Articles tagged with Cancer Cells
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Researchers discovered that Barrett's esophagus, a precursor to esophageal cancer, arises from a small group of leftover embryonic cells present in all adults. This finding opens up new avenues for therapeutic intervention to prevent the progression of cancer. The study used mouse models and identified specific cell surface markers to ...
Research reveals that leftover embryonic cells found in all adults may be precursors of deadly esophageal cancers, including Barrett's esophagus. The study suggests targeting these precursor cells as a potential strategy for stopping the disease before it starts.
Researchers developed a novel approach to cancer therapy by creating a drug that inhibits the mobility of cancer-promoting proteins within cells. The treatment uses a 'glue' molecule that binds to these proteins, forcing them to the cell membrane and making cancer cells more vulnerable to chemotherapy.
Using Archimedes' principle, MIT scientists have devised a method to measure the density of individual cells, which could provide biophysical insight into fundamental cellular processes. The new device rapidly exchanges fluids, allowing for rapid measurement and potentially screening potential cancer drugs.
Researchers have found that ovarian cancer cells use brute force to invade surrounding tissues and organs. The study identified key proteins involved in this process, providing a potential target for future treatments.
Researchers at the IRCM have made a significant breakthrough in understanding the Sonic Hedgehog protein's role in cancer development. The team found that specific receptors play a crucial role in transmitting signals from the protein, which could lead to new avenues for treating diseases such as cancer.
A new study by NIH researchers reveals the interaction between telomeres and a toxic protein called progerin that triggers both premature aging syndrome and normal cellular aging. Shortened telomeres lead to increased production of progerin, causing cell damage and activation of programmed aging.
Scientists discovered that a single amino acid prevents perforin from killing host cells, protecting cytotoxic lymphocytes from destruction. The findings shed light on the immune system's ability to regulate cell death and disease.
Researchers at University of Western Ontario discovered how biochemical pathways can be rewired in cancer cells to resist apoptosis, a key process in normal cell turnover. This 'rewiring' allows cancer cells to ignore death signals and potentially evade therapy.
Researchers have discovered that cancer cells use specific chemokines to create a survival niche in the lymph nodes and spleen, allowing them to grow and develop. This niche is created by the interaction between cancer cells and stromal cells, which secrete increased quantities of chemokines CCL19/CCL21.
Cancer cells exploit a unique metabolic pathway fueled by sugar consumption to survive. Researchers identified HIF-1 as controlling gene expression in low-oxygen conditions, with PKM2 playing a crucial role in this process.
Researchers found that a specific section of the AKAP12 gene responds to retinoid treatment, reducing vascular cell growth. The study suggests that this gene could be a target for treating vascular diseases and potentially other cancers.
Researchers at Uppsala University have developed a new method to study signal systems in individual cells, revealing the molecular effect of drugs and facilitating the discovery of targeted pharmaceuticals for cancer treatment. This tool provides insight into how cancer cells communicate with normal cells and exploit their functions.
Researchers discovered a hyperactive Wnt signaling pathway in human sarcoma cells, which increases cell growth and proliferation by increasing CDC25A gene expression. This suggests that medications targeting the Wnt pathway may be effective in treating human sarcomas.
Scientists at Harvard School of Public Health discovered that cells exert forces on their neighbors, leading to a cooperative yet chaotic migration. The study found that collective cellular migration is not a smooth process, but rather an 'organized chaos' with pushing and pulling in all directions.
Researchers at UCSF have identified BCL6, a protein that leukemia cells use to survive treatment, as the basis for drug resistance. Targeting this protein may lead to more powerful cancer drugs and improved cure rates for children with leukemia.
Researchers at Wake Forest Baptist Medical Center found a specific mutation in the FLT3 receptor makes cells resistant to standard chemotherapy treatment for acute myeloid leukemia (AML). The study suggests a need for personalized approaches in treatment and may lead to new therapeutic research.
Researchers discovered a link between cell rigidity and proteins associated with cancer activity, using innovative collaboration between physics and cell biology. Exerting mechanical force on cells activates Rho GEF proteins, leading to tumor growth and metastasis.
A study suggests that evaluating gene expression changes in nasal cells can serve as a non-invasive approach for early detection of lung cancer. The researchers identified 170 genes that were differentially expressed between patients with and without lung cancer, including genes linked to colon cancer and tumor suppression.
Researchers at UT Southwestern Medical Center have discovered a protein that guides blood vessel development and may lead to a treatment to starve cancer cells of nutrients. The protein, Rasip1, is specific to blood vessels and essential for their formation, making it a potential target for blocking tumor growth.
