Articles tagged with Cancer Cells
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Researchers discovered that SUMO modifies RPA70, essential for DNA repair by homologous recombination. The connection offers a potential target to short-circuit repair, making cells more vulnerable to chemotherapy and ionizing radiation.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have uncovered a new role for polynucleotide phosphorylase (PNPASE) in regulating the import of RNA into mitochondria. Reducing PNPASE expression impairs mitochondrial energy production and cell growth.
Research published in the Journal of Thoracic Oncology defines timeframes for declaring early stage lung cancer cured. Patients with stage IA NSCLC without vascular invasion can be considered cured after five years, while those with vascular invasion require longer follow-up until at least nine years.
Scientists have developed a novel method to deliver therapeutic molecules, proteins, and DNA directly into living cells using laser-activated nanoparticles. The technique, which uses bursts of near-infrared light to create tiny holes in cell membranes, shows promise for gene-based therapies.
University of Pennsylvania researchers describe a novel mechanism involving calcium transfer between cell components to regulate cell energy. Without this transfer, cells undergo autophagy, or self-eating, as they struggle to produce enough ATP.
Scientists discovered that inhibiting a protein called N-cadherin prevents cancer cells from forming groups and migrating. This new approach could lead to more effective therapies for cancer treatment.
A recent study suggests that Porphyromonas gingivalis (P.g.) infection may contribute to the chronicity of inflammatory disorders leading to oral cancers. The research found that P.g. induces expression of immune-regulating receptors B7-H1 and B7-DC in squamous cell carcinoma cells, facilitating immune evasion.
A Michigan State University researcher is using $1.7 million in federal funding to study the role of microRNAs in regulating genes that control cell behavior. The goal is to determine how arsenic exposure leads to tumor development and identify potential treatments.
Researchers found 323 unique genes influenced by smoking, with a strong involvement in processes related to cancer, cell death, and metabolism. The study's results indicate that exposure to cigarette smoke alters gene expression, leading to a sobering scale of influence on human disease risk.
Researchers identified the Mahjong gene, which determines the winners of a life-or-death
Researchers discover Lgl and Mahjong proteins help identify how healthy cells fight cancer cells. Normal cells surround cancer cells, leading to their death, while cancerous cells break free and divide.
Scientists at Johns Hopkins University create method for pinpoint delivery of molecules to individual cells, enabling targeted cancer treatment. The technique uses gold nanowires coated with tumor necrosis factor-alpha, which triggers specific cellular responses without affecting surrounding cells.
Researchers at NUI Galway have discovered a protein that enables cancer cells to withstand intense stress. Understanding this interaction could lead to the development of more effective anticancer drugs by blocking its function and encouraging tumor cell death.
Researchers at Brandeis University found that DNA repair mechanisms can increase mutation rates and alter gene expression in cancer cells. The study suggests that these mutations may be a key factor in the development of cancer.
Researchers developed a groundbreaking laboratory model of hormone-induced human prostate cancer initiation and progression, offering new insights into the disease's hormonal mechanisms. The model enables the study of cancer development from normal tissue to initiation and progression, facilitating preventive therapy testing and accele...
Three scientists from Scripps Research will receive funding to develop advanced cancer therapies. Glenn Micalizio, Thomas Bannister, and Douglas Kojetin will explore novel protein targets and cancer treatment pathways.
Engineered allosteric regulation provides precise control of kinase activity in living cells, enabling scientists to understand cellular processes and dissect the functions of kinases. This new method has exciting applications in basic research and promises to open doors to new scientific insights into cancer and other human diseases.
Researchers discovered that different cells respond differently to stimuli, contradicting previous uniformity assumptions. The study used microfluidics to monitor individual cells' reactions and found nuanced variations in responses.
Rice University researchers developed a method to use an off-the-shelf digital camera to distinguish cancerous cells from healthy ones. The device uses fluorescent dyes and fiber-optic cables to capture images of tissues, allowing doctors to identify abnormal cells quickly and accurately.
A recent study published in Nature Cell Biology suggests that 3D cell culture may provide more accurate information to develop drugs preventing cancer's spread. The research found that cells behave differently in 3D environments compared to traditional 2D lab dishes.
Researchers deciphered a key pathway used by Myc oncogene, finding that disabling it can restore cellular senescence and prevent cancer growth. This discovery offers new potential for treating various types of cancer by targeting the oncogene's dependence on Miz1.
