Articles tagged with Epithelial Cells
Researchers discover that senescence-associated secretory phenotype (SASP) can induce neuroendocrine transdifferentiation (NED) in breast cancer epithelial cells, promoting tumor progression and aging-related features. SASP's dual role in cancer involves both antitumoral and tumorigenic effects.
The study, led by Professor Takashi Miura of Kyushu University, has discovered that interdigitated cell boundaries have a mathematically scaling pattern with self-similarity. The team used the Edwards-Wilkinson model to simulate and understand the molecular mechanism responsible for these dynamics.
Researchers generated a POLDIP2 knockout ARPE-19 cell line and found reduced mitochondrial superoxide levels, consistent with upregulated SOD2. The study demonstrates a potential role of POLDIP2 in regulating oxidative stress in AMD.
A UC Riverside-led study found that reduced PTPN2 activity in intestinal epithelial cells leads to decreased Paneth cell antimicrobial peptide production, disrupting the gut microbiota and increasing E. coli. This loss can serve as a marker of IBD disease.
Researchers have discovered that fungal spores can exploit the human protein p11 to hijack lung cells and prevent them from destroying the fungus. This finding offers a promising new target for treatment against Aspergillus fumigatus infections, which affect over 300,000 people worldwide each year.
A new study from the Keck School of Medicine of USC found that vaping and smoking both cause significant DNA damage in oral epithelial cells. The frequency and duration of vaping were associated with increased levels of DNA damage, which is linked to chronic diseases such as cancer and inflammatory conditions.
A research team led by Professor Kwang-Hyun Cho at KAIST has developed a fundamental technology to revert metastatic lung cancer cells to a non-metastatic state. This breakthrough could lead to the elimination of drug resistance and metastatic potential in cancer cells, while increasing their responsiveness to chemotherapy.
A new study published in The American Journal of Pathology suggests that promoting autophagy with rapamycin restores intestinal barrier function during sepsis. The study also identifies the PLK1-mTOR axis as a crucial regulator of autophagy and intestinal barrier dysfunction, providing novel insights for treatment of sepsis.
Researchers at UNIGE and FMI successfully modified the structure and function of tentacle cells in hydra by reducing Zic4 expression, resulting in transdifferentiation into foot cells. The study provides new insights into transdifferentiation mechanisms and could pave the way for therapies to regenerate deficient cell types in humans.
Researchers characterized prostate cancer cell dynamics at single-cell resolution, revealing an expansion of intermediate cells that correlates with treatment resistance and poor clinical outcomes. A 5-gene signature associated with treatment resistance was also discovered.
A new study reveals that HOXA5 binds to protein IκB-α, boosting its cancer-suppressing properties and reducing the development of breast cancers. The presence of HOXA5 suppresses malignancy in breast epithelial cells by blunting NF-κB action.
Researchers found that the Eya protein regulates cell contact behavior, allowing for self-organization of epithelial cells with nurse cells. This mechanism enables complex development processes, including egg chamber formation and sperm cell development, in Drosophila.
Researchers have used single-cell sequencing to uncover novel gene expression patterns in injured kidney cells, providing new avenues for biomarker discovery and treatment. The studies reveal that epithelial cells of all tubule segments are involved in the injury processes, with distinct molecular patterns across patients.
A new preclinical model of thymic cancer reveals how a common mutation sparks tumor formation and identifies potential targets for therapy. The model, developed by Weill Cornell Medicine researchers, shares molecular characteristics with human thymic tumors, paving the way for new treatments.
A study by Kumamoto University researchers found that a defective isoform of the SIGIRR gene activates an inflammatory pathway associated with cystic fibrosis. This defect leads to decreased expression and function of anti-inflammatory molecules, resulting in severe inflammation.
Scientists have identified a critical source of essential molecules that enables the intestine's self-renewal and regeneration after injury. The study reveals that lymphatic endothelial cells play a key role in maintaining stem cell activity and tissues in the intestine.
Researchers found that ancestral SARS-CoV-2 replicates less efficiently in pediatric nasal epithelial cells, with a heightened antiviral response. This protection is not observed with the Omicron variant, highlighting the need for further study on emerging variants.
Scientists at La Jolla Institute for Immunology discover how gut barrier cells send secret messages to patrolling T cells, keeping them alive and active. The study sheds light on conditions like inflammatory bowel disease and highlights the importance of HVEM protein in maintaining a healthy gut microbiome.
A UC Berkeley-led study identified specific human lung proteins that can promote or protect against SARS-CoV-2 infections. Researchers found that mucins, a key component of mucus in the lungs, help block the virus from entering cells, while other mucins may even promote infection.
