Articles tagged with Cell Extracts
Researchers at the University of Houston have discovered a potential therapeutic strategy for counteracting muscle wasting in pancreatic cancer by blocking a specific cell pathway. Muscle wasting, also known as cachexia, is a debilitating syndrome affecting 60-85% of patients with pancreatic cancer.
Researchers discovered that NDRG3 slows down cellular transport to conserve energy during low-oxygen conditions. The protein acts as a sensor for lactate, which accumulates in cells when oxygen is limited.
Scientists have discovered a protein called SCEP3 that ensures even chromosome segregation in plants, preventing infertility and genetic diseases. This finding has implications for plant breeding and understanding human fertility, with the equivalent gene SIX6OS1 potentially playing a role in promoting correct chromosome segregation.
Researchers visualize extracellular matrix in living organism and discover principles of self-organization, indicating large fluctuations in protein production between individual cells. The structure forms rounded or polygonal boundaries that dynamically evolve as the organism grows, making it resemble a foam.
Dr. Cara Boutte is studying how certain bacteria grow by building their cell walls, which could lead to more effective antibiotics. Understanding this growth pattern could help scientists develop targeted and effective treatments for infections like tuberculosis.
Researchers have studied the mechanism of action of bioactive compounds from papaya, passion fruit, and medicinal plant extracts. Modified pectins extracted from these plants show potential as supplements or food ingredients to boost biological activity against colon cancer and gut microbiota.
Researchers developed mucoadhesive films combining xyloglucan and green tea extract to treat oral mucositis, a painful inflammation caused by cancer treatment. The films demonstrated high strength and adhesion forces comparable to commercial products, showing promise as a novel treatment for oral mucositis.
A team of University of Florida chemical engineers has developed a microfluidic device for DNA purification that extracts genomic DNA without centrifuges or magnetic beads. The device uses fluid flow and electric fields to remove contaminants, resulting in more accurate results and reducing DNA fragmentation.
Researchers at Osaka Metropolitan University have discovered yeast cell wall-derived proteins that exhibit high emulsifying activity, comparable to commercial casein emulsifier. These easily released protein molecules could potentially replace emulsifiers derived from milk, eggs, and soybeans, reducing allergenic concerns.
Researchers at Tokyo University of Science have successfully captured viral infection process under a light microscope using the giant Mimivirus. The footage showcases the proliferation of the virus and its release from cells, highlighting its biological significance in ecosystems.
Scientists use machine learning-based classifiers to differentiate lung cancer and noncancer based on urinary miRNA ensembles. The study reveals high specificity and sensitivity in detecting early-stage lung cancer, offering new hope for improved patient outcomes.
Researchers found that fermented black garlic extract reduced tumor aggressiveness parameters, including cell proliferation, without affecting normal prostate cells. The extract altered key signaling pathways related to inflammation, suggesting its potential as a dietary supplement to prevent or slow down prostate cancer progression.
Researchers at KAUST have developed a new cooling system that extracts water from the air using gravity, eliminating the need for electricity. The system can double the rate of water collection compared to alternative technologies and offers significant energy savings.
Researchers have made breakthroughs in hot carrier solar cells by studying electron tunneling and collection, increasing generation and extraction. The study revealed that a new system comprising AlGaAs and GaAs materials can harness valley photovoltaics and realize solar cells beyond the current single bandgap limits.
Researchers have identified two compounds with strong antivirulence activity from actinobacteria in the Arctic Sea, targeting EPEC bacteria that cause severe diarrhea. The compounds inhibit virulence factor formation and binding to host cells, reducing disease severity and potential for resistance.
Researchers at Van Andel Institute discovered over 1,000 previously undetected proteins in common metabolite samples that persist despite extraction methods. A novel protocol for removing these proteins was developed to improve future metabolomics experiments.
Researchers found that bubbling olive products before oil extraction decreases oil quality. The study measured absolute phenolic compounds, antioxidant capacity, and acidity levels in bubbled oil (BO) compared to virgin olive oil (VOO). BO had lower antioxidant properties and higher acidity levels than VOO.
Researchers have developed new optical tweezers that can stably trap large and irregularly shaped particles using contour-tracking technology. This advancement could expand light-based trapping to a wider range of objects, including groups of cells, bacteria, and microplastics.
Researchers at the University of Surrey have developed a technique to study lipids in live cancer cells, one by cell. This breakthrough could lead to more targeted treatments and better understanding of how individual cells communicate with their neighbors.
NeXT Personal assay detects up to ~1,800 somatic variants specific to the patient's tumor with a detection threshold of 1.67 PPM and 99.9% specificity. The assay showed linearity over a range of 0.8 to 300,000 PPM.
