Articles tagged with Cancer Cells
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Researchers have found a genetic tool that specifically alters gene expression in the endometrium, leading to rapidly progressing cancer in mice. The Lkb1 gene is mutated in many other types of human cancers and regulates pathways contributing to aggressive cancer cell formation.
Scientists have revealed the 3-D structure of vesicular stomatitis virus (VSV), a model system for understanding negative-strand RNA viruses. The research provides insights into the assembly process and proposes a model for viral structure, potentially leading to advances in cancer treatment and HIV vaccines.
Scientists at Rice University have discovered a new technique for singling out individual diseased cells and destroying them with tiny explosions using lasers and nanoparticles. The method, known as nanobubbles, can be tuned to create either small, harmless bubbles or large bubbles that burst the cells.
Researchers at Medical College of Georgia have discovered celastrol's potential to target cancer cells by inhibiting the heat shock protein 90. Celastrol induces protein clustering, which inactivates it, helping to reduce cancer growth. Future studies aim to use more potent derivatives in combination with other therapeutic agents.
Researchers at the University of Michigan have shown that small mechanical forces can control gene expression by reducing DNA looping, a common mechanism for gene regulation. The study provides new insights into how cells regulate themselves and could lead to new understandings of diseases such as cancer and cardiac disease.
Researchers found that prostate cancer cells can lose the DAB2IP protein, which acts as scaffolding to prevent cell growth, allowing them to break free and spread to other parts of the body. The study suggests that restoring this function could inhibit cancer progression.
Researchers developed a microfluidic device that selectively isolates targeted cells, including cancer cells, based on their electrical properties. This breakthrough enables the screening of entire blood samples for cancer detection.
A study at Cold Spring Harbor Laboratory has identified three molecular factors that contribute to high levels of PK-M2 in cancer cells, which promotes rapid cell proliferation and tumor growth. The researchers found that forcing a reduction in the levels of these factors could reverse the Warburg effect and restore normal metabolism.
Researchers at the University of Illinois Chicago have discovered a mechanism for cell flattening, a crucial step in processes like clot formation and cancer spread. The study found that a G protein interacts with integrins to inhibit RhoA, allowing cells to flatten and move.
Cancer cells co-opt the fat metabolism pathway to produce free fatty acids, promoting aggressive behaviors and potentially linking obesity to cancer progression. This discovery offers a new target for treating malignant cancers and preventing cancer progression.
Researchers have developed a vaccine that appears to reduce leukemia cells in some chronic myeloid leukemia (CML) patients taking the drug Gleevec. The study found significant reductions in residual cancer cells and complete remission in seven patients.
The androgen receptor, crucial for male hormones like testosterone, also plays a significant role in the body's ability to heal wounds. Blocking this receptor accelerates wound healing by reducing inflammation.
Researchers found TRAP-1 to be highly expressed in prostate cancer cells, inhibiting cell death, while Gamitrinib treatment killed cancer cells but not healthy ones. This suggests targeting TRAP-1 may provide a new approach for treating advanced prostate cancer.
Researchers found that restricting glucose intake extends normal human cell lifespan and impairs precancerous cell growth through epigenetic control. The study, published in the FASEB Journal, could lead to novel approaches to extend human lifespan and prevent cancer.
A new study found that relatives of boys with hypospadias and cryptorchidism do not have an increased risk of developing testicular germ cell cancer. Researchers followed over 2 million men born since 1953, identifying a total of 5,441 patients with the condition.
Researchers at Texas A&M University have discovered a potential new approach to slowing the spread of cancer by modifying the structure of malignant cells. By understanding how signals alter the cytoskeleton, they may uncover new targets for treatment.
Researchers at UAB have discovered that restricting glucose consumption can extend the life of healthy human-lung cells and speed the death of precancerous cells. The study found that calorie reduction aids the body's natural ability to kill off cancer-forming cells through epigenetic control of telomerase and p16 expression.
Researchers have identified a crucial step in apoptosis, a process that removes unwanted cells to prevent cancer development. Understanding the role of proteins Bak and Bax could lead to the development of drugs regulating cell death, with potential applications in treating cancer and degenerative disorders.
A new study by Brown University and Caltech scientists reveals how cells interact with their environment, including the force exerted on tissues as they move. The research provides the most complete assessment to date of cell movement in three dimensions.
Researchers used DNA sequencing technology to analyze genetic mutations in small-cell lung cancer cells and compared them to normal DNA. They found over 23,000 mutations and identified a new gene, CHD7, involved in lung cancer.
