Articles tagged with Cell Cycle
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Scientists have developed a new fluorescent protein probe to study cyclic AMP activity in living cells. The probe allows for real-time monitoring of cyclic AMP's impact on cellular responses, revealing its importance in various biological processes.
Scientists at Virginia Tech have developed a new class of inhibitors that target the Pin1 enzyme, which regulates cell division in cancer cells. The researchers found that one of the inhibitors was 23 times more effective than a similar compound, offering promise for treating various types of cancer including breast and prostate cancer.
Researchers at Boston College are studying the molecular mechanisms of B-1a cells, which can lead to autoimmune diseases and leukemias like chronic lymphocytic leukemia. The new NIH-funded program project aims to understand how these cells proliferate and enter the cell cycle.
Researchers identified frequent BRAF mutations in intermittent sun-exposed skin melanomas, but rare mutations in chronically sun-damaged or unseen skin. Additionally, bladder cancer cell lines showed defective checkpoint function, suggesting barriers to carcinogenesis. These findings may inform therapeutic strategies for these diseases.
The Mayo Clinic research reveals a molecular mechanism involved in cell cycle regulation of the BRCA1 tumor suppressor gene. The team found that phosphorylation is required at certain stages to activate proteins associated with the BRCA1 gene.
Researchers at UGA discovered a gene called CUL-4 that regulates DNA replication and prevents uncontrolled cell growth. The study used the tiny worm Caenorhabditis elegans as a model organism and found that CUL-4 promotes the degradation of a protein required for DNA replication initiation.
Researchers from Virginia Tech have validated a mathematical model of cell division using experiments on frog egg extracts. They found that the control system is bi-stable and hysteretic, requiring specific levels of cyclin to regulate mitosis.
Scientists discovered that a protein called ATR protects fragile sites from breaking during DNA replication, controlling genome stability. Fragile site breaks are common in tumor cells and near genes associated with tumors, suggesting defects in the ATR pathway may contribute to cancer progression.
A recent study found that high levels of cyclin E are closely associated with aggressive breast cancer, making it a powerful predictive marker. The presence of low molecular weight forms of cyclin E also showed strong prognostic value, indicating a higher risk of recurrence and spread.
Researchers found that Clb2 is the real trigger for yeast cell division, contradicting previous findings on Clb5. This discovery has implications for treating cancer, as it reveals a new way to understand the cell cycle mechanism.
Researchers discovered that RING Finger proteins play a crucial role in targeting cellular molecules for proteolysis during the cell cycle. This process is essential for regulating cell growth and preventing cancer. The study provides new insights into how cells recognize which proteins to eliminate and when.
Leland Hartwell received the Nobel Prize for his work on cell cycle control, discovering over 100 genes involved in regulating cell division. His research has led to a deeper understanding of normal cellular function and the molecular basis of diseases like cancer.
Scientists have developed a technique to map the circuitry underlying fundamental life processes, shedding light on diseases such as cancer. The study reveals a circular network of regulators regulating regulators controlling the cell cycle, providing new insights into cellular processes and potential therapeutic targets.
Recent research reveals a master regulator protein that prevents DNA replication at the wrong time in the cell cycle, ensuring each progeny cell has the correct number of gene-bearing chromosomes. This discovery could lead to new design principles for operating autonomous devices.