Articles tagged with Downregulation
A UC Riverside-led research team found that obesity causes chronic changes in the brain, leading to reduced connections between neurons and lower testosterone levels. The study suggests that the primary site of obesity's effects on reproductive function is the brain, rather than the testes or pituitary gland.
The study found that downregulation of angulin-1/LSR leads to increased claudin-2 expression and altered cell metabolism in human lung adenocarcinoma cells, promoting malignancy. Researchers identified AG1478 and EW-7197 as potential therapeutic agents.
A recent study analyzed 7,301 metastatic breast cancer patients with MTAP loss, revealing younger age, higher TNBC cases, and BRCA1 mutations. The findings also suggest potential therapeutic agents targeting PRMT5 and MTA2 in MTAP-deficient cancers.
Researchers investigated the effects of everolimus on the STAT3/HIF-1α/VEGF pathway in TP53 mutant cell lines and xenograft models. Everolimus treatment significantly inhibited cell growth and reduced tumor angiogenesis and lymphangiogenesis.
Researchers found that MK256 induced differentiation and maturation in leukemia stem cells, inhibiting proliferation of AML cell lines. The study also showed dose-dependent inhibition of the STAT pathway in both in vitro and in vivo studies.
Researchers found that knockdown of secreted frizzled-related protein 4 (SFRP4) suppresses SASP and improves age-related skin phenotypes. This suggests a potential candidate for the development of new skin rejuvenation therapies.
Researchers discovered that stress triggers the formation of molecular droplets in the transcription regulator NELF, leading to a rapid downregulation of gene activity. This mechanism is essential for cell survival upon stress, as cells lacking proper NELF condensation experience higher death rates during stress.
Cells form 'lockdown' strategy by slowing down gene activity when stressed, allowing resources to be diverted for crisis response. NELF protein condensation plays key role in this process.
A research group at Hiroshima University found that downregulated spinal astrocyte connexin43 expression leads to sustained neuropathic pain following peripheral nerve injury. Restoring Cx43 function via adenovirus vector may reverse mechanical hypersensitivity and modulate glutamatergic neurotransmission.
A study published in PLoS Medicine found that CD36 deficiency leads to choroidal involution, a key feature of dry age-related macular degeneration. The research also showed that COX-2 down-regulation plays a crucial role in this process.