A new study reveals that a protein called Flower marks weaker cells for elimination, allowing fitter neighbors to dominate. This process of cell competition may provide insight into pathological conditions like cancer and aging.
Researchers at Sanford-Burnham Medical Research Institute have discovered a new application for the painkiller Sulindac as a potential anti-cancer treatment. By binding to the truncated form of nuclear receptor RXRα, Sulindac shuts down cancer cell growth and initiates cell death.
Researchers at University of Illinois College of Medicine found that adding ARC to anti-cancer agent ABT-737 makes it effective against a wide range of cancers. The combination of agents shows tremendous synergy, reducing the dose required while lessening side-effects.
Researchers at University of Florida have developed a two-pronged therapy targeting both leukemia cells and their environment. The therapy, called Oxi4503, uses an agent that poisons leukemia cells and destroys blood vessels supplying them with oxygen and nutrients.
Cancer cells form clusters of centrosomes to distribute chromosomes correctly, a trick that can be targeted for destroying them. Researchers identified 82 genes responsible for this survival strategy and found that silencing specific proteins disrupts tension in spindle fibers, leading to cancer cell death.
Scientists identified a novel enzyme, PEAK1, that regulates cell proliferation, shape and migration. The discovery may provide a new target for future anti-cancer therapies.
Research from Fox Chase Cancer Center shows that patients with stage IIIA non-small cell lung cancer (NSCLC) who receive surgery, particularly lobectomy, have increased overall survival rates. This is in contrast to those who received chemoradiation alone.
A Phase II trial found that sunitinib was not effective in patients with papillary renal cell carcinoma, highlighting the need for new therapies for this rare subtype of kidney cancer. The study suggests differences in response between clear- and non-clear cell subtypes.
Researchers have found a way to tap into the properties of p53 to kill cancer cells while sparing normal cells. By controlling the cell cycle and inducing endoreduplication in cancer cells, they can target tumour-specific killing while minimizing damage to healthy cells.
A new technique developed by UNC researchers uses light to manipulate protein behavior in cells, enabling precise control of cell movement. This discovery has significant implications for understanding embryonic development, nerve regeneration, and cancer metastasis.
Researchers at Thomas Jefferson University have identified a protein, IGF-IR, that regulates motility and invasion of bladder cancer cells. This finding offers a novel molecular target for treating patients with aggressive bladder cancer and may also serve as a tumor biomarker for diagnosis.
A new study finds that some immortal cancer cells have functioning biological clocks, but these clocks don't regulate cell division. This could lead to the development of new anti-cancer therapies by targeting the biological clock pathway.
Scientists have developed a fatty acid that enhances the delivery of an existing anticancer drug, increasing its effectiveness in treating certain types of blood cancer. By incorporating elaidic acid into azacytidine, researchers were able to improve the bioavailability of the agent and increase therapeutic efficacy.
Researchers at the University of Illinois have made a breakthrough in understanding how butyrate helps the intestine grow and become more functional. Butyrate increases the creation of intestinal cells and fortifies them by increasing the transcription of a protein called GLUT2, which plays an important role in intestinal function.
A new study reveals that cancer cells' miRNA networks are rewired and fragmented, with small clusters of two to six miRNAs existing outside the main network. This finding suggests a new approach to identifying cancer genes and targets for drug development.
Research suggests extending HPV testing intervals to five years for women over 30 could significantly reduce cervical cancer cases. The study found HPV tests detect early signs of cervical cancer more accurately than current cytology screening.
Cancer cells require actin, microtubules, and intermediate filaments to break through the basement membrane and escape. The study found that these components collaborate in a specific order to facilitate metastasis.
Cancer genetics expert Bert Vogelstein will review the landscape of cancer genome research and its applications. He predicts that early detection and prevention will be key to reducing cancer deaths in the future.
Researchers found that the Retinoblastoma protein targets DNA replication genes during cellular senescence, preventing cancer cells from replicating. This mechanism is crucial for tumor suppression, and its disruption can lead to genomic instability and malignant tumors.
Researchers at Ohio State University have discovered a new molecular network that contributes to abnormal KIT protein abundance in acute leukemia cells. Targeting this network with therapeutic drugs may prove more effective than current standard of care.
