Articles tagged with Epithelial Cells
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Researchers have identified a protein complex regulating epithelial cell connections, shedding light on cancer proliferation. This discovery has implications for understanding diseases like asthma and inflammatory bowel disease, as well as developing targeted therapies for cancer.
Researchers have identified key factors behind the decline of thymus function with age, which affects T cell production. The findings provide a new target for developing treatments to combat infections and cancers in older adults.
A new high-performance computing-driven model of the gut predicts emerging behaviors and responses to biological threats, simulating cell phenotype changes, signaling pathways, and immune responses. The model identifies key factors that delineate the outcome of infection, including epithelial cells, macrophages, and dendritic cells.
Researchers have developed an 'anaerobic Intestine Chip' that stably maintains a complex human microbiome and provides a protective physiological barrier. This breakthrough technology allows for direct investigations of health and disease-related human-microbiome interactions under low oxygen conditions.
Using CRISPR gene editing, researchers have successfully treated lethal lung diseases in mice by introducing genetic changes during fetal development. The study shows promise for developing new therapies for congenital lung diseases, such as surfactant protein deficiency and cystic fibrosis.
Researchers used CRISPR to edit genes in mice, targeting cells that line the airways of the lungs. The study demonstrated promising results for developing new therapies for congenital lung diseases such as cystic fibrosis and surfactant protein deficiency.
Researchers from Kanazawa University discovered that genes turned on in response to inflammation are a major cause of gastric cancer. The study found that NOXO1, a component of the NOX1 complex, produces tissue-damaging molecules called reactive oxygen species, leading to mutations in stomach cells and tumor formation.
Researchers have developed a new therapeutic strategy that targets the MLCK1 enzyme to restore epithelial barrier function and prevent gastrointestinal disease. By preserving and restoring the gut's critical lining of cells, this approach may help break the cycle of inflammation driving chronic diseases.
Researchers found that ZEB1 forces KRAS-driven lung cancer cells to switch from stable to mobile, resistant mesenchymal cells, making them less responsive to MEK inhibitors. A combination of an HDAC inhibitor and a MEK inhibitor reversed this transition and restored vulnerability to targeted therapy.
Researchers have developed a new live-imaging technique that detects short-lived leaks in epithelial tissues and reveals an active repair mechanism involving the protein Rho. This discovery could provide insights into diseases targeting the epithelial barrier, such as those caused by microbes, allergens, and cancers.
A new study published in ERJ Open Research directly compares new heated tobacco devices with vaping and traditional cigarettes, showing that all three are toxic to human lung cells. The study's findings suggest that these newer electronic nicotine delivery devices may not be a safer substitute for cigarette smoking.
Two common e-cigarette chemical flavorings, diacetyl and 2,3-pentanedione, have been linked to impaired lung function by altering gene expression related to cilia production. This study suggests that even low levels of these chemicals can be hazardous, highlighting the need for stricter safety standards.
A metabolite from pomegranate diet, Urolithin A, and its synthetic analog mitigate IBD by increasing proteins that tighten epithelial cell junctions in the gut. These compounds reduce inflammation and restore gut barrier integrity.
Researchers discovered that Clostridium difficile toxins induce apoptosis in intestinal epithelial cells, providing a defense mechanism against the pathogen. The findings suggest that this cell death response protects the host from C. difficile infection, raising potential for therapeutic strategies to target gastrointestinal pathogens.
Researchers found that sharks' tooth-like skin follows a similar patterning mechanism to bird feathers, using the reaction-diffusion model to explain its development. This discovery suggests a shared developmental pathway across vertebrates, with implications for our understanding of evolution and animal diversity.
A study using single-cell transcriptomics reveals the cellular and functional changes underlying type 2-high asthma, which can lead to more severe disease. The research provides new insights into how airway epithelial cells produce mucus and could inform the development of targeted treatments for asthma and other airway diseases.
Researchers at OIST Graduate University have discovered a molecular 'tuning mechanism' that helps control eye lens development in zebrafish. By studying the impact of a mutated gene, they found that a signaling pathway called TGF-ß became enhanced, leading to abnormal lens development.
Researchers at Stanford University have found a unique way that animal cells stay intact in the marine organism Trichoplax adhaerens (Tplax), using fast contractions in its epithelial layers. This discovery could inform our understanding of complex animals and the creation of advanced materials.
Exposure to energetic heavy ions from deep space radiation impairs intestinal epithelial cell migration and triggers senescent signaling. This effect persists for at least a year after exposure, suggesting potential adverse impacts on astronaut GI function and health.
A study using Drosophila has demonstrated that chromosomal instability promotes invasive behavior in epithelial cells, activating key signaling pathways. The researchers identified the oncogene Fos and tumour suppressor Capicua as crucial players in this process, paving the way for future treatments.
