Articles tagged with Epithelial Cells
Scientists have developed a way to generate and correct specific lung cells using pluripotent stem cells, which could lead to new therapies for conditions like neonatal respiratory distress and COPD. The corrected cells were able to produce essential surfactant, previously an elusive milestone.
A study found that macrophages can produce Interleukin-10 (IL-10), a healing factor, which promotes wound repair in the intestine. This discovery could lead to new treatments for inflammatory bowel disease (IBD). The researchers used a colonoscope with biopsy forceps to create a wound in mice and observed its healing process.
A Penn State researcher has received a $7.3 million grant to investigate the Ah receptor's impact on immune function and epithelial barrier integrity. The study aims to understand how activating the receptor enhances or disrupts the immune response in different tissues, with potential implications for diseases such as colon cancer.
Epithelial tumours can grow independently of their microenvironment, driven by a feedback amplification loop that activates the JNK stress signalling pathway. This internal mechanism triggers proliferation in non-proliferating cells, leading to chromosomal instability and loss of epithelial polarity.
Researchers discovered mesenchymal cells drive lung cell formation through molecular interactions, guiding the production of alveolar and airway cells. This finding offers new avenues for treating lung disorders like asthma and emphysema.
Researchers at UMass Amherst have found that layered black phosphorous (BP) nanoparticle toxicity is dependent on particle size and concentration. The study reveals that BP's cytotoxicity is based on reactive oxygen species generation, disrupting cell membrane integrity in a particle-size-dependent manner.
A team of researchers has discovered a network of genes and genetic regulatory elements in the lining of the intestines that remains remarkably consistent across 420 million years of evolution. This conserved genetic signature is linked to various human diseases, including inflammatory bowel diseases, diabetes, and obesity.
Researchers at LSU Health Sciences Center have discovered a new class of biochemical triggers called elovanoids, which are derived from omega-3 fatty acids. These molecules play a significant role in protecting retinal pigment epithelial and photoreceptor cells from damage.
Researchers discovered that endothelial cells lining blood vessels are not as effective at removing invading bacteria via xenophagy, a process used by epithelial cells. The study suggests that targeting the ubiquitination pathway could lead to new approaches for fighting infections like GAS.
Researchers discovered a unique repair mechanism in zebrafish spinal discs that protects fluid-filled cells from mechanical stress and promotes regeneration. The study suggests that this mechanism, triggered by the release of nucleotides, may be present in humans at early stages but is lost over time.
Researchers have identified a new approach to protect patients from graft-versus-host disease by activating signal paths in the gut. The key to preventing GVHD is protecting the epithelial cells, which can be achieved by using RIG-I and STING proteins.
A recent study reveals that overexpression of the Cd14 gene offers protection against inflammatory bowel disease in mice, enhancing intestinal barrier function. The research suggests that soluble Cd14 could be an interesting new therapeutic target for future clinical research.
Scientists discover that physical arrangement of cells drives cell death and removal, with topological defects causing cells to realign and leading to extrusion. This finding provides new insights into tissue development and control of cell growth.
A UC Riverside researcher has received a two-year grant to explore a therapeutic target for IBD patients with TCPTP mutations. The study aims to correct intestinal barrier defects and reduce inflammation in the intestine.
Researchers discover Fat2 and Lar proteins trigger leading and trailing edge movements during epithelial migration, enabling coordinated tissue movement. This process is crucial for embryonic development, wound healing, and cancer progression.
Researchers demonstrate resveratrol treatments can slow lung function decline and alveolar damage in mouse lungs. The study suggests direct lung administration of resveratrol may be an effective way to prevent chronic lung disease.
A recent study published in Developmental Cell reveals that surface cells play a key role in coordinating tissue movements during early zebrafish development. By reducing surface tension, these cells drive both surface cell layer expansion and inner cell intercalation, resulting in coordinated tissue spreading.
Researchers tracked lens epithelial cells in live zebrafish using genetically engineered fluorescent proteins to determine factors responsible for regulating eye development. The study reveals a complex interplay between E-cadherin and N-cadherin proteins controlling cell movement and adhesion.
Dying cells must be detached from their neighbors to avoid causing further damage to surrounding healthy tissue. The study reveals a carefully choreographed sequence of molecular events that revolve around an interplay between cell adhesions and protein-based contractile cables.
Researchers used a laboratory model of the human gut to study how rotavirus evades the immune system. They found that the virus suppresses the production of IFN proteins aimed at controlling its growth, but adding type I IFN can reduce viral replication.
Researchers from Cincinnati Children's Hospital Medical Center identify novel targets and molecular pathways for IPF, which inflames and scars lung tissues. Analysis of single-cell RNA sequence data reveals genetic markers linked to abnormal cell formation and loss of normal genetic control systems.