A team of scientists discovered a mathematical principle explaining how cells connect to form tissues and organs, shedding light on embryonic development and organ formation. The study found that epithelial cells can adopt complex three-dimensional shapes like scutoids, which determine cellular connectivity and tissue properties.
An international team of scientists has discovered a new mathematical principle that explains how cells connect with each other to form tissues. The finding reveals important properties of cellular connectivity, including the relationship between cell geometry and energy consumption.
A UC Riverside study reports that switching from combustible cigarettes to electronic cigarettes does not restore the nasal epithelium to that of a non-smoker. The researchers found alterations in gene expression profiles associated with cigarette smokers, indicating potential harm from prolonged EC use.
Researchers at Osaka University identified Src as a key molecule in the process of epithelial cells becoming invasive and cancerous. The study found that CDCP1 forms a molecular scaffold that activates Src, promoting cancer cell invasion.
A study by Charité researchers found that SARS-CoV-2 causes limited direct tissue damage, instead triggering an inflammatory response through alveolar macrophages. This suggests that most cases of SARS-CoV-2 infection show relatively moderate disease severity.
A recent review article highlights the crucial role of macrophages in the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). The study suggests that targeting specific signaling pathways and altering macrophage activation can prevent renal fibrosis and CKD. Therapeutic strategies such as clodronate liposomes an...
In a mouse model, stromal cells developed before weaning age promote the maturation of the intestinal barrier by forming a specialized niche. Absence of these cells induces defect in postnatal growth and increases susceptibility to intestinal inflammatory diseases.
A new study found that microgravity analog culture profoundly affects the microbial infection process in 3-D human tissue models. This is critical for ensuring astronaut health on extended space missions and sheds light on mysterious processes of infection on Earth.
Researchers found that severe asthma patients produce growth factors that block corticosteroids from working, leading to frequent breathing problems. This discovery may lead to new treatments targeting these growth factors to improve outcomes for patients with severe asthma.
Researchers discovered that hydrating the surface of airways in people with cystic fibrosis restores their protective barrier against bacterial infections. This breakthrough opens the way to new therapies based on mucus hydration, offering a promising alternative to current treatments.
Researchers found microbes influence which genes are used for fat digestion and absorption, leading to changes in epithelial cells. The study also showed microbes promote lipid absorption and impact systemic processes like weight gain.
Researchers found that hypoxia can activate immune cells called ILC2s, which respond to harmless environmental allergens and drive mucus production and inflammation in the lungs. The study identifies adrenomedullin as a new target for treating inflammatory and allergic lung diseases.
Researchers found phosphatidylinositol bisphosphate (PIP2) essential for epithelial cell-cell adhesion and maintaining cellular identity. PIP2 regulates epithelial properties by recruiting Par3 to the plasma membrane, facilitating the formation of adherens junctions and preventing epithelial-mesenchymal transformation.
A molecular switch, p57, enables stomach stem cells to change allegiance from normal digestion to injury response, potentially leading to new treatments for gastric pathologies. The study's findings suggest that p57 is a key regulator of reserve stem cell state in gastric chief cells.
Researchers at the Lewis Katz School of Medicine defined 11 subsets of cells found in esophageal tissue using single cell gene-expression profiling. This study could help clinicians diagnose or treat certain types of cancer by identifying functional cell types contributing to cancer progression.
A study led by the University of Minnesota Medical School found that exposure to helminths can stimulate the immune system and reduce predisposition for inflammatory bowel disease. The research revealed a unique glycosylation mechanism, O-GlcNAcylation, which activates epithelial cells to orchestrate an anti-helminth response.
Scientists have constructed a detailed map of lung development after birth, providing insights into the genetic and epigenetic factors that affect lung health. The study used next-generation single-cell sequencing technologies to analyze over 80,000 human and mouse lung cells, revealing clues on how cell types communicate and develop.
Researchers create detailed 'atlas' of fallopian tube cells to better understand fertility and disease. The study identifies 10 epithelial cell subtypes and reveals new insights into ovarian cancer origins.
A National Jewish Health-led study found that over a third of identified genetic risk factors for asthma are associated with altered function of airway epithelium. The research discovered genetic changes in genes related to mucus production and type 2 inflammatory pathways, increasing asthma risk.
Researchers sequenced genes expressed in individual single cells from human GI tracts, revealing new cell-type characteristics and gaining insights into important cell functions. The study opens the door to exploring gut health in a more precise manner at greater resolution than ever before.
A new study suggests that incomplete lung cell repair may contribute to the development of chronic fibrotic lung disease in COVID-19 and non-COVID patients. The research proposes novel therapies to promote healthy regeneration and prevent scarring.
Scientists from Tokyo Medical and Dental University have developed a protocol to transplant 3D cellular structures called organoids into the colon to repair damaged intestinal tissue. This approach shows promise as a quick, reproducible, and minimally invasive method for treating ulcerative colitis.