The T2oFu method offers a new approach to quantitative phase and polarization-sensitive tomography, enabling high-contrast images of muscle fibers with implications for diagnosing skeletal myopathies. The technique has been successfully tested on heart tissue samples with cardiac amyloidosis, providing promising results.
Researchers have developed a nanosurgical tool that enables them to study individual living cancer cells in real-time, allowing for vital understanding of how they react to treatment and change over time. This breakthrough could lead to more effective cancer medication, particularly for glioblastoma, the deadliest form of brain tumour.
Researchers at NTNU have developed a new method to extract better alginate from cultivated kelp by using epimerases. This breakthrough allows for cost-effective production and opens up new market opportunities, benefiting both the kelp farmers and the industry.
Researchers found that Angelica gigas extract improves vascular function in high-fat diet rats, reversing endothelial dysfunction and increasing NO bioavailability. The extract regulates IRE1α sulfonation and RIDD signaling, promoting NO production via the SIRT1-eNOS axis.
Researchers at MIT have developed an alternative method to study molecular signals in cells, allowing them to track up to seven different molecules simultaneously. The technique uses fluorescent proteins that flicker on and off at different rates, enabling the tracking of specific cellular functions over time.
Researchers developed a technique to capture extracellular vesicles using sustainable wood cellulose-based nanofiber sheets, revealing new insights into cancer treatment. The technology has the potential to revolutionize early cancer diagnosis and open up personalized medicine.
Researchers have developed a novel optical on-demand droplet release (OODR) system that uses lasers to efficiently sort and export single-cell cultures from static droplet arrays. The system reduces reagent usage and sample size, while maintaining cell viability and analysis accuracy.
Researchers at UTSA are studying the bioactive properties of Sweet Annie, a plant used in traditional Chinese medicine for over 2,000 years. The study reveals that arteannuin B from the plant has anti-COVID and anti-glioblastoma properties, offering new avenues for targeted therapy.
A new technique converts kale waste into phytochemicals for use in health and personal care products, preserving potency and using non-toxic solvents. The method reduces energy consumption and emissions, making it attractive for industry adoption and supporting a circular economy.
Researchers developed a gene signature called CisSig to predict cancer patients' response to cisplatin. The approach aims to overcome the obstacle of interpreting gene signatures in the human body and has been validated in muscle-invasive bladder cancer patients.
Studies elucidate key aspects of traditional Chinese compounds and modern cancer therapeutics, highlighting the efficacy of R. serra in treating colitis and identifying active components of Gan Cao in treating pneumonia. A new radiolabeled antibody-based probe for detecting PD-L1 expression in cancers also provides a novel approach to ...
Researchers have developed an edible plant-based ink derived from food waste to create cost-effective scaffolds for culturing meat. This innovation could significantly reduce the cost of large-scale cultured meat production, making it more affordable and environmentally friendly.
Researchers developed a new method to study membrane proteins in their native environment, the cell, using electron spin resonance spectroscopy. This technique allows for precise determination of protein properties and could lead to better understanding and targeting of membrane proteins involved in anti-cancer drug resistance.
A team of researchers from Ritsumeikan University in Japan has elucidated the mechanism behind the liquid-solid phase transition of FUS protein that leads to ALS. They discovered a new therapeutic target, arginine, which suppresses FUS aggregation and could delay ALS progression.
Researchers discover that type 1 TPCs encode SV channels in plant vacuoles, while type 2 TPCs likely encode distinct ion channels. This study provides functional and evolutionary insights into the TPC family in plants, shedding light on their role in plant growth and defence mechanisms.
Researchers at Northwestern University have developed optimized yeast extracts for cell-free biosynthesis, enabling faster and more efficient chemical production. This breakthrough integrates cellular engineering with cell-free systems, paving the way for sustainable alternatives to current petrochemical processes.
A team of researchers has identified a novel splicing mechanism for human short introns, involving the distinct factor SPF45. This discovery sheds light on alternative splicing and its potential applications in cancer treatment.
Researchers at Virginia Tech and the University of Cadiz have developed a method to extract antioxidants from grape seeds using carbon dioxide, producing an extract with greater potency without toxic chemicals. The new process takes 25% less time and can be fully automated.
Researchers have identified a water extract from potatoes that inhibits the attachment of certain bacteria, such as oral streptococcus and E. coli, to their target tissue. This finding could provide a new direction for antibiotic research and potentially help solve the growing problem of antibiotic resistance.
Researchers found that extracts from Scutellaria baicalensis significantly reduce cellular damage due to free radicals. The extract helped cells regain their ability to contract rhythmically after simulating cardiac arrest, reducing cell death by 47% compared to untreated cells.
Scientists found that osteonectin, a bone protein, attracts prostate cancer cells and stimulates their invasion. This discovery has important implications for the treatment of prostate cancer and other bone-seeking cancers.