Research on the cell biology of tumors. Covers cancer-cell vulnerabilities, tumor spread, nanoreactor therapies, and AI-guided cancer research.
Research from Fox Chase Cancer Center shows that patients with stage IIIA non-small cell lung cancer (NSCLC) who receive surgery, particularly lobectomy, have increased overall survival rates. This is in contrast to those who received chemoradiation alone.
A Phase II trial found that sunitinib was not effective in patients with papillary renal cell carcinoma, highlighting the need for new therapies for this rare subtype of kidney cancer. The study suggests differences in response between clear- and non-clear cell subtypes.
Researchers have found a way to tap into the properties of p53 to kill cancer cells while sparing normal cells. By controlling the cell cycle and inducing endoreduplication in cancer cells, they can target tumour-specific killing while minimizing damage to healthy cells.
A new technique developed by UNC researchers uses light to manipulate protein behavior in cells, enabling precise control of cell movement. This discovery has significant implications for understanding embryonic development, nerve regeneration, and cancer metastasis.
Researchers at Thomas Jefferson University have identified a protein, IGF-IR, that regulates motility and invasion of bladder cancer cells. This finding offers a novel molecular target for treating patients with aggressive bladder cancer and may also serve as a tumor biomarker for diagnosis.
A new study finds that some immortal cancer cells have functioning biological clocks, but these clocks don't regulate cell division. This could lead to the development of new anti-cancer therapies by targeting the biological clock pathway.
Scientists have developed a fatty acid that enhances the delivery of an existing anticancer drug, increasing its effectiveness in treating certain types of blood cancer. By incorporating elaidic acid into azacytidine, researchers were able to improve the bioavailability of the agent and increase therapeutic efficacy.
Researchers at the University of Illinois have made a breakthrough in understanding how butyrate helps the intestine grow and become more functional. Butyrate increases the creation of intestinal cells and fortifies them by increasing the transcription of a protein called GLUT2, which plays an important role in intestinal function.
A new study reveals that cancer cells' miRNA networks are rewired and fragmented, with small clusters of two to six miRNAs existing outside the main network. This finding suggests a new approach to identifying cancer genes and targets for drug development.
Research suggests extending HPV testing intervals to five years for women over 30 could significantly reduce cervical cancer cases. The study found HPV tests detect early signs of cervical cancer more accurately than current cytology screening.
Cancer cells require actin, microtubules, and intermediate filaments to break through the basement membrane and escape. The study found that these components collaborate in a specific order to facilitate metastasis.
Cancer genetics expert Bert Vogelstein will review the landscape of cancer genome research and its applications. He predicts that early detection and prevention will be key to reducing cancer deaths in the future.
Researchers found that the Retinoblastoma protein targets DNA replication genes during cellular senescence, preventing cancer cells from replicating. This mechanism is crucial for tumor suppression, and its disruption can lead to genomic instability and malignant tumors.
Researchers at Ohio State University have discovered a new molecular network that contributes to abnormal KIT protein abundance in acute leukemia cells. Targeting this network with therapeutic drugs may prove more effective than current standard of care.
Researchers from Ontario Cancer Institute and US scientists have discovered a compound that blocks protein BCL6, a cancer-causing culprit in about half of all non-Hodgkins lymphoma cases. This breakthrough accelerates developing targeted drugs to fight the most common form of non-Hodgkins lymphoma.
Researchers at MIT and Harvard developed a new sensor to measure the rate of cell mass accumulation, finding that individual cells exhibit varying growth rates. The discovery sheds light on how cells control their growth, with implications for understanding cancer development.
Researchers at UEA have discovered a new group of molecules that can inhibit glycosyltransferases, enzymes used by cells to create sugar chains. This breakthrough could lead to significant advances in cancer treatment and therapy.
Researchers have discovered that blocking Mcl-1, a protein inhibiting Bak activation, enables TRAIL to activate Bak and kill resistant tumor cells. This strategy has potential for improving the efficacy of anti-cancer treatment.
A study published in Immunity reveals that immune cells' signals can interfere with the ability of intestinal cells to regenerate, leading to hyper-activation of growth and increasing the risk of colon cancer. Interfering with a protein called dickkopf 1 may aid in controlling inflammatory bowel diseases.
Researchers at Van Andel Institute developed a new model to study prostate cancer, finding that normal secretory cells depend on E-cadherin binding for survival, unlike cancer cells which rely on androgen. This discovery could lead to therapies targeting tumor cells without harming normal cells.