Researchers at Hebrew University discovered that insufficient building blocks in cancer cells lead to DNA damage. External supply of DNA building blocks can reactivate normal DNA synthesis and reduce cancerous features.
Researchers discovered that lopinavir selectively kills HPV-infected non-cancerous cells while leaving healthy cells relatively unaffected. The study suggests a potential treatment for HPV-related cervical cancer using locally applied lopinavir cream or pessary.
Cancer cells survive by ignoring signals to become senescent and continuing to make copies of themselves at will. Researchers discovered a molecular switch required for entry into quiescence and senescence, which may provide new targets for cancer treatment and help develop neurons in infants with Down syndrome.
Researchers have found that over-expression of motor protein km23-1 can block human ovarian tumor growth, leading to eventual cancer cell death. This discovery offers promise for new therapies to treat ovarian cancer, a disease affecting U.S. women with an estimated 21,880 new cases and 13,850 deaths in 2010.
A study by Fred Hutchinson Cancer Center researchers reveals a signaling protein called Reelin helps brain cells navigate during development. This finding may hold clues to understanding how cancer cells migrate within the body.
Researchers at the Salk Institute have uncovered a new structural beacon, called the C-tail, which is found in half of all telomeres in alternative lengthening of telomeres (ALT) tumors. This unique feature may be a key to understanding cancer cell immortality and developing effective treatments.
Researchers discovered a worm protein controlling growth factor secretion, which is linked to human cancers. The study proposes that abnormal growth factor secretion may stimulate cancer formation and offers a potential targeted treatment approach.
Researchers have created nanoparticles that can store large amounts of drugs, allowing for a millionfold increase in efficiency over comparable methods. The 'protocells' can target specific cancer cells while restricting toxic chemotherapy drugs from leaking into the system, mitigating side effects.
Researchers at The Wistar Institute have identified a connection between Merlin and angiomotin, two proteins involved in cell signaling pathways. This discovery may lead to a new therapeutic approach for NF2 by targeting tumor cells directly and starving them of nutrients.
Researchers at UT Southwestern Medical Center found that Klotho, an anti-aging hormone, suppresses renal fibrosis and cancer growth in mice. This discovery offers a potential new treatment for patients with chronic kidney disease and acute kidney injury.
The TET1 enzyme controls gene activity during fetal development, preventing genes from being turned off at critical stages. By modifying methyl groups, TET1 acts as a safeguard to ensure normal cell growth and development.
Researchers study sea squirts' simple body structure to unravel complex mechanisms of heart formation, shedding light on GATA's role in congenital heart defects. Disrupting GATA function independently in the developing gut preserves heart cell identity, while disrupting it in heart precursor cells causes limbo-like state.
A Wayne State University study found that soy isoflavones can sensitize cancer cells to radiation while protecting normal tissue. The study demonstrated that soy isoflavones can block DNA repair mechanisms in cancer cells, leading to increased killing of lung cancer cells by radiation
Researchers unveiled groundbreaking cellular analysis tools, drug-delivery methods, and novel approaches to high-throughput drug discovery. The session highlighted advances in imaging and simultaneous identification of biological compounds, as well as the use of peptides as potential drugs and biological probes.
Researchers from UPCI and Pitt will present over 80 posters, talks, and tutorials on various cancer studies, including the effects of immunomodulatory derivatives on blood cell production pathways and the role of inflammatory mediators in immune system dysfunction. Additionally, they will discuss the development of vaccines targeting p...
Scientists at the University of Hull have identified a cellular mechanism controlling tissue factor inclusion in endothelial microparticles, which may help treat cardiovascular disease and cancer. The on-off switch, involving tandem amino acids, regulates phosphate molecule addition to control tissue factor release.
A new study finds that vismodegib, a hedgehog pathway inhibitor, prevents the development of advanced basal cell carcinomas in patients with basal cell nevus syndrome. The treatment also shows promise for patients with an inherited predisposition to basal cell carcinoma.
Cancer cells that reign during leukemia relapses have distinct DNA profiles compared to those at diagnosis. These mutated cells exhibit aggressive behavior in mice, suggesting a possible link between human and mouse models.
A new hedgehog pathway inhibitor, GDC-0449, demonstrated efficacy in preventing and treating basal cell cancer among patients with basal cell nevus syndrome. The drug reduced the development of new lesions and decreased tumor size, offering a promising treatment option for these patients.
A recent study published in the Journal of Thoracic Oncology found that soy isoflavones can sensitize cancer cells to radiation, increasing killing efficiency while protecting normal lung tissue from damage. Researchers used a soy mixture consisting of genistein, daidzein and glycitein to demonstrate this effect.