Scientists at UC San Diego School of Medicine discovered a key protein involved in protecting epithelial cells during stress, and found that the widely prescribed anti-diabetic drug Metformin works by activating this pathway to prevent cancer. The study provides new insights into the mechanism behind Metformin's tumor-suppressive action.
Dr. Mary Ann Stepp's research on corneal wound healing has been continuously funded for 32 years, with a new $2.8M grant continuing her studies on the role of nerves in wound healing. Her team uses the cornea to study cell migration and epithelial cell adhesion, shedding light on general wound healing and cancer metastasis.
Researchers discovered two distinct mechanisms of cell extrusion from epithelial sheets, with low-density cell crawling and lamellipodia extension being the predominant mechanism at low cell density, while purse-string contraction takes over at high densities.
The study found that when mitochondria are disrupted, stem cells lose their ability to self-regenerate, but stressed cells initiate a growth program leading to tissue regeneration. This highlights the fundamental role of functioning mitochondria in regulating intestinal tissue renewal.
A study by Thomas Hummel found that the nasal cavity's epithelial lining reacts stronger to inhaled odors, making it easier to detect them. The results suggest that retronasal olfaction, which involves smelling through the mouth, is less sensitive but still allows for a more nuanced experience of food and drinks.
Scientists in Japan have successfully demonstrated the transplantation of stem cell-derived retinal cells generated from immunologically matched donor animals without the need for harmful immunosuppressants. MHC-mismatched grafts produced tissue damage and signs of immune rejection, while matched grafts survived without immunosuppression.
Researchers discovered that tumors in fruit flies always originate from specific regions of epithelial tissue, which also occurs in humans and other animals. This finding may lead to a better understanding of cancer development and the discovery of potential treatments.
Researchers discovered a new mechanism explaining BPH development, linking inflammation and cell proliferation. Deleting the androgen receptor in prostate epithelial cells triggers an inflammatory response promoting luminal cell proliferation.
Two studies reveal unique properties of cells in Drosophila larvae that exhibit resistance to cell death and participate in tissue regeneration. Cells from specific 'tumor hotspots' express conserved signaling pathways necessary for tumor formation, while deregulation of these pathways is implicated in human cancer therapy resistance.
Researchers at Baylor College of Medicine have successfully grown human noroviruses in laboratory cultures of human intestinal epithelial cells by adding bile to the cultures. This breakthrough allows researchers to explore and develop procedures to prevent and treat infection, as well as better understand norovirus biology.
A team of researchers has identified the genes controlled by Foxn1, a protein essential for thymus development and function. The study reveals that Foxn1 regulates vital functions in the postnatal thymus, providing insights into its role in autoimmune diseases, vaccination responses, and tumor defense.
Researchers at TSRI have made a breakthrough in treating aqueous deficiency dry eye (ADDE), also known as painful blindness, by injecting regenerative progenitor cells into the lacrimal gland. The treatment shows significant promise in restoring tear production and repairing damaged gland tissue.
A team of researchers at St. Jude Children's Research Hospital discovered that the loss of essential protein Alix leads to hydrocephalus in mice by compromising the epithelial barrier and disrupting tight junctions. This study provides new insights into the molecular mechanisms underlying brain homeostasis.
A study by UNC researchers found that vaping e-cigarettes alters dozens of genes essential for upper airway immune defense, similar to cigarette smoking. This discovery suggests that inhaling flavored liquids in e-cigarettes has consequences on epithelial cell gene expression, potentially increasing the risk of respiratory problems.
A University of California, Riverside study explains how the balance of two transcription factor isoforms in the colon influences the risk of developing colon cancer and colitis. Maintaining a balance between these isoforms is crucial for reducing disease risk.
Researchers found that breast cancer stem cells secrete molecules that allow neighboring cells to detach and metastasize. The hedgehog signaling pathway plays a crucial role in this process, suggesting that targeting it could reduce metastatic potential.
Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. CAPN14 overexpression impairs tight junction protein desmoglein 1.
A study by Children's Hospital Los Angeles researchers found that epidermal growth factor (EGF) negatively regulates epithelial cell shedding in the intestine through a selective MAPK-dependent signaling pathway. This insight could identify potential targets for correcting pathological shedding in diseases like IBD.
Researchers have developed a system called Skinbow that labels individual skin cells in zebrafish with different colors, allowing for real-time tracking of cell populations. This technology enables the study of skin regeneration and cellular behavior in high resolution, providing insights into the dynamics of wound healing.