A new study by Monell Center scientists has identified a mysterious sensory cell called microvillous cells (MVCs) that protect the vulnerable olfactory epithelium from viruses and bacteria. These cells may represent potential therapeutic targets to maintain a healthy sense of smell.
Dr. Lan Zhou's research focuses on the impact of gut microbiome imbalance, immune response, and genetics on colorectal cancer development through the serrated pathway. Her team will use mouse models and human tissue to study carcinogenic transformation and inflammation-related pathways.
Researchers created a 3D lung cell model system to investigate how carbon-based combustion byproducts interact with human epithelial tissue. The study found that charged particles tend to stick together before penetrating the gas-exchange barrier, while neutrally charged nanodots pass through the tissue more easily.
Researchers found that juvenile pigs' mucosal environment can stimulate repair of intestinal injuries in newborn piglets. The study aims to understand why humans and other young animals have trouble repairing these injuries, with potential implications for treatments.
Researchers at MIT and Brigham and Women's Hospital discovered a novel mechanism for chronic rhinosinusitis, which involves distinct gene-expression patterns in epithelial cells. The study suggests that basal cells from patients with nasal polyps retain a memory of IL-4 and IL-13, immune response cytokines driving allergic inflammation.
Investigators from Brigham and Women's Hospital used massively-parallel, single-cell RNA sequencing to analyze nasal polyp samples and identify dramatically altered cells. The team found that epithelial progenitor cells had been permanently altered and expressed an aberrant program, pointing to many pathways that have been altered in t...
Researchers discover epithelial cells can adopt a new geometric shape called scutoid, allowing tissues to curve and form complex organs. This finding has significant implications for understanding organ development and potentially treating diseases related to altered tissue curvature.
A team of scientists has uncovered a previously undescribed geometric shape, the scutoid, adopted by epithelial cells during embryonic development. This discovery could lead to advancements in tissue engineering by understanding the three-dimensional organization of epithelial organs.
A study by Johns Hopkins Bloomberg School of Public Health suggests that males recover more quickly from influenza infections because they produce more of the key lung-healing protein, amphiregulin. The research found that females have slower tissue-repair during recovery due to relatively low production of amphiregulin.
A new study reveals that rapid cell division powers the growth of the small intestine, a critical discovery for understanding congenital short bowel syndrome. Researchers witnessed an intricate cellular dance, where cells must navigate to maintain proper length and prevent deadly conditions.
Researchers discovered that the tumor suppressor protein ARID1A controls global transcription in ovarian epithelial cells, regulating a large set of genes. Its loss causes dysregulation of important cell functions, including DNA repair and cell proliferation.
Researchers reveal how oncogenic mutant cells selectively occupy space in tissues without cell division. They found that after the death of normal cells, oncogenic mutant cells expanded through rearrangement of the honeycomb packing pattern.
The human intestine constantly regenerates itself, with 10 billion epithelial cells replaced each day. Researchers have identified the stem-cell niche responsible for providing the activating signal to these stem cells, called Gli1-positive cells surrounding crypts.
A team led by Prof. Stein Aerts uncovers how access to relevant DNA regions is orchestrated in epithelial cells, shedding light on biological mechanisms of gene regulation and potential new avenues for cellular reprogramming. Grainyhead, a pioneer factor, acts as a key that can be used to access specific DNA regions.
The study reveals the discovery of three new distinct epithelial cell populations, including L1- and L2-type luminal cells, which can aid in understanding the origins of breast cancer. The researchers used single-cell mRNA sequencing to create a high-resolution molecular census of human breast epithelial cells.
Researchers have developed an in vitro model of urethral mucosa to visualize the HIV transmission process. The study reveals that infected T cells target epithelial cells above macrophages, leading to viral production and shedding via transcytosis. Macrophages then capture and store the virus, posing a challenge for treatment efforts.
Researchers identified age-related differences in breast tissue that contribute to increased risk of developing breast cancer in older women. The study found that accumulation of multipotent progenitor cells leads to defective luminal cells, which may be related to the increased susceptibility to breast cancer with age.
Researchers have identified tuft cells as the primary target of norovirus infection, a discovery that could pave the way for new treatments. The study found that administering immune signaling proteins IL-4 and IL-25 increased viral transmission and abundance in mice.
Researchers found that cell shapes play a key role in jamming and unjamming, driving biological events like embryonic development and wound healing. This insight could lead to potential treatments for conditions like asthma and cancer.
Research investigates the link between chronic periodontitis and age-related macular degeneration, finding a common oral pathobiont, Porphyromonas gingivalis, that can invade human retinal-pigment epithelial cells. The study reveals significant molecular links between CP and AMD.