Researchers from Ontario Cancer Institute and US scientists have discovered a compound that blocks protein BCL6, a cancer-causing culprit in about half of all non-Hodgkins lymphoma cases. This breakthrough accelerates developing targeted drugs to fight the most common form of non-Hodgkins lymphoma.
Researchers at MIT and Harvard developed a new sensor to measure the rate of cell mass accumulation, finding that individual cells exhibit varying growth rates. The discovery sheds light on how cells control their growth, with implications for understanding cancer development.
Researchers at UEA have discovered a new group of molecules that can inhibit glycosyltransferases, enzymes used by cells to create sugar chains. This breakthrough could lead to significant advances in cancer treatment and therapy.
Researchers have discovered that blocking Mcl-1, a protein inhibiting Bak activation, enables TRAIL to activate Bak and kill resistant tumor cells. This strategy has potential for improving the efficacy of anti-cancer treatment.
A study published in Immunity reveals that immune cells' signals can interfere with the ability of intestinal cells to regenerate, leading to hyper-activation of growth and increasing the risk of colon cancer. Interfering with a protein called dickkopf 1 may aid in controlling inflammatory bowel diseases.
Researchers at Van Andel Institute developed a new model to study prostate cancer, finding that normal secretory cells depend on E-cadherin binding for survival, unlike cancer cells which rely on androgen. This discovery could lead to therapies targeting tumor cells without harming normal cells.
Scientists have successfully grown and loaded empty nano containers with useful chemicals from a plant virus, opening up new areas of research in targeted drug delivery. The technology has potential applications in cancer treatment, delivering drugs directly to diseased cells while sparing healthy ones.
Researchers have developed 'smart' nanoparticles that can selectively target and destroy colorectal cancer cells using near-infrared laser radiation, leaving healthy tissue intact. The goal is to improve the technology for testing in human clinical trials and explore its potential as a new cancer treatment.
A new sensor array made of carbon nanotubes can detect single molecules of hydrogen peroxide emanating from a single living cell. The detection could lead to new targets for potential cancer drugs and diagnostic devices for some types of cancer.
Researchers identified a new drug target to inhibit genes vital for leukaemia cell growth, which could prevent disease progression. Targeting Stat5 may provide a novel therapeutic approach for treating acute and chronic leukaemias.
Researchers at the University of Pennsylvania School of Medicine have found that mixed lineage leukemia (MLL) cancer cells rely on a normal version of an associated protein to stay alive. Deleting this gene from leukemia cells blocks uncontrolled growth triggered by a fusion protein, suggesting that it is essential for MLL proliferation.
New research from UNC suggests that acetylation of metabolic enzymes plays a key role in regulating cellular metabolism. The study identified approximately 1,000 new proteins with acetyl groups, expanding the previously recognized repertoire of 50, and found that altering metabolic fuels can alter acetylation levels.
Researchers at U-M Comprehensive Cancer Center found a third protein, TIN2, that overrides Fbx4 by binding to TRF1, stabilizing it and keeping telomere length in control. This finding could lead to developing a drug to block Fbx4, impacting all cancer types.
Researchers developed a method to distinguish driver mutations from passenger mutations in cancer genomes by analyzing deletions at known tumour suppressor genes and fragile sites. The study found at least one in nine genes can be removed without killing human cells.
Researchers at Georgia Institute of Technology have developed a system using gold nanoparticles that can kill cancer cells by targeting their nuclei, preventing cell division and inducing apoptosis. This breakthrough offers a promising treatment for cancers in areas inaccessible to traditional laser-based therapies.
Using hydrogels to deliver small interfering RNA (siRNA) into cancer cells has been shown to effectively target and kill them. The technique inhibits EGFR growth, increasing programmed cell death and enhancing the effects of traditional chemotherapy.
Researchers at Yale University have streamlined the synthesis of a family of compounds known as kinamycins, which are naturally produced by bacteria and show potent toxicity. By reducing the number of steps required to synthesize them from 24 to 12, the team can now prepare these molecules in larger quantities for further studies.
A team of scientists is researching self-cannibalizing cancer cells to develop new therapies. Cancer cells can stop proliferating and consume themselves when stressed, allowing them to survive enormous amounts of stress.
Researchers have found a genetic tool that specifically alters gene expression in the endometrium, leading to rapidly progressing cancer in mice. The Lkb1 gene is mutated in many other types of human cancers and regulates pathways contributing to aggressive cancer cell formation.