Researchers have identified a protein that can be disabled to prevent cancer cells from forming in children with mixed-lineage leukemia. The discovery could lead to the development of more effective treatments for this devastating disease.
Researchers at Tel Aviv University have discovered a new mechanism for DNA packaging that affects RNA splicing, leading to differences in protein production. This finding has significant implications for disease diagnosis and treatment, including the development of innovative drug therapies.
Researchers created algorithm to systematically analyze cancer cell pathways and reveal regulatory code in DNA. This breakthrough could lead to more precise treatments and improve patient outcomes.
A cancer researcher has identified a protein called RanBPM that regulates apoptosis, a process by which damaged cells self-destruct. The discovery has implications for both diagnosing and treating cancer, as it may enable targeted therapy to reactivate apoptosis and kill cancer cells.
MIT chemists develop a new platinum compound called mitaplatin that selectively destroys tumor cells while leaving normal cells intact. The compound combines cisplatin and dichloroacetate to target cancer cells' altered mitochondrial properties.
Research reveals that HPV16 oncoprotein silences the production of interferon-kappa, a key protein in the innate immune response. This allows cancer cells to grow unchecked, highlighting a potential new target for cancer treatment. The study provides insight into the mechanisms by which high-risk HPV types cause cervical cancer.
Researchers at Johns Hopkins University discovered a fibrous structure that holds the nucleus in place, which could provide clues to diseases such as cancer, muscular dystrophy, and progeria. The perinuclear actin cap is a domed structure of bundled filaments that sits above the nucleus, controlling its shape and potentially affecting ...
Research on heparanase-specific shRNA reveals its potential as a novel therapeutic strategy for human gastric cancer. The study successfully knocked down HPA expression in gastric cancer cells, leading to decreased invasiveness and metastasis. This finding suggests a new approach for treating cancers overexpressing HPA.
Researchers have identified a number of proteins that allow them to distinguish between cancer and normal cells with high accuracy. This discovery may lead to the development of drugs specifically targeting these proteins to inhibit their activation.
A new study by Université de Montréal scientists has developed a simple way to decouple one cellular network from another, allowing researchers to distinguish between different cell functions. This discovery could have applications in cancer research, where blood-thirsty cells can be targeted and their growth slowed.
Researchers developed a tool to visualize bacterial communication, revealing that chemical signals function simultaneously in interspecies interactions. This approach may aid in understanding microbial interactions with human cells, leading to novel immune system modulators and anti-infectives.
Researchers at Yale University developed synthetic molecules that enhance the body's immune response to HIV and prostate cancer cells. The molecules work by binding to antibodies and proteins on infected cells, triggering an immune response and preventing infection.
A new study found that preventative brain radiation therapy for lung cancer patients reduces the risk of developing brain metastases by 10%, but negatively affects short-term and long-term memory. Despite this, the treatment has no significant impact on survival or quality of life.
A team of researchers at the University of Pennsylvania School of Medicine has identified a small molecule that inhibits heat shock protein HSP70, which is overexpressed in tumor cells. The inhibitor, called PES, blocks HSP70's stress-relieving functions and induces cell death by disrupting autophagy.
Researchers from Texas A&M University and the University of Cincinnati have discovered a new set of essential telomere proteins in Arabidopsis, a plant found worldwide. The team identified human counterparts to these proteins, which could help understand human cancers and cellular aging.
Arizona State University scientists will study cancer cells as physical objects, examining forces, mechanical properties, and electrical properties to develop new methods for arresting tumor growth and metastasis. The goal is to understand cancer's role in the biological scheme of things and its behavior as a physical object.
A new Johns Hopkins Engineering in Oncology Center will study physical underpinnings of cancer growth and spread, aiming to develop innovative therapies and diagnostic tools. Researchers hope to gain a better understanding of the complex forces involved in metastasis.
Researchers found a two-tier defense mechanism in the DNA of naked mole rats, which expresses a gene called p16 that stops cell proliferation when too many cells crowd together. This discovery could potentially lead to new cancer treatments for humans.
Researchers exploit a relationship between the KRAS and TBK1 genes, known as 'synthetic lethality,' to kill cancer cells that are resistant to standard treatments. By targeting TBK1, the strategy bypasses the difficulties in treating KRAS-driven tumors, offering a new approach against aggressive cancers.
The Penn team demonstrated a novel method for controlled formation of patchy particles using charged, self-assembling molecules. The positive electrical charges of calcium ions form bridges between negatively-charged polymers, creating patchy structures that can be used as drug-delivery vehicles or in small batteries.