Scientists have successfully grown and loaded empty nano containers with useful chemicals from a plant virus, opening up new areas of research in targeted drug delivery. The technology has potential applications in cancer treatment, delivering drugs directly to diseased cells while sparing healthy ones.
Researchers have developed 'smart' nanoparticles that can selectively target and destroy colorectal cancer cells using near-infrared laser radiation, leaving healthy tissue intact. The goal is to improve the technology for testing in human clinical trials and explore its potential as a new cancer treatment.
A new sensor array made of carbon nanotubes can detect single molecules of hydrogen peroxide emanating from a single living cell. The detection could lead to new targets for potential cancer drugs and diagnostic devices for some types of cancer.
Researchers identified a new drug target to inhibit genes vital for leukaemia cell growth, which could prevent disease progression. Targeting Stat5 may provide a novel therapeutic approach for treating acute and chronic leukaemias.
Researchers at the University of Pennsylvania School of Medicine have found that mixed lineage leukemia (MLL) cancer cells rely on a normal version of an associated protein to stay alive. Deleting this gene from leukemia cells blocks uncontrolled growth triggered by a fusion protein, suggesting that it is essential for MLL proliferation.
New research from UNC suggests that acetylation of metabolic enzymes plays a key role in regulating cellular metabolism. The study identified approximately 1,000 new proteins with acetyl groups, expanding the previously recognized repertoire of 50, and found that altering metabolic fuels can alter acetylation levels.
Researchers at U-M Comprehensive Cancer Center found a third protein, TIN2, that overrides Fbx4 by binding to TRF1, stabilizing it and keeping telomere length in control. This finding could lead to developing a drug to block Fbx4, impacting all cancer types.
Researchers developed a method to distinguish driver mutations from passenger mutations in cancer genomes by analyzing deletions at known tumour suppressor genes and fragile sites. The study found at least one in nine genes can be removed without killing human cells.
Using hydrogels to deliver small interfering RNA (siRNA) into cancer cells has been shown to effectively target and kill them. The technique inhibits EGFR growth, increasing programmed cell death and enhancing the effects of traditional chemotherapy.
Researchers at Georgia Institute of Technology have developed a system using gold nanoparticles that can kill cancer cells by targeting their nuclei, preventing cell division and inducing apoptosis. This breakthrough offers a promising treatment for cancers in areas inaccessible to traditional laser-based therapies.
Researchers at Yale University have streamlined the synthesis of a family of compounds known as kinamycins, which are naturally produced by bacteria and show potent toxicity. By reducing the number of steps required to synthesize them from 24 to 12, the team can now prepare these molecules in larger quantities for further studies.
A team of scientists is researching self-cannibalizing cancer cells to develop new therapies. Cancer cells can stop proliferating and consume themselves when stressed, allowing them to survive enormous amounts of stress.
Scientists have revealed the 3-D structure of vesicular stomatitis virus (VSV), a model system for understanding negative-strand RNA viruses. The research provides insights into the assembly process and proposes a model for viral structure, potentially leading to advances in cancer treatment and HIV vaccines.
Researchers have found a genetic tool that specifically alters gene expression in the endometrium, leading to rapidly progressing cancer in mice. The Lkb1 gene is mutated in many other types of human cancers and regulates pathways contributing to aggressive cancer cell formation.
A team of researchers mapped the fragile sites of the yeast Saccharomyces cerevisiae genome, revealing a key mechanism in DNA repair. Inactive genes are wrapped more tightly than active ones, making them vulnerable to damage.
Scientists at Rice University have discovered a new technique for singling out individual diseased cells and destroying them with tiny explosions using lasers and nanoparticles. The method, known as nanobubbles, can be tuned to create either small, harmless bubbles or large bubbles that burst the cells.
Researchers at Medical College of Georgia have discovered celastrol's potential to target cancer cells by inhibiting the heat shock protein 90. Celastrol induces protein clustering, which inactivates it, helping to reduce cancer growth. Future studies aim to use more potent derivatives in combination with other therapeutic agents.
Researchers at the University of Michigan have shown that small mechanical forces can control gene expression by reducing DNA looping, a common mechanism for gene regulation. The study provides new insights into how cells regulate themselves and could lead to new understandings of diseases such as cancer and cardiac disease.
Researchers found that prostate cancer cells can lose the DAB2IP protein, which acts as scaffolding to prevent cell growth, allowing them to break free and spread to other parts of the body. The study suggests that restoring this function could inhibit cancer progression.
