatments.
Scientists propose 'Lance Armstrong effect' to overcome resistance in pancreatic and other cancers, with promising results in testicular cancer patients who beat metastatic disease despite low survival rates elsewhere. Researchers explore nanoparticle therapies to target tumors with high temperatures.
Researchers at the University of Gothenburg have discovered a modified aquaporin, AQP10, which is more stable due to its carbohydrate structure. This stability makes it potentially useful for treating diseases such as eczema and cancer.
Researchers at Sanford-Burnham Medical Research Institute have identified a new component of the cellular machinery that senses dietary amino acids, which is essential for mTORC1 activation. This finding provides new information about mTORC1 and its role in cellular metabolism in both normal cells and cancer cells.
Researchers are utilizing Office of Naval Research's FARSIGHT to identify and classify cancer-related cells. The technology, originally developed for mine hunting, improves accuracy and consistency in cell identification, potentially saving lives in the future.
A new study uses the Tilman model of competition between invasive species to understand how prostate cells invade bone marrow and take over the microenvironment. The research reveals that cancer cells follow a similar path to ecological invasions, highlighting the potential for ecological modeling to understand metastasis.
Researchers found that later-stage prostate cancer cells lack Pten, a tumor-suppressor gene, leading to rapid cell division and mutations. Plk1 inhibitor BI 2356 showed promise in killing cancer cells without Pten.
A team of researchers at McGill University developed a new device that can float over cell surfaces without touching them, allowing for the study of cellular processes such as cancer cell formation and neuron alignment. The device uses quadrupoles to create force fields and deliver molecules selectively to cells.
A new multispectral fluorescence imaging system has been developed to localize cancer cells during surgery, enabling surgeons to detect small clusters of tumor cells that might otherwise go undetected. In a study on nine patients with ovarian cancer, the system successfully detected and removed all cancer cells in eight cases.
A team of researchers at UC Santa Barbara has developed a novel technique using laser spectroscopy and silver nanoparticles to discriminate between cancerous and non-cancerous cells. The technology can help identify unique tumor cells that may spread to other parts of the body, improving diagnosis and treatment outcomes.
A study by University of Texas Medical Branch researchers has identified fortilin as a key protein that promotes the growth of cancer cells by inhibiting p53, a tumor suppressor. This finding may lead to new treatments for cancers and atherosclerosis.
Researchers at Vanderbilt University School of Medicine found that BVES regulates EMT in human colon cancer cells and is silenced via promoter methylation in human colorectal carcinoma. Restoring BVES expression decreased cancer cell characteristics.
Researchers have successfully delivered chemotherapy to cancer cells inside tiny microparticles, reducing ovarian cancer tumours by 65 times more than traditional methods. The 'Trojan Horse' approach uses a special protein called CD95 to hijack cancer cells and deliver the chemotherapy cargo.
Researchers have discovered how p53 binds to Hsp90, revealing new insights into cancer development and potential therapeutic targets. The study found that p53 binds to both the middle and C-terminal domains of Hsp90, with negatively charged amino acids playing a crucial role in stabilizing the bond.
Cells can switch between sender and receiver mode, inhibiting their own signals while allowing them to receive information from other cells. This mechanism could lead to the development of cancer drugs that target specific cell communications, potentially stopping uncontrollable proliferation.
Researchers developed a diagnostic biological 'computer' network in human cells that recognizes cancer cells and triggers their destruction. The network uses a combination of five specific miRNAs to identify HeLa cancer cells and destroy them, while leaving healthy cells intact.
New research from Brown University finds that nickel nanoparticles can activate a cellular pathway that contributes to cancer in human lung cells. The study shows that smaller nanoscale particles are more harmful and potentially cancer-causing than larger microscale particles.
Researchers successfully created a computerized model of cancer cell metabolism, predicting which drugs are lethal to cancer cells' function and demonstrating efficacy in kidney cancer models. The approach holds promise for future investigations aimed at effective drug therapies for other types of cancer.
Researchers at the University of Pittsburgh Cancer Institute have identified the small tumor protein (sT) as the oncoprotein that triggers Merkel Cell Carcinoma (MCC), a rare but deadly skin cancer. The discovery could improve diagnosis and understanding of MCC, potentially shedding light on other cancers.
A collaborative study between UNC and Duke scientists reveals that disruptions in protein signals can lead to improper mitochondrial distribution during cell division, resulting in reduced ATP levels. This finding has implications for diseases such as cancer and neurodegenerative disorders.