Research by University of York scientists shows how ketamine causes inflammation and cell death in the bladder, leading to cystitis. The studies found that direct contact with urinary ketamine is critical to the toxicity, ruling out systemic factors.
Researchers at St. Jude Children's Research Hospital identified an enzyme that aids pneumococcus survival by removing its capsule, making it harder to be detected and destroyed by the immune system. This discovery has profound implications for treatment and vaccine strategies to combat invasive pneumococcal disease.
Researchers at MUSC have discovered a safe method for producing retinal pigment epithelial-like cells using human proteins, which can be transplanted to treat macular degeneration. The study also found an effective way to repair the damaged Bruch's membrane beneath these cells, rejuvenating the tissue.
A team of scientists from Singapore and France has revealed the underlying mechanism for the formation and growth of epithelial tubes. They found that the shape and size of these tubes are governed by mechanical forces arising from cell interaction with the extracellular matrix, influencing lumen morphology and elongation direction.
Researchers at University of Tsukuba discover that dying epithelial cells suppress proliferation of regulatory T cells, promoting inflammation. Beneficial bacteria in the gut can help Treg cell proliferation, but this effect is blocked by apoptotic epithelial cells.
Researchers at CNIO have identified a protein called BPTF that is essential for MYC to cause cancer in mouse models, suggesting it could be a new target for future anti-cancer drugs. Inhibiting BPTF reduces the aggressiveness of tumours.
Researchers have discovered two new genes, Aip1 and AncA, that protect human airway cells from damage caused by cigarette smoke. These findings provide a promising approach to developing new treatments for chronic obstructive pulmonary disease (COPD).
Researchers at the University of Geneva discovered that Hydra cells can modify their genetic program by overexpressing genes involved in nervous functions. This study sheds light on cellular plasticity, a phenomenon that could influence research into regenerative medicine and neurodegenerative diseases.
Researchers at UT Southwestern Medical Center have identified a pathogen-sensing molecule called Absent in Melanoma 2 (AIM2) that plays a vital role in maintaining gastrointestinal health. AIM2 detects DNA of harmful microorganisms and regulates inflammation in the gut, which could lead to targeted therapies for inflammatory bowel dise...
A team of researchers from SISSA investigated the mechanism behind biological tissues' resistance to external strain, discovering that cracks appear in multiple places rather than one. This study aims to create artificial materials with similar features for biomedical applications.
Researchers have created a high-resolution gene expression map of newborn mouse inner ear cells, providing insight into their development and differentiation. The findings may lead to the development of cell-based therapies for hearing loss and balance disorders.
A new study from the University of Pennsylvania reveals that disruptions in splicing proteins cause facial and skin barrier defects in mice. The research highlights the importance of these genes in normal development, particularly in the formation of epithelial tissues.
Researchers at Boston University School of Medicine have discovered a new protein, TMIGD1, that protects kidney epithelial cells from injury. Increasing expression of this protein can reduce cell death and potentially prevent kidney failure. The findings could lead to the development of therapeutic agents that target these cells.
A collaborative study led by NUS scientists has identified a universal mechanism that regulates forces during epithelial tissue repair. The researchers found that cells respond to the shape and geometry of gaps in the tissue, with convex edges facilitating faster movement than concave edges.
Researchers discovered that human induced pluripotent stem cells can be differentiated into retinal pigment epithelial cells without immune rejection. This finding provides hope for the development of human stem cell therapies to treat macular degeneration, a condition affecting 30-50 million people globally.
A new study demonstrates the ability to apply a thin coating of viable respiratory epithelial cells to tissue engineered constructs using a commercially available spray device, providing a promising approach for repairing or replacing challenging structures like trachea or bronchi. The effects of air pressure and nozzle diameter on cel...
Researchers found that type II lung epithelial cells differentiated into mesenchymal cells instead of type I cells when seeded onto decellularized lung matrix. This study highlights the importance of factors like cell populations, growth medium, and stimuli in achieving physiologically appropriate environments for lung tissue growth.
Researchers found that certain electronic cigarette flavors can alter important cellular functions in lung tissue, including changes in cell viability, proliferation, and calcium signaling. Flavors such as Hot Cinnamon Candies, Banana Pudding (Southern Style), and Menthol Tobacco were shown to be toxic to cells at higher doses.
A study reveals that an unfavorable bacterial network configuration in the gut can cause inflammation similar to Crohn's disease. Researchers found that transplanting 'healthy' bacteria into patients' intestines may provide a conventional treatment option.
Researchers from MDC have discovered a novel molecular signaling pathway in the kidney that regulates epithelial barrier function and lumen expansion. The Grhl2 transcription factor teams up with Ovol2 to control genes essential for forming an impermeable barrier.