Researchers developed a microfluidic device that selectively isolates targeted cells, including cancer cells, based on their electrical properties. This breakthrough enables the screening of entire blood samples for cancer detection.
A study at Cold Spring Harbor Laboratory has identified three molecular factors that contribute to high levels of PK-M2 in cancer cells, which promotes rapid cell proliferation and tumor growth. The researchers found that forcing a reduction in the levels of these factors could reverse the Warburg effect and restore normal metabolism.
Researchers at the University of Illinois Chicago have discovered a mechanism for cell flattening, a crucial step in processes like clot formation and cancer spread. The study found that a G protein interacts with integrins to inhibit RhoA, allowing cells to flatten and move.
Cancer cells co-opt the fat metabolism pathway to produce free fatty acids, promoting aggressive behaviors and potentially linking obesity to cancer progression. This discovery offers a new target for treating malignant cancers and preventing cancer progression.
Researchers have developed a vaccine that appears to reduce leukemia cells in some chronic myeloid leukemia (CML) patients taking the drug Gleevec. The study found significant reductions in residual cancer cells and complete remission in seven patients.
The androgen receptor, crucial for male hormones like testosterone, also plays a significant role in the body's ability to heal wounds. Blocking this receptor accelerates wound healing by reducing inflammation.
Researchers found TRAP-1 to be highly expressed in prostate cancer cells, inhibiting cell death, while Gamitrinib treatment killed cancer cells but not healthy ones. This suggests targeting TRAP-1 may provide a new approach for treating advanced prostate cancer.
A new study found that relatives of boys with hypospadias and cryptorchidism do not have an increased risk of developing testicular germ cell cancer. Researchers followed over 2 million men born since 1953, identifying a total of 5,441 patients with the condition.
Researchers found that restricting glucose intake extends normal human cell lifespan and impairs precancerous cell growth through epigenetic control. The study, published in the FASEB Journal, could lead to novel approaches to extend human lifespan and prevent cancer.
Researchers at Texas A&M University have discovered a potential new approach to slowing the spread of cancer by modifying the structure of malignant cells. By understanding how signals alter the cytoskeleton, they may uncover new targets for treatment.
Researchers have identified a crucial step in apoptosis, a process that removes unwanted cells to prevent cancer development. Understanding the role of proteins Bak and Bax could lead to the development of drugs regulating cell death, with potential applications in treating cancer and degenerative disorders.
Researchers at UAB have discovered that restricting glucose consumption can extend the life of healthy human-lung cells and speed the death of precancerous cells. The study found that calorie reduction aids the body's natural ability to kill off cancer-forming cells through epigenetic control of telomerase and p16 expression.
A new study by Brown University and Caltech scientists reveals how cells interact with their environment, including the force exerted on tissues as they move. The research provides the most complete assessment to date of cell movement in three dimensions.
Researchers used DNA sequencing technology to analyze genetic mutations in small-cell lung cancer cells and compared them to normal DNA. They found over 23,000 mutations and identified a new gene, CHD7, involved in lung cancer.
Researchers at Tel Aviv University have discovered a new mechanism for DNA packaging that affects RNA splicing, leading to differences in protein production. This finding has significant implications for disease diagnosis and treatment, including the development of innovative drug therapies.
Researchers have identified a protein that can be disabled to prevent cancer cells from forming in children with mixed-lineage leukemia. The discovery could lead to the development of more effective treatments for this devastating disease.
Researchers created algorithm to systematically analyze cancer cell pathways and reveal regulatory code in DNA. This breakthrough could lead to more precise treatments and improve patient outcomes.
A cancer researcher has identified a protein called RanBPM that regulates apoptosis, a process by which damaged cells self-destruct. The discovery has implications for both diagnosing and treating cancer, as it may enable targeted therapy to reactivate apoptosis and kill cancer cells.
MIT chemists develop a new platinum compound called mitaplatin that selectively destroys tumor cells while leaving normal cells intact. The compound combines cisplatin and dichloroacetate to target cancer cells' altered mitochondrial properties.
Research reveals that HPV16 oncoprotein silences the production of interferon-kappa, a key protein in the innate immune response. This allows cancer cells to grow unchecked, highlighting a potential new target for cancer treatment. The study provides insight into the mechanisms by which high-risk HPV types cause cervical cancer.
Researchers at Johns Hopkins University discovered a fibrous structure that holds the nucleus in place, which could provide clues to diseases such as cancer, muscular dystrophy, and progeria. The perinuclear actin cap is a domed structure of bundled filaments that sits above the nucleus, controlling its shape and potentially affecting ...