Researchers have discovered a compound that attacks cancer cells by depriving them of glucose, a process found in most rapidly dividing cells. The team tested the compound on kidney cancer cells and found it nearly halved glucose uptake and slowed tumor growth, with minimal side effects.
The UBC device allows scientists to analyze individual cells rapidly and cost-effectively, accelerating genetic research and cancer diagnosis. By analyzing isolated cells, researchers can distinguish between normal and cancer cells, leading to more accurate treatments.
Researchers at Ohio State University designed a nanocarrier that maximizes gene silencing by targeting equivalent highways for entry into cells. The carrier, called SPANosome, reduces protein production by 95% compared to traditional carriers.
Cancer researcher Peter Duesberg suggests that cancer is a form of speciation, where tumors are new species that operate independently and can grow without host control. This theory could lead to new insights into cancer growth and metastasis, as well as new approaches to therapy.
A research team led by Bradley Davidson discovered that specialized structures in sea squirt cells, called invadopodia, may help cancer cells evade elimination processes. In contrast to cancer cells, sea squirt cells use these structures to pick up chemical signals for development, not invasion.
Researchers at the University of Maryland School of Medicine have found a complex molecular relationship between ERK and CHK2 proteins, which could lead to new treatments for diffuse large B-cell lymphoma. The study showed that inhibiting both proteins simultaneously killed more cancer cells than treating them separately.
Researchers developed a new mouse model to test cancer drugs by simulating gene inhibition, preventing rapid cell division in cancer cells while leaving healthy cells unaffected. The study published in Nature Communications validates the preclinical relevance and predictive value of the inducible RNAi-based mouse model.
Researchers at Hebrew University identified the molecular basis for DNA breakage, a key feature of cancer development. The study sheds light on how DNA replication stress leads to breaks, providing new insights into cancer development and potential therapeutic approaches.
The LuCED test uses 3D imaging to accurately detect cancer cells in sputum samples from high-risk individuals. This approach can significantly lower the number of false positive cases, making mass screening programs more feasible and cost-effective.
Researchers at Johns Hopkins have identified two genes, ATRX and DAXX, that contribute to the lengthening of telomeres in cancer cells. The study found a correlation between mutations in these genes and alternative lengthening of telomeres in various types of tumors.
Researchers at Salk Institute find that a short segment of p53 regulates activity in blood-forming stem cells, affecting their survival and proliferation after DNA damage. The study suggests that targeting this regulatory mechanism with drugs could reduce unwanted tissue damage from chemotherapy or radiation treatment.
A new study by UCSF researchers reveals that complex mutations in genes like TP53 occur earlier in skin and ovarian cancers than previously thought. The findings could help doctors develop new diagnostics for early cancer detection.
Researchers at Columbia University developed a new technique to evaluate human stem cells using cell micropatterning, enabling the study of developmental processes and disease diagnosis. The technique reveals directional motion patterns in cells, which can distinguish between normal and pathological behaviors.
Research reveals that leftover embryonic cells found in all adults may be precursors of deadly esophageal cancers, including Barrett's esophagus. The study suggests targeting these precursor cells as a potential strategy for stopping the disease before it starts.
Researchers discovered that Barrett's esophagus, a precursor to esophageal cancer, arises from a small group of leftover embryonic cells present in all adults. This finding opens up new avenues for therapeutic intervention to prevent the progression of cancer. The study used mouse models and identified specific cell surface markers to ...
Researchers developed a novel approach to cancer therapy by creating a drug that inhibits the mobility of cancer-promoting proteins within cells. The treatment uses a 'glue' molecule that binds to these proteins, forcing them to the cell membrane and making cancer cells more vulnerable to chemotherapy.
Using Archimedes' principle, MIT scientists have devised a method to measure the density of individual cells, which could provide biophysical insight into fundamental cellular processes. The new device rapidly exchanges fluids, allowing for rapid measurement and potentially screening potential cancer drugs.
Researchers have found that ovarian cancer cells use brute force to invade surrounding tissues and organs. The study identified key proteins involved in this process, providing a potential target for future treatments.
A new study by NIH researchers reveals the interaction between telomeres and a toxic protein called progerin that triggers both premature aging syndrome and normal cellular aging. Shortened telomeres lead to increased production of progerin, causing cell damage and activation of programmed aging.