PBS-Bio presents two abstracts at the AACR conference, showing how drugs UNBS1450 and NDC-1308 affect cancer cells. The technology allows real-time measurement of cellular responses to drugs, identifying potential biomarkers for patient selection and drug development.
Forced splicing of p21Cip1 gene leads to its down-regulation and induction of programmed cell death in cancer cells. This finding suggests new approaches to enhance chemotherapeutic drug efficacy by inhibiting splicing.
Researchers at Dana-Farber Cancer Institute have developed a targeted therapy strategy that slows the progression of NUT midline carcinoma in children. The approach uses an HDAC inhibitor to distract cancer proteins from their usual activity, causing cells to behave like normal cells.
A study identified three critical steps to transform normal blood cells into leukaemic ones, each subverting a different cellular process. The researchers found that NPM1 mutation is a key event in acute myeloid leukaemia development and can cooperate with other mutations to cause the disease.
Researchers at LSU Health Sciences Center have identified a protein called c-MYC oncoprotein that enables cancer cells to resist DNA-damaging agents like cisplatin. The study suggests that inhibiting this protein may provide a novel strategy for cancer therapy in combination with DNA-damaging agents.
Researchers created a computational model that describes how intestinal cells in mice respond to TNF, revealing the importance of location and protein interactions in cell fate. The study demonstrates the power of systems biology in modeling complex biological systems and predicting disease outcomes.
A Cardiff University-led study has discovered a protein, calmodulin, that protects pancreatic cells against the harmful effects of alcohol. The findings could lead to the development of new treatments for pancreatitis and reduce the risk of pancreatic cancer.
The authors refine the original six hallmarks using information from transgenic animals and biochemical assays, adding two new categories: enabling characteristics and emerging hallmarks. This updated review provides a solid basis for cancer research and identifies therapeutic targets.
Researchers found that MeSeCys killed more lung cancer cells than SeMet, which may explain conflicting results on selenium's health benefits. The study could provide insight into the chemopreventive properties of different selenium forms.
A Purdue University scientist has developed a nanopolymer that can detect the effectiveness of cancer drugs against biochemical processes leading to cancer cell formation. This innovation could replace radioisotopes and antibodies in screening kinase inhibitors, making it a universal method for pharmaceuticals.
Scientists have identified a distinct group of effector regulatory T cells responsible for suppressing immune responses. The discovery has significant repercussions for the treatment of autoimmune diseases, organ transplantation, and cancer, as well as how the efficacy of newly developed drugs is measured.
Researchers have synthesized cancer literature to introduce the concept of enabling and emerging hallmarks, which are features that set the stage for cancer and may become core characteristics in nearly all cancers. This review article provides a cohesive foundation for biomedical researchers to develop new cancer treatments.
Researchers at NIST and NCI have developed a technique that slices off the top of a cell, making structures accessible for spectroscopic examination. This allows for chemical mapping of cells at submicrometer resolution, potentially enabling early detection of cancer.
Researchers at Arizona State University have received a $1 million grant to develop a next-generation 3D imaging microscope called Cell-CT. This technology enables scientists to observe and assess the functional pathways of disease, such as cancer, by performing CT imaging on individual living cells.
Researchers at Trinity College Dublin have discovered how autophagy, a process of 'self-eating', safeguards against cancer development. The discovery highlights an unexpected role for Noxa in triggering the self-destructive process that kills fledgling tumour cells.
A new study reveals that the CCCTC-binding factor (CTCF) and BORIS proteins directly regulate Rb2/p130 gene expression in lung cells. The findings show that small lung cancer cells exhibit low expression levels of Rb2/p130, while non-small lung cancer cells are overexpressed compared to normal lung cells.
A recent study published in PLOS Biology reveals that Break-induced Replication (BIR) is up to 2,800 times more likely to cause genetic mutations than normal DNA synthesis. The researchers found that this method of DNA repair can lead to sudden bursts of mutagenesis, increasing the risk of cancerous cell development.
Research team designed synthetic molecules to study proline residue's role in cancer cell apoptosis by XIAP protein. The results suggest that these tetrapeptide analogs can be further developed into new molecular tools to analyze protein-protein interactions and signal transduction pathways of XIAP in cancer cells.
Researchers have discovered a compound, ABT-737, that sensitizes hypoxic cancer cells to apoptosis. This compound synergizes with conventional chemotherapeutic agents in tumor-bearing mice, suggesting improved treatment of solid tumors.
UBE4B is a molecule that binds to p53 and MDM2, allowing them to degrade the tumor-suppressing protein p53 in cancer cells. This discovery could lead to novel anti-cancer therapies and improve prognosis for cancer patients.