Researchers have developed a human intestinal lining that mirrors living tissue when placed inside microengineered Intestine-Chips. This breakthrough enables personalized testing of drug treatments for debilitating gastrointestinal diseases such as Crohn's disease and ulcerative colitis.
Researchers created an organ-on-a-chip model of the human gut to mimic radiation damage and tested a potential radioprotective drug, DMOG. The study found that DMOG significantly reduced cell damage, apoptosis, and intestinal permeability in both epithelial and endothelial cells.
Researchers discovered that intestinal stem cells, previously thought to be essential only for normal turnover, play a crucial role in repairing epithelial cell damage caused by rotavirus. The study also found that WNT signaling molecules from epithelial cells are essential for triggering the repair response.
A team of scientists developed a novel platform to study lumen formation in epithelial tubes, which can lead to diseases like atherosclerosis and kidney failure. The 3D microtube setup allows cells to form tubes under different physical constraints, revealing the importance of mechanical forces in tissue development.
Researchers found that primary cilia on cells of the retinal pigment epithelium are crucial for the survival of photoreceptors. The discovery has advanced efforts to create stem cell-derived RPE cells for transplantation into patients with geographic atrophy, a leading cause of blindness in the US.
Scientists have obtained detailed snapshots of the structure of a membrane pore that enables epithelial cells to absorb calcium. This finding could accelerate the development of drugs to correct abnormalities in calcium uptake, which are linked to various types of cancer.
A study published in Journal of Cell Biology identifies SUV420H2 as an epigenetic orchestrator of pancreatic cancer cells' aggressive behavior. Reducing SUV420H2 levels makes pancreatic cancer cells more vulnerable to existing therapies.
The study reveals that protein ZO-1 perceives mechanical signals and activates cellular responses accordingly, influencing epithelial cell proliferation and differentiation. Targeted inhibition of ZO-1 in tumors could be a potential pathway to explore for cancer treatment.
A LSU Health New Orleans study found that DHA in fish oil 'preconditions' photoreceptor and RPE cells to survive future insults, reducing the risk of retinal degeneration. The researchers also discovered that daily omega-3 supplementation may provide an opportunity for halting debilitating eye diseases.
Scientists studied how intestinal epithelial stem cells respond to varying glucose levels, discovering a switch from renewal to growth mode triggered by higher glucose. This finding has implications for understanding cancer cell proliferation and developing new therapeutic strategies.
A team of researchers at Massachusetts General Hospital has successfully created functional small intestine segments using human induced pluripotent stem cells. The segments were able to absorb nutrients and transfer glucose and fatty acids into the bloodstream when transplanted into rats. This breakthrough could potentially provide a ...
Scientists have developed a way to generate and correct specific lung cells using pluripotent stem cells, which could lead to new therapies for conditions like neonatal respiratory distress and COPD. The corrected cells were able to produce essential surfactant, previously an elusive milestone.
A study found that macrophages can produce Interleukin-10 (IL-10), a healing factor, which promotes wound repair in the intestine. This discovery could lead to new treatments for inflammatory bowel disease (IBD). The researchers used a colonoscope with biopsy forceps to create a wound in mice and observed its healing process.
A Penn State researcher has received a $7.3 million grant to investigate the Ah receptor's impact on immune function and epithelial barrier integrity. The study aims to understand how activating the receptor enhances or disrupts the immune response in different tissues, with potential implications for diseases such as colon cancer.
Epithelial tumours can grow independently of their microenvironment, driven by a feedback amplification loop that activates the JNK stress signalling pathway. This internal mechanism triggers proliferation in non-proliferating cells, leading to chromosomal instability and loss of epithelial polarity.
Researchers discovered mesenchymal cells drive lung cell formation through molecular interactions, guiding the production of alveolar and airway cells. This finding offers new avenues for treating lung disorders like asthma and emphysema.
Researchers at UMass Amherst have found that layered black phosphorous (BP) nanoparticle toxicity is dependent on particle size and concentration. The study reveals that BP's cytotoxicity is based on reactive oxygen species generation, disrupting cell membrane integrity in a particle-size-dependent manner.
A team of researchers has discovered a network of genes and genetic regulatory elements in the lining of the intestines that remains remarkably consistent across 420 million years of evolution. This conserved genetic signature is linked to various human diseases, including inflammatory bowel diseases, diabetes, and obesity.
Researchers at LSU Health Sciences Center have discovered a new class of biochemical triggers called elovanoids, which are derived from omega-3 fatty acids. These molecules play a significant role in protecting retinal pigment epithelial and photoreceptor cells from damage.
Researchers discovered that endothelial cells lining blood vessels are not as effective at removing invading bacteria via xenophagy, a process used by epithelial cells. The study suggests that targeting the ubiquitination pathway could lead to new approaches for fighting infections like GAS.