Researchers at the IRCM have made a significant breakthrough in understanding the Sonic Hedgehog protein's role in cancer development. The team found that specific receptors play a crucial role in transmitting signals from the protein, which could lead to new avenues for treating diseases such as cancer.
Scientists discovered that a single amino acid prevents perforin from killing host cells, protecting cytotoxic lymphocytes from destruction. The findings shed light on the immune system's ability to regulate cell death and disease.
Researchers at University of Western Ontario discovered how biochemical pathways can be rewired in cancer cells to resist apoptosis, a key process in normal cell turnover. This 'rewiring' allows cancer cells to ignore death signals and potentially evade therapy.
Researchers have discovered that cancer cells use specific chemokines to create a survival niche in the lymph nodes and spleen, allowing them to grow and develop. This niche is created by the interaction between cancer cells and stromal cells, which secrete increased quantities of chemokines CCL19/CCL21.
Cancer cells exploit a unique metabolic pathway fueled by sugar consumption to survive. Researchers identified HIF-1 as controlling gene expression in low-oxygen conditions, with PKM2 playing a crucial role in this process.
Researchers found that a specific section of the AKAP12 gene responds to retinoid treatment, reducing vascular cell growth. The study suggests that this gene could be a target for treating vascular diseases and potentially other cancers.
Researchers at Uppsala University have developed a new method to study signal systems in individual cells, revealing the molecular effect of drugs and facilitating the discovery of targeted pharmaceuticals for cancer treatment. This tool provides insight into how cancer cells communicate with normal cells and exploit their functions.
Researchers discovered a hyperactive Wnt signaling pathway in human sarcoma cells, which increases cell growth and proliferation by increasing CDC25A gene expression. This suggests that medications targeting the Wnt pathway may be effective in treating human sarcomas.
Scientists at Harvard School of Public Health discovered that cells exert forces on their neighbors, leading to a cooperative yet chaotic migration. The study found that collective cellular migration is not a smooth process, but rather an 'organized chaos' with pushing and pulling in all directions.
Researchers at UCSF have identified BCL6, a protein that leukemia cells use to survive treatment, as the basis for drug resistance. Targeting this protein may lead to more powerful cancer drugs and improved cure rates for children with leukemia.
Researchers discovered a link between cell rigidity and proteins associated with cancer activity, using innovative collaboration between physics and cell biology. Exerting mechanical force on cells activates Rho GEF proteins, leading to tumor growth and metastasis.
Researchers at Wake Forest Baptist Medical Center found a specific mutation in the FLT3 receptor makes cells resistant to standard chemotherapy treatment for acute myeloid leukemia (AML). The study suggests a need for personalized approaches in treatment and may lead to new therapeutic research.
A study suggests that evaluating gene expression changes in nasal cells can serve as a non-invasive approach for early detection of lung cancer. The researchers identified 170 genes that were differentially expressed between patients with and without lung cancer, including genes linked to colon cancer and tumor suppression.
Researchers at UT Southwestern Medical Center have discovered a protein that guides blood vessel development and may lead to a treatment to starve cancer cells of nutrients. The protein, Rasip1, is specific to blood vessels and essential for their formation, making it a potential target for blocking tumor growth.
Researchers at Hebrew University discovered that insufficient building blocks in cancer cells lead to DNA damage. External supply of DNA building blocks can reactivate normal DNA synthesis and reduce cancerous features.
Researchers discovered that lopinavir selectively kills HPV-infected non-cancerous cells while leaving healthy cells relatively unaffected. The study suggests a potential treatment for HPV-related cervical cancer using locally applied lopinavir cream or pessary.
Researchers have found that over-expression of motor protein km23-1 can block human ovarian tumor growth, leading to eventual cancer cell death. This discovery offers promise for new therapies to treat ovarian cancer, a disease affecting U.S. women with an estimated 21,880 new cases and 13,850 deaths in 2010.
Cancer cells survive by ignoring signals to become senescent and continuing to make copies of themselves at will. Researchers discovered a molecular switch required for entry into quiescence and senescence, which may provide new targets for cancer treatment and help develop neurons in infants with Down syndrome.
A study by Fred Hutchinson Cancer Center researchers reveals a signaling protein called Reelin helps brain cells navigate during development. This finding may hold clues to understanding how cancer cells migrate within the body.
Researchers at the Salk Institute have uncovered a new structural beacon, called the C-tail, which is found in half of all telomeres in alternative lengthening of telomeres (ALT) tumors. This unique feature may be a key to understanding cancer cell immortality and developing effective treatments.