A new class of compounds containing Ruthenium and Osmium has been found to be highly effective in killing ovarian and colon cancer cells, even those resistant to Cisplatin. The discovery is a significant step forward in the field of medicinal chemistry.
A team of international molecular scientists has discovered a fast mechanism by which cells communicate changes, such as location during cancer spread, to adjacent cells. This discovery sheds light on cell behavior and could lead to the development of new drugs for diseases like cancer, rheumatoid arthritis, and Alzheimer's disease.
A human liver fluke contributes to the development of bile duct (liver) cancer by secreting granulin, a growth hormone that causes uncontrolled cell growth. The International Agency for Research on Cancer classifies the parasite as a Group I Carcinogen.
Researchers discovered that plasmacytoid dendritic cells assist in the growth of multiple myeloma cells by promoting their survival and shielding them from drugs. Compounds targeting pDCs restore immune system function, stopping myeloma cell growth.
Xiaoqi Liu's research found that cytoplasmic linker protein-170 plays a major role in proper cell duplication and DNA distribution. The absence of this protein can lead to uneven DNA distribution, resulting in cancerous cells. Without proper regulation, cells may become confused, leading to an increased chance of becoming cancerous.
Scripps researchers have discovered the Nbs1 component of the Mre11-Rad50-Nbs1 complex, which helps cells repair severe DNA damage. The complex is critical in preventing cancer development and can also repair diseased cells targeted by chemotherapy.
Researchers decipher missing piece of MRN complex, revealing how Nsb1 bends and channels molecules for homologous recombination. This discovery could lead to improved cancer treatments with fewer side effects.
Researchers have successfully reprogrammed human umbilical cord blood cells into cells with properties similar to human embryonic stem cells. This breakthrough identifies cord blood as a potential alternative to adult cells for generating cells with theoretically limitless potential.
Case Western Reserve University scientist Dave Wilson has developed a cryo-imaging system that enables the identification of single molecules, counting of cells in organs, and comparison of normal and abnormal tissues. The system produces incredibly detailed images showing the effectiveness of different drug therapies.
A study published in the British Journal of Cancer found that 60% of prostate cancer cases lack aggressive protein Hsp-27, allowing for careful monitoring instead of treatment. The research could lead to a blood test to distinguish between aggressive and non-aggressive forms of prostate cancer.
A new study has associated Merkel cell polyomavirus (MCPyV) with Merkel cell carcinoma, a rare and aggressive skin cancer. The study found that nearly all patients with Merkel cell carcinoma carried antibodies against MCPyV, suggesting a strong link between the virus and the disease.
The team found that the particles' interactions allow them to heat up better when exposed to an alternating magnetic field, destroying cancer cells without harming surrounding tissue. This breakthrough could lead to more effective treatment methods and design of better nanoparticles.
Johns Hopkins researchers find two force-sensitive proteins, myosin II and cortexillin I, cooperate to sense cell shape disturbances and resculpt cells for smooth division. This discovery could lead to new targets for diagnosing and treating diseases like cancer.
Researchers at UCSB have developed a novel drug delivery system that uses nanoparticles and laser exposure to deliver siRNA into cancer cells, providing temporal and spatial control over gene expression. The technique has potential applications in delivering multiple drugs against diverse biological targets.
Researchers at Fox Chase Cancer Center have identified a unique method to inhibit signaling enzymes called kinases using the small molecular inhibitor IPA-3. By targeting PAK1's regulatory domain, IPA-3 is highly selective and takes a more-or-less backdoor approach to shutting down cancer cells.
A Syracuse University research team discovered a second molecular switch within the Mixed Lineage Leukemia protein complex, which could be exploited to prevent abnormal cell production. The W-RAD switching mechanism signals cells to create multiple copies of cancer cells.
A team of researchers from Mayo Clinic and Harvard Medical School found that the protein FOXO3a, previously believed to prevent cancer development, can actually fuel tumor growth in certain situations. This discovery sheds light on the complex roles proteins play in cancer progression.
A small molecule called DAz-2 helps identify over 190 proteins involved in diverse biological processes affected by reactive oxygen species (ROS). The tool will aid in understanding chronic oxidative stress and its role in diseases.
University of Michigan scientists have identified a fundamental mechanism regulating immune T-cell activity, with implications for conditions like autoimmune diseases, cancer, and organ transplants. The discovery reveals that regulatory T cells influence aggressive immune cells through redox chemistry.
Researchers found a way for healthy cells to take charge of cancerous cells by opening up communication channels, stopping them from developing into tumors. The chemicals, known as kinase inhibitors, appear to be relatively non-toxic and can persist even when withdrawn.