Researchers have discovered that p53 protein activates a molecular program turning damaged cells into migratory leader cells for quick epithelial repair. Once repaired, these highly migratory cells are eliminated to restore normal epithelial tissue structure.
A University of Illinois study discovered that cadherin proteins can sense mechanical stress and alter cell communication, promoting tissue growth and tumorigenesis. The findings suggest a potential mechanism for preventing certain types of tissue growth by mutating cadherin molecules.
A team led by Case Western Reserve University discovered the novel repair properties of Gasdermin B protein, promoting restoration of epithelial layers and effective wound-healing. The findings have significant implications for designing therapeutics to enhance wound repair in various organs.
A combined treatment strategy targeting SARS-CoV-2 symptoms and severe lung tissue injury is essential to minimize lung sequelae. Researchers are exploring therapy using lung epithelial stem and progenitor cells to mitigate virus-induced inflammatory storm and promote tissue regeneration efficiently.
Researchers at TIFR Hyderabad discover that soft ECM allows Filamin to push out precancerous cells, while stiff ECM enables their growth. This study sheds light on the link between ECM stiffness and increased cancer incidence.
Researchers at the University of Louisville School of Dentistry found that oral bacteria like Porphyromonas gingivalis can suppress the production and effectiveness of proteins that protect humans from viral infection. This suppression increases vulnerability to infection, allowing viruses to enter the body more easily.
Scientists from Tokyo Medical and Dental University create polyrotaxane-based biomaterials that improve epithelial cell-cell adhesion, enabling the repair of damaged tissues. The study suggests a potential application in clinical dentistry for treating periodontal disease.
Researchers have identified a novel immune-like mechanism by which healthy epithelial cells recognize and eliminate precancerous cells through a MHC class I-LILRB3 interaction. This process generates mechanical force to extrude the precancerous cells from the body, offering new hope for cancer prevention and treatment.
A study led by LSU Health found how late-onset retinal degeneration develops and identified a surprising potential therapeutic, metformin. The research suggests that an enzyme called AMPK activates the protein CTRP5 to regulate fatty acid metabolism and energy stability.
Researchers used imaging mass cytometry to analyze protein expression and cell location in tumor samples. High density of antigen-presenting cells with high PD-L1 and IDO expression was associated with higher pathological complete response rate in patients treated with atezolizumab plus chemotherapy.
Researchers find SARS-CoV-2 infects sustentacular cells in the olfactory epithelium of COVID-19 patients, replicating vigorously within these cells. The virus does not appear to infect nerve cells, instead affecting sensory neurons indirectly through insufficient support from sustentacular cells.
Researchers identified specific mesenchymal stromal cells within the bronchovascular bundle of lungs that play a crucial role in creating scarring through interaction with epithelial cells. These cells are thought to be triggered by immune cell attacks, leading to fibrotic scarring and rejection.
A new study provides evidence supporting the involvement of aquaporins in corneal cell proliferation and nerve regeneration, suggesting AQP5 induction as a potential therapy to accelerate corneal defect resurfacing. The study found that AQP5 deficiency can slow down corneal epithelial repair, but its specific mechanism remained unclear.
A clinical trial conducted by TTUHSC researchers found that corneal epithelial stem cell-derived eye drops significantly improved symptoms of severe dry eye disease, with patients experiencing a 23% improvement in SPEED questionnaire scores and a 17.1% improvement in OSDI scores. No adverse reactions were reported during the 12-week tr...
Researchers at the University of São Paulo found that a hypertonic saline solution can inhibit SARS-CoV-2 replication by up to 88% in human epithelial lung cells. The study suggests that the use of such a solution could contribute to the development of novel prophylactic interventions or treatments for COVID-19.
Researchers link repeated injury to airway stem cells with chronic lung disease, suggesting that biological aging of these cells may contribute to the development of this condition. The study found that injury caused activation of a subset of stem cells, leading to their premature aging and loss of functional capacity.
Researchers at Osaka University found that E-NTPD8 regulates luminal ATP levels, which affects immune cells and promotes inflammation in colitis. Depletion of neutrophils improved symptoms, highlighting the enzyme's role in preventing severe colitis.
A UC Riverside-led study identifies how loss-of-function mutations in the gene PTPN2 affect intestinal epithelial cells' ability to maintain a barrier. The researchers found that increased fluid loss and diarrhea are linked to the mutation, which can be reversed by treating cells with synthetic matriptase.
A high-fat diet causes inflammation and damages intestinal epithelial cells, leading to the growth of harmful microbes and increased production of trimethylamine-N-oxide, a metabolite associated with cardiovascular disease. Researchers found that restoring intestinal function with a drug can blunt this effect.